Motif ID: PAX5.p2

Z-value: 1.611


Transcription factors associated with PAX5.p2:

Gene SymbolEntrez IDGene Name
PAX5 5079 paired box 5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
PAX5chr9_-_37034358-0.452.3e-02Click!


Activity profile for motif PAX5.p2.

activity profile for motif PAX5.p2


Sorted Z-values histogram for motif PAX5.p2

Sorted Z-values for motif PAX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_80679897 4.733 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr5_+_118604504 4.239 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr15_+_67358161 4.175 SMAD3
SMAD family member 3
chr4_+_103422553 3.836 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr16_+_11762235 3.522 NM_003498
SNN
stannin
chr5_+_118604417 3.414 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr15_+_67358194 3.285 NM_005902
SMAD3
SMAD family member 3
chr21_+_46293925 3.204


chr4_+_103422822 2.999 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_+_103422730 2.998 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_+_103422479 2.941 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr6_+_37137882 2.759 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr9_-_123691442 2.591 NM_001190945
TRAF1
TNF receptor-associated factor 1
chr6_+_14117857 2.499 NM_001040280
NM_004233
CD83

CD83 molecule

chr6_+_14118002 2.467 CD83
CD83 molecule
chr5_-_131826426 2.414 NM_002198
IRF1
interferon regulatory factor 1
chr6_-_109804322 2.362 ZBTB24
zinc finger and BTB domain containing 24
chr21_+_33784751 2.344 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr6_-_160114186 2.309 SOD2
superoxide dismutase 2, mitochondrial
chr18_+_77155927 2.296 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr8_-_141645603 2.257 NM_001164623
NM_012154
EIF2C2

eukaryotic translation initiation factor 2C, 2

chr7_-_105925329 2.247 NAMPT
nicotinamide phosphoribosyltransferase
chr13_+_44453968 2.170 NM_153218
LACC1
laccase (multicopper oxidoreductase) domain containing 1
chr11_+_109964086 2.048 NM_033390
ZC3H12C
zinc finger CCCH-type containing 12C
chr18_+_77155966 2.018 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr7_-_105925410 1.995 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr3_+_133292714 1.935 CDV3
CDV3 homolog (mouse)
chr22_+_31608284 1.911 LIMK2
LIM domain kinase 2
chr22_+_31608145 1.890 LIMK2
LIM domain kinase 2
chr17_-_31204071 1.864 MYO1D
myosin ID
chr5_+_56111379 1.855 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr4_+_38665587 1.826 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr6_+_4776826 1.788 CDYL
chromodomain protein, Y-like
chr6_+_12012723 1.730 NM_002114
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chr20_+_6748744 1.726 NM_001200
BMP2
bone morphogenetic protein 2
chr8_+_90769974 1.715 NM_003821
RIPK2
receptor-interacting serine-threonine kinase 2
chr19_+_45504686 1.707 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr14_+_103243813 1.677 NM_001199427
NM_003300
NM_145725
NM_145726
TRAF3



TNF receptor-associated factor 3



chr2_+_162016926 1.652 NM_001199135
TANK
TRAF family member-associated NFKB activator
chr20_-_43977023 1.631 NM_002999
SDC4
syndecan 4
chr10_+_35415768 1.617 NM_001881
NM_182850
NM_182853
NM_183013
CREM



cAMP responsive element modulator



chr14_+_103589711 1.616 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr6_-_44233499 1.594 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr6_-_109804432 1.582 NM_001164313
NM_014797
ZBTB24

zinc finger and BTB domain containing 24

chr8_-_8750739 1.509 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr8_+_90770201 1.461 RIPK2
receptor-interacting serine-threonine kinase 2
chr16_-_11680756 1.445 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr3_+_53195214 1.444 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr6_-_160114318 1.443 NM_000636
NM_001024465
NM_001024466
SOD2


