Motif ID: PRDM1.p3

Z-value: 2.973


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
PRDM1chr6_+_1065341880.452.4e-02Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_29527477 44.240 UBD
ubiquitin D
chr6_-_29527701 43.185 NM_006398
UBD
ubiquitin D
chr6_+_32821924 23.739 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr22_-_36556781 22.126 NM_145640
APOL3
apolipoprotein L, 3
chr4_+_142557722 19.345 NM_000585
NM_172175
IL15

interleukin 15

chr16_-_67970734 18.968 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr6_-_32806545 17.783 NM_000544
NM_018833
TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

chr17_+_6659155 16.959 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr16_-_67970651 15.623 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr11_-_4414887 15.540 NM_003141
TRIM21
tripartite motif containing 21
chr1_+_212781969 15.534 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr1_+_212782103 14.278 ATF3
activating transcription factor 3
chr17_+_6659356 13.420 XAF1
XIAP associated factor 1
chr5_+_131746579 13.028 C5orf56
chromosome 5 open reading frame 56
chr6_+_127439803 12.975 RSPO3
R-spondin 3
chr6_+_127440047 12.254 NM_032784
RSPO3
R-spondin 3
chr4_+_186990308 11.299 NM_003265
TLR3
toll-like receptor 3
chr11_+_71710971 10.814 NM_001145055
IL18BP
interleukin 18 binding protein
chr21_+_43933983 10.454 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr1_+_110453232 9.950 NM_000757
NM_172210
NM_172212
CSF1


colony stimulating factor 1 (macrophage)


chr11_+_71710662 9.850 NM_001145057
IL18BP
interleukin 18 binding protein
chr8_-_23540401 9.775 NM_006167
NKX3-1
NK3 homeobox 1
chr2_+_239756672 9.685 NM_057179
TWIST2
twist homolog 2 (Drosophila)
chr1_+_110453456 9.575 CSF1
colony stimulating factor 1 (macrophage)
chr10_+_91092238 9.191 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_-_111746917 9.140 DENND2D
DENN/MADD domain containing 2D
chr12_-_57505176 8.903 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr6_+_126240369 8.121 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr12_-_57505121 7.543 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr5_-_142815076 7.432 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr6_-_10412606 7.383 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_+_41158741 7.332 NM_005533
IFI35
interferon-induced protein 35
chr5_+_96212167 7.265 ERAP2
endoplasmic reticulum aminopeptidase 2
chr9_-_117568292 7.151 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr12_+_121570630 7.143 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr2_-_231084600 7.008 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr11_-_128392061 7.004 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr14_+_24605393 6.983 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr11_+_93862143 6.950 PANX1
pannexin 1
chr4_+_154605421 6.568 NM_003264
TLR2
toll-like receptor 2
chr14_+_24605366 6.551 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr12_-_57504935 5.994 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr14_-_69259654 5.759 ZFP36L1
zinc finger protein 36, C3H type-like 1
chr2_+_231280906 5.654 SP100
SP100 nuclear antigen
chr7_-_92463211 5.595 NM_001259
CDK6
cyclin-dependent kinase 6
chr10_+_114135965 5.429 ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_+_388941 5.389 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr4_+_154605441 5.375 TLR2
toll-like receptor 2
chr20_+_388717 5.307 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr21_+_26934440 5.168 MIR155HG
MIR155 host gene (non-protein coding)
chr22_+_39473009 5.167 NM_021822
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr10_+_114135937 5.123 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_+_50776012 5.053 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr11_+_71709951 5.044 NM_001039659
NM_001039660
NM_173044
NM_005699
NM_173042
IL18BP




interleukin 18 binding protein




chr16_+_50775960 4.972 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr22_-_30642683 4.968 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr11_+_93862060 4.957 NM_015368
PANX1
pannexin 1
chr19_+_36239445 4.931 LIN37
lin-37 homolog (C. elegans)
chr5_-_96143573 4.901 ERAP1
endoplasmic reticulum aminopeptidase 1
chr19_+_13105970 4.869 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr15_-_80263460 4.866 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr5_-_96143689 4.859 NM_001040458
NM_016442
ERAP1

endoplasmic reticulum aminopeptidase 1

chr12_+_6561176 4.806 NM_018009
TAPBPL
TAP binding protein-like
chr10_+_91087601 4.790 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr2_+_231191877 4.628 NM_138402
SP140L
SP140 nuclear body protein-like
chr10_+_91061705 4.493 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr1_-_150738255 4.435 CTSS
cathepsin S
chr12_+_102271349 4.434 DRAM1
DNA-damage regulated autophagy modulator 1
chr4_-_185395616 4.214 NM_002199
IRF2
interferon regulatory factor 2
chr6_-_33282006 4.192 NM_003190
NM_172208
NM_172209
TAPBP


