Motif ID: SOX2.p2

Z-value: 1.292


Transcription factors associated with SOX2.p2:

Gene SymbolEntrez IDGene Name
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
SOX2chr3_+_1814297110.038.8e-01Click!


Activity profile for motif SOX2.p2.

activity profile for motif SOX2.p2


Sorted Z-values histogram for motif SOX2.p2

Sorted Z-values for motif SOX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_84647342 10.490 NM_001242862
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_-_101439071 8.184 NM_001159694
NM_016242
 EMCN

endomucin

chr4_-_186732047 7.306 NM_001145672
 SORBS2
sorbin and SH3 domain containing 2
chr3_-_149051258 5.639 NM_001184723
NM_138786
 TM4SF18

transmembrane 4 L six family member 18

chr4_-_186732208 5.215 NM_001145671
 SORBS2
sorbin and SH3 domain containing 2
chr1_+_61547388 4.864 NM_001145512
 NFIA
nuclear factor I/A
chr2_-_188312872 4.616 NM_005795
 CALCRL
calcitonin receptor-like
chr6_-_130031278 4.532 NM_033515
 ARHGAP18
Rho GTPase activating protein 18
chr8_-_80993009 4.235 NM_001025252
 TPD52
tumor protein D52
chr1_+_100111430 3.936 NM_017734
 PALMD
palmdelphin
chr17_-_67138013 3.777 NM_080284
 ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr7_-_11871735 3.537 NM_015204
 THSD7A
thrombospondin, type I, domain containing 7A
chr4_+_41614933 3.495 LIMCH1
LIM and calponin homology domains 1
chr4_+_41614725 3.459 LIMCH1
LIM and calponin homology domains 1
chr4_+_41614911 3.391 NM_001112719
NM_001112720
 LIMCH1

LIM and calponin homology domains 1

chrX_+_86772714 3.202 NM_019117
NM_057162
 KLHL4

kelch-like 4 (Drosophila)

chr4_+_41540187 3.132 LIMCH1
LIM and calponin homology domains 1
chr5_-_88199868 3.075 NM_001131005
NM_001193347
 MEF2C

myocyte enhancer factor 2C

chr1_+_61547625 2.966 NM_001134673
NM_005595
 NFIA

nuclear factor I/A

chr4_+_41540320 2.804 LIMCH1
LIM and calponin homology domains 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
3.02 1.21e-09 GO:0007156 homophilic cell adhesion
1.89 8.65e-04 GO:0016337 cell-cell adhesion
1.67 4.03e-02 GO:0016568 chromatin modification
1.65 4.57e-03 GO:0006325 chromatin organization
1.51 3.80e-02 GO:0051276 chromosome organization
1.35 3.89e-03 GO:0007399 nervous system development
1.27 3.23e-06 GO:0007275 multicellular organismal development
1.27 1.76e-04 GO:0048731 system development
1.25 7.36e-06 GO:0032502 developmental process
1.24 5.26e-04 GO:0048856 anatomical structure development
1.15 7.88e-03 GO:0032501 multicellular organismal process
1.14 1.84e-05 GO:0065007 biological regulation
1.14 6.51e-04 GO:0050794 regulation of cellular process
1.12 8.88e-03 GO:0050789 regulation of biological process
1.08 5.39e-04 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
3.25 2.98e-02 GO:0042641 actomyosin
2.58 1.62e-04 GO:0005925 focal adhesion
2.46 5.40e-04 GO:0005924 cell-substrate adherens junction
2.44 4.23e-04 GO:0030055 cell-substrate junction
2.16 9.49e-04 GO:0005912 adherens junction
2.10 8.62e-04 GO:0070161 anchoring junction
1.80 1.05e-02 GO:0016323 basolateral plasma membrane
1.18 2.38e-06 GO:0005634 nucleus
1.06 2.59e-03 GO:0005622 intracellular
1.06 1.11e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.50 2.24e-02 GO:0008092 cytoskeletal protein binding
1.47 1.16e-02 GO:0005509 calcium ion binding
1.46 6.15e-03 GO:0019899 enzyme binding
1.28 2.14e-04 GO:0003677 DNA binding
1.21 7.32e-04 GO:0003676 nucleic acid binding
1.19 1.20e-03 GO:0046872 metal ion binding
1.19 1.30e-03 GO:0043169 cation binding
1.18 1.77e-03 GO:0043167 ion binding
1.11 4.59e-03 GO:0005515 protein binding
1.08 2.98e-05 GO:0005488 binding