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Motif ID: SREBF1,2.p2

Z-value: 1.891

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_46688362	12.788	NM_004502	HOXB7	homeobox B7
chr17_-_46688279	12.009		HOXB7	homeobox B7
chr20_-_39317875	11.060	NM_005461	MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_-_11866079	8.419	NM_005957	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)
chrX_+_101975641	7.465	NM_001142524 NM_001142525 NM_001142526 NM_001142527 NM_001142528 NM_030639	BHLHB9	basic helix-loop-helix domain containing, class B, 9
chr17_-_46687925	7.456		HOXB7	homeobox B7
chr12_+_93964801	7.448		SOCS2	suppressor of cytokine signaling 2
chr3_-_122512526	7.386	NM_024610	HSPBAP1	HSPB (heat shock 27kDa) associated protein 1
chr17_+_25621105	6.572	NM_015626 NM_134265	WSB1	WD repeat and SOCS box containing 1
chr4_+_100871625	6.564		LOC256880	uncharacterized LOC256880
chr1_+_61869699	6.525		NFIA	nuclear factor I/A
chr5_-_172198160	6.240	NM_004417	DUSP1	dual specificity phosphatase 1
chrX_+_55744049	6.183	NM_006064 NM_016656	RRAGB	Ras-related GTP binding B
chr6_+_160390128	6.065	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chrX_+_77166178	6.049	NM_000052	ATP7A	ATPase, Cu++ transporting, alpha polypeptide
chr12_-_10021932	5.964		CLEC2B	C-type lectin domain family 2, member B
chr17_+_65821625	5.927	NM_004459 NM_182641	BPTF	bromodomain PHD finger transcription factor
chr1_-_154928564	5.875	NM_020524	PBXIP1	pre-B-cell leukemia homeobox interacting protein 1
chr11_+_67159421	5.786	NM_004584	RAD9A	RAD9 homolog A (S. pombe)
chr3_+_112280871	5.677	NM_017945	SLC35A5	solute carrier family 35, member A5
chr6_-_33386064	5.646	NM_001014433 NM_001014837 NM_001014838 NM_001014840 NM_015921	CUTA	cutA divalent cation tolerance homolog (E. coli)
chr6_-_84418705	5.586	NM_001242792	SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)
chr7_-_27183225	5.484	NM_019102	HOXA5	homeobox A5
chr8_+_120220554	5.388	NM_052886	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
chr11_-_18343670	5.194	NM_007216 NM_181507 NM_181508	HPS5	Hermansky-Pudlak syndrome 5
chr10_-_93392857	5.085	NM_005398	PPP1R3C	protein phosphatase 1, regulatory subunit 3C
chr6_+_87865261	4.992	NM_015021	ZNF292	zinc finger protein 292
chr6_-_84419108	4.911	NM_001242793 NM_001242794 NM_014841	SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)
chr8_-_9009050	4.887	NM_001201329	PPP1R3B	protein phosphatase 1, regulatory subunit 3B
chr6_-_84937313	4.885	NM_014895	KIAA1009	KIAA1009
chr16_+_5083671	4.874		LOC100507589	uncharacterized LOC100507589
chr12_-_65153182	4.819		GNS	glucosamine (N-acetyl)-6-sulfatase
chr6_-_84419018	4.802		SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)
chr22_-_36903086	4.793	NM_024955 NM_001102371	FOXRED2	FAD-dependent oxidoreductase domain containing 2
chr11_+_59522801	4.581		STX3	syntaxin 3
chr17_+_78075299	4.543	NM_000152 NM_001079803 NM_001079804	GAA	glucosidase, alpha; acid
chr2_-_238499317	4.496		RAB17	RAB17, member RAS oncogene family
chr14_-_54955664	4.484		GMFB	glia maturation factor, beta
chr17_-_47841517	4.483	NM_030802	FAM117A	family with sequence similarity 117, member A
chr17_-_62915580	4.423		LRRC37A3	leucine rich repeat containing 37, member A3
chr17_-_47841468	4.408		FAM117A	family with sequence similarity 117, member A
chr11_+_9595451	4.389		WEE1	WEE1 homolog (S. pombe)