superoxide dismutase 2, mitochondrial


chr2_-_235405692 1.402 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr6_+_127439803 1.385 RSPO3
R-spondin 3
chr14_+_103243832 1.383 TRAF3
TNF receptor-associated factor 3
chr6_+_14117486 1.368 NM_001251901
CD83
CD83 molecule
chr7_-_22396511 1.364 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr15_-_23086290 1.352 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr19_+_57106622 1.351 NM_021216
ZNF71
zinc finger protein 71
chr6_+_4776641 1.351 NM_004824
CDYL
chromodomain protein, Y-like
chr22_+_31608280 1.345 LIMK2
LIM domain kinase 2
chr8_-_37756971 1.298 NM_001002814
NM_025151
RAB11FIP1

RAB11 family interacting protein 1 (class I)

chr11_-_128392061 1.295 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr6_+_160148608 1.289 NM_152857
WTAP
Wilms tumor 1 associated protein
chr22_+_31608249 1.276 NM_005569
LIMK2
LIM domain kinase 2
chr1_+_25071967 1.270 CLIC4
chloride intracellular channel 4
chr1_+_227058241 1.256 NM_000447
NM_012486
PSEN2

presenilin 2 (Alzheimer disease 4)

chr3_+_133292557 1.235 CDV3
CDV3 homolog (mouse)
chr1_-_161102367 1.235 DEDD
death effector domain containing
chr16_-_57318574 1.230 NM_015993
PLLP
plasmolipin
chr6_+_138188352 1.228 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr12_-_133338389 1.228 NM_015114
ANKLE2
ankyrin repeat and LEM domain containing 2
chr14_+_73603140 1.225 NM_000021
NM_007318
PSEN1

presenilin 1

chr18_-_48723689 1.218 MEX3C
mex-3 homolog C (C. elegans)
chr8_+_86089618 1.213 NM_001083588
NM_001951
E2F5

E2F transcription factor 5, p130-binding

chr1_-_65432203 1.196 JAK1
Janus kinase 1
chr13_-_114898013 1.194 RASA3
RAS p21 protein activator 3
chr7_+_18126543 1.193 NM_001204144
HDAC9
histone deacetylase 9
chr5_-_16936290 1.193 MYO10
myosin X
chr13_+_44453419 1.184 NM_001128303
LACC1
laccase (multicopper oxidoreductase) domain containing 1
chr3_+_128997713 1.181 NM_001006109
C3orf37
chromosome 3 open reading frame 37
chr16_-_57318452 1.160 PLLP
plasmolipin
chr11_+_43963809 1.150 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr11_+_93862143 1.142 PANX1
pannexin 1
chr20_-_17662704 1.141 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr4_-_177713664 1.140 NM_005429
VEGFC
vascular endothelial growth factor C
chr10_+_6186758 1.140 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr13_-_114897964 1.124 RASA3
RAS p21 protein activator 3
chr10_+_6186903 1.116 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr2_+_170590454 1.111 KLHL23
kelch-like 23 (Drosophila)
chr2_-_178129858 1.107 NM_006164
NFE2L2
nuclear factor (erythroid-derived 2)-like 2
chr15_+_75494235 1.101 C15orf39
chromosome 15 open reading frame 39
chr11_-_64646053 1.096 NM_006795
EHD1
EH-domain containing 1
chr6_-_154831652 1.088 CNKSR3
CNKSR family member 3
chr21_+_44073650 1.083 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr2_+_234263153 1.077 DGKD
diacylglycerol kinase, delta 130kDa
chr6_+_127440047 1.074 NM_032784
RSPO3
R-spondin 3
chrX_+_9432980 1.068 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr6_+_160148485 1.060 WTAP
Wilms tumor 1 associated protein
chr6_-_101329006 1.057 ASCC3
activating signal cointegrator 1 complex subunit 3
chr2_+_234263141 1.055 NM_152879
DGKD
diacylglycerol kinase, delta 130kDa
chr10_-_121632265 1.052 NM_024834
MCMBP
minichromosome maintenance complex binding protein
chr1_+_206858308 1.052 NM_004759
NM_032960
MAPKAPK2

