Motif ID: RXR{A,B,G}.p2

Z-value: 1.179


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
RXRAchr9_+_1372183240.491.4e-02Click!
RXRBchr6_-_331684480.252.3e-01Click!
RXRGchr1_-_165414499-0.145.2e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_35873823 1.965 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr11_+_73087670 1.412 NM_032871
RELT
RELT tumor necrosis factor receptor
chr6_+_14118002 1.405 CD83
CD83 molecule
chr19_-_1174201 1.359


chr19_-_1174263 1.339 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr2_+_27301693 1.184 EMILIN1
elastin microfibril interfacer 1
chr4_-_38666429 1.090 FLJ13197
uncharacterized FLJ13197
chr17_+_36861857 1.073 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr12_-_109251333 1.054 NM_001161330
NM_018984
SSH1

slingshot homolog 1 (Drosophila)

chr19_-_50432647 1.051 IL4I1
interleukin 4 induced 1
chr19_-_50432672 1.049 IL4I1
interleukin 4 induced 1
chr19_-_1174257 1.028 SBNO2
strawberry notch homolog 2 (Drosophila)
chr7_+_143078399 0.999 ZYX
zyxin
chr19_+_50354417 0.998 PTOV1
prostate tumor overexpressed 1
chr19_+_10381516 0.977 NM_000201
ICAM1
intercellular adhesion molecule 1
chr19_+_50354368 0.976 NM_017432
PTOV1
prostate tumor overexpressed 1
chr19_+_17830302 0.932 NM_018174
MAP1S
microtubule-associated protein 1S
chr19_+_45251933 0.923 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr9_-_110251308 0.922 KLF4
Kruppel-like factor 4 (gut)
chr9_-_110251754 0.918 KLF4
Kruppel-like factor 4 (gut)
chr22_-_19511777 0.890 CLDN5
claudin 5
chr17_-_61777478 0.862 NM_030576
LIMD2
LIM domain containing 2
chr19_-_49658645 0.856 NM_002152
HRC
histidine rich calcium binding protein
chr21_+_46825291 0.840


chr11_-_65430214 0.838 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr22_-_19512001 0.827 CLDN5
claudin 5
chr3_+_122399665 0.824 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr5_+_149865310 0.815 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr7_+_143078447 0.812 ZYX
zyxin
chr16_+_30675777 0.805 NM_001105079
FBRS
fibrosin
chr7_+_143078444 0.797 ZYX
zyxin
chr4_-_74904329 0.776 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr12_-_52779362 0.759 NM_033045
KRT84
keratin 84
chr11_+_65405538 0.750 NM_006747
SIPA1
signal-induced proliferation-associated 1
chr11_+_450346 0.748 PTDSS2
phosphatidylserine synthase 2
chr20_+_33292117 0.745 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr7_+_143078395 0.745 ZYX
zyxin
chr7_+_143078608 0.726 ZYX
zyxin
chr6_-_32805819 0.725 TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr22_+_38302296 0.714 MICALL1
MICAL-like 1
chrX_+_153665468 0.713 GDI1
GDP dissociation inhibitor 1
chr11_+_450260 0.710 NM_030783
PTDSS2
phosphatidylserine synthase 2
chr2_+_27301434 0.707 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr7_-_75623932 0.705 TMEM120A
transmembrane protein 120A
chr2_-_27603584 0.697 NM_144631
ZNF513
zinc finger protein 513
chr19_-_6424536 0.696 KHSRP
KH-type splicing regulatory protein
chr19_-_7990974 0.696 NM_206833
CTXN1
cortexin 1
chr19_-_50432679 0.691 NUP62
IL4I1
nucleoporin 62kDa
interleukin 4 induced 1
chr16_-_87903028 0.685 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr19_+_676346 0.681 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr12_-_109251271 0.676 SSH1
slingshot homolog 1 (Drosophila)
chr1_-_153919140 0.669 NM_014856
DENND4B
DENN/MADD domain containing 4B
chr20_-_43977023 0.666 NM_002999
SDC4
syndecan 4
chr17_+_6926366 0.665 NM_181844
BCL6B
B-cell CLL/lymphoma 6, member B
chr9_-_140009158 0.661 DPP7
dipeptidyl-peptidase 7
chr19_+_17830283 0.653 MAP1S
microtubule-associated protein 1S
chr19_-_50432734 0.645 NM_012346
NM_153718
NM_153719
NM_001193357
NM_172374
NUP62