chr6_+_42018264	4.367		TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chrX_+_102883891	4.316	NM_001006639 NM_004780	TCEAL1	transcription elongation factor A (SII)-like 1
chr13_-_50159628	4.309		RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr11_+_59522905	4.291		STX3	syntaxin 3
chr14_+_38677186	4.232	NM_001049	SSTR1	somatostatin receptor 1
chr5_+_122110778	4.221		SNX2	sorting nexin 2
chr17_+_78075390	4.173		GAA	glucosidase, alpha; acid
chr5_+_122110762	4.168		SNX2	sorting nexin 2
chr6_-_33385814	4.134
chr7_+_106685007	4.130	NM_002736	PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta
chr14_-_54955714	4.026	NM_004124	GMFB	glia maturation factor, beta
chr10_-_46090191	3.951	NM_001002265 NM_145021	MARCH8	membrane-associated ring finger (C3HC4) 8
chr11_+_7535213	3.936		PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr20_+_44520021	3.880		CTSA	cathepsin A
chr5_-_154230157	3.847		C5orf4	chromosome 5 open reading frame 4
chr3_+_112280911	3.830		SLC35A5	solute carrier family 35, member A5
chr17_-_76124767	3.803		TMC6	transmembrane channel-like 6
chr8_-_54755821	3.759		ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr8_-_54755546	3.747	NM_213620	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr20_-_2821245	3.743	NM_022760	FAM113A	family with sequence similarity 113, member A
chr12_-_65153148	3.733		GNS	glucosamine (N-acetyl)-6-sulfatase
chr11_+_7535000	3.699	NM_003621	PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr8_-_54755836	3.694	NM_015941 NM_213619	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr7_-_27196163	3.649	NM_006896	HOXA7	homeobox A7
chr5_-_154230212	3.605	NM_032385	C5orf4	chromosome 5 open reading frame 4
chr17_-_57184116	3.580		TRIM37	tripartite motif containing 37
chr10_+_69644341	3.572	NM_012238	SIRT1	sirtuin 1
chr17_+_25621141	3.563		WSB1	WD repeat and SOCS box containing 1
chr8_+_74903563	3.557	NM_001195797 NM_015364	LY96	lymphocyte antigen 96
chr17_-_35969401	3.540	NM_001163544 NM_001163545 NM_001163546 NM_001163547 NM_007247 NM_080550 NM_198882	SYNRG	synergin, gamma
chr19_-_36545298	3.531		THAP8	THAP domain containing 8
chr7_-_27224762	3.529	NM_005523	HOXA11	homeobox A11
chr12_-_65153055	3.527		GNS	glucosamine (N-acetyl)-6-sulfatase
chr1_-_154928595	3.514		PBXIP1	pre-B-cell leukemia homeobox interacting protein 1
chrX_+_77166223	3.498		ATP7A	ATPase, Cu++ transporting, alpha polypeptide
chr2_+_148778573	3.490	NM_018328	MBD5	methyl-CpG binding domain protein 5
chr5_+_122110737	3.489	NM_003100	SNX2	sorting nexin 2
chr17_-_73975507	3.451	NM_001185039 NM_004035 NM_007292	ACOX1	acyl-CoA oxidase 1, palmitoyl
chr3_-_4508939	3.450		SUMF1	sulfatase modifying factor 1
chr11_+_9595429	3.450		WEE1	WEE1 homolog (S. pombe)
chr3_+_158519888	3.420		MFSD1	major facilitator superfamily domain containing 1
chr3_-_4508928	3.362		SUMF1	sulfatase modifying factor 1
chr6_+_42018250	3.337	NM_138572	TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr10_-_105452878	3.312		SH3PXD2A	SH3 and PX domains 2A
chr14_-_74551159	3.277	NM_005589	ALDH6A1	aldehyde dehydrogenase 6 family, member A1
chr16_-_28503079	3.259	NM_000086	CLN3	ceroid-lipofuscinosis, neuronal 3
chr22_+_35695872	3.254		TOM1	target of myb1 (chicken)
chr19_-_291168	3.236	NM_177543	PPAP2C	phosphatidic acid phosphatase type 2C
chr1_+_10092990	3.209	NM_001105562 NM_006048	UBE4B	ubiquitination factor E4B
chr16_+_81812897	3.191	NM_002661	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr3_-_4508955	3.172	NM_001164674 NM_001164675 NM_182760	SUMF1	sulfatase modifying factor 1
