Motif ID: SOX{8,9,10}.p2

Z-value: 1.208


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
SOX9chr17_+_701171540.395.5e-02Click!
SOX10chr22_-_383798680.367.9e-02Click!
SOX8chr16_+_10320630.009.9e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_11232900 3.907 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr21_+_26934440 3.207 MIR155HG
MIR155 host gene (non-protein coding)
chr5_-_131826426 3.052 NM_002198
IRF1
interferon regulatory factor 1
chr19_+_45504686 2.796 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr6_-_11232883 2.570 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr10_+_6244839 2.472 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr1_-_205290756 2.463 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr6_-_11232901 2.384 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr2_+_228678556 2.211 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr19_-_49658645 2.171 NM_002152
HRC
histidine rich calcium binding protein
chr15_+_52311438 2.160 MAPK6
mitogen-activated protein kinase 6
chr3_+_186648515 2.132 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr6_-_10415438 2.112 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr2_-_208031570 2.052 KLF7
Kruppel-like factor 7 (ubiquitous)
chr21_+_43710190 2.018 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr5_-_16936290 2.012 MYO10
myosin X
chr14_-_51135021 1.932 NM_021818
SAV1
salvador homolog 1 (Drosophila)
chr16_-_75590107 1.915 NM_001077416
NM_001077418
NM_001077419
TMEM231


transmembrane protein 231


chr15_+_52311432 1.908 MAPK6
mitogen-activated protein kinase 6
chr22_-_19512859 1.886 NM_001130861
NM_003277
CLDN5

claudin 5


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
2.75 2.65e-03 GO:0007265 Ras protein signal transduction
1.85 1.12e-02 GO:0007264 small GTPase mediated signal transduction
1.71 2.09e-02 GO:0007417 central nervous system development
1.52 2.63e-05 GO:0007399 nervous system development
1.40 7.76e-10 GO:0007275 multicellular organismal development
1.37 1.09e-09 GO:0032502 developmental process
1.37 4.54e-06 GO:0048731 system development
1.35 2.03e-06 GO:0048856 anatomical structure development
1.32 3.06e-02 GO:0030154 cell differentiation
1.31 4.33e-02 GO:0048869 cellular developmental process
1.23 4.38e-02 GO:0016043 cellular component organization
1.22 7.98e-05 GO:0032501 multicellular organismal process
1.16 1.77e-04 GO:0050789 regulation of biological process
1.16 9.07e-04 GO:0050794 regulation of cellular process
1.15 6.80e-04 GO:0065007 biological regulation
1.10 1.62e-04 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
3.29 3.33e-03 GO:0000786 nucleosome
1.22 2.02e-06 GO:0005634 nucleus
1.10 2.00e-02 GO:0043227 membrane-bounded organelle
1.10 2.11e-02 GO:0043231 intracellular membrane-bounded organelle
1.08 7.25e-04 GO:0005622 intracellular
1.08 1.33e-03 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.46 1.06e-02 GO:0001071 nucleic acid binding transcription factor activity
1.46 1.06e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.29 6.50e-03 GO:0003677 DNA binding
1.16 5.60e-05 GO:0005515 protein binding
1.09 6.06e-05 GO:0005488 binding