IL4I1
nucleoporin 62kDa



interleukin 4 induced 1
chr19_+_17186569 0.644 NM_001130065
NM_004145
MYO9B

myosin IXB

chr22_+_30821610 0.642 NM_001003704
NM_016498
MTFP1

mitochondrial fission process 1

chr12_-_133306531 0.636 ANKLE2
ankyrin repeat and LEM domain containing 2
chr11_-_65430427 0.627 NM_001145138
NM_001243984
NM_001243985
NM_021975
RELA



v-rel reticuloendotheliosis viral oncogene homolog A (avian)



chr6_+_69344939 0.623 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr7_+_143078457 0.623 ZYX
zyxin
chr17_-_61777467 0.622 LIMD2
LIM domain containing 2
chr11_-_65381641 0.616 NM_002419
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr19_-_56632644 0.613 NM_001002836
ZNF787
zinc finger protein 787
chr11_-_615649 0.611 NM_004031
IRF7
interferon regulatory factor 7
chr1_-_33815498 0.610 NM_004427
PHC2
polyhomeotic homolog 2 (Drosophila)
chr8_+_145149985 0.606 CYC1
cytochrome c-1
chr14_+_93799564 0.605 NM_020818
UNC79
unc-79 homolog (C. elegans)
chr5_+_170846659 0.603 NM_003862
FGF18
fibroblast growth factor 18
chr7_+_143078358 0.598 NM_001010972
NM_003461
ZYX

zyxin

chr17_+_6926414 0.597 BCL6B
B-cell CLL/lymphoma 6, member B
chr3_+_5021096 0.593 NM_003670
BHLHE40
basic helix-loop-helix family, member e40
chr19_+_50353942 0.587 PTOV1
prostate tumor overexpressed 1
chr16_+_718080 0.581 NM_138769
RHOT2
ras homolog gene family, member T2
chr19_-_50432731 0.579 NUP62
nucleoporin 62kDa
chr9_+_116930778 0.579 COL27A1
collagen, type XXVII, alpha 1
chr6_-_160114318 0.575 NM_000636
NM_001024465
NM_001024466
SOD2


superoxide dismutase 2, mitochondrial


chr8_+_145149936 0.574 NM_001916
CYC1
cytochrome c-1
chr1_-_33336289 0.568 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr11_-_615998 0.565 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr11_+_66886735 0.562 NM_012308
KDM2A
lysine (K)-specific demethylase 2A
chr19_-_50432678 0.559 NUP62
nucleoporin 62kDa
chr19_+_42788605 0.546 NM_015125
CIC
capicua homolog (Drosophila)
chr4_+_38665587 0.544 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr7_-_2595327 0.538 NM_152743
BRAT1
BRCA1-associated ATM activator 1
chr6_-_160114186 0.534 SOD2
superoxide dismutase 2, mitochondrial
chr7_-_2595112 0.531 BRAT1
BRCA1-associated ATM activator 1
chr6_-_46459010 0.524 NM_001251974
RCAN2
regulator of calcineurin 2
chr3_+_5021141 0.521 BHLHE40
basic helix-loop-helix family, member e40
chr9_-_110250707 0.516 KLF4
Kruppel-like factor 4 (gut)
chr21_+_46293925 0.511


