Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 0.745


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
POU5F1chr6_-_31138180-0.471.7e-02Click!
SOX2chr3_+_1814297110.252.3e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_101185195 2.486 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr12_+_7942025 2.423 NANOG
Nanog homeobox
chr15_+_67458492 2.410 NM_001145104
SMAD3
SMAD family member 3
chr11_+_5710926 2.348 TRIM22
tripartite motif containing 22
chr11_+_69455938 2.173 CCND1
cyclin D1
chr11_+_69455978 1.943 CCND1
cyclin D1
chr16_+_57050985 1.834 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr2_-_175712276 1.794 NM_001206602
CHN1
chimerin (chimaerin) 1
chr11_+_69455837 1.773 NM_053056
CCND1
cyclin D1
chr11_+_5710816 1.680 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr1_-_150738292 1.623 NM_001199739
NM_004079
CTSS

cathepsin S

chr12_-_105322056 1.509 NM_032148
SLC41A2
solute carrier family 41, member 2
chr5_+_76114881 1.476 F2RL1
coagulation factor II (thrombin) receptor-like 1
chrX_+_144908927 1.325 NM_004709
CXorf1
chromosome X open reading frame 1
chr21_+_43710190 1.284 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr2_+_102979096 1.260 NM_003855
IL18R1
interleukin 18 receptor 1
chr4_+_100495972 1.105 MTTP
microsomal triglyceride transfer protein
chr5_+_125758818 1.100 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr11_+_69455884 1.081 CCND1
cyclin D1
chr5_+_76114832 1.064 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr13_+_109281569 1.015 NM_001198950
MYO16
myosin XVI
chr7_+_142919129 0.999 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr2_-_231989755 0.962 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr12_+_7941994 0.909 NM_024865
NANOG
Nanog homeobox
chr11_-_9225780 0.899 DENND5A
DENN/MADD domain containing 5A
chr7_-_139763520 0.891 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr5_+_140809957 0.882 PCDHGA12
protocadherin gamma subfamily A, 12
chr13_+_97794050 0.879 MBNL2
muscleblind-like 2 (Drosophila)
chr6_+_64286348 0.871 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_50574589 0.846 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr2_+_36923832 0.843 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr10_+_114043413 0.836 NM_058222
TECTB
tectorin beta
chr4_-_70826712 0.806 NM_001891
CSN2
casein beta
chr5_-_58295758 0.787 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_-_27057776 0.781 ABI1
abl-interactor 1
chr10_+_7745284 0.777 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr18_+_63417487 0.764 NM_033646
CDH7
cadherin 7, type 2
chr12_-_15091441 0.723 NM_152321
ERP27
endoplasmic reticulum protein 27
chr4_+_100432160 0.723 NM_032149
C4orf17
chromosome 4 open reading frame 17
chr17_+_32582295 0.715 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr4_-_122085475 0.712 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr7_-_122339186 0.707 NM_139175
RNF133
ring finger protein 133
chr3_+_133494275 0.701 TF
transferrin
chr2_+_90077732 0.691


chr9_-_33465191 0.673 NOL6
nucleolar protein family 6 (RNA-associated)
chr1_-_150738255 0.673 CTSS
cathepsin S
chr3_+_63428752 0.669 NM_144642
SYNPR
synaptoporin
chr18_+_28898051 0.647 NM_001942
DSG1
desmoglein 1
chr2_+_103035148 0.599 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr6_+_26156552 0.598 HIST1H1E
histone cluster 1, H1e
chr2_-_233641225 0.585 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr15_-_89089792 0.569 NM_001144074
NM_017996
DET1

de-etiolated homolog 1 (Arabidopsis)

chr8_+_12869772 0.566 NM_001099677
KIAA1456
KIAA1456
chr13_-_28543143 0.564 CDX2
caudal type homeobox 2
chr13_+_23755059 0.561 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr12_+_113344738 0.556 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr8_+_120079423 0.556 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr11_-_128457452 0.550 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr10_-_69455926 0.545 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr2_+_228678556 0.544 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr11_-_16424391 0.531 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr12_+_21168629 0.524 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr18_-_3845295 0.523 NM_001003809
NM_001242765
NM_001242766
DLGAP1