TAP binding protein (tapasin)


chr17_+_78237389 4.078


chr1_-_148176392 4.061


chr10_+_114136014 4.008 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_33281847 3.975 TAPBP
TAP binding protein (tapasin)
chr9_-_123676849 3.909 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr1_-_154580677 3.850 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr2_+_231280933 3.841 SP100
SP100 nuclear antigen
chr12_+_102271082 3.811 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr2_+_231280870 3.744 NM_001080391
NM_001206701
NM_001206702
NM_001206703
NM_003113
SP100




SP100 nuclear antigen




chr6_-_32811773 3.692 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr11_-_85430117 3.601 NM_206929
SYTL2
synaptotagmin-like 2
chr2_-_152146373 3.585 NM_004688
NMI
N-myc (and STAT) interactor
chr14_-_24615794 3.538 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr6_+_26440699 3.494 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr22_-_36635552 3.490 APOL2
apolipoprotein L, 2
chr11_+_64008412 3.372 NM_004470
FKBP2
FK506 binding protein 2, 13kDa
chr1_-_150738232 3.331 CTSS
cathepsin S
chr10_+_123754141 3.305 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_101361688 3.284 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr20_+_389346 3.247 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr13_+_108922205 3.194 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr13_+_108922474 3.178 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr2_-_190044330 3.162 NM_000393
COL5A2
collagen, type V, alpha 2
chr9_+_109625347 3.146 NM_021224
ZNF462
zinc finger protein 462
chr19_+_49977465 3.119 NM_001204502
NM_001459
FLT3LG

fms-related tyrosine kinase 3 ligand

chr8_+_144640476 3.055 NM_024736
GSDMD
gasdermin D
chr14_+_58711457 2.968 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr1_+_32666201 2.926 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr3_-_71353910 2.913 NM_001244812
FOXP1
forkhead box P1
chr20_+_388693 2.890 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr14_+_58711555 2.882 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr6_-_11779279 2.827 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_-_154580632 2.806 ADAR
adenosine deaminase, RNA-specific
chr20_+_388963 2.720 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr19_+_36239261 2.524 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr11_+_131240370 2.488 NM_001048209
NTM
neurotrimin
chr11_+_64323089 2.467 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr22_+_39436608 2.441 NM_001006666
NM_145298
APOBEC3F

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

chr19_+_52266640 2.437 NM_001462
FPR2
formyl peptide receptor 2
chr7_+_155250705 2.416 NM_001427
EN2
engrailed homeobox 2
chr8_-_145060563 2.308 PARP10
poly (ADP-ribose) polymerase family, member 10
chr4_-_153303663 2.301 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr14_-_69262959 2.288 NM_001244701
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr22_-_36562224 2.274 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr14_+_58711599 2.189 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_+_7465284 2.167 NM_015670
SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr11_-_104905849 2.160 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr9_+_102677457 2.141 STX17
syntaxin 17
chr6_-_33281790 2.084 TAPBP
TAP binding protein (tapasin)
chr2_+_7017795 2.067 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr1_-_57045235 2.016 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr16_-_73092533 1.948 NM_001164766
ZFHX3
zinc finger homeobox 3
chr14_-_24615772 1.939 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_+_64008530 1.912 NM_001135208
FKBP2
FK506 binding protein 2, 13kDa
chr15_-_56209305 1.893 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr18_+_55816546 1.870 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr11_+_65190272 1.866


chr8_+_134203281 1.833 NM_001204869
NM_001204870
NM_003882
NM_080838
WISP1



WNT1 inducible signaling pathway protein 1



chr14_-_69260630 1.813 NM_001244698
NM_004926
ZFP36L1

zinc finger protein 36, C3H type-like 1

chr13_+_108921976 1.797 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr19_-_47735858 1.786 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr17_+_7465316 1.772 SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr1_+_2985730 1.737 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr11_+_60609428 1.720 NM_024098
CCDC86
coiled-coil domain containing 86
chr20_-_47894591 1.684 NM_021035
ZNFX1
zinc finger, NFX1-type containing 1
chr6_-_32812189 1.675 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr4_+_37892698 1.673 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chrX_+_30261847 1.664 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr6_+_32811895 1.609


chr15_+_71184781 1.581 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr2_-_231090443 1.536 NM_001185015
SP110
SP110 nuclear body protein
chr11_-_796175 1.508 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr10_-_82049178 1.470 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr3_-_11623829 1.447 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr3_+_174577069 1.411 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr22_-_36635666 1.401 NM_030882
APOL2
apolipoprotein L, 2
chr1_-_244006471 1.400 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr10_-_94003002 1.399 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr5_+_96211643 1.390 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr14_-_81864726 1.371 NM_033104
STON2
stonin 2
chr4_+_15376174 1.341 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr22_-_36635999 1.303 NM_145637
APOL2
apolipoprotein L, 2
chrX_-_154563735 1.301 NM_001289
CLIC2
chloride intracellular channel 2
chr1_-_217250230 1.258 NM_001243507
NM_001243509
ESRRG

