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• Activity deltas table
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Motif ID: SPIB.p2

Z-value: 1.352

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_-_169703178	3.445	NM_000450	SELE	selectin E
chr7_+_150147882	2.635		GIMAP8	GTPase, IMAP family member 8
chr19_+_10381516	2.634	NM_000201	ICAM1	intercellular adhesion molecule 1
chr1_+_101185195	2.612	NM_001078 NM_001199834 NM_080682	VCAM1	vascular cell adhesion molecule 1
chr6_-_11382501	2.337	NM_001142393	NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr10_+_102107074	2.301		SCD	stearoyl-CoA desaturase (delta-9-desaturase)
chr11_-_10830034	1.995		EIF4G2	eukaryotic translation initiation factor 4 gamma, 2
chr10_+_102107256	1.905
chr10_+_102107001	1.839		SCD	stearoyl-CoA desaturase (delta-9-desaturase)
chr3_+_46448678	1.776	NM_003965 NM_001130910	CCRL2	chemokine (C-C motif) receptor-like 2
chr1_+_114522029	1.718	NM_020190	OLFML3	olfactomedin-like 3
chr2_-_26101091	1.631
chr10_+_102106958	1.615		SCD	stearoyl-CoA desaturase (delta-9-desaturase)
chr4_+_103422822	1.615		NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_+_103422730	1.560		NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chrX_-_45060081	1.474	NM_024689 NM_176819	CXorf36	chromosome X open reading frame 36
chr3_+_113465901	1.467		ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr21_-_35899046	1.405	NM_203418	RCAN1	regulator of calcineurin 1
chr13_+_111855406	1.358		ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7
chr1_+_164528586	1.334	NM_001204961 NM_001204963 NM_002585	PBX1	pre-B-cell leukemia homeobox 1
chr11_+_102188180	1.318	NM_001165 NM_182962	BIRC3	baculoviral IAP repeat containing 3
chr4_+_139936938	1.315	NM_012118	CCRN4L	CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr17_+_40610940	1.285		ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1
chr16_+_29674564	1.285		SPN	sialophorin
chr17_+_40610897	1.284		ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1
chr15_-_59665069	1.273	NM_004998	MYO1E	myosin IE
chr9_-_107690526	1.270	NM_005502	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1
chr7_+_150148078	1.269		GIMAP8	GTPase, IMAP family member 8
chr10_+_18948276	1.203	NM_178815	ARL5B	ADP-ribosylation factor-like 5B
chr8_-_48650683	1.164		CEBPD	CCAAT/enhancer binding protein (C/EBP), delta
chr17_+_40610875	1.153		ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1
chr6_-_10412606	1.142	NM_001032280	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr2_+_28616346	1.128		FOSL2	FOS-like antigen 2
chr17_+_47288068	1.126		ABI3	ABI family, member 3
chr4_+_74606222	1.125	NM_000584	IL8	interleukin 8
chr4_+_41540187	1.113		LIMCH1	LIM and calponin homology domains 1
chr21_+_27107731	1.108		GABPA	GA binding protein transcription factor, alpha subunit 60kDa
chr17_+_40610905	1.105		ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1
chr11_-_33890931	1.094		LMO2	LIM domain only 2 (rhombotin-like 1)
chr7_-_32931409	1.079	NM_015483	KBTBD2	kelch repeat and BTB (POZ) domain containing 2
chr4_+_41700736	1.064		LIMCH1	LIM and calponin homology domains 1
chr7_-_32931363	1.055		KBTBD2	kelch repeat and BTB (POZ) domain containing 2
chr4_-_101439071	1.028	NM_001159694 NM_016242	EMCN	endomucin
chr13_-_72441312	1.027	NM_004392 NM_080759 NM_080760	DACH1	dachshund homolog 1 (Drosophila)
chr17_+_21191347	1.024	NM_002756	MAP2K3	mitogen-activated protein kinase kinase 3
chr19_+_10381763	1.017		ICAM1	intercellular adhesion molecule 1