chr12_-_65153189	3.172	NM_002076	GNS	glucosamine (N-acetyl)-6-sulfatase
chr3_+_184529871	3.120	NM_001009921 NM_015303	VPS8	vacuolar protein sorting 8 homolog (S. cerevisiae)
chr11_+_9595183	3.109	NM_003390	WEE1	WEE1 homolog (S. pombe)
chr16_+_30960413	3.090		ORAI3	ORAI calcium release-activated calcium modulator 3
chr21_-_46237978	3.089		SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr10_+_23728197	3.075	NM_001145373	OTUD1	OTU domain containing 1
chr16_+_30960377	3.066	NM_152288	ORAI3	ORAI calcium release-activated calcium modulator 3
chr16_+_30960434	3.057		ORAI3	ORAI calcium release-activated calcium modulator 3
chr16_-_28503622	3.051	NM_001042432	CLN3	ceroid-lipofuscinosis, neuronal 3
chr7_-_30029284	3.047	NM_001145515 NM_014766 NM_001145513	SCRN1	secernin 1
chr16_-_2097818	3.046	NM_002528	NTHL1	nth endonuclease III-like 1 (E. coli)
chr7_+_27225009	3.036		HOXA11-AS1	HOXA11 antisense RNA 1 (non-protein coding)
chr11_+_118938530	3.006		VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)
chr2_+_177053306	2.966	NM_024501	HOXD1	homeobox D1
chr1_-_40562909	2.965		PPT1	palmitoyl-protein thioesterase 1
chr17_+_47865980	2.962	NM_001199155 NM_001199156 NM_001199157 NM_001199158 NM_007067	KAT7	K(lysine) acetyltransferase 7
chr11_+_118938528	2.935		VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)
chr16_+_81812899	2.934		PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr1_-_40562917	2.932		PPT1	palmitoyl-protein thioesterase 1
chr11_+_9595309	2.926		WEE1	WEE1 homolog (S. pombe)
chr19_+_5720687	2.913	NM_152784	TMEM146	transmembrane protein 146
chr17_-_66951381	2.906	NM_007168	ABCA8	ATP-binding cassette, sub-family A (ABC1), member 8
chr10_+_51827710	2.885		FAM21A	family with sequence similarity 21, member A
chr20_-_2821120	2.883		FAM113A	family with sequence similarity 113, member A
chr2_-_197036301	2.872	NM_004226	STK17B	serine/threonine kinase 17b
chr7_+_17338182	2.859	NM_001621	AHR	aryl hydrocarbon receptor
chr3_+_158519911	2.855		MFSD1	major facilitator superfamily domain containing 1
chr10_+_69644708	2.850		SIRT1	sirtuin 1
chr17_-_73975443	2.843		ACOX1	acyl-CoA oxidase 1, palmitoyl
chr20_+_44519590	2.839	NM_000308 NM_001127695 NM_001167594	CTSA	cathepsin A
chr17_+_47866061	2.828		KAT7	K(lysine) acetyltransferase 7
chr14_+_96505566	2.823	NM_001252507	C14orf132	chromosome 14 open reading frame 132
chr1_-_11865963	2.821		MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)
chr16_+_81812925	2.792		PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr11_+_118938515	2.757		VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)
chr6_-_144329342	2.716	NM_001080952 NM_001080953 NM_001080954 NM_001080956 NM_002656 NM_006718	PLAGL1 HYMAI	pleiomorphic adenoma gene-like 1 hydatidiform mole associated and imprinted (non-protein coding)
chr11_+_18343794	2.710	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr5_+_172483285	2.709	NM_001168393 NM_001168394 NM_153607	C5orf41	chromosome 5 open reading frame 41
chr9_-_126030854	2.688	NM_001171137	STRBP	spermatid perinuclear RNA binding protein
chr16_-_23521755	2.657		GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr19_-_36545119	2.623		THAP8	THAP domain containing 8
chr6_+_123110345	2.620		SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A
chr4_-_149363498	2.613	NM_000901 NM_001166104	NR3C2	nuclear receptor subfamily 3, group C, member 2
chr10_-_116418056	2.600	NM_002313	ABLIM1	actin binding LIM protein 1
