Motif ID: NR5A1,2.p2

Z-value: 0.921


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NR5A1chr9_-_1272696890.125.8e-01Click!
NR5A2chr1_+_199996729-0.009.9e-01Click!


Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_33859835 1.559 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_-_123339178 1.301 MYLK
myosin light chain kinase
chr12_-_10151689 1.261 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr9_+_72658735 1.231 MAMDC2
MAM domain containing 2
chr3_-_123339423 1.125 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr11_+_71710662 0.910 NM_001145057
IL18BP
interleukin 18 binding protein
chr22_+_31518923 0.908 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr21_+_42792441 0.773 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr18_-_46469118 0.739 NM_001190823
SMAD7
SMAD family member 7
chr5_-_172755418 0.734 STC2
stanniocalcin 2
chr12_-_106532447 0.698 NUAK1
NUAK family, SNF1-like kinase, 1
chr11_-_27741192 0.694 NM_001143807
BDNF
brain-derived neurotrophic factor
chr6_+_132891460 0.693 NM_175067
TAAR6
trace amine associated receptor 6
chr12_+_52626953 0.631 NM_005556
KRT7
keratin 7
chr20_+_18794369 0.627 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr7_-_138458781 0.621 NM_130841
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4
chr16_+_57050985 0.618 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr20_-_35488275 0.607 NM_199181
KIAA0889
KIAA0889
chr8_+_54764367 0.606 NM_170587
RGS20
regulator of G-protein signaling 20
chr5_+_35856990 0.593 NM_002185
IL7R
interleukin 7 receptor
chr12_+_52627007 0.589 KRT7
keratin 7
chr3_+_107096187 0.562 NM_032600
CCDC54
coiled-coil domain containing 54
chr19_-_13213973 0.561 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr20_+_35504514 0.554 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr22_+_20909221 0.552 MED15
mediator complex subunit 15
chr5_-_172755195 0.549 STC2
stanniocalcin 2
chr9_+_72658496 0.545 NM_153267
MAMDC2
MAM domain containing 2
chr7_-_41742666 0.541 NM_002192
INHBA
inhibin, beta A
chr5_-_41213513 0.533 NM_000065
C6
complement component 6
chr11_-_86383164 0.531 NM_001014811
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr16_-_66952729 0.504 NM_001204744
NM_001204745
NM_001204746
NM_004062
CDH16



cadherin 16, KSP-cadherin



chr13_-_44361032 0.500 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr3_-_9994057 0.498 NM_207351
PRRT3
proline-rich transmembrane protein 3
chr19_-_11305186 0.489 NM_015493
KANK2
KN motif and ankyrin repeat domains 2
chr19_-_13213669 0.486 LYL1
lymphoblastic leukemia derived sequence 1
chr5_-_19988293 0.484 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr4_-_76944585 0.476 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr1_+_184356186 0.471 C1orf21
chromosome 1 open reading frame 21
chr6_+_27782793 0.466 NM_003521
HIST1H2BM
histone cluster 1, H2bm
chr17_-_73505914 0.465 NM_001142643
CASKIN2
CASK interacting protein 2
chr19_-_36036870 0.461 LOC100506469
uncharacterized LOC100506469
chr11_+_71709951 0.458 NM_001039659
NM_001039660
NM_173044
NM_005699
NM_173042
IL18BP




interleukin 18 binding protein




chr9_+_127420690 0.453 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr3_+_132036210 0.452 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr11_+_61248584 0.448 NM_001170753
NM_145017
PPP1R32

protein phosphatase 1, regulatory subunit 32

chr22_+_21128378 0.445 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr1_-_149908098 0.444 NM_181873
MTMR11
myotubularin related protein 11
chr19_-_49558996 0.443 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chr2_-_224903324 0.439 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr19_-_49552362 0.437 NM_033183
CGB8
chorionic gonadotropin, beta polypeptide 8
chr11_+_63706433 0.434 NM_024771
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr13_-_34250899 0.431 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr19_-_17356022 0.418 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr10_-_86001197 0.418 NM_015613
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr18_+_616671 0.417 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr1_+_203097427 0.413 ADORA1
adenosine A1 receptor
chr5_+_172068188 0.410 NM_001142651
NEURL1B
neuralized homolog 1B (Drosophila)
chr9_-_130742803 0.405 NM_001035254
FAM102A
family with sequence similarity 102, member A
chr9_-_130890026 0.402 PTGES2
prostaglandin E synthase 2
chr13_+_108955763 0.401


