Motif ID: PDX1.p2

Z-value: 0.519


Transcription factors associated with PDX1.p2:

Gene SymbolEntrez IDGene Name
PDX1 3651 pancreatic and duodenal homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
PDX1chr13_+_284941360.358.9e-02Click!


Activity profile for motif PDX1.p2.

activity profile for motif PDX1.p2


Sorted Z-values histogram for motif PDX1.p2

Sorted Z-values for motif PDX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PDX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_46020496 1.253 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr9_-_8733893 1.245 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr16_-_70557430 0.989 NM_001195139
NM_015386
COG4

component of oligomeric golgi complex 4

chr10_+_63808968 0.943 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr10_+_35484829 0.845 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr8_-_17580024 0.814 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr8_-_17579729 0.765 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr11_+_5410606 0.654 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr8_-_17555158 0.640 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr17_+_38119225 0.547 NM_178171
GSDMA
gasdermin A
chr4_+_108814419 0.472 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr1_+_63063186 0.450 NM_014495
ANGPTL3
angiopoietin-like 3
chr16_+_19078916 0.427 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr16_+_19078958 0.427 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr12_+_47610244 0.420 FAM113B
family with sequence similarity 113, member B
chr15_+_25281105 0.419 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_+_158979681 0.417 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr3_+_100238063 0.412 TMEM45A
transmembrane protein 45A
chr9_+_82187469 0.384 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr15_+_67841341 0.374 NM_001206804
MAP2K5
mitogen-activated protein kinase kinase 5
chr12_+_47610051 0.362 NM_138371
FAM113B
family with sequence similarity 113, member B
chr8_-_80993009 0.350 NM_001025252
TPD52
tumor protein D52
chr1_+_84768333 0.333 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr1_+_84609941 0.314 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr20_+_42574535 0.302 NM_001098798
TOX2
TOX high mobility group box family member 2
chr16_-_67517715 0.291 NM_001138
AGRP
agouti related protein homolog (mouse)
chr8_+_76452202 0.284 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr16_+_19079220 0.259 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chrX_+_110366304 0.249 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr17_-_7082654 0.242 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr19_-_7766978 0.235 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr9_+_136501484 0.226 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr17_+_7482980 0.221 CD68
CD68 molecule
chr6_+_144612872 0.212 NM_007124
UTRN
utrophin
chr5_+_42565562 0.209 NM_001242406
GHR
growth hormone receptor
chr2_-_188419049 0.206 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr7_-_44228880 0.192 NM_000162
GCK
glucokinase (hexokinase 4)
chr1_-_33841142 0.187 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr2_-_188419185 0.186 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr9_+_82187599 0.185 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_-_39150384 0.183 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr11_-_66445318 0.177 RBM4B
RNA binding motif protein 4B
chr12_-_50616425 0.177 NM_001113547
LIMA1
LIM domain and actin binding 1
chr11_+_111789600 0.174 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr7_+_80267972 0.166 CD36
CD36 molecule (thrombospondin receptor)
chr11_+_22696318 0.165 NM_005256
GAS2
growth arrest-specific 2
chr5_+_147648374 0.162 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr10_+_115310589 0.158 NM_001177660
HABP2
hyaluronan binding protein 2
chr6_-_51952368 0.156 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr16_+_8814567 0.155 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr11_+_123986103 0.151 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr10_+_94594469 0.150 NM_001013848
EXOC6
exocyst complex component 6
chr19_+_37180301 0.149 NM_152603
ZNF567
zinc finger protein 567
chrX_-_10645726 0.146 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr9_+_97521930 0.143 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr6_-_43423785 0.143 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chr12_+_51318515 0.140 NM_014033
METTL7A
methyltransferase like 7A
chr1_+_163038934 0.140 NM_001113381
RGS4
regulator of G-protein signaling 4
chr2_+_38893238 0.139 GALM
galactose mutarotase (aldose 1-epimerase)
chr2_+_169921298 0.138 NM_005771
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_+_33043702 0.133 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr1_+_163038564 0.133 NM_005613
RGS4
regulator of G-protein signaling 4
chr10_+_116697914 0.132 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr7_+_80275967 0.129 CD36
CD36 molecule (thrombospondin receptor)
chr4_-_46996423 0.125 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr1_-_20250051 0.119 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr2_+_38893051 0.118 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr12_-_14849427 0.112 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr12_-_11214892 0.110 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr6_-_31107110 0.110 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr3_+_97868169 0.108 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr2_+_169926084 0.099 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr16_-_3085541 0.099 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr2_-_158300517 0.095 NM_004288
CYTIP
cytohesin 1 interacting protein
chr3_-_69037498 0.095 C3orf64
chromosome 3 open reading frame 64
chr3_-_51813202 0.094 NM_001143833
IQCF6
IQ motif containing F6
chr17_+_47923271 0.086 NM_001242791
FLJ45513
uncharacterized LOC729220
chrX_+_99899388 0.083 SRPX2
sushi-repeat containing protein, X-linked 2
chr6_-_131291480 0.082 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr9_-_21228132 0.081 NM_021268
IFNA17
interferon, alpha 17
chr17_-_15554809 0.079 TRIM16
tripartite motif containing 16
chr6_+_72922513 0.079 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr7_+_104681378 0.078 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr1_+_28764660 0.077 NM_023923
PHACTR4
phosphatase and actin regulator 4
chrX_-_62780748 0.073 LOC92249
uncharacterized LOC92249
chrX_+_118708540 0.073 UBE2A
ubiquitin-conjugating enzyme E2A
chr17_-_39156106 0.070 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr1_-_161601251 0.068 NM_001244753
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr7_-_27166638 0.067 NM_153631
HOXA3
homeobox A3
chr14_+_21510384 0.067 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr2_-_218808705 0.067 NM_022648
TNS1
tensin 1
chr10_+_118187381 0.066 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr1_+_153190059 0.064 NM_001195571
PRR9
proline rich 9
chr12_+_4829751 0.063 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr17_-_29641068 0.060 EVI2B
ecotropic viral integration site 2B
chr15_+_48498497 0.058 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr21_-_31744546 0.057 NM_181621
KRTAP13-2
keratin associated protein 13-2
chr5_+_79615789 0.057 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr3_-_114478117 0.055 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr15_+_80364902 0.055 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr6_+_35310399 0.054 PPARD
peroxisome proliferator-activated receptor delta
chr5_-_172083569 0.054