mitogen-activated protein kinase-activated protein kinase 2

chr2_-_11484699 1.047 NM_004850
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
chr16_+_84682126 1.038 NM_024731
KLHL36
kelch-like 36 (Drosophila)
chr17_-_17399494 1.037 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr19_+_676346 1.034 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr1_-_1149495 1.034 NM_003327
TNFRSF4
tumor necrosis factor receptor superfamily, member 4
chr18_+_55711890 1.030 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr7_+_77166331 1.029 PTPN12
protein tyrosine phosphatase, non-receptor type 12
chr6_-_10419786 1.029 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr14_-_53417636 1.026 FERMT2
fermitin family member 2
chr14_+_73603168 1.018 PSEN1
presenilin 1
chr14_+_73603160 1.009 PSEN1
presenilin 1
chr22_+_45705965 1.007 FAM118A
family with sequence similarity 118, member A
chr17_-_80606095 0.994 NM_019613
WDR45L
WDR45-like
chr7_-_139477437 0.982 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr9_-_132805256 0.982 FNBP1
formin binding protein 1
chr2_-_208634051 0.977 NM_003468
FZD5
frizzled family receptor 5
chr2_-_101767714 0.976 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr2_+_150187028 0.970 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr4_+_1005609 0.964 NM_001004356
NM_001004358
FGFRL1

fibroblast growth factor receptor-like 1

chr13_-_114898057 0.956 RASA3
RAS p21 protein activator 3
chr5_+_10564431 0.952 NM_001164440
ANKRD33B
ankyrin repeat domain 33B
chr1_+_212781969 0.950 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr10_+_30723050 0.948 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr18_-_48724031 0.947 NM_016626
MEX3C
mex-3 homolog C (C. elegans)
chr1_-_161102210 0.945 NM_001039712
DEDD
death effector domain containing
chr13_-_114898084 0.939 NM_007368
RASA3
RAS p21 protein activator 3
chr5_-_1112106 0.931 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr6_+_158244306 0.924 SNX9
sorting nexin 9
chr21_+_43639930 0.920 NM_207174
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr1_-_95007139 0.917 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr21_+_43639202 0.917 NM_004915
NM_016818
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr18_+_9136742 0.909 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr10_+_135192694 0.906 NM_152911
NM_207127
NM_207128
PAOX


polyamine oxidase (exo-N4-amino)


chr21_+_40177754 0.903 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr22_+_45705766 0.897 NM_017911
FAM118A
family with sequence similarity 118, member A
chr15_+_75494196 0.887 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr17_-_76778306 0.886 NM_004762
NM_017456
CYTH1

cytohesin 1

chr1_+_25071906 0.886 CLIC4
chloride intracellular channel 4
chr1_+_212782103 0.882 ATF3
activating transcription factor 3
chr3_-_197024879 0.879 DLG1
discs, large homolog 1 (Drosophila)
chr12_-_129308293 0.877 NM_145648
SLC15A4
solute carrier family 15, member 4
chr3_+_133293256 0.872 NM_001134423
CDV3
CDV3 homolog (mouse)
chr14_+_21538339 0.865 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr8_-_101322245 0.865 NM_183419
RNF19A
ring finger protein 19A
chr1_-_224033383 0.863 TP53BP2
tumor protein p53 binding protein, 2
chr5_+_102594406 0.862 NM_033211
C5orf30
chromosome 5 open reading frame 30
chr2_-_25564745 0.861 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr11_+_134201897 0.856 GLB1L2
galactosidase, beta 1-like 2
chr8_+_142138684 0.854 NM_014957
DENND3
DENN/MADD domain containing 3
chr15_+_101420004 0.853 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr2_-_25474948 0.852 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr2_-_96657538 0.850 ANKRD36C
ankyrin repeat domain 36C
chr2_-_178129294 0.849 NFE2L2
nuclear factor (erythroid-derived 2)-like 2
chr19_+_6739697 0.846 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr6_+_83073954 0.845 NM_001166392
TPBG
trophoblast glycoprotein
chr10_+_35416089 0.844 CREM
cAMP responsive element modulator
chr17_+_26662547 0.843 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr1_+_45265896 0.843 PLK3
polo-like kinase 3
chr19_-_47734215 0.839 NM_014417
BBC3
BCL2 binding component 3
chr6_+_160148145 0.831 NM_004906
NM_152858
WTAP

