Motif ID: NR1H4.p2

Z-value: 0.949


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NR1H4chr12_+_1008675500.213.1e-01Click!


Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_45274153 3.025 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr1_+_84647342 2.559 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_53442732 2.265 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr4_-_186697065 2.214 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr19_+_1026608 1.551 CNN2
calponin 2
chr21_-_27945267 1.532 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr1_+_65210724 1.480 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr1_+_33231260 1.478 KIAA1522
KIAA1522
chr1_+_32042122 1.466 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_32042125 1.455 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_32042085 1.453 NM_001204414
NM_022164
TINAGL1

tubulointerstitial nephritis antigen-like 1

chr4_+_41614725 1.447 LIMCH1
LIM and calponin homology domains 1
chr18_+_8717368 1.337 NM_015210
CCDC165
coiled-coil domain containing 165
chr1_+_162351519 1.225 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr3_-_149051258 1.223 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr17_+_40913211 1.214 NM_005854
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr13_+_32605436 1.206 NM_023037
FRY
furry homolog (Drosophila)
chr7_+_63773185 1.193 NM_001170905
ZNF736
zinc finger protein 736
chr19_+_1026627 1.156 CNN2
calponin 2
chr4_-_16900348 1.155 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr11_-_71746966 1.155


chr1_+_33231227 1.127 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr5_+_140579182 1.094 NM_018931
PCDHB11
protocadherin beta 11
chr14_-_100772774 1.089 NM_001039355
SLC25A29
solute carrier family 25, member 29
chr20_-_62462568 1.063 ZBTB46
zinc finger and BTB domain containing 46
chr19_+_1026271 1.035 NM_004368
NM_201277
CNN2

calponin 2

chr2_-_110874142 1.022 NM_005434
MALL
mal, T-cell differentiation protein-like
chr16_-_4562979 1.005 C16orf5
chromosome 16 open reading frame 5
chr5_+_61874561 0.961 NM_181506
LRRC70
leucine rich repeat containing 70
chrX_+_69454504 0.935 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr5_+_159656436 0.927 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr10_+_94594469 0.925 NM_001013848
EXOC6
exocyst complex component 6
chr3_+_52489646 0.918 NISCH
nischarin
chr1_+_32757702 0.907 HDAC1
histone deacetylase 1
chr11_-_6341708 0.878 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr1_+_32757707 0.876 NM_004964
HDAC1
histone deacetylase 1
chrX_+_152240726 0.876 NM_001170944
NM_001242319
NM_032882
PNMA6C
PNMA6D
PNMA6A
paraneoplastic antigen like 6C
paraneoplastic antigen like 6D
paraneoplastic antigen like 6A
chr22_+_19705891 0.866 NM_001009939
SEPT5
septin 5
chr7_-_21985421 0.847 NM_001127370
NM_001127371
NM_018719
CDCA7L


cell division cycle associated 7-like


chr3_+_52489503 0.844 NM_007184
NISCH
nischarin
chr14_+_100531745 0.841 NM_016337
EVL
Enah/Vasp-like
chr3_+_132036210 0.835 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr1_+_32757711 0.834 HDAC1
histone deacetylase 1
chr3_+_52489617 0.831 NISCH
nischarin
chr1_-_225616556 0.827 NM_194442
LBR
lamin B receptor
chr12_-_27167332 0.823 NM_016551
TM7SF3
transmembrane 7 superfamily member 3
chr17_+_34136437 0.819 NM_003487
NM_139215
TAF15

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa

chr1_-_209979388 0.784 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr11_+_10879763 0.783 LOC729013
uncharacterized LOC729013
chr22_+_29702950 0.780 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr1_-_76076762 0.776 NM_001130058
NM_152697
SLC44A5

solute carrier family 44, member 5

chr12_-_46121489 0.754 LOC400027
uncharacterized LOC400027
chr22_+_19705990 0.726 SEPT5-GP1BB
SEPT5-GP1BB readthrough
chr12_-_27167033 0.720 TM7SF3
transmembrane 7 superfamily member 3
chr3_-_57113292 0.716 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr11_+_67250504 0.682 NM_003977
AIP
aryl hydrocarbon receptor interacting protein
chr9_+_127054567 0.679 NM_001166169
NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr1_+_26872342 0.675 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr7_-_30029904 0.655 NM_001145514
SCRN1
secernin 1
chr11_-_71781091 0.651 NUMA1
nuclear mitotic apparatus protein 1
chr1_+_86046434 0.650 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr11_+_114167197 0.643 NNMT
nicotinamide N-methyltransferase
chr16_-_70557430 0.643 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr3_+_46448678 0.638 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr1_+_26872306 0.634 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_+_50706868 0.628 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr19_-_58864820 0.626 NM_130786
A1BG
alpha-1-B glycoprotein
chr11_+_114167168 0.624 NNMT
nicotinamide N-methyltransferase
chr10_-_75634219 0.623 NM_001204492
NM_001222
NM_172169
NM_172170
NM_172171
NM_172173
CAMK2G