chr9_-_130616592	1.003		ENG	endoglin
chr21_+_27107522	0.989		GABPA	GA binding protein transcription factor, alpha subunit 60kDa
chr1_+_212738675	0.988	NM_001030287	ATF3	activating transcription factor 3
chr17_+_32582295	0.971	NM_002982	CCL2	chemokine (C-C motif) ligand 2
chr3_-_64211111	0.960	NM_198859	PRICKLE2	prickle homolog 2 (Drosophila)
chr2_+_28616360	0.956		FOSL2	FOS-like antigen 2
chr17_+_32597239	0.940	NM_006273	CCL7	chemokine (C-C motif) ligand 7
chr18_-_53068755	0.938		TCF4	transcription factor 4
chr8_-_6420454	0.932	NM_001118887 NM_001118888 NM_001147	ANGPT2	angiopoietin 2
chr12_-_48499840	0.929		SENP1	SUMO1/sentrin specific peptidase 1
chr20_-_43977023	0.926	NM_002999	SDC4	syndecan 4
chr4_+_103422553	0.926		NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr7_+_150147936	0.895	NM_175571	GIMAP8	GTPase, IMAP family member 8
chr5_+_56111379	0.881		MAP3K1	mitogen-activated protein kinase kinase kinase 1
chr15_-_59665053	0.879		MYO1E	myosin IE
chr5_+_140734767	0.873	NM_018917 NM_032053	PCDHGA4	protocadherin gamma subfamily A, 4
chr10_+_35484829	0.873	NM_182721 NM_182722 NM_182723 NM_182724 NM_182725	CREM	cAMP responsive element modulator
chr1_-_150241409	0.862	NM_001077628 NM_001243771 NM_001243772 NM_016022	APH1A	anterior pharynx defective 1 homolog A (C. elegans)
chr19_-_54692132	0.858		MBOAT7	membrane bound O-acyltransferase domain containing 7
chr10_+_99400469	0.847		PI4K2A	phosphatidylinositol 4-kinase type 2 alpha
chr3_+_113465860	0.838	NM_001690	ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr5_+_118691692	0.832		TNFAIP8	tumor necrosis factor, alpha-induced protein 8
chr15_-_43785368	0.826		TP53BP1	tumor protein p53 binding protein 1
chr5_+_180794268	0.825	NM_001005224 NM_001005221 NM_001005277	OR4F3 OR4F29 OR4F16	olfactory receptor, family 4, subfamily F, member 3 olfactory receptor, family 4, subfamily F, member 29 olfactory receptor, family 4, subfamily F, member 16
chr6_-_31550065	0.820	NM_002341 NM_009588	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr14_-_76448091	0.811	NM_003239	TGFB3	transforming growth factor, beta 3
chr10_+_6186878	0.810		PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr10_-_33623978	0.809		NRP1	neuropilin 1
chr6_+_106534188	0.802	NM_001198	PRDM1	PR domain containing 1, with ZNF domain
chr4_+_134070443	0.797	NM_020815 NM_032961	PCDH10	protocadherin 10
chr11_-_33891258	0.797		LMO2	LIM domain only 2 (rhombotin-like 1)
chr5_-_158635080	0.793	NM_001199381	RNF145	ring finger protein 145
chr1_+_25943958	0.786	NM_020379	MAN1C1	mannosidase, alpha, class 1C, member 1
chr12_-_9268440	0.780		A2M	alpha-2-macroglobulin
chr1_+_100818052	0.775		CDC14A	CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr2_-_54198055	0.775
chr1_-_160313056	0.774		COPA	coatomer protein complex, subunit alpha
chr11_-_33891361	0.771	NM_001142316	LMO2	LIM domain only 2 (rhombotin-like 1)
chr12_-_9268513	0.755		A2M	alpha-2-macroglobulin
chr1_-_150241210	0.752		APH1A	anterior pharynx defective 1 homolog A (C. elegans)
chr2_+_28615668	0.744		FOSL2	FOS-like antigen 2
chr17_-_31204071	0.742		MYO1D	myosin ID
chr1_+_84609941	0.742	NM_182948	PRKACB	protein kinase, cAMP-dependent, catalytic, beta
chr12_-_9268522	0.742	NM_000014	A2M	alpha-2-macroglobulin
chr7_-_32931189	0.730		KBTBD2	kelch repeat and BTB (POZ) domain containing 2
chr17_+_40610857	0.729	NM_001130020 NM_001130021 NM_005177	ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1
chr5_+_139060295	0.727		CXXC5	CXXC finger protein 5