chr19_-_48059112 0.399 NM_001101419
ZNF541
zinc finger protein 541
chr11_-_86666211 0.397 NM_012193
FZD4
frizzled family receptor 4
chr9_+_35829375 0.394 NM_001042590
TMEM8B
transmembrane protein 8B
chr22_+_32010152 0.394 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr16_+_691901 0.393 FAM195A
family with sequence similarity 195, member A
chr12_-_111358353 0.392 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr12_+_56075329 0.381 NM_152637
METTL7B
methyltransferase like 7B
chr20_+_58152563 0.380 NM_001199505
PHACTR3
phosphatase and actin regulator 3
chr1_+_64059479 0.380 NM_001172819
PGM1
phosphoglucomutase 1
chr19_-_40931880 0.379 NM_013376
SERTAD1
SERTA domain containing 1
chr7_-_27205148 0.377 NM_152739
HOXA9
homeobox A9
chr4_-_76928601 0.377 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr4_+_189060597 0.376 NM_178556
TRIML1
tripartite motif family-like 1
chr19_+_11350282 0.375 NM_018687
C19orf80
chromosome 19 open reading frame 80
chr9_-_130890007 0.374 PTGES2
prostaglandin E synthase 2
chr12_-_16759531 0.370 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_-_46408105 0.367 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr1_-_111743297 0.367 DENND2D
DENN/MADD domain containing 2D
chr8_-_37457357 0.367 LOC157860
uncharacterized LOC157860
chr7_-_27205123 0.366 HOXA9
homeobox A9
chr12_+_7942025 0.365 NANOG
Nanog homeobox
chr11_+_66188474 0.365 NM_178864
NPAS4
neuronal PAS domain protein 4
chrX_+_119738542 0.364 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr1_-_171621750 0.362 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr3_+_6902797 0.362 NM_000844
NM_181874
GRM7

glutamate receptor, metabotropic 7

chr20_+_30193083 0.361 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr9_-_130889965 0.361 PTGES2
prostaglandin E synthase 2
chr19_+_49547101 0.357 NM_033043
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr6_-_2840683 0.354 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr12_+_56075418 0.352 METTL7B
methyltransferase like 7B
chr10_-_101380217 0.350 NM_031212
SLC25A28
solute carrier family 25, member 28
chr18_-_46477080 0.341 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr3_+_16306666 0.340 NM_138381
OXNAD1
oxidoreductase NAD-binding domain containing 1
chr12_+_52306112 0.340 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr9_+_17578952 0.336 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr7_+_150076405 0.334 NM_173680
ZNF775
zinc finger protein 775
chr6_-_82462374 0.334 NM_017633
FAM46A
family with sequence similarity 46, member A
chr18_-_24220307 0.333 NM_198991
KCTD1
potassium channel tetramerisation domain containing 1
chr7_+_138145179 0.333 TRIM24
tripartite motif containing 24
chr3_-_45267068 0.330 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr3_-_42744318 0.330 NM_020707
HHATL
hedgehog acyltransferase-like
chr12_+_78225068 0.329 NM_014903
NAV3
neuron navigator 3
chr3_+_50306578 0.327 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chrX_-_108868250 0.325 NM_012282
KCNE1L
KCNE1-like
chr2_+_201756639 0.325 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr14_+_94577078 0.324 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr9_-_130889993 0.322 PTGES2
prostaglandin E synthase 2
chr10_+_74033676 0.322 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chr1_+_184356364 0.320 C1orf21
chromosome 1 open reading frame 21
chr16_-_28621279 0.320 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr3_-_79817058 0.318 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr11_-_16424391 0.317 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr20_+_30865435 0.316 NM_004798
KIF3B
kinesin family member 3B
chr19_-_55574434 0.315 NM_001145971
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr20_-_62130390 0.315 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr18_-_30352841 0.314 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr16_-_28608367 0.313 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr12_-_121476770 0.312 NM_003733
NM_198213
OASL