calcium/calmodulin-dependent protein kinase II gamma





chr10_-_105212149 0.621 NM_015916
CALHM2
calcium homeostasis modulator 2
chrX_+_149613719 0.619 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr16_-_67217825 0.615 NM_001040715
KIAA0895L
KIAA0895-like
chrX_-_118827116 0.594 SEPT6
septin 6
chr5_+_68800003 0.594 NM_001205255
OCLN
occludin
chr1_+_109102970 0.592 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr3_+_193853937 0.589 HES1
hairy and enhancer of split 1, (Drosophila)
chr11_+_7535213 0.586 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr12_-_71003622 0.581 NM_001206971
NM_001206972
NM_002837
PTPRB


protein tyrosine phosphatase, receptor type, B


chrX_+_7137471 0.581 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr21_+_18885104 0.578 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr3_+_52828783 0.578 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr12_+_12878718 0.576 NM_001130415
APOLD1
apolipoprotein L domain containing 1
chr6_+_96025343 0.571 NM_024641
MANEA
mannosidase, endo-alpha
chr18_-_46469118 0.568 NM_001190823
SMAD7
SMAD family member 7
chr11_-_6676851 0.567 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr19_-_4559713 0.560 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr6_-_13408368 0.560 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr14_-_25103365 0.558 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr2_+_219646448 0.558 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr7_+_94139331 0.554 CASD1
CAS1 domain containing 1
chr17_-_40306988 0.552 RAB5C
RAB5C, member RAS oncogene family
chr3_-_128294928 0.548 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr2_+_109237679 0.547 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr9_-_16727887 0.545 BNC2
basonuclin 2
chr3_-_132378492 0.542 NM_032169
ACAD11
acyl-CoA dehydrogenase family, member 11
chr2_+_177016112 0.541 NM_014621
HOXD4
homeobox D4
chr3_-_160117314 0.527 NM_001190241
NM_020800
IFT80

intraflagellar transport 80 homolog (Chlamydomonas)

chr14_-_38725253 0.516 CLEC14A
C-type lectin domain family 14, member A
chr16_-_24942662 0.515 ARHGAP17
Rho GTPase activating protein 17
chr3_+_190105660 0.515 NM_006580
CLDN16
claudin 16
chr10_-_21814610 0.511 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr19_-_51875790 0.506 NM_005601
NKG7
natural killer cell group 7 sequence
chr16_+_81478774 0.505 NM_198390
CMIP
c-Maf inducing protein
chr2_+_177016337 0.503


chr20_+_30598244 0.501 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr14_-_75078669 0.498 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr3_-_49851217 0.494 UBA7
ubiquitin-like modifier activating enzyme 7
chr22_+_21321446 0.490 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr6_+_127587984 0.487 RNF146
ring finger protein 146
chr21_+_18885296 0.487 CXADR
coxsackie virus and adenovirus receptor
chr17_-_47841517 0.486 NM_030802
FAM117A
family with sequence similarity 117, member A
chr10_+_35464514 0.484 NM_182769
NM_182770
CREM

cAMP responsive element modulator

chr19_-_1020995 0.482 C19orf6
chromosome 19 open reading frame 6
chr11_-_46717657 0.481 ARHGAP1
Rho GTPase activating protein 1
chr19_-_39826625 0.479 GMFG
glia maturation factor, gamma
chr3_-_28390280 0.478 AZI2
5-azacytidine induced 2
chr14_-_34931413 0.477 NM_138288
SPTSSA
serine palmitoyltransferase, small subunit A
chr11_-_68518910 0.477 MTL5
metallothionein-like 5, testis-specific (tesmin)
chr4_+_41614911 0.477 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr7_+_30951414 0.474 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr11_+_67250595 0.469 AIP
aryl hydrocarbon receptor interacting protein
chr6_+_127587826 0.469 NM_001242851
NM_001242844
NM_001242849
NM_001242852
NM_001242845
NM_001242846
NM_001242850
NM_030963
RNF146







ring finger protein 146







chrX_-_118827322 0.466 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chrX_-_153640358 0.466 NM_001009932
NM_001009933
NM_001009934
DNASE1L1


deoxyribonuclease I-like 1


chr3_+_50654868 0.465 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr3_-_105421044 0.463 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr11_-_119076888 0.462 CCDC153
coiled-coil domain containing 153
chr11_-_64377332 0.462


chr18_+_42260774 0.457 NM_015559
SETBP1
SET binding protein 1
chr2_-_191878924 0.457 NM_007315
NM_139266
STAT1