chr9_+_33624214 0.051 ANXA2P2
annexin A2 pseudogene 2
chr16_+_29674282 0.051 NM_001030288
SPN
sialophorin
chr1_-_16763887 0.051 NM_198546
SPATA21
spermatogenesis associated 21
chr2_+_169757749 0.051 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chrX_-_133931146 0.051 NM_001166599
NM_001166600
NM_001170757
FAM122B


family with sequence similarity 122B


chr3_-_114343791 0.050 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_36748164 0.048 THRAP3
thyroid hormone receptor associated protein 3
chr1_+_84874033 0.047 NM_058248
DNASE2B
deoxyribonuclease II beta
chr3_-_51909599 0.045 NM_001145059
IQCF5
IQ motif containing F5
chr17_+_76000248 0.044 NM_001142640
NM_018996
TNRC6C

trinucleotide repeat containing 6C

chr17_+_18625335 0.042 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr4_+_86396251 0.042 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr2_+_228192227 0.042 NM_020194
MFF
mitochondrial fission factor
chr3_-_143567163 0.041 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr17_-_39637351 0.040 NM_002280
KRT35
keratin 35
chr7_+_129269916 0.039 NM_001040110
NRF1
nuclear respiratory factor 1
chr12_+_75784878 0.036 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr4_+_187187342 0.036 F11
coagulation factor XI
chr4_+_95376396 0.035 PDLIM5
PDZ and LIM domain 5
chr3_+_183770834 0.033 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr5_+_54398473 0.033 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr12_+_21525801 0.033 NM_000415
IAPP
islet amyloid polypeptide
chr7_+_26400503 0.033 NM_001199837
SNX10
sorting nexin 10
chr19_-_14952688 0.032 NM_001005190
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr5_+_140201221 0.032 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr2_-_216259197 0.032 FN1
fibronectin 1
chr5_+_147582338 0.032 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr12_+_10460416 0.032 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr14_+_70918873 0.031 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr11_+_28131830 0.031 METTL15
methyltransferase like 15
chr2_+_113735595 0.031 NM_019618
IL36G
interleukin 36, gamma
chr8_-_27850368 0.030 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr9_-_21239975 0.030 NM_002172
IFNA14
interferon, alpha 14
chr5_-_77844975 0.029 LHFPL2
lipoma HMGIC fusion partner-like 2
chr16_+_28505920 0.029 NM_018690
APOBR
apolipoprotein B receptor
chrX_+_99899162 0.028 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr5_+_140227356 0.028 NM_014005
NM_031857
PCDHA9

