Motif ID: SREBF1,2.p2

Z-value: 1.891


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
SREBF2chr22_+_42229105-0.135.4e-01Click!
SREBF1chr17_-_17740309-0.125.7e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_46688362 12.788 NM_004502
 HOXB7
homeobox B7
chr17_-_46688279 12.009 HOXB7
homeobox B7
chr20_-_39317875 11.060 NM_005461
 MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_-_11866079 8.419 NM_005957
 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chrX_+_101975641 7.465 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
 BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr17_-_46687925 7.456 HOXB7
homeobox B7
chr12_+_93964801 7.448 SOCS2
suppressor of cytokine signaling 2
chr3_-_122512526 7.386 NM_024610
 HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr17_+_25621105 6.572 NM_015626
NM_134265
 WSB1

WD repeat and SOCS box containing 1

chr4_+_100871625 6.564 LOC256880
uncharacterized LOC256880
chr1_+_61869699 6.525 NFIA
nuclear factor I/A
chr5_-_172198160 6.240 NM_004417
 DUSP1
dual specificity phosphatase 1
chrX_+_55744049 6.183 NM_006064
NM_016656
 RRAGB

Ras-related GTP binding B

chr6_+_160390128 6.065 NM_000876
 IGF2R
insulin-like growth factor 2 receptor
chrX_+_77166178 6.049 NM_000052
 ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr12_-_10021932 5.964 CLEC2B
C-type lectin domain family 2, member B
chr17_+_65821625 5.927 NM_004459
NM_182641
 BPTF

bromodomain PHD finger transcription factor

chr1_-_154928564 5.875 NM_020524
 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr11_+_67159421 5.786 NM_004584
 RAD9A
RAD9 homolog A (S. pombe)
chr3_+_112280871 5.677 NM_017945
 SLC35A5
solute carrier family 35, member A5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
5.82 2.12e-03 GO:0007040 lysosome organization
4.76 1.98e-04 GO:0007033 vacuole organization
1.41 2.90e-02 GO:0034645 cellular macromolecule biosynthetic process
1.36 1.44e-02 GO:0090304 nucleic acid metabolic process
1.28 2.00e-02 GO:0006807 nitrogen compound metabolic process
1.27 4.63e-02 GO:0034641 cellular nitrogen compound metabolic process
1.26 1.13e-03 GO:0044260 cellular macromolecule metabolic process
1.24 1.13e-05 GO:0044237 cellular metabolic process
1.22 1.03e-02 GO:0043170 macromolecule metabolic process
1.21 4.82e-04 GO:0044238 primary metabolic process
1.20 3.66e-05 GO:0008152 metabolic process
1.10 5.70e-03 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
3.13 1.06e-04 GO:0005765 lysosomal membrane
3.11 9.26e-07 GO:0044437 vacuolar part
3.07 3.99e-06 GO:0005774 vacuolar membrane
2.78 1.37e-10 GO:0005773 vacuole
2.74 2.45e-08 GO:0000323 lytic vacuole
2.74 2.45e-08 GO:0005764 lysosome
1.47 3.18e-03 GO:0005654 nucleoplasm
1.39 1.57e-04 GO:0031974 membrane-enclosed lumen
1.39 2.19e-04 GO:0070013 intracellular organelle lumen
1.38 2.59e-04 GO:0043233 organelle lumen
1.35 2.00e-02 GO:0031981 nuclear lumen
1.26 4.34e-08 GO:0044444 cytoplasmic part
1.25 4.02e-06 GO:0044446 intracellular organelle part
1.24 7.10e-06 GO:0044422 organelle part
1.19 4.53e-07 GO:0005737 cytoplasm
1.18 6.22e-08 GO:0043227 membrane-bounded organelle
1.18 7.19e-08 GO:0043231 intracellular membrane-bounded organelle
1.16 8.58e-08 GO:0043226 organelle
1.16 1.81e-07 GO:0043229 intracellular organelle
1.15 1.30e-09 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.17 4.61e-04 GO:0005515 protein binding
1.08 1.39e-02 GO:0005488 binding