2'-5'-oligoadenylate synthetase-like

chr5_-_134914968 0.310 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr16_+_31366519 0.306 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr3_-_49377485 0.305 USP4
ubiquitin specific peptidase 4 (proto-oncogene)
chr20_+_58179601 0.304 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr6_+_43149925 0.304 CUL9
cullin 9
chr1_-_111743261 0.303 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr11_-_34379526 0.303 NM_145804
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr14_+_24674902 0.303 NM_001184739
NM_174944
TSSK4

testis-specific serine kinase 4

chr1_+_152635871 0.302 NM_178430
LCE2D
late cornified envelope 2D
chr1_+_107683548 0.302 NTNG1
netrin G1
chr10_-_101380160 0.302 SLC25A28
solute carrier family 25, member 28
chr7_-_27187367 0.300 NM_024014
HOXA6
homeobox A6
chr3_+_196295708 0.300 NM_001105573
FBXO45
F-box protein 45
chr3_-_49377478 0.299 USP4
ubiquitin specific peptidase 4 (proto-oncogene)
chr12_-_16759430 0.298 LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_-_69259654 0.298 ZFP36L1
zinc finger protein 36, C3H type-like 1
chr1_-_27481400 0.297 NM_003047
SLC9A1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr3_-_38691118 0.294 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr17_+_45726838 0.292 KPNB1
karyopherin (importin) beta 1
chr14_+_78266419 0.292 NM_001142545
NM_020421
ADCK1

aarF domain containing kinase 1

chr3_-_49377439 0.290 USP4
ubiquitin specific peptidase 4 (proto-oncogene)
chr12_-_91576579 0.290 DCN
decorin
chr3_-_49377459 0.290 USP4
ubiquitin specific peptidase 4 (proto-oncogene)
chr12_-_56848398 0.290 NM_012064
MIP
major intrinsic protein of lens fiber
chrX_-_151619669 0.290 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chrX_+_48368063 0.289 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr12_+_7167979 0.288 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr17_-_27139391 0.287 C17orf63
chromosome 17 open reading frame 63
chr10_+_85954390 0.284 NM_001171971
NM_033100
CDHR1

cadherin-related family member 1

chr17_+_55163077 0.284 NM_001242903
NM_001242902
AKAP1

A kinase (PRKA) anchor protein 1

chr14_+_75898836 0.283 NM_001135049
JDP2
Jun dimerization protein 2
chr14_-_74226890 0.283 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr1_+_209859524 0.282 NM_001206741
NM_181755
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chrX_-_47489703 0.275 NM_002621
CFP
complement factor properdin
chr8_-_12973752 0.275 NM_001164271
DLC1
deleted in liver cancer 1
chr15_-_42783293 0.274 ZFP106
zinc finger protein 106 homolog (mouse)
chr1_-_158656487 0.274 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr17_-_39306053 0.273 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr18_-_13915534 0.272 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr9_-_15307148 0.271 TTC39B
tetratricopeptide repeat domain 39B
chr12_+_133067156 0.269 NM_001142641
FBRSL1
fibrosin-like 1
chrX_+_152110214 0.269 NM_001178115
ZNF185
zinc finger protein 185 (LIM domain)
chr3_-_126236593 0.268 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr20_-_36156082 0.268 NM_001167822
NM_001167821
BLCAP

bladder cancer associated protein

chr14_+_24616658 0.268 NM_017999
RNF31
ring finger protein 31
chr1_-_59248287 0.265 JUN
jun proto-oncogene
chr20_-_36156282 0.265 NM_001167820
NM_006698
BLCAP

bladder cancer associated protein

chr5_+_161274196 0.264 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_186317964 0.262 ANKRD37
ankyrin repeat domain 37
chr3_-_47621729 0.261 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chr5_-_54603401 0.259 NM_019030
DHX29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chr5_-_137911317 0.259 NM_004134
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr1_+_167064086 0.258 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr15_-_75932509 0.257 NM_018285
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr3_+_113666544 0.256 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr12_+_54378929 0.256 NM_017409
HOXC10
homeobox C10
chr7_+_139208673 0.255 NM_001080511
CLEC2L
C-type lectin domain family 2, member L
chr19_-_7968426 0.254


chr16_+_57481336 0.254 NM_020312
COQ9
coenzyme Q9 homolog (S. cerevisiae)
chr7_+_2443164 0.253 NM_001243794
NM_001243795
NM_018641
CHST12