chr6_+_29894105 0.508


chr19_+_18723666 0.507 NM_012109
TMEM59L
transmembrane protein 59-like
chr8_-_101322180 0.504 RNF19A
ring finger protein 19A
chr17_-_80044975 0.497 FASN
fatty acid synthase
chr2_+_74757243 0.496 HTRA2
HtrA serine peptidase 2
chr19_-_47922339 0.492 MEIS3
Meis homeobox 3
chr12_+_124773709 0.489 NM_181709
FAM101A
family with sequence similarity 101, member A
chr9_-_140009169 0.484 DPP7
dipeptidyl-peptidase 7
chr20_+_53092131 0.482 NM_018431
DOK5
docking protein 5
chr22_-_41682187 0.480 NM_002883
RANGAP1
Ran GTPase activating protein 1
chr22_-_43116796 0.479 NM_017436
A4GALT
alpha 1,4-galactosyltransferase
chr9_-_140009171 0.478 DPP7
dipeptidyl-peptidase 7
chr6_-_33266297 0.477 RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr2_+_74757127 0.477 HTRA2
HtrA serine peptidase 2
chr20_+_43538667 0.474 NM_001124756
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr22_+_50624353 0.473 NM_025204
TRABD
TraB domain containing
chr16_+_718157 0.471 RHOT2
ras homolog gene family, member T2
chr22_-_41682169 0.469 RANGAP1
Ran GTPase activating protein 1
chr19_+_3506264 0.468 NM_016263
FZR1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr9_+_139780974 0.468 TRAF2
TNF receptor-associated factor 2
chr22_+_42229137 0.467 SREBF2
sterol regulatory element binding transcription factor 2
chr5_+_139060295 0.466 CXXC5
CXXC finger protein 5
chr1_+_212781969 0.462 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr2_+_74756986 0.460 HTRA2
HtrA serine peptidase 2
chr19_-_50432952 0.458 NM_016553
NUP62
nucleoporin 62kDa
chr17_+_21188021 0.457 MAP2K3
mitogen-activated protein kinase kinase 3
chr9_-_140009162 0.457 DPP7
dipeptidyl-peptidase 7
chr9_-_110252045 0.452 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr19_+_10381763 0.449 ICAM1
intercellular adhesion molecule 1
chr6_-_4079390 0.449 NM_173563
C6orf146
chromosome 6 open reading frame 146
chr6_+_31588523 0.448 PRRC2A
proline-rich coiled-coil 2A
chr1_+_19972259 0.447 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr20_-_2821245 0.447 NM_022760
FAM113A
family with sequence similarity 113, member A
chr1_-_153521717 0.443 NM_002960
S100A3
S100 calcium binding protein A3
chr3_+_5021305 0.441 BHLHE40
basic helix-loop-helix family, member e40
chr7_+_100318422 0.438 NM_000799
EPO
erythropoietin
chr13_+_37006628 0.435 CCNA1
cyclin A1
chr6_+_31588444 0.434 NM_004638
NM_080686
PRRC2A

proline-rich coiled-coil 2A

chr17_-_79829174 0.433 ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr19_+_10362886 0.433 MRPL4
mitochondrial ribosomal protein L4
chr5_+_131593388 0.432 PDLIM4
PDZ and LIM domain 4
chr21_+_46825001 0.432 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr6_+_14117857 0.430 NM_001040280
NM_004233
CD83

CD83 molecule

chr11_+_67806517 0.427 TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr13_+_37006408 0.423 NM_001111045
NM_003914
CCNA1

cyclin A1

chr19_+_39390567 0.423 NM_002503
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr11_-_2017822 0.423 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr1_+_212782103 0.422 ATF3
activating transcription factor 3
chr17_-_79829272 0.421 NM_001185078
NM_004309
ARHGDIA

Rho GDP dissociation inhibitor (GDI) alpha

chr19_+_10362912 0.418 MRPL4
mitochondrial ribosomal protein L4
chr17_-_27467395 0.417 MYO18A
myosin XVIIIA
chr17_-_2614926 0.416 NM_015229
KIAA0664
KIAA0664
chr19_-_6424820 0.415 NM_003685
KHSRP
KH-type splicing regulatory protein
chr17_+_36861398 0.415 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr7_-_75623961 0.413 NM_031925
TMEM120A
transmembrane protein 120A
chr19_+_10362598 0.411 NM_015956
NM_146387
NM_146388
MRPL4


mitochondrial ribosomal protein L4


chr20_-_10654139 0.409 JAG1
jagged 1
chr17_-_48207113 0.409 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr3_-_48672807 0.409 SLC26A6
solute carrier family 26, member 6
chr6_+_31588524 0.406 PRRC2A
proline-rich coiled-coil 2A
chr18_+_57567191 0.406 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr11_-_59436488 0.405 NM_152716
PATL1
protein associated with topoisomerase II homolog 1 (yeast)
chr7_-_37488554 0.404 NM_014800
ELMO1
engulfment and cell motility 1
chr17_+_7792034 0.403 NM_001005273
NM_005852
CHD3

chromodomain helicase DNA binding protein 3

chr18_-_77711603 0.403 PQLC1
PQ loop repeat containing 1
chr15_+_52311438 0.402 MAPK6
mitogen-activated protein kinase 6
chr11_+_45825873 0.401 SLC35C1
solute carrier family 35, member C1
chr19_+_7587436 0.399 NM_020533
MCOLN1
mucolipin 1
chr21_+_40177847 0.398 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr11_-_2018446 0.397 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr15_+_52311432 0.396 MAPK6
mitogen-activated protein kinase 6
chr17_+_38137185 0.396 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr9_-_130661886 0.396 ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr19_+_39390570 0.394 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr11_-_71159371 0.392 DHCR7
7-dehydrocholesterol reductase
chr6_+_29855506 0.391