chr11_-_64647136	0.724		EHD1	EH-domain containing 1
chr3_+_196466806	0.715		PAK2	p21 protein (Cdc42/Rac)-activated kinase 2
chr6_+_143999058	0.711	NM_001100164 NM_001100165	PHACTR2	phosphatase and actin regulator 2
chr5_-_158634641	0.707	NM_001199382	RNF145	ring finger protein 145
chr3_+_9476506	0.705
chr11_-_46717657	0.704		ARHGAP1	Rho GTPase activating protein 1
chr4_+_156587861	0.703	NM_000856 NM_001130682 NM_001130686 NM_001130687 NM_001130683 NM_001130685	GUCY1A3	guanylate cyclase 1, soluble, alpha 3
chr10_+_102106771	0.697	NM_005063	SCD	stearoyl-CoA desaturase (delta-9-desaturase)
chr14_+_55034329	0.696	NM_001161576 NM_015589	SAMD4A	sterile alpha motif domain containing 4A
chrX_+_70521627	0.694	NM_012278	ITGB1BP2	integrin beta 1 binding protein (melusin) 2
chr21_+_27107671	0.694		GABPA	GA binding protein transcription factor, alpha subunit 60kDa
chr15_+_81293286	0.694	NM_022566	MESDC1	mesoderm development candidate 1
chr3_+_9439533	0.678		SETD5	SET domain containing 5
chr15_-_50411405	0.676	NM_024837	ATP8B4	ATPase, class I, type 8B, member 4
chr12_-_30848744	0.662		IPO8	importin 8
chr1_-_62190740	0.662		TM2D1	TM2 domain containing 1
chr3_+_113465910	0.657		ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr21_+_41117333	0.657	NM_001080444	IGSF5	immunoglobulin superfamily, member 5
chr8_-_22550708	0.654	NM_004430	EGR3	early growth response 3
chr12_-_110434028	0.649		GIT2	G protein-coupled receptor kinase interacting ArfGAP 2
chr10_+_102121371	0.649		SCD	stearoyl-CoA desaturase (delta-9-desaturase)
chr13_+_97928414	0.648		MBNL2	muscleblind-like 2 (Drosophila)
chr16_+_30406432	0.646	NM_001214909	ZNF48	zinc finger protein 48
chr11_-_71791734	0.645		NUMA1	nuclear mitotic apparatus protein 1
chr17_-_73401775	0.643		GRB2	growth factor receptor-bound protein 2
chr8_+_90770201	0.642		RIPK2	receptor-interacting serine-threonine kinase 2
chr13_+_97928196	0.637		MBNL2	muscleblind-like 2 (Drosophila)
chr5_+_10353829	0.633		MARCH6	membrane-associated ring finger (C3HC4) 6
chr13_+_97874704	0.632		MBNL2	muscleblind-like 2 (Drosophila)
chr5_+_173315313	0.631	NM_030627	CPEB4	cytoplasmic polyadenylation element binding protein 4
chr8_+_90769974	0.630	NM_003821	RIPK2	receptor-interacting serine-threonine kinase 2
chr3_-_71179736	0.626		FOXP1	forkhead box P1
chr2_+_85766286	0.625		MAT2A	methionine adenosyltransferase II, alpha
chr1_-_47082529	0.625	NM_201403	MOB3C	MOB kinase activator 3C
chr8_-_117023	0.624	NM_001005504	OR4F21	olfactory receptor, family 4, subfamily F, member 21
chr8_-_22550057	0.623	NM_001199881	EGR3	early growth response 3
chr1_-_221910801	0.623	NM_144728	DUSP10	dual specificity phosphatase 10
chr12_-_10251520	0.620	NM_016511	CLEC1A	C-type lectin domain family 1, member A
chr5_-_158634833	0.615	NM_144726	RNF145	ring finger protein 145
chr14_+_100531764	0.613		EVL	Enah/Vasp-like
chr6_-_47253962	0.613		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr9_+_116343169	0.613		RGS3	regulator of G-protein signaling 3
chr9_+_116342939	0.610	NM_021106	RGS3	regulator of G-protein signaling 3
chr6_-_47254143	0.608		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr22_+_45704821	0.608	NM_001104595	FAM118A	family with sequence similarity 118, member A
chr1_-_21605984	0.606	NM_001113347	ECE1	endothelin converting enzyme 1
chr4_+_74735107	0.604	NM_001511	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr17_+_57785010	0.603		VMP1	vacuole membrane protein 1
chr14_+_53019865	0.602	NM_001099652	GPR137C	G protein-coupled receptor 137C