protocadherin alpha 9

chr3_-_151034514 0.027 NM_023915
GPR87
G protein-coupled receptor 87
chr3_+_52813936 0.026 NM_001166435
NM_001166436
ITIH1

inter-alpha-trypsin inhibitor heavy chain 1

chr12_+_15475190 0.025 NM_002848
NM_030667
PTPRO

protein tyrosine phosphatase, receptor type, O

chr6_+_130339715 0.023 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr2_-_166060552 0.023 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chrX_-_118726852 0.022 NM_001173488
NKRF
NFKB repressing factor
chr6_+_72926144 0.022 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr6_-_123957941 0.020 NM_001251987
NM_006073
TRDN

triadin

chr3_+_52811601 0.020 NM_002215
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr6_-_46825942 0.020 GPR116
G protein-coupled receptor 116
chr21_-_32253843 0.020 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr6_+_147524866 0.020 STXBP5
syntaxin binding protein 5 (tomosyn)
chr14_-_23504353 0.019 NM_001144932
NM_002797
NM_001130725
PSMB5


proteasome (prosome, macropain) subunit, beta type, 5


chr17_-_1412995 0.019 INPP5K
inositol polyphosphate-5-phosphatase K
chr1_-_204135420 0.018 NM_000537
REN
renin
chr3_-_108672547 0.017 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr4_-_120225599 0.017 NM_001170330
C4orf3
chromosome 4 open reading frame 3
chr16_+_57728711 0.017 NM_032269
CCDC135
coiled-coil domain containing 135
chrX_+_123480131 0.016 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr14_+_23789396 0.015 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr4_+_74281884 0.015 ALB
albumin
chr7_-_113559048 0.015 NM_002711
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr6_-_131321868 0.014 NM_001252660
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr3_+_45017729 0.014 NM_015004
EXOSC7
exosome component 7
chr20_+_31037447 0.013


chr12_+_105153258 0.013 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr7_+_148287656 0.013 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr19_-_14785626 0.013 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr2_-_96947640 0.011 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr6_-_29455678 0.011 NM_052967
MAS1L
MAS1 oncogene-like
chr5_-_75919051 0.009 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr5_+_140718353 0.009 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr3_+_45017749 0.009 EXOSC7
exosome component 7
chr15_-_44969085 0.009 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr5_-_119740531 0.009


chr2_-_47134945 0.008 MCFD2
multiple coagulation factor deficiency 2
chr11_-_62457370 0.008 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr5_+_76382458 0.008 LOC728723
uncharacterized LOC728723
chr1_+_101003692 0.007 NM_022049
GPR88
G protein-coupled receptor 88
chr13_-_41593491 0.007 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr4_+_88720701 0.007 NM_004967
IBSP
integrin-binding sialoprotein
chr17_-_39197663 0.007 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr1_-_186417855 0.006 NM_022576
PDC
phosducin
chr15_+_40509628 0.006 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr3_+_108541544 0.005 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr1_+_92632608 0.004 NM_015237
KIAA1107
KIAA1107
chr12_-_9885859 0.003 NM_001253748
NM_001253750
NM_172004
CLECL1


C-type lectin-like 1


chr10_+_32856650 0.003 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr6_+_167536240 0.003 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr4_-_24981769 0.002 NM_173463
CCDC149
coiled-coil domain containing 149
chr7_+_120965420 0.001 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr6_-_32731266 0.000 NM_001198858
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.00 7.89e-03 GO:0005576 extracellular region
8.19 1.23e-02 GO:0045095 keratin filament
5.30 1.87e-02 GO:0005882 intermediate filament
4.59 4.96e-02 GO:0045111 intermediate filament cytoskeleton

Nothing significant found in function category.