carbohydrate (chondroitin 4) sulfotransferase 12


chr1_+_184356227 0.251 C1orf21
chromosome 1 open reading frame 21
chr6_-_29055048 0.251 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chr19_+_3185927 0.250 NCLN
nicalin
chr2_-_224903933 0.249 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr22_-_38506532 0.248 BAIAP2L2
BAI1-associated protein 2-like 2
chr11_-_86383355 0.248 NM_006680
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr19_-_44831907 0.248 ZFP112
zinc finger protein 112 homolog (mouse)
chr9_-_130712866 0.248 NM_203305
FAM102A
family with sequence similarity 102, member A
chr6_+_143382045 0.247 AIG1
androgen-induced 1
chr11_+_35198199 0.247 CD44
CD44 molecule (Indian blood group)
chr15_+_45021319 0.247 TRIM69
tripartite motif containing 69
chr19_+_3185965 0.247 NCLN
nicalin
chr19_-_49527419 0.246 NM_000737
CGB
chorionic gonadotropin, beta polypeptide
chr5_+_52284903 0.246 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr13_+_33160610 0.246 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr6_-_108145507 0.245 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr1_+_64088886 0.244 NM_001172818
PGM1
phosphoglucomutase 1
chr6_+_107349327 0.244 NM_001142468
NM_001142470
NM_016487
C6orf203


chromosome 6 open reading frame 203


chr21_+_41029253 0.243 NM_006057
NM_033170
NM_033171
NM_033172
NM_033173
B3GALT5




UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5




chr16_+_31484497 0.242 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr11_-_102668822 0.241 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr6_-_125623071 0.240 HDDC2
HD domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 1.24e-07 GO:0009987 cellular process
3.04 1.58e-07 GO:0022904 respiratory electron transport chain
1.29 2.48e-06 GO:0048731 system development
1.26 1.07e-05 GO:0048856 anatomical structure development
2.53 1.27e-05 GO:0045333 cellular respiration
1.24 1.48e-05 GO:0007275 multicellular organismal development
1.80 4.28e-05 GO:0006091 generation of precursor metabolites and energy
2.41 6.38e-05 GO:0022900 electron transport chain
1.21 9.09e-05 GO:0032502 developmental process
1.90 4.01e-04 GO:0015980 energy derivation by oxidation of organic compounds
1.34 1.72e-03 GO:0009653 anatomical structure morphogenesis
1.33 3.71e-03 GO:0007399 nervous system development
1.22 4.35e-03 GO:0006810 transport
1.21 9.83e-03 GO:0051234 establishment of localization
1.11 2.54e-02 GO:0008152 metabolic process
2.06 2.56e-02 GO:0006006 glucose metabolic process
1.17 4.22e-02 GO:0051179 localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.76 2.04e-08 GO:0044455 mitochondrial membrane part
2.03 6.01e-08 GO:0005743 mitochondrial inner membrane
1.92 4.37e-07 GO:0019866 organelle inner membrane
1.60 1.44e-06 GO:0031967 organelle envelope
1.59 1.49e-06 GO:0031975 envelope
1.77 1.96e-06 GO:0031966 mitochondrial membrane
1.74 2.70e-06 GO:0005740 mitochondrial envelope
1.59 6.59e-06 GO:0044429 mitochondrial part
1.37 4.85e-05 GO:0005739 mitochondrion
2.82 7.50e-04 GO:0000786 nucleosome
2.68 1.35e-03 GO:0070469 respiratory chain
2.65 4.06e-03 GO:0005746 mitochondrial respiratory chain
3.02 1.09e-02 GO:0005747 mitochondrial respiratory chain complex I
3.02 1.09e-02 GO:0030964 NADH dehydrogenase complex
3.02 1.09e-02 GO:0045271 respiratory chain complex I

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.67 6.18e-03 GO:0016563 transcription activator activity
2.73 1.12e-02 GO:0004879 ligand-dependent nuclear receptor activity
2.74 1.66e-02 GO:0003707 steroid hormone receptor activity
5.72 2.04e-02 GO:0003706 ligand-regulated transcription factor activity
1.33 3.49e-02 GO:0001071 nucleic acid binding transcription factor activity
1.33 3.49e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
2.98 3.94e-02 GO:0003954 NADH dehydrogenase activity
2.98 3.94e-02 GO:0008137 NADH dehydrogenase (ubiquinone) activity
2.98 3.94e-02 GO:0050136 NADH dehydrogenase (quinone) activity