Motif ID: REST.p3

Z-value: 0.756


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
RESTchr4_+_57775127,
chr4_+_57774365		0.386.3e-02Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 142 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_72667255 1.275 NM_175738
 RAB37
RAB37, member RAS oncogene family
chr4_+_8582216 1.045 NM_080819
 GPR78
G protein-coupled receptor 78
chr5_+_71014989 0.923 NM_004291
 CARTPT
CART prepropeptide
chrX_-_153141284 0.790 L1CAM
L1 cell adhesion molecule
chr5_-_151304322 0.766 NM_000171
NM_001146040
 GLRA1

glycine receptor, alpha 1

chr17_-_27240982 0.757 PHF12
PHD finger protein 12
chr3_+_193853930 0.722 NM_005524
 HES1
hairy and enhancer of split 1, (Drosophila)
chr10_+_99609994 0.684 NM_001010917
 GOLGA7B
golgin A7 family, member B
chr8_-_145559831 0.677 NM_031309
 SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr5_+_33936490 0.653 NM_016568
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr11_+_22359666 0.642 NM_020346
 SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr2_-_27531113 0.637 NM_003353
 UCN
urocortin
chr12_+_175872 0.625 NM_001170738
 IQSEC3
IQ motif and Sec7 domain 3
chr3_+_193853937 0.625 HES1
hairy and enhancer of split 1, (Drosophila)
chr11_-_27742224 0.616 NM_001143805
NM_001143806
NM_170732
 BDNF


brain-derived neurotrophic factor


chr1_-_151689246 0.538 NM_007185
 CELF3
CUGBP, Elav-like family member 3
chr8_-_57358511 0.500 NM_006211
 PENK
proenkephalin
chr6_+_154360442 0.485 NM_000914
NM_001008503
NM_001008504
NM_001008505
NM_001145282
NM_001145283
NM_001145284
NM_001145285
NM_001145286
 OPRM1








opioid receptor, mu 1








chr15_-_32162778 0.484 OTUD7A
OTU domain containing 7A
chr5_+_175298604 0.462 CPLX2
complexin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
33.78 4.51e-02 GO:0042749 regulation of circadian sleep/wake cycle
33.78 4.51e-02 GO:0045187 regulation of circadian sleep/wake cycle, sleep
25.99 8.09e-03 GO:0050433 regulation of catecholamine secretion
25.03 9.45e-03 GO:0045776 negative regulation of blood pressure
18.27 3.40e-02 GO:0051952 regulation of amine transport
12.61 2.45e-02 GO:0030534 adult behavior
9.75 1.81e-02 GO:0008217 regulation of blood pressure
9.48 2.12e-02 GO:0007611 learning or memory
8.67 3.50e-02 GO:0050890 cognition
8.64 8.67e-03 GO:0031644 regulation of neurological system process
8.18 4.84e-02 GO:0051969 regulation of transmission of nerve impulse
7.63 9.20e-09 GO:0007268 synaptic transmission
7.63 7.46e-06 GO:0007610 behavior
7.17 6.88e-09 GO:0019226 transmission of nerve impulse
7.17 6.88e-09 GO:0035637 multicellular organismal signaling
5.76 2.60e-06 GO:0007186 G-protein coupled receptor protein signaling pathway
5.38 4.32e-04 GO:0055082 cellular chemical homeostasis
5.14 1.88e-03 GO:0006873 cellular ion homeostasis
5.04 2.31e-03 GO:0046903 secretion
4.98 4.29e-02 GO:0055080 cation homeostasis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
84.45 2.53e-02 GO:0032590 dendrite membrane
29.81 1.57e-02 GO:0032589 neuron projection membrane
22.53 3.02e-05 GO:0030672 synaptic vesicle membrane
15.54 5.42e-06 GO:0008021 synaptic vesicle
13.92 8.40e-05 GO:0030665 clathrin coated vesicle membrane
10.29 6.46e-04 GO:0030662 coated vesicle membrane
9.45 5.64e-05 GO:0030136 clathrin-coated vesicle
8.22 1.79e-07 GO:0044456 synapse part
8.00 3.36e-03 GO:0045211 postsynaptic membrane
7.72 3.04e-04 GO:0030135 coated vesicle
6.56 3.60e-04 GO:0030659 cytoplasmic vesicle membrane
6.54 1.01e-06 GO:0045202 synapse
6.33 4.88e-04 GO:0012506 vesicle membrane
6.30 1.53e-02 GO:0030425 dendrite
5.44 1.86e-03 GO:0044433 cytoplasmic vesicle part
5.30 3.22e-04 GO:0043005 neuron projection
4.48 1.38e-04 GO:0030054 cell junction
4.45 1.09e-05 GO:0016023 cytoplasmic membrane-bounded vesicle
4.37 1.45e-05 GO:0031988 membrane-bounded vesicle
4.19 2.71e-05 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
84.45 2.36e-02 GO:0016933 extracellular-glycine-gated ion channel activity
84.45 2.36e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
67.56 3.92e-02 GO:0022824 transmitter-gated ion channel activity
67.56 3.92e-02 GO:0022835 transmitter-gated channel activity
38.98 6.29e-03 GO:0016594 glycine binding
24.13 2.83e-02 GO:0005184 neuropeptide hormone activity
17.97 9.39e-04 GO:0005231 excitatory extracellular ligand-gated ion channel activity
14.08 4.76e-04 GO:0005230 extracellular ligand-gated ion channel activity
8.54 3.44e-02 GO:0005179 hormone activity
8.12 1.11e-02 GO:0015276 ligand-gated ion channel activity
8.12 1.11e-02 GO:0022834 ligand-gated channel activity
4.50 4.70e-02 GO:0022836 gated channel activity
4.00 4.83e-02 GO:0005216 ion channel activity