Motif ID: SPI1.p2

Z-value: 1.356


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
SPI1chr11_-_474000960.145.1e-01Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_184943673 5.540 NM_052966
 FAM129A
family with sequence similarity 129, member A
chr1_-_184943532 5.060 FAM129A
family with sequence similarity 129, member A
chr4_-_76944585 4.638 NM_001565
 CXCL10
chemokine (C-X-C motif) ligand 10
chr15_+_67358161 3.540 SMAD3
SMAD family member 3
chr6_-_31550065 3.443 NM_002341
NM_009588
 LTB

lymphotoxin beta (TNF superfamily, member 3)

chr6_-_29595746 3.105 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_-_60719116 3.019 NM_016582
 SLC15A3
solute carrier family 15, member 3
chr5_+_118691692 2.817 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr15_+_67358194 2.383 NM_005902
 SMAD3
SMAD family member 3
chr10_-_49812996 2.322 NM_021226
 ARHGAP22
Rho GTPase activating protein 22
chr5_-_172756505 2.271 NM_003714
 STC2
stanniocalcin 2
chr6_+_160148608 2.123 NM_152857
 WTAP
Wilms tumor 1 associated protein
chr9_+_109625347 2.118 NM_021224
 ZNF462
zinc finger protein 462
chr5_-_172755418 1.934 STC2
stanniocalcin 2
chr5_+_131409484 1.777 NM_000758
 CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr2_+_150187028 1.751 NM_194317
 LYPD6
LY6/PLAUR domain containing 6
chr16_-_65155881 1.719 NM_001797
 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr9_+_35732498 1.705 CREB3
cAMP responsive element binding protein 3
chr14_-_24616429 1.699 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr4_-_185395616 1.694 NM_002199
 IRF2
interferon regulatory factor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 93 entries
enrichment   p-value GO term description
1.81 6.09e-03 GO:0050851 antigen receptor-mediated signaling pathway
1.53 4.50e-02 GO:0002757 immune response-activating signal transduction
1.45 2.92e-03 GO:0007411 axon guidance
1.45 9.14e-03 GO:0051130 positive regulation of cellular component organization
1.40 1.77e-04 GO:0006935 chemotaxis
1.40 1.77e-04 GO:0042330 taxis
1.38 7.70e-03 GO:0007409 axonogenesis
1.36 1.22e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.36 1.52e-02 GO:0048812 neuron projection morphogenesis
1.35 6.75e-03 GO:0000904 cell morphogenesis involved in differentiation
1.35 2.14e-02 GO:0002684 positive regulation of immune system process
1.33 3.86e-03 GO:0048666 neuron development
1.33 2.40e-02 GO:0001775 cell activation
1.31 8.62e-03 GO:0032989 cellular component morphogenesis
1.30 2.25e-05 GO:0009605 response to external stimulus
1.30 1.40e-04 GO:0048468 cell development
1.30 1.47e-04 GO:0006351 transcription, DNA-dependent
1.30 2.50e-04 GO:0040011 locomotion
1.30 2.74e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.30 3.26e-04 GO:0009891 positive regulation of biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
1.50 8.02e-03 GO:0030425 dendrite
1.36 3.15e-04 GO:0005730 nucleolus
1.35 5.87e-03 GO:0043005 neuron projection
1.32 4.75e-05 GO:0044451 nucleoplasm part
1.30 1.76e-13 GO:0031981 nuclear lumen
1.29 1.05e-02 GO:0005694 chromosome
1.28 1.77e-14 GO:0044428 nuclear part
1.26 6.16e-07 GO:0005654 nucleoplasm
1.22 2.57e-09 GO:0043233 organelle lumen
1.22 2.94e-09 GO:0031974 membrane-enclosed lumen
1.22 5.72e-09 GO:0070013 intracellular organelle lumen
1.22 1.48e-02 GO:0042995 cell projection
1.19 1.43e-02 GO:0031226 intrinsic to plasma membrane
1.18 1.83e-02 GO:0005887 integral to plasma membrane
1.17 6.15e-17 GO:0005634 nucleus
1.17 9.05e-07 GO:0043234 protein complex
1.16 3.81e-04 GO:0044459 plasma membrane part
1.15 5.79e-03 GO:0005829 cytosol
1.14 3.22e-06 GO:0032991 macromolecular complex
1.14 8.31e-04 GO:0043228 non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
1.51 2.19e-05 GO:0016563 transcription activator activity
1.51 2.26e-05 GO:0016564 transcription repressor activity
1.50 8.57e-03 GO:0000975 regulatory region DNA binding
1.50 8.57e-03 GO:0001067 regulatory region nucleic acid binding
1.50 8.57e-03 GO:0044212 transcription regulatory region DNA binding
1.49 1.73e-02 GO:0010843 promoter binding
1.47 1.80e-03 GO:0032403 protein complex binding
1.36 7.16e-10 GO:0030528 transcription regulator activity
1.36 5.08e-06 GO:0043565 sequence-specific DNA binding
1.27 3.95e-03 GO:0019899 enzyme binding
1.25 7.98e-04 GO:0001071 nucleic acid binding transcription factor activity
1.25 7.98e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.19 2.28e-33 GO:0005515 protein binding
1.15 4.34e-03 GO:0000166 nucleotide binding
1.11 2.93e-02 GO:0003676 nucleic acid binding
1.08 2.18e-19 GO:0005488 binding