Motif ID: RUNX1..3.p2

Z-value: 1.604


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
RUNX1chr21_-_36421586,
chr21_-_36421630		0.872.1e-08Click!
RUNX2chr6_+_452960530.663.0e-04Click!
RUNX3chr1_-_25256767,
chr1_-_25256364		0.385.8e-02Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_131409484 14.116 NM_000758
 CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr9_-_123688352 12.224 TRAF1
TNF receptor-associated factor 1
chr21_-_36421586 11.202 NM_001754
 RUNX1
runt-related transcription factor 1
chr21_-_36421630 10.250 RUNX1
runt-related transcription factor 1
chr1_-_173174611 7.995 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr5_+_113698304 5.791 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr1_+_206643786 4.849 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr2_+_228678556 4.776 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr10_+_91092238 4.684 NM_001031683
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_-_71179715 4.216 FOXP1
forkhead box P1
chr9_-_123689172 4.196 NM_005658
 TRAF1
TNF receptor-associated factor 1
chr3_-_71180061 4.049 NM_001244815
 FOXP1
forkhead box P1
chr1_+_206643830 4.044 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr11_-_128457452 3.829 NM_001143820
 ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr2_+_103035148 3.706 NM_003853
 IL18RAP
interleukin 18 receptor accessory protein
chr1_-_89488412 3.583 NM_018284
 GBP3
guanylate binding protein 3
chr5_+_35856990 3.570 NM_002185
 IL7R
interleukin 7 receptor
chr5_+_125695787 3.564 NM_001146319
 GRAMD3
GRAM domain containing 3
chr21_-_36421578 3.497 RUNX1
runt-related transcription factor 1
chr12_+_121570630 3.417 NM_002562
 P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
2.69 8.12e-03 GO:0042110 T cell activation
2.42 8.15e-04 GO:0046649 lymphocyte activation
2.20 2.13e-03 GO:0045321 leukocyte activation
2.12 1.43e-07 GO:0001775 cell activation
1.99 3.08e-02 GO:0048534 hemopoietic or lymphoid organ development
1.98 3.77e-02 GO:0001817 regulation of cytokine production
1.92 3.96e-08 GO:0006955 immune response
1.87 1.94e-03 GO:0051094 positive regulation of developmental process
1.83 4.46e-12 GO:0002376 immune system process
1.82 1.60e-03 GO:0006935 chemotaxis
1.82 1.60e-03 GO:0042330 taxis
1.79 1.58e-02 GO:0002684 positive regulation of immune system process
1.77 8.65e-03 GO:0000904 cell morphogenesis involved in differentiation
1.77 3.11e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.77 4.12e-02 GO:0007409 axonogenesis
1.73 2.30e-02 GO:0009967 positive regulation of signal transduction
1.72 7.66e-06 GO:0009611 response to wounding
1.70 1.15e-03 GO:0002682 regulation of immune system process
1.68 2.88e-04 GO:0048584 positive regulation of response to stimulus
1.66 1.47e-02 GO:0032989 cellular component morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
2.39 5.24e-03 GO:0009897 external side of plasma membrane
1.74 1.87e-02 GO:0009986 cell surface
1.58 1.55e-06 GO:0031226 intrinsic to plasma membrane
1.56 6.97e-06 GO:0005887 integral to plasma membrane
1.49 2.82e-02 GO:0005615 extracellular space
1.39 1.22e-05 GO:0044459 plasma membrane part
1.25 2.41e-05 GO:0071944 cell periphery
1.25 3.22e-05 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
2.23 5.19e-03 GO:0005126 cytokine receptor binding