Wilms tumor 1 associated protein

chr15_-_23086842 0.828 NM_001142275
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr20_-_62462568 0.823 ZBTB46
zinc finger and BTB domain containing 46
chr3_+_128997616 0.816 NM_020187
C3orf37
chromosome 3 open reading frame 37
chr4_+_128982483 0.814 LARP1B
La ribonucleoprotein domain family, member 1B
chr3_+_186648515 0.813 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr1_+_24286311 0.811 PNRC2
proline-rich nuclear receptor coactivator 2
chr15_+_75494233 0.809 C15orf39
chromosome 15 open reading frame 39
chr11_-_72353435 0.806 NM_001143839
NM_001243784
PDE2A

phosphodiesterase 2A, cGMP-stimulated

chr4_+_4861371 0.805 NM_002448
MSX1
msh homeobox 1
chr8_-_48650703 0.802 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr14_-_53417808 0.799 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr7_+_55086922 0.797 EGFR
epidermal growth factor receptor
chr22_-_18257194 0.794 BID
BH3 interacting domain death agonist
chr6_+_29855506 0.789


chr9_+_101867392 0.788 TGFBR1
transforming growth factor, beta receptor 1
chr3_-_66551341 0.786 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr21_-_47648685 0.784 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr7_+_77166750 0.783 NM_002835
PTPN12
protein tyrosine phosphatase, non-receptor type 12
chr3_-_122233764 0.782 KPNA1
karyopherin alpha 1 (importin alpha 5)
chr3_+_10206562 0.781 NM_001570
IRAK2
interleukin-1 receptor-associated kinase 2
chr15_+_76135992 0.778 UBE2Q2
ubiquitin-conjugating enzyme E2Q family member 2
chr1_+_12040475 0.776 MFN2
mitofusin 2
chr1_-_41328019 0.774 CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr20_+_53092131 0.774 NM_018431
DOK5
docking protein 5
chr16_+_50775960 0.768 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr1_-_229761716 0.762 TAF5L
TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr10_+_28966419 0.762 NM_012342
BAMBI
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr1_-_33336289 0.761 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr22_+_50247528 0.761 ZBED4
zinc finger, BED-type containing 4
chr22_-_18257160 0.761 BID
BH3 interacting domain death agonist
chr2_+_10091791 0.759 NM_198182
GRHL1
grainyhead-like 1 (Drosophila)
chr7_+_116139619 0.759 NM_001206747
NM_001233
NM_198212
CAV2


