Motif ID: NR6A1.p2

Z-value: 0.482


Transcription factors associated with NR6A1.p2:

Gene SymbolEntrez IDGene Name
NR6A1 2649 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NR6A1chr9_-_127533397-0.019.5e-01Click!


Activity profile for motif NR6A1.p2.

activity profile for motif NR6A1.p2


Sorted Z-values histogram for motif NR6A1.p2

Sorted Z-values for motif NR6A1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR6A1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_84743250 2.459 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr4_+_41614725 2.214 LIMCH1
LIM and calponin homology domains 1
chr9_-_14313509 2.186 NFIB
nuclear factor I/B
chr9_-_14313899 2.075 NFIB
nuclear factor I/B
chr9_-_14314036 1.694 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr3_-_148804122 1.550 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chr1_+_78511588 0.886 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr2_+_33701678 0.549 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_+_7169192 0.529


chr8_-_93115453 0.511 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr6_+_31973358 0.498 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr6_+_43028181 0.468 NM_201522
KLC4
kinesin light chain 4
chr11_+_111789658 0.438 C11orf52
chromosome 11 open reading frame 52
chr7_-_65447206 0.421 GUSB
glucuronidase, beta
chr17_-_27402626 0.374 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr10_-_105238996 0.372 NM_001129742
CALHM3
calcium homeostasis modulator 3
chr7_-_65447233 0.366 NM_000181
GUSB
glucuronidase, beta
chr9_-_14313943 0.359 NFIB
nuclear factor I/B
chr6_+_155411422 0.333 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr1_+_33231260 0.323 KIAA1522
KIAA1522
chr11_+_65192284 0.301 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr7_-_65447162 0.289 GUSB
glucuronidase, beta
chr11_+_111789600 0.266 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr9_-_21217303 0.261 NM_002173
IFNA16
interferon, alpha 16
chr9_+_139981338 0.258 MAN1B1
mannosidase, alpha, class 1B, member 1
chr2_+_33172368 0.249 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr3_-_128294928 0.244 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr12_-_7261788 0.239 NM_016546
C1RL
complement component 1, r subcomponent-like
chr11_-_5462782 0.236 NM_001005288
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr12_-_110252600 0.234 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr4_-_90758126 0.227 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr7_+_26403944 0.219 NM_001199838
SNX10
sorting nexin 10
chr16_-_28222700 0.218 XPO6
exportin 6
chr8_+_142432006 0.189 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr1_+_176432306 0.185 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr13_-_42535066 0.182 KIAA0564
KIAA0564
chr7_+_63773185 0.181 NM_001170905
ZNF736
zinc finger protein 736
chr11_+_111957611 0.177 SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr9_+_124043719 0.177 GSN
gelsolin
chr11_-_111957417 0.176 NM_012459
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chr5_-_42175355 0.170


chr2_-_162930629 0.170 DPP4
dipeptidyl-peptidase 4
chr1_+_19923457 0.165 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr7_+_1577118 0.157 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr20_-_3149070 0.149 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr4_+_1953831 0.148 WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr1_+_45274153 0.140 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr2_-_31361364 0.139


chr9_-_21228132 0.137 NM_021268
IFNA17
interferon, alpha 17
chr8_-_145690737 0.133 NM_032687
NM_001129888
CYHR1

cysteine/histidine-rich 1

chr16_-_420508 0.131 NM_006428
MRPL28
mitochondrial ribosomal protein L28
chr16_+_31366529 0.128 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr9_-_38069082 0.128 SHB
Src homology 2 domain containing adaptor protein B
chr12_+_109273856 0.119 NM_001917
DAO
D-amino-acid oxidase
chr1_-_935469 0.112 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr2_-_162930544 0.109 DPP4
dipeptidyl-peptidase 4
chr3_-_14989857 0.106 LOC100505641
uncharacterized LOC100505641
chr19_-_7796977 0.104 NM_001244856
NM_198492
CLEC4G

