Motif ID: RREB1.p2

Z-value: 1.490


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
RREB1chr6_+_71077990.311.3e-01Click!


Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_+_27011766 2.423 JAM2
junctional adhesion molecule 2
chrX_+_151903218 2.368 NM_001102576
NM_153478
 CSAG1

chondrosarcoma associated gene 1

chr21_+_27012067 2.334 JAM2
junctional adhesion molecule 2
chr6_-_29595746 2.291 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_-_72353435 2.288 NM_001143839
NM_001243784
 PDE2A

phosphodiesterase 2A, cGMP-stimulated

chr10_+_115438934 2.184 NM_033340
 CASP7
caspase 7, apoptosis-related cysteine peptidase
chr3_+_122399665 2.138 NM_017554
 PARP14
poly (ADP-ribose) polymerase family, member 14
chr11_-_134281725 2.035 NM_018644
NM_054025
 B3GAT1

beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

chr1_+_955468 1.990 NM_198576
 AGRN
agrin
chr20_+_48599511 1.874 NM_005985
 SNAI1
snail homolog 1 (Drosophila)
chr16_-_3285359 1.873 NM_001145448
NM_198088
NM_001145446
NM_198087
 ZNF200



zinc finger protein 200



chr16_-_65155965 1.654 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr6_+_44095357 1.597 NM_018426
 TMEM63B
transmembrane protein 63B
chr7_+_21468293 1.594


chr16_-_65155984 1.576 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr6_-_32806545 1.563 NM_000544
NM_018833
 TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

chr21_+_27011588 1.513 NM_021219
 JAM2
junctional adhesion molecule 2
chr21_+_27012045 1.498 JAM2
junctional adhesion molecule 2
chr1_+_955609 1.497 AGRN
agrin
chr6_+_4776826 1.491 CDYL
chromodomain protein, Y-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 172 entries
enrichment   p-value GO term description
3.54 8.34e-05 GO:0033138 positive regulation of peptidyl-serine phosphorylation
3.26 6.85e-05 GO:0033135 regulation of peptidyl-serine phosphorylation
3.15 2.66e-02 GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway
2.52 3.28e-02 GO:0048663 neuron fate commitment
2.44 2.88e-04 GO:0048638 regulation of developmental growth
2.26 9.20e-03 GO:0050770 regulation of axonogenesis
2.23 3.50e-06 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.21 5.04e-06 GO:0022604 regulation of cell morphogenesis
2.09 4.79e-02 GO:0021953 central nervous system neuron differentiation
2.04 6.14e-03 GO:0010720 positive regulation of cell development
2.01 9.01e-06 GO:0030900 forebrain development
2.01 4.79e-05 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
2.01 3.92e-02 GO:0021537 telencephalon development
2.00 1.96e-02 GO:0043410 positive regulation of MAPKKK cascade
1.96 3.47e-02 GO:0051924 regulation of calcium ion transport
1.95 1.07e-05 GO:0032582 negative regulation of gene-specific transcription
1.95 7.43e-03 GO:0010959 regulation of metal ion transport
1.94 2.11e-03 GO:0016055 Wnt receptor signaling pathway
1.89 2.48e-02 GO:0010975 regulation of neuron projection development
1.88 1.84e-02 GO:0030111 regulation of Wnt receptor signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
3.12 1.68e-02 GO:0005891 voltage-gated calcium channel complex
2.78 1.53e-02 GO:0034704 calcium channel complex
2.02 5.72e-03 GO:0008021 synaptic vesicle
1.83 3.60e-03 GO:0034703 cation channel complex
1.82 4.49e-08 GO:0044456 synapse part
1.80 2.44e-03 GO:0045211 postsynaptic membrane
1.71 1.66e-08 GO:0045202 synapse
1.67 2.29e-03 GO:0034702 ion channel complex
1.56 1.48e-04 GO:0031012 extracellular matrix
1.54 1.99e-04 GO:0043005 neuron projection
1.53 3.85e-03 GO:0005578 proteinaceous extracellular matrix
1.52 1.18e-06 GO:0030054 cell junction
1.42 3.95e-02 GO:0009986 cell surface
1.32 2.79e-03 GO:0042995 cell projection
1.31 4.50e-10 GO:0044459 plasma membrane part
1.31 1.20e-02 GO:0031982 vesicle
1.31 2.39e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.30 1.12e-02 GO:0005626 insoluble fraction
1.30 1.28e-02 GO:0005624 membrane fraction
1.30 2.17e-02 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
2.90 2.64e-02 GO:0005245 voltage-gated calcium channel activity
2.10 4.43e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
2.02 2.40e-05 GO:0022843 voltage-gated cation channel activity
2.00 8.65e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.90 3.44e-02 GO:0005249 voltage-gated potassium channel activity
1.84 2.66e-02 GO:0051020 GTPase binding
1.79 1.26e-04 GO:0000975 regulatory region DNA binding
1.79 1.26e-04 GO:0001067 regulatory region nucleic acid binding
1.79 1.26e-04 GO:0044212 transcription regulatory region DNA binding
1.78 6.30e-04 GO:0005244 voltage-gated ion channel activity
1.78 6.30e-04 GO:0022832 voltage-gated channel activity
1.76 5.72e-04 GO:0010843 promoter binding
1.74 6.55e-16 GO:0043565 sequence-specific DNA binding
1.70 8.57e-05 GO:0005261 cation channel activity
1.61 4.36e-04 GO:0016564 transcription repressor activity
1.61 5.17e-04 GO:0022836 gated channel activity
1.59 8.59e-04 GO:0016563 transcription activator activity
1.56 1.14e-04 GO:0022838 substrate-specific channel activity
1.55 2.90e-04 GO:0005216 ion channel activity
1.54 4.30e-02 GO:0005096 GTPase activator activity