caveolin 2


chr1_-_65431826 0.759 NM_002227
JAK1
Janus kinase 1
chr1_+_166808721 0.757 NM_017542
POGK
pogo transposable element with KRAB domain
chr2_-_204399906 0.756 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr1_+_45266035 0.756 NM_004073
PLK3
polo-like kinase 3
chr8_-_105601124 0.753 LRP12
low density lipoprotein receptor-related protein 12
chr18_+_77155943 0.753 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr1_-_41328002 0.752 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr15_-_38856830 0.746 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 1.68e-19 GO:0009987 cellular process
1.15 5.83e-17 GO:0044237 cellular metabolic process
1.13 3.14e-15 GO:0008152 metabolic process
1.14 2.54e-14 GO:0044238 primary metabolic process
1.18 8.01e-14 GO:0044260 cellular macromolecule metabolic process
1.15 3.54e-11 GO:0043170 macromolecule metabolic process
1.22 1.77e-10 GO:0048518 positive regulation of biological process
1.23 2.61e-10 GO:0048522 positive regulation of cellular process
1.10 3.31e-10 GO:0065007 biological regulation
1.11 8.82e-10 GO:0050789 regulation of biological process
1.23 5.17e-09 GO:0048523 negative regulation of cellular process
1.18 1.54e-08 GO:0016043 cellular component organization
1.11 2.78e-08 GO:0050794 regulation of cellular process
1.18 2.93e-08 GO:0006807 nitrogen compound metabolic process
1.17 3.43e-08 GO:0071840 cellular component organization or biogenesis
1.36 5.46e-08 GO:0008219 cell death
1.19 6.52e-08 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36 1.15e-07 GO:0016265 death
1.17 1.65e-07 GO:0034641 cellular nitrogen compound metabolic process
1.30 1.82e-07 GO:0044248 cellular catabolic process
1.20 1.85e-07 GO:0044267 cellular protein metabolic process
1.15 3.33e-07 GO:0019222 regulation of metabolic process
1.20 4.32e-07 GO:0048519 negative regulation of biological process
1.29 6.58e-07 GO:0010604 positive regulation of macromolecule metabolic process
1.16 1.23e-06 GO:0060255 regulation of macromolecule metabolic process
1.37 1.42e-06 GO:0012501 programmed cell death
1.26 1.62e-06 GO:0009966 regulation of signal transduction
1.15 1.71e-06 GO:0080090 regulation of primary metabolic process
1.24 1.92e-06 GO:0023051 regulation of signaling
1.15 1.92e-06 GO:0031323 regulation of cellular metabolic process
1.33 1.97e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.35 3.39e-06 GO:0016192 vesicle-mediated transport
1.15 4.20e-06 GO:0051179 localization
1.27 4.27e-06 GO:0009893 positive regulation of metabolic process
1.25 4.36e-06 GO:0009056 catabolic process
1.36 4.83e-06 GO:0006915 apoptosis
1.16 5.48e-06 GO:0019538 protein metabolic process
1.22 5.69e-06 GO:0006464 protein modification process
1.30 5.94e-06 GO:0009892 negative regulation of metabolic process
1.21 6.01e-06 GO:0043412 macromolecule modification
1.29 7.94e-06 GO:0051246 regulation of protein metabolic process
1.26 8.58e-06 GO:0051641 cellular localization
1.29 1.03e-05 GO:0032268 regulation of cellular protein metabolic process
1.26 2.14e-05 GO:0031325 positive regulation of cellular metabolic process
1.17 4.60e-05 GO:0071842 cellular component organization at cellular level
1.37 5.18e-05 GO:0010629 negative regulation of gene expression
1.40 6.65e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.16 6.84e-05 GO:0071841 cellular component organization or biogenesis at cellular level
1.15 6.92e-05 GO:0051234 establishment of localization
1.23 8.27e-05 GO:0065009 regulation of molecular function
1.35 9.54e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.29 9.99e-05 GO:0031324 negative regulation of cellular metabolic process