chr6_-_151773168	2.599	NM_017909	RMND1	required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr9_-_126030792	2.596	NM_018387	STRBP	spermatid perinuclear RNA binding protein
chrX_+_102883647	2.585	NM_001006640	TCEAL1	transcription elongation factor A (SII)-like 1
chrX_+_118108575	2.582		LONRF3	LON peptidase N-terminal domain and ring finger 3
chr4_-_76439582	2.580	NM_001008925 NM_001009922 NM_015436	RCHY1	ring finger and CHY zinc finger domain containing 1
chr12_+_12869818	2.577	NM_004064	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr8_-_95274540	2.556	NM_005261 NM_181702	GEM	GTP binding protein overexpressed in skeletal muscle
chr16_+_2570322	2.546	NM_001145815 NM_015944	AMDHD2	amidohydrolase domain containing 2
chr16_-_4588379	2.540	NM_001199054	C16orf5	chromosome 16 open reading frame 5
chr1_+_10093149	2.536		UBE4B	ubiquitination factor E4B
chr20_-_36156226	2.535		BLCAP	bladder cancer associated protein
chr7_-_100808832	2.512	NM_003378	VGF	VGF nerve growth factor inducible
chrX_-_100872926	2.508	NM_001009584 NM_001184768 NM_019007	ARMCX6	armadillo repeat containing, X-linked 6
chr5_+_68710938	2.508	NM_001038603 NM_001244734	MARVELD2	MARVEL domain containing 2
chr3_+_158519714	2.495	NM_001167903 NM_022736	MFSD1	major facilitator superfamily domain containing 1
chrX_-_34675366	2.492	NM_031442	TMEM47	transmembrane protein 47
chr8_+_98788014	2.486		LAPTM4B	lysosomal protein transmembrane 4 beta
chr11_+_95523809	2.486		CEP57	centrosomal protein 57kDa
chr11_+_63706433	2.480	NM_024771	NAA40	N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr11_+_18344113	2.480		GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr6_-_80656870	2.470	NM_022726	ELOVL4	ELOVL fatty acid elongase 4
chr10_+_112327411	2.455	NM_005445	SMC3	structural maintenance of chromosomes 3
chr10_+_46222647	2.455	NM_001169106 NM_001169107 NM_015262	FAM21C	family with sequence similarity 21, member C
chr6_-_31830551	2.447		NEU1	sialidase 1 (lysosomal sialidase)
chr10_-_93392744	2.444		PPP1R3C	protein phosphatase 1, regulatory subunit 3C
chr7_+_116312412	2.440	NM_000245 NM_001127500	MET	met proto-oncogene (hepatocyte growth factor receptor)
chrX_+_118108595	2.427	NM_001031855 NM_024778	LONRF3	LON peptidase N-terminal domain and ring finger 3
chr3_-_126076057	2.427	NM_014079	KLF15	Kruppel-like factor 15
chr10_+_51827654	2.423	NM_001005751	FAM21C FAM21A	family with sequence similarity 21, member C family with sequence similarity 21, member A
chr2_+_109204745	2.422	NM_004987	LIMS1	LIM and senescent cell antigen-like domains 1
chr8_-_95274520	2.421		GEM	GTP binding protein overexpressed in skeletal muscle
chr16_-_1525040	2.420	NM_001114331 NM_001287	CLCN7	chloride channel 7
chr16_-_23521794	2.418		GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr6_+_127587984	2.417		RNF146	ring finger protein 146
chr3_+_158519877	2.414		MFSD1	major facilitator superfamily domain containing 1
chr3_+_158519925	2.392		MFSD1	major facilitator superfamily domain containing 1
chr21_-_46237974	2.392		SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr18_-_46987016	2.385	NM_017653	DYM	dymeclin
chr11_+_9685650	2.363		SWAP70	SWAP switching B-cell complex 70kDa subunit
chr16_-_23521803	2.357	NM_015044	GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr8_-_81083660	2.342	NM_001025253 NM_005079	TPD52	tumor protein D52
chr8_-_126104004	2.318		KIAA0196	KIAA0196
chr8_+_71581599	2.317	NM_001011720	XKR9	XK, Kell blood group complex subunit-related family, member 9
