Motif ID: STAT5{A,B}.p2

Z-value: 0.983


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
STAT5Bchr17_-_40428391-0.414.3e-02Click!
STAT5Achr17_+_40440481-0.395.4e-02Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_44860798 3.732 NM_001083335
NM_013380
 ZFP112

zinc finger protein 112 homolog (mouse)

chr19_+_44556163 3.466 NM_013361
 ZNF223
zinc finger protein 223
chr19_+_35168558 2.872 NM_001012320
NM_018443
 ZNF302

zinc finger protein 302

chr19_+_44576266 2.091 NM_001037813
 ZNF284
zinc finger protein 284
chr19_+_44645728 2.088 ZNF234
zinc finger protein 234
chr6_-_27440459 1.932 NM_007149
 ZNF184
zinc finger protein 184
chr19_+_35225095 1.883 ZNF181
zinc finger protein 181
chr19_+_44669214 1.647 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
 ZNF226




zinc finger protein 226




chr19_+_37709068 1.527 ZNF383
zinc finger protein 383
chr5_+_178450775 1.525 NM_001136116
 ZNF879
zinc finger protein 879
chr19_+_44716683 1.254 NM_182490
 ZNF227
zinc finger protein 227
chr5_+_178286913 1.190 NM_058230
 ZNF354B
zinc finger protein 354B
chr19_-_40596781 1.150 NM_001010880
NM_001142577
NM_001142578
NM_001142579
 ZNF780A



zinc finger protein 780A



chr19_-_37157718 1.140 NM_153257
 ZNF461
zinc finger protein 461
chr19_+_35225479 1.059 NM_001029997
NM_001145665
 ZNF181

zinc finger protein 181

chr11_-_82996898 1.025 CCDC90B
coiled-coil domain containing 90B
chr19_+_44331443 1.022 NM_181845
 ZNF283
zinc finger protein 283
chr3_+_58484091 1.013 NM_153331
 KCTD6
potassium channel tetramerisation domain containing 6
chr17_-_48945338 0.952 NM_001243877
 TOB1
transducer of ERBB2, 1
chr19_+_44507076 0.950 NM_006300
 ZNF230
zinc finger protein 230
chr19_-_38085646 0.916 NM_016536
 ZNF571
zinc finger protein 571
chr7_-_93633527 0.905 NM_005868
 BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr7_+_76090971 0.900 NM_001102594
NM_001102595
NM_020892
 DTX2


deltex homolog 2 (Drosophila)


chr3_-_14166292 0.896 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr3_-_14166370 0.894 NM_001098502
NM_144636
 CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr3_-_14166228 0.887 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr19_-_44439410 0.863 NM_003425
 ZNF45
zinc finger protein 45
chr2_+_95831176 0.862 NM_001017396
NM_021088
 ZNF2

zinc finger protein 2

chr3_-_14166246 0.861 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr19_+_58341661 0.835 NM_001204818
 LOC100293516
zinc finger protein
chr9_+_130186652 0.810 NM_007135
 ZNF79
zinc finger protein 79
chr19_+_58258160 0.793 NM_173632
 ZNF776
zinc finger protein 776
chr19_+_44529493 0.775 NM_001129996
NM_013360
 ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr1_+_40997290 0.756 ZNF684
zinc finger protein 684
chr19_-_45004482 0.732 NM_013256
 ZNF180
zinc finger protein 180
chr19_-_58326280 0.731 NM_024762
 ZNF552
zinc finger protein 552
chr19_-_44405934 0.689 LOC100505715
uncharacterized LOC100505715
chr12_-_46384346 0.685 SCAF11
SR-related CTD-associated factor 11
chr19_+_40502942 0.667 NM_178544
 ZNF546
zinc finger protein 546
chr19_+_54024176 0.664 NM_018555
 ZNF331
zinc finger protein 331
chr5_-_137514299 0.652 NM_001164326
NM_006696
NM_139199
 BRD8


