Motif ID: STAT2,4,6.p2

Z-value: 2.312


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
STAT6chr12_-_575051760.912.0e-10Click!
STAT4chr2_-_192015934,
chr2_-_192016293,
chr2_-_192015706		-0.855.8e-08Click!
STAT2chr12_-_567538560.116.0e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_10381763 25.604 ICAM1
intercellular adhesion molecule 1
chr19_+_10381516 21.068 NM_000201
 ICAM1
intercellular adhesion molecule 1
chr14_-_51134862 8.220 SAV1
salvador homolog 1 (Drosophila)
chr14_-_51135021 7.566 NM_021818
 SAV1
salvador homolog 1 (Drosophila)
chr14_-_51135041 7.412 SAV1
salvador homolog 1 (Drosophila)
chr3_-_71294229 7.399 NM_001244814
 FOXP1
forkhead box P1
chr6_-_137113721 7.172 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr6_-_137113529 7.162 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr6_-_137113602 7.106 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr4_-_185395616 6.870 NM_002199
 IRF2
interferon regulatory factor 2
chrX_-_154563735 6.812 NM_001289
 CLIC2
chloride intracellular channel 2
chr4_+_74606222 6.622 NM_000584
 IL8
interleukin 8
chr6_+_32821924 6.527 NM_002800
 PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr19_+_4229494 6.476 NM_005755
 EBI3
Epstein-Barr virus induced 3
chr6_-_32821592 6.390 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32821743 6.336 NM_000593
 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32821412 6.166 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_169703178 6.097 NM_000450
 SELE
selectin E
chr3_+_122399665 6.065 NM_017554
 PARP14
poly (ADP-ribose) polymerase family, member 14
chr6_-_137113624 6.051 NM_005923
 MAP3K5
mitogen-activated protein kinase kinase kinase 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
1.59 2.05e-05 GO:0006955 immune response
1.58 8.17e-03 GO:0006935 chemotaxis
1.58 8.17e-03 GO:0042330 taxis
1.43 2.76e-03 GO:0009605 response to external stimulus
1.43 1.49e-02 GO:0040011 locomotion
1.43 3.05e-02 GO:0048584 positive regulation of response to stimulus
1.42 3.98e-02 GO:0006952 defense response
1.36 5.46e-03 GO:0009893 positive regulation of metabolic process
1.35 1.01e-02 GO:0051239 regulation of multicellular organismal process
1.34 3.06e-02 GO:0031325 positive regulation of cellular metabolic process
1.29 8.67e-06 GO:0048518 positive regulation of biological process
1.25 3.79e-03 GO:0048522 positive regulation of cellular process
1.24 2.75e-02 GO:0048519 negative regulation of biological process
1.22 3.28e-02 GO:0031326 regulation of cellular biosynthetic process
1.21 2.24e-03 GO:0060255 regulation of macromolecule metabolic process
1.20 4.13e-03 GO:0080090 regulation of primary metabolic process
1.20 4.46e-03 GO:0031323 regulation of cellular metabolic process
1.19 2.34e-03 GO:0019222 regulation of metabolic process
1.19 3.02e-02 GO:0007165 signal transduction
1.18 1.62e-02 GO:0023052 signaling

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.15 1.09e-06 GO:0005515 protein binding
1.07 1.26e-03 GO:0005488 binding