1.31 1.05e-04 GO:0031399 regulation of protein modification process
1.30 2.31e-04 GO:0051128 regulation of cellular component organization
1.18 2.42e-04 GO:0065008 regulation of biological quality
1.15 2.99e-04 GO:0006810 transport
1.19 3.21e-04 GO:0048583 regulation of response to stimulus
1.17 6.60e-04 GO:0090304 nucleic acid metabolic process
1.25 1.58e-03 GO:0007049 cell cycle
1.34 1.66e-03 GO:0051253 negative regulation of RNA metabolic process
1.42 1.76e-03 GO:0090066 regulation of anatomical structure size
1.32 1.91e-03 GO:0009057 macromolecule catabolic process
1.15 2.20e-03 GO:0044249 cellular biosynthetic process
1.21 2.32e-03 GO:0033036 macromolecule localization
1.15 2.59e-03 GO:0009058 biosynthetic process
1.23 2.73e-03 GO:0051649 establishment of localization in cell
1.24 2.93e-03 GO:0010646 regulation of cell communication
1.18 3.00e-03 GO:0016070 RNA metabolic process
1.30 3.15e-03 GO:0009890 negative regulation of biosynthetic process
1.30 3.37e-03 GO:0051254 positive regulation of RNA metabolic process
1.27 4.84e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.33 5.25e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.29 5.72e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.27 5.77e-03 GO:0046907 intracellular transport
1.33 6.00e-03 GO:0044265 cellular macromolecule catabolic process
1.18 6.19e-03 GO:0034645 cellular macromolecule biosynthetic process
1.23 6.79e-03 GO:0008104 protein localization
1.29 8.29e-03 GO:0010628 positive regulation of gene expression
1.30 8.72e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.30 9.13e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 9.42e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.13 9.48e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.21 9.89e-03 GO:0050790 regulation of catalytic activity
1.57 1.04e-02 GO:0051493 regulation of cytoskeleton organization
1.18 1.08e-02 GO:0009059 macromolecule biosynthetic process
1.18 1.16e-02 GO:0006996 organelle organization
1.41 1.18e-02 GO:0009150 purine ribonucleotide metabolic process
1.40 1.23e-02 GO:0009259 ribonucleotide metabolic process
1.25 1.27e-02 GO:0006351 transcription, DNA-dependent
1.23 1.35e-02 GO:0042981 regulation of apoptosis
1.41 1.37e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.27 1.38e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.24 1.59e-02 GO:0045184 establishment of protein localization
1.32 1.61e-02 GO:0006753 nucleoside phosphate metabolic process
1.32 1.61e-02 GO:0009117 nucleotide metabolic process
1.39 1.70e-02 GO:0044257 cellular protein catabolic process
1.22 1.73e-02 GO:0043067 regulation of programmed cell death
1.18 1.73e-02 GO:0007399 nervous system development
1.14 1.73e-02 GO:0010468 regulation of gene expression
1.38 1.77e-02 GO:0030163 protein catabolic process
1.37 1.80e-02 GO:0006163 purine nucleotide metabolic process
1.48 1.81e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.40 1.91e-02 GO:0033043 regulation of organelle organization
1.40 2.35e-02 GO:0043632 modification-dependent macromolecule catabolic process
1.39 2.48e-02 GO:0032535 regulation of cellular component size
1.22 2.49e-02 GO:0010941 regulation of cell death
1.36 2.49e-02 GO:0007264 small GTPase mediated signal transduction
1.29 2.60e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.30 2.61e-02 GO:0000278 mitotic cell cycle
1.39 2.63e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.39 2.71e-02 GO:0019941 modification-dependent protein catabolic process
1.10 3.25e-02 GO:0051716 cellular response to stimulus