chr16_-_4838316 0.391 NM_001154458
NM_144605
SEPT12

septin 12

chr11_-_71159442 0.391 NM_001163817
NM_001360
DHCR7

7-dehydrocholesterol reductase

chr6_+_29910246 0.390 NM_001242758
NM_002116
HLA-A

major histocompatibility complex, class I, A

chr5_-_139944045 0.389 NM_006051
NM_133172
NM_133173
NM_133174
APBB3



amyloid beta (A4) precursor protein-binding, family B, member 3



chr19_+_13906207 0.389 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr17_-_79829237 0.387 ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr20_-_2821120 0.386 FAM113A
family with sequence similarity 113, member A
chr6_+_32936400 0.386 NM_005104
BRD2
bromodomain containing 2
chr15_+_52311408 0.386 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr2_-_27603249 0.383 NM_001201459
ZNF513
zinc finger protein 513
chr16_+_67694795 0.380 NM_001037281
NM_016948
PARD6A

par-6 partitioning defective 6 homolog alpha (C. elegans)

chr20_+_32399046 0.379 NM_176812
CHMP4B
charged multivesicular body protein 4B
chr11_-_57092283 0.379 NM_033396
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr7_+_155089614 0.379 INSIG1
insulin induced gene 1
chr17_-_79828691 0.377 NM_001185077
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr11_-_1785104 0.374 CTSD
cathepsin D
chr5_-_180237114 0.373 NM_001114617
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr20_+_45523523 0.371 EYA2
eyes absent homolog 2 (Drosophila)
chr1_-_44820923 0.362 ERI3
ERI1 exoribonuclease family member 3
chr12_+_102271349 0.361 DRAM1
DNA-damage regulated autophagy modulator 1
chr9_+_139780939 0.360 NM_021138
TRAF2
TNF receptor-associated factor 2
chr7_+_44646220 0.360 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr19_+_39899749 0.359


chr6_+_126111782 0.359 NM_001122842
NM_001199621
NM_181782
NCOA7


nuclear receptor coactivator 7


chr2_+_74757116 0.358 HTRA2
HtrA serine peptidase 2
chr19_-_47249629 0.357 STRN4
striatin, calmodulin binding protein 4
chr17_+_21188032 0.356 MAP2K3
mitogen-activated protein kinase kinase 3
chr20_+_61904158 0.355 NM_018209
NM_175609
ARFGAP1

ADP-ribosylation factor GTPase activating protein 1

chr12_+_102271082 0.355 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr19_+_50432399 0.355 NM_001193646
ATF5
activating transcription factor 5
chr22_+_42229105 0.354 NM_004599
SREBF2
sterol regulatory element binding transcription factor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.51 2.20e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.39 1.37e-03 GO:0009966 regulation of signal transduction
1.33 1.40e-03 GO:0048583 regulation of response to stimulus
1.27 1.61e-03 GO:0048518 positive regulation of biological process
1.58 1.98e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.14 2.22e-03 GO:0050794 regulation of cellular process
1.58 2.45e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.35 2.50e-03 GO:0023051 regulation of signaling
1.28 2.55e-03 GO:0048522 positive regulation of cellular process
1.60 2.75e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.60 3.13e-03 GO:0010629 negative regulation of gene expression
1.69 3.21e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.13 3.46e-03 GO:0050789 regulation of biological process
1.48 4.03e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.45 4.44e-03 GO:0009892 negative regulation of metabolic process
1.43 5.34e-03 GO:0010646 regulation of cell communication
1.54 5.67e-03 GO:0009890 negative regulation of biosynthetic process
1.12 7.09e-03 GO:0065007 biological regulation
4.17 8.76e-03 GO:0043535 regulation of blood vessel endothelial cell migration
1.27 8.86e-03 GO:0048519 negative regulation of biological process
1.28 9.06e-03 GO:0048523 negative regulation of cellular process
1.59 1.51e-02 GO:0051253 negative regulation of RNA metabolic process
1.45 1.52e-02 GO:0031324 negative regulation of cellular metabolic process
1.07 1.70e-02 GO:0009987 cellular process
1.52 1.93e-02 GO:0010628 positive regulation of gene expression
1.59 2.06e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.53 3.29e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.52 3.84e-02 GO:0045893 positive regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 5.56e-04 GO:0005737 cytoplasm
1.10 2.35e-03 GO:0043231 intracellular membrane-bounded organelle
1.10 2.37e-03 GO:0043227 membrane-bounded organelle
1.07 5.35e-03 GO:0044424 intracellular part
1.07 6.85e-03 GO:0005622 intracellular
1.08 3.75e-02 GO:0043226 organelle
1.08 3.87e-02 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 8.54e-11 GO:0005515 protein binding
1.08 1.61e-05 GO:0005488 binding