chr6_-_44225024	2.313	NM_178148	SLC35B2	solute carrier family 35, member B2
chr7_+_155089614	2.313		INSIG1	insulin induced gene 1
chr7_-_17980102	2.299	NM_015132	SNX13	sorting nexin 13
chr9_-_125667493	2.295	NM_001100588 NM_018835	RC3H2	ring finger and CCCH-type domains 2
chr1_-_156265395	2.293	NM_144580	C1orf85	chromosome 1 open reading frame 85
chr17_-_7137675	2.292		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr19_-_19051112	2.291	NM_001145722 NM_001145721	HOMER3	homer homolog 3 (Drosophila)
chr2_+_228189919	2.291		MFF	mitochondrial fission factor
chr8_-_126103926	2.290		KIAA0196	KIAA0196
chr5_+_43603312	2.282		NNT	nicotinamide nucleotide transhydrogenase
chr2_-_20251788	2.280	NM_014713	LAPTM4A	lysosomal protein transmembrane 4 alpha
chr12_+_72233486	2.279	NM_001146213 NM_001146214 NM_022771	TBC1D15	TBC1 domain family, member 15
chr1_+_76540374	2.272	NM_001160011 NM_152996	ST6GALNAC3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr7_+_16793320	2.269	NM_014399	TSPAN13	tetraspanin 13
chr15_-_72668301	2.265	NM_000520	HEXA	hexosaminidase A (alpha polypeptide)
chr19_+_5681016	2.254	NM_198704 NM_198705 NM_198533 NM_198707 NM_198706 NM_198708	HSD11B1L	hydroxysteroid (11-beta) dehydrogenase 1-like
chr7_+_12726910	2.247	NM_001195396 NM_005738	ARL4A	ADP-ribosylation factor-like 4A
chr16_-_1877140	2.243	NM_001040427 NM_005326	HAGH	hydroxyacylglutathione hydrolase
chr1_-_154531083	2.239	NM_017582	UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr11_+_9685624	2.236	NM_015055	SWAP70	SWAP switching B-cell complex 70kDa subunit

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.24	1.13e-05	GO:0044237	cellular metabolic process
1.20	3.66e-05	GO:0008152	metabolic process
4.76	1.98e-04	GO:0007033	vacuole organization
1.21	4.82e-04	GO:0044238	primary metabolic process
1.26	1.13e-03	GO:0044260	cellular macromolecule metabolic process
5.82	2.12e-03	GO:0007040	lysosome organization
1.10	5.70e-03	GO:0009987	cellular process
1.22	1.03e-02	GO:0043170	macromolecule metabolic process
1.36	1.44e-02	GO:0090304	nucleic acid metabolic process
1.28	2.00e-02	GO:0006807	nitrogen compound metabolic process
1.41	2.90e-02	GO:0034645	cellular macromolecule biosynthetic process
1.27	4.63e-02	GO:0034641	cellular nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
2.78	1.37e-10	GO:0005773	vacuole
1.14	8.13e-10	GO:0005622	intracellular
1.15	1.30e-09	GO:0044424	intracellular part
2.74	2.45e-08	GO:0000323	lytic vacuole
2.74	2.45e-08	GO:0005764	lysosome
1.26	4.34e-08	GO:0044444	cytoplasmic part
1.18	6.22e-08	GO:0043227	membrane-bounded organelle
1.18	7.19e-08	GO:0043231	intracellular membrane-bounded organelle
1.16	8.58e-08	GO:0043226	organelle
1.16	1.81e-07	GO:0043229	intracellular organelle
1.19	4.53e-07	GO:0005737	cytoplasm
3.11	9.26e-07	GO:0044437	vacuolar part
3.07	3.99e-06	GO:0005774	vacuolar membrane
1.25	4.02e-06	GO:0044446	intracellular organelle part
1.24	7.10e-06	GO:0044422	organelle part
3.13	1.06e-04	GO:0005765	lysosomal membrane
1.39	1.57e-04	GO:0031974	membrane-enclosed lumen
1.39	2.19e-04	GO:0070013	intracellular organelle lumen
1.38	2.59e-04	GO:0043233	organelle lumen
1.47	3.18e-03	GO:0005654	nucleoplasm
1.05	1.48e-02	GO:0044464	cell part
1.05	1.51e-02	GO:0005623	cell
1.35	2.00e-02	GO:0031981	nuclear lumen

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.17	4.61e-04	GO:0005515	protein binding
1.08	1.39e-02	GO:0005488	binding