Motif ID: SPIB.p2

Z-value: 1.352


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
SPIBchr19_+_509221940.501.1e-02Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_169703178 3.445 NM_000450
 SELE
selectin E
chr7_+_150147882 2.635 GIMAP8
GTPase, IMAP family member 8
chr19_+_10381516 2.634 NM_000201
 ICAM1
intercellular adhesion molecule 1
chr1_+_101185195 2.612 NM_001078
NM_001199834
NM_080682
 VCAM1


vascular cell adhesion molecule 1


chr6_-_11382501 2.337 NM_001142393
 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr10_+_102107074 2.301 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr11_-_10830034 1.995 EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr10_+_102107256 1.905


chr10_+_102107001 1.839 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr3_+_46448678 1.776 NM_003965
NM_001130910
 CCRL2

chemokine (C-C motif) receptor-like 2

chr1_+_114522029 1.718 NM_020190
 OLFML3
olfactomedin-like 3
chr2_-_26101091 1.631


chr10_+_102106958 1.615 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr4_+_103422822 1.615 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_+_103422730 1.560 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chrX_-_45060081 1.474 NM_024689
NM_176819
 CXorf36

chromosome X open reading frame 36

chr3_+_113465901 1.467 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr21_-_35899046 1.405 NM_203418
 RCAN1
regulator of calcineurin 1
chr13_+_111855406 1.358 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_+_164528586 1.334 NM_001204961
NM_001204963
NM_002585
 PBX1


pre-B-cell leukemia homeobox 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
1.86 1.62e-03 GO:0050900 leukocyte migration
1.65 4.27e-03 GO:0045321 leukocyte activation
1.56 7.32e-05 GO:0050776 regulation of immune response
1.53 4.49e-04 GO:0002684 positive regulation of immune system process
1.49 6.61e-04 GO:0007596 blood coagulation
1.49 6.61e-04 GO:0050817 coagulation
1.48 9.01e-04 GO:0001775 cell activation
1.48 1.02e-03 GO:0007599 hemostasis
1.45 5.93e-05 GO:0002682 regulation of immune system process
1.44 2.95e-05 GO:0006955 immune response
1.44 1.13e-03 GO:0042060 wound healing
1.43 5.51e-10 GO:0002376 immune system process
1.42 5.74e-03 GO:0050878 regulation of body fluid levels
1.40 1.93e-02 GO:0006928 cellular component movement
1.37 3.45e-04 GO:0009611 response to wounding
1.30 4.43e-02 GO:0040011 locomotion
1.24 1.22e-09 GO:0007165 signal transduction
1.24 6.71e-04 GO:0048583 regulation of response to stimulus
1.23 3.95e-03 GO:0007166 cell surface receptor linked signaling pathway
1.22 2.21e-09 GO:0023052 signaling

Gene overrepresentation in compartment category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
1.98 9.95e-03 GO:0030027 lamellipodium
1.87 1.60e-02 GO:0005788 endoplasmic reticulum lumen
1.87 4.24e-02 GO:0042470 melanosome
1.87 4.24e-02 GO:0048770 pigment granule
1.80 2.79e-02 GO:0030055 cell-substrate junction
1.51 8.40e-03 GO:0015629 actin cytoskeleton
1.31 7.19e-03 GO:0031410 cytoplasmic vesicle
1.31 1.35e-02 GO:0044432 endoplasmic reticulum part
1.30 1.41e-02 GO:0031982 vesicle
1.30 2.09e-02 GO:0031988 membrane-bounded vesicle
1.30 2.91e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.23 2.58e-02 GO:0005887 integral to plasma membrane
1.22 8.00e-05 GO:0044459 plasma membrane part
1.20 2.81e-02 GO:0012505 endomembrane system
1.08 4.33e-04 GO:0005737 cytoplasm
1.05 2.55e-03 GO:0005622 intracellular
1.05 8.78e-03 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
2.29 9.99e-03 GO:0019903 protein phosphatase binding
1.30 4.77e-02 GO:0019899 enzyme binding
1.28 4.81e-03 GO:0005102 receptor binding
1.26 2.82e-02 GO:0001071 nucleic acid binding transcription factor activity
1.26 2.82e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.16 5.25e-15 GO:0005515 protein binding
1.07 2.76e-09 GO:0005488 binding