signal transducer and activator of transcription 1, 91kDa

chr17_+_7812703 0.455 CHD3
chromodomain helicase DNA binding protein 3
chr19_-_3969734 0.454 NM_001348
DAPK3
death-associated protein kinase 3
chr1_-_47695442 0.453 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr20_-_29993955 0.450 NM_001011878
DEFB121
defensin, beta 121
chr12_-_25055966 0.449 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr5_+_36152221 0.444 SKP2
S-phase kinase-associated protein 2 (p45)
chr11_+_60552820 0.439 NM_206893
MS4A10
membrane-spanning 4-domains, subfamily A, member 10
chr11_+_72983246 0.437 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_-_221910801 0.437 NM_144728
DUSP10
dual specificity phosphatase 10
chr6_+_108616059 0.436 NM_145315
LACE1
lactation elevated 1
chr5_+_79783799 0.436 NM_205548
FAM151B
family with sequence similarity 151, member B
chr20_-_35488275 0.432 NM_199181
KIAA0889
KIAA0889
chrX_-_45060081 0.428 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr5_+_36152142 0.426 NM_001243120
NM_005983
NM_032637
SKP2


S-phase kinase-associated protein 2 (p45)


chr3_-_187452669 0.426 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr7_+_155089614 0.421 INSIG1
insulin induced gene 1
chr17_+_1665233 0.421 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chrX_-_118827155 0.416 SEPT6
septin 6
chr10_-_95360959 0.415 NM_006744
RBP4
retinol binding protein 4, plasma
chr19_+_7741934 0.409 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr17_-_3704437 0.408 ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr1_+_6615337 0.406 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chrX_-_112066353 0.403 NM_001113490
AMOT
angiomotin
chr4_+_41614933 0.400 LIMCH1
LIM and calponin homology domains 1
chr17_+_1665281 0.400 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_106111114 0.398 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr14_-_38725539 0.394 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr11_-_118123001 0.392 NM_198275
MPZL3
myelin protein zero-like 3
chr11_+_63581031 0.389 C11orf84
chromosome 11 open reading frame 84
chr20_-_45927496 0.387 ZMYND8
zinc finger, MYND-type containing 8
chr14_-_23426265 0.387 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chr17_+_1665342 0.386 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr2_+_179184970 0.385 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr6_-_31698033 0.384 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chrX_-_21776158 0.383 NM_014332
SMPX
small muscle protein, X-linked
chr1_+_44457231 0.381 NM_152499
CCDC24
coiled-coil domain containing 24
chr3_-_151102536 0.377 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr11_-_62380202 0.376 NM_153265
EML3
echinoderm microtubule associated protein like 3
chr22_+_31090792 0.374 NM_030758
OSBP2
oxysterol binding protein 2
chr2_+_16080639 0.373 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr6_-_32191779 0.372 NM_004557
NOTCH4
notch 4
chr11_+_12960793 0.371 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr15_+_63569748 0.370 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr6_-_133084585 0.369 NM_078488
VNN2
vanin 2
chr1_+_44412582 0.369 IPO13
importin 13
chr14_+_61447949 0.368 SLC38A6
solute carrier family 38, member 6
chr1_+_210502639 0.363 NM_001170580
HHAT
hedgehog acyltransferase
chr3_+_194407412 0.362 FAM43A
family with sequence similarity 43, member A
chr5_-_177423242 0.361 NM_006261
PROP1
PROP paired-like homeobox 1
chr17_-_73840495 0.361 UNC13D
unc-13 homolog D (C. elegans)
chr17_+_48503607 0.361 ACSF2
acyl-CoA synthetase family member 2
chr17_-_49337370 0.354 NM_017643
MBTD1
mbt domain containing 1
chr9_+_35042222 0.354 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131

chr12_+_48516428 0.354 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr3_-_49158357 0.354 NM_001199160
NM_001199161
NM_001199162
NM_006677
USP19



ubiquitin specific peptidase 19



chr7_-_37488408 0.353 ELMO1
engulfment and cell motility 1
chr17_-_7166505 0.347 NM_001185022
CLDN7
claudin 7
chr16_+_58534045 0.346 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr1_+_44412640 0.345 IPO13
importin 13
chr3_-_112359251 0.344 CCDC80
coiled-coil domain containing 80
chr6_+_2245965 0.344


chr8_+_21911062 0.340 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr17_-_7082654 0.339 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr19_-_11689591 0.339 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chrX_-_117119282 0.338 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr1_+_156785470 0.338 NM_001007792
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr1_+_12123433 0.336 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr15_+_67835002 0.335 NM_002757
NM_145160
MAP2K5

mitogen-activated protein kinase kinase 5

chr1_+_45792544 0.335 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr19_+_11546085 0.334 NM_001001329
NM_002743
PRKCSH

protein kinase C substrate 80K-H


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 1.04e-03 GO:0044444 cytoplasmic part
1.12 2.64e-02 GO:0005737 cytoplasm

Nothing significant found in function category.