chr8_+_86157693	0.600	NM_198584	CA13	carbonic anhydrase XIII
chr10_+_30723050	0.599		MAP3K8	mitogen-activated protein kinase kinase kinase 8
chr3_+_100328432	0.597	NM_032787	GPR128	G protein-coupled receptor 128
chr14_+_100531745	0.596	NM_016337	EVL	Enah/Vasp-like
chr6_-_43595079	0.596		GTPBP2	GTP binding protein 2
chr22_+_38453478	0.594		PICK1	protein interacting with PRKCA 1
chr1_-_112046742	0.592	NM_000677 NM_020683	ADORA3	adenosine A3 receptor
chr7_-_37488894	0.591	NM_001206480	ELMO1	engulfment and cell motility 1
chr17_-_63052707	0.589		GNA13	guanine nucleotide binding protein (G protein), alpha 13
chrX_-_48815582	0.584		OTUD5	OTU domain containing 5
chr4_-_185395616	0.584	NM_002199	IRF2	interferon regulatory factor 2
chr9_+_120466607	0.582		TLR4	toll-like receptor 4
chr1_-_155948206	0.577		ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr8_+_68864589	0.574	NM_024870 NM_025170	PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr10_+_73555527	0.564	NM_001171933 NM_001171934	CDH23	cadherin-related 23
chr12_-_89746238	0.564		DUSP6	dual specificity phosphatase 6
chr2_+_28615771	0.561	NM_005253	FOSL2	FOS-like antigen 2
chr20_-_42839423	0.561	NM_016470	C20orf111	chromosome 20 open reading frame 111
chr7_-_37488408	0.556		ELMO1	engulfment and cell motility 1
chr4_-_16900256	0.555		LDB2	LIM domain binding 2
chr3_-_129035069	0.555	NM_006026	H1FX	H1 histone family, member X
chr1_-_155948317	0.555	NM_001162383 NM_001162384	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr7_-_37488554	0.553	NM_014800	ELMO1	engulfment and cell motility 1
chr10_-_98480174	0.550	NM_152309	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1
chr14_-_21852161	0.550		SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)
chr5_-_39425030	0.550		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr12_-_9268475	0.550		A2M	alpha-2-macroglobulin
chr14_-_21852085	0.549		SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)
chr4_-_16900348	0.546	NM_001130834 NM_001290	LDB2	LIM domain binding 2
chr4_-_16900028	0.544		LDB2	LIM domain binding 2
chr20_-_30311693	0.541		BCL2L1	BCL2-like 1
chr17_-_73389708	0.541		GRB2	growth factor receptor-bound protein 2
chr4_+_156588811	0.540	NM_001130684	GUCY1A3	guanylate cyclase 1, soluble, alpha 3
chr13_+_46039024	0.540	NM_031431	COG3	component of oligomeric golgi complex 3
chr10_-_116286570	0.540		ABLIM1	actin binding LIM protein 1
chr10_+_30722856	0.537	NM_001244134 NM_005204	MAP3K8	mitogen-activated protein kinase kinase kinase 8
chr4_+_42399855	0.531	NM_001080505	SHISA3	shisa homolog 3 (Xenopus laevis)
chr6_-_154831788	0.529		CNKSR3	CNKSR family member 3
chr1_-_91487543	0.527		ZNF644	zinc finger protein 644
chr6_+_14118002	0.526		CD83	CD83 molecule
chr19_+_45251933	0.526	NM_005178	BCL3	B-cell CLL/lymphoma 3
chr10_+_37414784	0.522	NM_052997	ANKRD30A	ankyrin repeat domain 30A
chr5_-_32403310	0.521		ZFR	zinc finger RNA binding protein
chr1_+_218519576	0.517		TGFB2	transforming growth factor, beta 2
chr10_-_33623771	0.517	NM_001024628 NM_001024629 NM_001244972 NM_001244973 NM_003873	NRP1	neuropilin 1
chr10_-_103578179	0.514		MGEA5	meningioma expressed antigen 5 (hyaluronidase)
chr17_-_35656691	0.514	NM_198837 NM_198838	ACACA	acetyl-CoA carboxylase alpha
chr6_+_14117857	0.513	NM_001040280 NM_004233	CD83	CD83 molecule
chr1_+_153175918	0.513	NM_001010857	LELP1	late cornified envelope-like proline-rich 1
chr20_-_42839295	0.511		C20orf111	chromosome 20 open reading frame 111
chr11_-_61124223	0.505	NM_001161452	CYBASC3	cytochrome b, ascorbate dependent 3
