Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 0.745


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
POU5F1chr6_-_31138180-0.471.7e-02Click!
SOX2chr3_+_1814297110.252.3e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_101185195 2.486 NM_001078
NM_001199834
NM_080682
 VCAM1


vascular cell adhesion molecule 1


chr12_+_7942025 2.423 NANOG
Nanog homeobox
chr15_+_67458492 2.410 NM_001145104
 SMAD3
SMAD family member 3
chr11_+_5710926 2.348 TRIM22
tripartite motif containing 22
chr11_+_69455938 2.173 CCND1
cyclin D1
chr11_+_69455978 1.943 CCND1
cyclin D1
chr16_+_57050985 1.834 NM_032206
 NLRC5
NLR family, CARD domain containing 5
chr2_-_175712276 1.794 NM_001206602
 CHN1
chimerin (chimaerin) 1
chr11_+_69455837 1.773 NM_053056
 CCND1
cyclin D1
chr11_+_5710816 1.680 NM_001199573
NM_006074
 TRIM22

tripartite motif containing 22

chr1_-_150738292 1.623 NM_001199739
NM_004079
 CTSS

cathepsin S

chr12_-_105322056 1.509 NM_032148
 SLC41A2
solute carrier family 41, member 2
chr5_+_76114881 1.476 F2RL1
coagulation factor II (thrombin) receptor-like 1
chrX_+_144908927 1.325 NM_004709
 CXorf1
chromosome X open reading frame 1
chr21_+_43710190 1.284 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr2_+_102979096 1.260 NM_003855
 IL18R1
interleukin 18 receptor 1
chr4_+_100495972 1.105 MTTP
microsomal triglyceride transfer protein
chr5_+_125758818 1.100 NM_001146320
NM_001146321
NM_023927
 GRAMD3


GRAM domain containing 3


chr11_+_69455884 1.081 CCND1
cyclin D1
chr5_+_76114832 1.064 NM_005242
 F2RL1
coagulation factor II (thrombin) receptor-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
3.65 1.32e-02 GO:0007156 homophilic cell adhesion
2.24 1.06e-04 GO:0006955 immune response
1.93 8.30e-05 GO:0002376 immune system process
1.90 3.12e-02 GO:0006952 defense response
1.26 1.23e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
1.85 6.56e-04 GO:0044421 extracellular region part
1.84 1.10e-02 GO:0005615 extracellular space
1.61 1.18e-04 GO:0005576 extracellular region
1.54 8.12e-04 GO:0044459 plasma membrane part
1.38 1.91e-04 GO:0071944 cell periphery
1.37 4.67e-04 GO:0005886 plasma membrane

Nothing significant found in function category.