C-type lectin domain family 4, member G

chr2_-_162930500 0.102 DPP4
dipeptidyl-peptidase 4
chr5_+_43603312 0.102 NNT
nicotinamide nucleotide transhydrogenase
chr1_+_36387788 0.101 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr19_+_41699076 0.099 NM_030622
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr9_+_75136716 0.097 NM_138691
TMC1
transmembrane channel-like 1
chr1_+_225997742 0.097 NM_001136018
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr14_+_105391150 0.095 PLD4
phospholipase D family, member 4
chr22_-_24059436 0.093


chr6_+_117803779 0.090 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr17_+_74075262 0.089 NM_180990
ZACN
zinc activated ligand-gated ion channel
chrX_-_44402088 0.086 NM_173794
FUNDC1
FUN14 domain containing 1
chr14_-_106471439 0.082 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chrX_-_21776158 0.082 NM_014332
SMPX
small muscle protein, X-linked
chr5_+_175308843 0.081 CPLX2
complexin 2
chr1_+_225997804 0.078 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr17_+_75446735 0.078 SEPT9
septin 9
chr14_-_73453651 0.076 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr6_-_56407681 0.070


chr20_+_57264186 0.070 NM_001204872
NM_001204873
NPEPL1

aminopeptidase-like 1

chr1_-_159825136 0.068 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr1_-_211666258 0.065 NM_001164688
NM_183059
RD3

retinal degeneration 3

chr16_+_776957 0.064 NM_032304
HAGHL
hydroxyacylglutathione hydrolase-like
chr11_+_111957533 0.064 NM_003002
SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr7_+_26438186 0.060 LOC441204
uncharacterized LOC441204
chr1_+_76190042 0.060 NM_000016
NM_001127328
ACADM

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

chr9_-_21166609 0.059 NM_002175
IFNA21
interferon, alpha 21
chr5_-_14871555 0.059 NM_054027
ANKH
ankylosis, progressive homolog (mouse)
chrX_+_54466840 0.059 NM_058163
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr22_+_23229959 0.058 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chrX_-_153095332 0.055 PDZD4
PDZ domain containing 4
chr17_-_47925378 0.054 NM_001077503
NM_001077504
NM_001077505
NM_001077506
NM_170685
TAC4




tachykinin 4 (hemokinin)




chr6_-_132910824 0.054 NM_003967
TAAR5
trace amine associated receptor 5
chr22_-_24059524 0.053 GUSBP11
glucuronidase, beta pseudogene 11
chr12_-_6484389 0.053 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr11_+_66624501 0.052 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr17_+_46970128 0.052 NM_001002027
NM_005175
ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr20_-_43024303 0.052


chr14_+_93118793 0.051 RIN3
Ras and Rab interactor 3
chr2_-_200715895 0.051 FONG
uncharacterized LOC348751
chr6_+_42982221 0.050 NM_001242872
KLHDC3
kelch domain containing 3
chrX_+_17653412 0.047 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr7_+_37960418 0.047 EPDR1
ependymin related protein 1 (zebrafish)
chr14_+_105391154 0.047 PLD4
phospholipase D family, member 4
chr9_-_21207141 0.046 NM_002171
IFNA10
interferon, alpha 10
chr1_-_160617042 0.046 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr3_+_133464883 0.045 NM_001063
TF
transferrin
chr7_+_37960162 0.042 NM_001242946
NM_017549
EPDR1

ependymin related protein 1 (zebrafish)

chr22_-_24059502 0.041 GUSBP11
glucuronidase, beta pseudogene 11
chr16_+_31494438 0.039 NM_003041
SLC5A2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr16_-_3306586 0.039 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr12_-_10562142 0.038 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 readthrough
killer cell lectin-like receptor subfamily C, member 4
chr3_+_133465098 0.038 TF
transferrin
chr9_-_135230358 0.034 NM_015046
SETX
senataxin
chr14_+_93118576 0.033 RIN3
Ras and Rab interactor 3
chr2_-_31361591 0.033 NM_001253826
NM_024572
GALNT14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)

chr11_+_66188474 0.031 NM_178864
NPAS4
neuronal PAS domain protein 4
chr3_+_133465204 0.030 TF
transferrin
chr13_-_28024700 0.030 NM_001166263
NM_152912
MTIF3

mitochondrial translational initiation factor 3

chr8_+_11188494 0.030 NM_054028
SLC35G5
solute carrier family 35, member G5
chr17_+_75446612 0.029 NM_001113496
SEPT9
septin 9
chr14_+_89029371 0.029 ZC3H14
zinc finger CCCH-type containing 14
chr5_+_140749830 0.028 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr2_-_211090146 0.028 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr19_-_46974789 0.028 NM_001103149
NM_018215
PNMAL1