chrX_+_149613719	0.505	NM_001177466 NM_005491	MAMLD1	mastermind-like domain containing 1
chr4_+_41540320	0.503		LIMCH1	LIM and calponin homology domains 1
chr1_+_16259046	0.502
chr2_-_26101173	0.501		ASXL2	additional sex combs like 2 (Drosophila)
chr21_-_39870303	0.495	NM_001136155 NM_182918	ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr21_-_47704166	0.494		MCM3AP	minichromosome maintenance complex component 3 associated protein
chr14_-_35344852	0.491	NM_013448 NM_182648	BAZ1A	bromodomain adjacent to zinc finger domain, 1A

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.10	1.10e-12	GO:0009987	cellular process
1.43	5.51e-10	GO:0002376	immune system process
1.24	1.22e-09	GO:0007165	signal transduction
1.22	2.21e-09	GO:0023052	signaling
1.12	1.59e-07	GO:0065007	biological regulation
1.19	2.89e-07	GO:0051716	cellular response to stimulus
1.12	1.86e-05	GO:0050794	regulation of cellular process
1.44	2.95e-05	GO:0006955	immune response
1.11	5.10e-05	GO:0050789	regulation of biological process
1.45	5.93e-05	GO:0002682	regulation of immune system process
1.56	7.32e-05	GO:0050776	regulation of immune response
1.37	3.45e-04	GO:0009611	response to wounding
1.53	4.49e-04	GO:0002684	positive regulation of immune system process
1.49	6.61e-04	GO:0007596	blood coagulation
1.49	6.61e-04	GO:0050817	coagulation
1.24	6.71e-04	GO:0048583	regulation of response to stimulus
1.19	8.49e-04	GO:0048518	positive regulation of biological process
1.11	8.97e-04	GO:0050896	response to stimulus
1.48	9.01e-04	GO:0001775	cell activation
1.48	1.02e-03	GO:0007599	hemostasis
1.44	1.13e-03	GO:0042060	wound healing
1.22	1.25e-03	GO:0065008	regulation of biological quality
1.86	1.62e-03	GO:0050900	leukocyte migration
1.20	1.74e-03	GO:0048522	positive regulation of cellular process
1.23	3.95e-03	GO:0007166	cell surface receptor linked signaling pathway
1.19	4.24e-03	GO:0006950	response to stress
1.65	4.27e-03	GO:0045321	leukocyte activation
1.42	5.74e-03	GO:0050878	regulation of body fluid levels
1.22	7.56e-03	GO:0006464	protein modification process
1.40	1.93e-02	GO:0006928	cellular component movement
1.12	4.21e-02	GO:0044260	cellular macromolecule metabolic process
1.30	4.43e-02	GO:0040011	locomotion

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.22	8.00e-05	GO:0044459	plasma membrane part
1.08	4.33e-04	GO:0005737	cytoplasm
1.05	2.55e-03	GO:0005622	intracellular
1.31	7.19e-03	GO:0031410	cytoplasmic vesicle
1.51	8.40e-03	GO:0015629	actin cytoskeleton
1.05	8.78e-03	GO:0044424	intracellular part
1.98	9.95e-03	GO:0030027	lamellipodium
1.31	1.35e-02	GO:0044432	endoplasmic reticulum part
1.30	1.41e-02	GO:0031982	vesicle
1.87	1.60e-02	GO:0005788	endoplasmic reticulum lumen
1.30	2.09e-02	GO:0031988	membrane-bounded vesicle
1.23	2.58e-02	GO:0005887	integral to plasma membrane
1.80	2.79e-02	GO:0030055	cell-substrate junction
1.20	2.81e-02	GO:0012505	endomembrane system
1.30	2.91e-02	GO:0016023	cytoplasmic membrane-bounded vesicle
1.87	4.24e-02	GO:0042470	melanosome
1.87	4.24e-02	GO:0048770	pigment granule

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.16	5.25e-15	GO:0005515	protein binding
1.07	2.76e-09	GO:0005488	binding
1.28	4.81e-03	GO:0005102	receptor binding
2.29	9.99e-03	GO:0019903	protein phosphatase binding
1.26	2.82e-02	GO:0001071	nucleic acid binding transcription factor activity
1.26	2.82e-02	GO:0003700	sequence-specific DNA binding transcription factor activity
1.30	4.77e-02	GO:0019899	enzyme binding