discs, large (Drosophila) homolog-associated protein 1


chr18_+_63418156 0.519 NM_004361
CDH7
cadherin 7, type 2
chr6_+_26156558 0.508 NM_005321
HIST1H1E
histone cluster 1, H1e
chr10_+_124151818 0.508 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr12_+_113344811 0.495 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr7_-_92855780 0.491 NM_001039372
HEPACAM2
HEPACAM family member 2
chr20_+_68312 0.491 NM_153325
DEFB125
defensin, beta 125
chr1_-_183622447 0.490 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr1_+_87012758 0.481 NM_012128
CLCA4
chloride channel accessory 4
chr2_-_152146373 0.476 NM_004688
NMI
N-myc (and STAT) interactor
chr11_-_35441501 0.471 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr10_+_114133775 0.461 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_+_55039070 0.457 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr1_+_50574601 0.444 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr8_+_55528626 0.442 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr10_+_123923104 0.435 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr7_+_28452143 0.435 NM_182898
CREB5
cAMP responsive element binding protein 5
chr18_-_58040000 0.423 NM_005912
MC4R
melanocortin 4 receptor
chr5_+_125759076 0.423 GRAMD3
GRAM domain containing 3
chrX_+_111119278 0.418 NM_001195576
NM_001195578
LOC100329135

uncharacterized LOC100329135

chr2_-_166060552 0.417 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr5_+_173472692 0.416 NM_015980
HMP19
HMP19 protein
chr10_+_118305427 0.414 NM_000936
PNLIP
pancreatic lipase
chr4_+_70796798 0.410 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr6_+_123100860 0.400 FABP7
fatty acid binding protein 7, brain
chr3_-_123603144 0.399 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr1_-_150552077 0.396 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr3_-_71542628 0.394 FOXP1
forkhead box P1
chr12_+_130647002 0.387 NM_007197
FZD10
frizzled family receptor 10
chr1_-_89591685 0.385 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr12_-_21487831 0.380 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr10_+_96522457 0.375 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr6_-_13295817 0.373 NM_001242698
LOC100130357
uncharacterized LOC100130357
chr18_-_75705682 0.364


chr18_+_72167021 0.364 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr3_-_196911001 0.361 NM_001204387
NM_001204388
DLG1

discs, large homolog 1 (Drosophila)

chr1_+_167298280 0.359 NM_001198783
POU2F1
POU class 2 homeobox 1
chr10_+_114133838 0.350 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_177133950 0.345 NM_004319
NM_207108
ASTN1

astrotactin 1

chr1_+_205473683 0.343 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr16_-_54962707 0.333 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr8_-_57026540 0.331 NM_005372
MOS
v-mos Moloney murine sarcoma viral oncogene homolog
chr9_-_137809710 0.329 NM_002003
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr22_+_18043147 0.328 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr5_+_140771482 0.328 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr14_-_106453162 0.326 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrM_+_9217 0.325


chr5_+_140729723 0.324 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr8_+_32579350 0.321 NM_001159996
NRG1
neuregulin 1
chr4_-_123542165 0.317 NM_001207006
NM_021803
IL21

interleukin 21

chr17_-_42908178 0.311 NM_001080383
GJC1
gap junction protein, gamma 1, 45kDa
chr4_-_111563278 0.308 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr7_-_84751246 0.306 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr9_+_2717525 0.305 NM_133497
KCNV2
potassium channel, subfamily V, member 2
chr10_+_123754141 0.302 TACC2
transforming, acidic coiled-coil containing protein 2
chr17_-_46608271 0.298 NM_002144
HOXB1
homeobox B1
chr3_+_156008775 0.296 NM_172159
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr17_+_51900238 0.295 NM_032559
KIF2B
kinesin family member 2B
chr14_+_32798478 0.292 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chrX_+_30261847 0.291 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr3_+_121774208 0.290 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr14_-_106733392 0.287 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr13_-_70682458 0.284 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr4_-_153273683 0.283 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr17_-_40190043 0.279 NM_001242704
ZNF385C
zinc finger protein 385C
chrX_-_55020510 0.276 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr2_+_36923902 0.273 VIT
vitrin
chr3_+_148447966 0.273 NM_032049
AGTR1
angiotensin II receptor, type 1
chr4_+_184826427 0.272 NM_020225
STOX2
storkhead box 2
chr8_+_92261515 0.268 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr19_+_20959109 0.267


chr4_-_15940362 0.267 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr18_+_9102618 0.262 NM_021074
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr1_-_115238091 0.261 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr2_+_233734993 0.258 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr6_-_89927495 0.257 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chrX_-_124097601 0.255 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chrX_+_128913897 0.255 SASH3
SAM and SH3 domain containing 3
chr2_-_202563353 0.253 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr6_-_22297729 0.252 NM_000948
PRL
prolactin
chrX_+_128913881 0.252 NM_018990
SASH3
SAM and SH3 domain containing 3
chr10_+_7745325 0.251 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_98072697 0.250 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr13_-_28543290 0.249 NM_001265
CDX2
caudal type homeobox 2
chr5_+_27472382 0.246 LOC643401
uncharacterized LOC643401
chr6_+_32407618 0.242 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr5_+_140739589 0.241 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr2_+_169659099 0.239 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr12_+_7864049 0.238 NM_199286
DPPA3
STELLAR
developmental pluripotency associated 3
developmental pluripotency associated 3 pseudogene
chr11_+_8060179 0.237 NM_003320
TUB
tubby homolog (mouse)
chr2_-_75062214 0.237