1.28 3.46e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.37 3.95e-02 GO:0018193 peptidyl-amino acid modification
1.40 4.08e-02 GO:0009141 nucleoside triphosphate metabolic process
1.52 4.29e-02 GO:0032869 cellular response to insulin stimulus
1.43 4.48e-02 GO:0009166 nucleotide catabolic process
1.23 4.81e-02 GO:0009891 positive regulation of biosynthetic process
1.22 4.87e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 2.20e-49 GO:0005622 intracellular
1.13 4.54e-49 GO:0044424 intracellular part
1.19 1.94e-46 GO:0005737 cytoplasm
1.16 4.34e-38 GO:0043227 membrane-bounded organelle
1.16 4.77e-38 GO:0043231 intracellular membrane-bounded organelle
1.14 1.41e-37 GO:0043226 organelle
1.14 2.33e-37 GO:0043229 intracellular organelle
1.21 1.67e-34 GO:0044444 cytoplasmic part
1.17 3.87e-19 GO:0044446 intracellular organelle part
1.31 4.05e-18 GO:0005829 cytosol
1.16 6.51e-18 GO:0044422 organelle part
1.04 1.94e-16 GO:0044464 cell part
1.04 2.20e-16 GO:0005623 cell
1.15 4.36e-14 GO:0005634 nucleus
1.24 2.99e-11 GO:0031090 organelle membrane
1.26 5.39e-09 GO:0012505 endomembrane system
1.21 6.21e-08 GO:0044428 nuclear part
1.19 3.47e-07 GO:0031974 membrane-enclosed lumen
1.19 3.67e-07 GO:0070013 intracellular organelle lumen
1.19 5.12e-07 GO:0043233 organelle lumen
1.35 1.32e-06 GO:0031967 organelle envelope
1.34 1.54e-06 GO:0031975 envelope
1.29 1.60e-06 GO:0005794 Golgi apparatus
1.20 1.17e-05 GO:0031981 nuclear lumen
1.33 1.04e-04 GO:0044431 Golgi apparatus part
1.38 1.08e-04 GO:0005768 endosome
1.37 1.61e-04 GO:0000139 Golgi membrane
1.29 4.30e-04 GO:0015630 microtubule cytoskeleton
1.20 7.91e-04 GO:0005739 mitochondrion
1.41 9.82e-04 GO:0005815 microtubule organizing center
1.34 1.15e-03 GO:0005740 mitochondrial envelope
1.26 1.55e-03 GO:0031982 vesicle
1.27 2.22e-03 GO:0044429 mitochondrial part
1.25 2.89e-03 GO:0031410 cytoplasmic vesicle
1.19 3.79e-03 GO:0005654 nucleoplasm
1.70 1.18e-02 GO:0042470 melanosome
1.70 1.18e-02 GO:0048770 pigment granule
1.31 1.29e-02 GO:0031966 mitochondrial membrane
1.12 1.37e-02 GO:0043228 non-membrane-bounded organelle
1.12 1.37e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.11 1.51e-02 GO:0043234 protein complex
1.24 1.53e-02 GO:0031988 membrane-bounded vesicle
1.38 1.54e-02 GO:0015629 actin cytoskeleton
1.24 1.84e-02 GO:0016023 cytoplasmic membrane-bounded vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 1.69e-29 GO:0005515 protein binding
1.08 2.02e-17 GO:0005488 binding
1.20 2.13e-07 GO:0000166 nucleotide binding
1.11 7.48e-06 GO:0003824 catalytic activity
1.19 3.27e-05 GO:0017076 purine nucleotide binding
1.19 3.96e-05 GO:0032553 ribonucleotide binding
1.19 3.96e-05 GO:0032555 purine ribonucleotide binding
1.18 1.03e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.30 1.16e-04 GO:0019899 enzyme binding
1.37 4.43e-04 GO:0019904 protein domain specific binding
1.44 1.29e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.45 2.55e-03 GO:0016881 acid-amino acid ligase activity
1.36 5.53e-03 GO:0000988 protein binding transcription factor activity
1.36 5.53e-03 GO:0000989 transcription factor binding transcription factor activity
1.67 6.40e-03 GO:0017124 SH3 domain binding
1.36 7.64e-03 GO:0003712 transcription cofactor activity
1.17 9.63e-03 GO:0030554 adenyl nucleotide binding
1.17 1.36e-02 GO:0032559 adenyl ribonucleotide binding
1.24 1.73e-02 GO:0042802 identical protein binding
1.43 1.99e-02 GO:0019787 small conjugating protein ligase activity
1.54 3.08e-02 GO:0003714 transcription corepressor activity
1.16 3.49e-02 GO:0005524 ATP binding