estrogen-related receptor gamma

chr17_-_4642638 1.240 CXCL16
chemokine (C-X-C motif) ligand 16
chr3_+_119013216 1.202 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr2_+_205410716 1.144 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr2_-_220252569 1.101 DNPEP
aspartyl aminopeptidase
chr2_-_202508223 1.090 NM_001044385
TMEM237
transmembrane protein 237
chr1_-_143744355 1.072 LOC100286793
FLJ39739
uncharacterized LOC100286793
uncharacterized FLJ39739
chr1_-_150780705 1.062 NM_000396
CTSK
cathepsin K
chr5_+_140430960 1.054 NM_013340
PCDHB1
protocadherin beta 1
chr6_+_105404922 1.029 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr11_-_104839263 0.986 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr1_-_144521169 0.976 FAM91A2
family with sequence similarity 91, member A2
chr15_-_41408329 0.969 NM_017553
INO80
INO80 homolog (S. cerevisiae)
chr2_+_205410556 0.956 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr4_-_56412968 0.954 NM_004898
CLOCK
clock homolog (mouse)
chr19_+_49977817 0.914 NM_001204503
FLT3LG
fms-related tyrosine kinase 3 ligand
chr19_-_48547180 0.910 NM_019855
CABP5
calcium binding protein 5
chr1_-_147931877 0.900 FLJ39739
uncharacterized FLJ39739
chr10_-_13749622 0.893 FRMD4A
FERM domain containing 4A
chr17_-_4643162 0.885 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr9_-_73736513 0.849 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr10_+_86131546 0.829 FAM190B
family with sequence similarity 190, member B
chr11_-_85430382 0.829 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr7_-_51384331 0.774 COBL
cordon-bleu homolog (mouse)
chr1_+_19971865 0.762 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr1_+_19972259 0.760 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr15_+_74833517 0.757 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr1_-_13390747 0.753 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr9_+_18474078 0.746 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr12_-_56709777 0.739 CNPY2
canopy 2 homolog (zebrafish)
chr5_+_6746100 0.697 NM_001171806
PAPD7
PAP associated domain containing 7
chr2_-_152146133 0.694 NMI
N-myc (and STAT) interactor
chr11_-_40314510 0.678 LRRC4C
leucine rich repeat containing 4C
chr6_+_167525294 0.677 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr21_-_35899046 0.674 NM_203418
RCAN1
regulator of calcineurin 1
chr16_-_72206348 0.663 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr14_+_24616095 0.654 RNF31
ring finger protein 31
chr19_+_49838700 0.646 CD37
CD37 molecule
chr15_-_42749710 0.622 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr4_-_120243257 0.620 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr21_-_43346780 0.613 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr4_+_146403955 0.609 NM_001003688
SMAD1
SMAD family member 1
chr9_+_112542496 0.596 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr11_-_85338313 0.592 NM_001142699
DLG2
discs, large homolog 2 (Drosophila)
chr11_-_92931045 0.585 NM_152313
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr2_-_175260349 0.582 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr6_+_25962978 0.581 NM_006355
TRIM38
tripartite motif containing 38

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
61.98 1.33e-04 GO:0002483 antigen processing and presentation of endogenous peptide antigen
61.98 1.33e-04 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
1.99 2.37e-04 GO:0048522 positive regulation of cellular process
2.51 2.78e-04 GO:0002376 immune system process
1.89 5.90e-04 GO:0048518 positive regulation of biological process
2.96 7.37e-04 GO:0006955 immune response
44.27 9.13e-04 GO:0019883 antigen processing and presentation of endogenous antigen
10.00 1.24e-03 GO:0060337 type I interferon-mediated signaling pathway
10.00 1.24e-03 GO:0071357 cellular response to type I interferon
9.84 1.41e-03 GO:0034340 response to type I interferon
2.69 1.86e-03 GO:0051704 multi-organism process
7.21 1.50e-02 GO:0030330 DNA damage response, signal transduction by p53 class mediator
23.84 1.75e-02 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
2.52 3.03e-02 GO:0006952 defense response
2.50 3.45e-02 GO:0006508 proteolysis
3.39 4.01e-02 GO:0045087 innate immune response
38.74 4.11e-02 GO:0016553 base conversion or substitution editing
1.70 4.60e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.33 4.69e-02 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
8.61 2.61e-03 GO:0000502 proteasome complex
15.50 1.80e-02 GO:0005839 proteasome core complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.34 5.15e-03 GO:0001071 nucleic acid binding transcription factor activity
2.34 5.15e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.18 1.16e-02 GO:0005488 binding
14.76 2.83e-02 GO:0004298 threonine-type endopeptidase activity
14.76 2.83e-02 GO:0070003 threonine-type peptidase activity