chr17_+_18625335 0.235 NM_001037330
TRIM16L
tripartite motif containing 16-like
chrY_-_2655478 0.235 NM_003140
SRY
sex determining region Y
chr12_+_9822205 0.234 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr3_-_195310770 0.234 APOD
apolipoprotein D
chr2_+_166326156 0.233 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr5_+_118965253 0.231 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr10_+_7745354 0.231 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr9_-_35958095 0.228 NM_019897
OR2S2
olfactory receptor, family 2, subfamily S, member 2
chr4_+_154178525 0.226 TRIM2
tripartite motif containing 2
chr4_-_46125929 0.224 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr10_+_7745229 0.224 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_77459198 0.224 NM_203394
E2F7
E2F transcription factor 7
chr8_-_27115897 0.224 NM_030795
STMN4
stathmin-like 4
chr16_+_78062985 0.223 NM_001244755
CLEC3A
C-type lectin domain family 3, member A
chr12_-_27599557 0.222 ARNTL2
aryl hydrocarbon receptor nuclear translocator-like 2
chr11_-_58611979 0.221 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr7_-_16505292 0.220 NM_015464
SOSTDC1
sclerostin domain containing 1
chr1_-_150738232 0.220 CTSS
cathepsin S
chr5_-_35230822 0.218 NM_000949
PRLR
prolactin receptor
chr12_-_102874373 0.216 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr18_+_61637262 0.214 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr6_+_30688144 0.214 NM_178014
TUBB
tubulin, beta class I
chr6_+_12717036 0.213 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr17_-_49124128 0.213 NM_001251971
SPAG9
sperm associated antigen 9
chr1_-_108786663 0.213 NM_001143989
NBPF4
NBPF6
neuroblastoma breakpoint family, member 4
neuroblastoma breakpoint family, member 6
chr18_-_28622624 0.211 NM_001941
NM_024423
DSC3

desmocollin 3

chr2_+_113763448 0.210 NM_014440
IL36A
interleukin 36, alpha
chr12_+_50869531 0.209 LARP4
La ribonucleoprotein domain family, member 4
chr3_-_108672547 0.206 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr19_+_51728369 0.206 CD33
CD33 molecule
chr3_+_189507448 0.204 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr6_-_11779279 0.203 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr7_-_135613197 0.203 LUZP6
leucine zipper protein 6
chr9_-_86584079 0.201 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr4_+_88720701 0.201 NM_004967
IBSP
integrin-binding sialoprotein
chr3_-_195310985 0.196 NM_001647
APOD
apolipoprotein D
chr11_-_102595623 0.196 NM_002424
MMP8
matrix metallopeptidase 8 (neutrophil collagenase)
chrX_+_72667089 0.195 NM_005193
CDX4
caudal type homeobox 4
chr1_+_206808751 0.194 NM_001004023
NM_003582
DYRK3

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

chr2_+_183608329 0.194 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr5_-_147162264 0.193 JAKMIP2
janus kinase and microtubule interacting protein 2
chr6_+_10585978 0.190 NM_145655
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr5_-_147162175 0.190 JAKMIP2
janus kinase and microtubule interacting protein 2
chr1_+_50569581 0.189 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr14_-_64749530 0.188 NM_001214902
NM_001214903
ESR2

estrogen receptor 2 (ER beta)

chr6_-_108145507 0.188 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr1_-_178840079 0.187 NM_004673
ANGPTL1
angiopoietin-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.93 8.30e-05 GO:0002376 immune system process
2.24 1.06e-04 GO:0006955 immune response
1.26 1.23e-02 GO:0050896 response to stimulus
3.65 1.32e-02 GO:0007156 homophilic cell adhesion
1.90 3.12e-02 GO:0006952 defense response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.61 1.18e-04 GO:0005576 extracellular region
1.38 1.91e-04 GO:0071944 cell periphery
1.37 4.67e-04 GO:0005886 plasma membrane
1.85 6.56e-04 GO:0044421 extracellular region part
1.54 8.12e-04 GO:0044459 plasma membrane part
1.84 1.10e-02 GO:0005615 extracellular space

Nothing significant found in function category.