PNMA-like 1

chr1_+_153606457 0.028 NM_001206612
NM_001244664
NM_015607
CHTOP


chromatin target of PRMT1


chr7_+_56032065 0.028 NM_001202469
NM_001483
GBAS

glioblastoma amplified sequence

chr10_+_51837885 0.027 NM_018232
FAM21B
family with sequence similarity 21, member B
chr3_-_38178463 0.026 ACAA1
acetyl-CoA acyltransferase 1
chr20_-_30000640 0.026 NM_001171832
DEFB121
defensin, beta 121
chr9_-_135230129 0.024 SETX
senataxin
chr2_-_25564745 0.024 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr7_+_73868111 0.023 NM_001199207
NM_005685
NM_016328
GTF2IRD1


GTF2I repeat domain containing 1


chr7_-_150038689 0.023 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr16_+_31366519 0.023 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr19_-_2717272 0.022 DIRAS1
DIRAS family, GTP-binding RAS-like 1
chr14_-_106967080 0.020 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_-_162929928 0.019 DPP4
dipeptidyl-peptidase 4
chr9_-_114362100 0.019 NM_001146108
NM_001146109
PTGR1

prostaglandin reductase 1

chr11_+_118754474 0.019 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr10_+_47894022 0.018 NM_018232
FAM21B
family with sequence similarity 21, member B
chr14_-_106111114 0.017 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr3_+_46619075 0.014 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr1_+_153606550 0.012 CHTOP
chromatin target of PRMT1
chr3_-_139396773 0.012 NM_001200047
NM_178177
NMNAT3

nicotinamide nucleotide adenylyltransferase 3

chr16_+_56995761 0.012 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr1_+_63063186 0.012 NM_014495
ANGPTL3
angiopoietin-like 3
chr11_-_62472901 0.011


chr14_-_106452693 0.011 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_1386197 0.010 NM_001199096
BAIAP3
BAI1-associated protein 3
chr1_+_26503973 0.010 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr19_+_8953268 0.010 NM_145208
MBD3L1
methyl-CpG binding domain protein 3-like 1
chr12_+_108956293 0.009 NM_014301
NM_213595
ISCU

iron-sulfur cluster scaffold homolog (E. coli)

chr6_-_43484503 0.008 YIPF3
Yip1 domain family, member 3
chr6_-_32339648 0.008 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr19_-_5846465 0.007 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chrX_+_48620153 0.007 NM_001080489
GLOD5
glyoxalase domain containing 5
chrY_-_1460901 0.006 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chrX_+_47229981 0.006 NM_003446
ZNF157
zinc finger protein 157
chr12_+_125811161 0.005 NM_052907
TMEM132B
transmembrane protein 132B
chr6_-_2751153 0.005 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr7_-_137531585 0.004 NM_004717
DGKI
diacylglycerol kinase, iota
chr14_-_106641585 0.004 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_-_26032287 0.003 NM_003537
HIST1H3B
histone cluster 1, H3b
chr19_+_41620336 0.003 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr7_-_87936202 0.002 NM_001205315
NM_001205316
NM_024636
STEAP4


STEAP family member 4


chr1_-_20834609 0.002 NM_024544
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr17_+_12692779 0.002 NM_014859
ARHGAP44
Rho GTPase activating protein 44
chr6_-_30899926 0.001 NM_205854
SFTA2
surfactant associated 2
chr19_-_7698569 0.001 NM_174895
PCP2
Purkinje cell protein 2
chr6_-_43484701 0.001 NM_015388
YIPF3
Yip1 domain family, member 3
chrX_-_104465349 0.001 NM_031274
TEX13A
testis expressed 13A
chr8_+_144349564 0.000 NM_138465
GLI4
GLI family zinc finger 4

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
23.65 2.13e-06 GO:0003823 antigen binding
5.23 2.09e-02 GO:0005506 iron ion binding