bromodomain containing 8


chr5_+_178368193 0.640 NM_001178089
NM_001178090
NM_182594
 ZNF454


zinc finger protein 454


chr19_-_37263653 0.633 NM_001193552
 ZNF850
zinc finger protein 850
chr19_+_58258189 0.627 ZNF776
zinc finger protein 776
chr11_-_125773086 0.621 NM_031307
 PUS3
pseudouridylate synthase 3
chr1_-_120935893 0.603 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr19_-_36980336 0.598 NM_032838
NM_001145343
NM_001145344
NM_001145345
 ZNF566



zinc finger protein 566



chr22_+_20748397 0.597 NM_003426
 ZNF74
zinc finger protein 74
chr19_+_44645708 0.593 NM_001144824
NM_006630
 ZNF234

zinc finger protein 234

chrX_+_106045880 0.590 NM_017752
NM_198881
 TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr11_-_82997376 0.572 NM_021825
 CCDC90B
coiled-coil domain containing 90B
chr19_+_58144510 0.571 NM_006385
NM_198855
 ZNF211

zinc finger protein 211

chr3_+_169940223 0.558 PRKCI
protein kinase C, iota
chr1_+_40997232 0.545 NM_152373
 ZNF684
zinc finger protein 684
chr12_-_46384208 0.524 SCAF11
SR-related CTD-associated factor 11
chr1_-_54519050 0.523 NM_004872
 TMEM59
transmembrane protein 59
chr9_+_130186714 0.519 ZNF79
zinc finger protein 79
chr19_-_36980758 0.518 ZNF566
zinc finger protein 566
chr7_-_112758604 0.518 LOC401397
uncharacterized LOC401397
chr7_+_90032771 0.493 CLDN12
claudin 12
chr19_+_58280996 0.492 NM_001077426
NM_001204814
NM_017652
 ZNF586


zinc finger protein 586


chr8_-_146012653 0.485 NM_030580
 ZNF34
zinc finger protein 34
chr2_+_44001177 0.481 NM_001193464
NM_015522
NM_016008
 DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr8_-_66546413 0.475 NM_018120
 ARMC1
armadillo repeat containing 1
chr13_+_115079943 0.474 NM_001164144
NM_001164145
NM_032436
 CHAMP1


chromosome alignment maintaining phosphoprotein 1


chr14_-_68162419 0.468 NM_001252650
NM_016026
 RDH11

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

chr19_-_45909566 0.468 NM_001142502
 PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr16_-_53737713 0.467 NM_001127897
NM_015272
 RPGRIP1L

RPGRIP1-like

chr22_-_38902281 0.466 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr19_+_58816714 0.462 ERVK3-1
endogenous retrovirus group K3, member 1
chr12_-_48963802 0.454 NM_002289
 LALBA
lactalbumin, alpha-
chr1_-_3773620 0.444 CEP104
centrosomal protein 104kDa
chr7_-_112758611 0.444 LOC401397
uncharacterized LOC401397
chr2_-_241500459 0.441 ANKMY1
ankyrin repeat and MYND domain containing 1
chr19_-_37019169 0.432 NM_001012756
NM_001166036
NM_001166037
NM_001166038
 ZNF260



zinc finger protein 260



chr7_+_90032647 0.430 NM_001185072
NM_001185073
NM_012129
 CLDN12


claudin 12


chr18_+_43684297 0.429 NM_138443
 HAUS1
HAUS augmin-like complex, subunit 1
chr19_+_58816757 0.427 ERVK3-1
endogenous retrovirus group K3, member 1
chr12_-_46384365 0.417 NM_004719
 SCAF11
SR-related CTD-associated factor 11
chr9_+_15422630 0.409 NM_001039697
 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chrY_+_2709596 0.409 NM_001008
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr7_+_142829169 0.408 NM_002652
 PIP
prolactin-induced protein
chr7_+_99102572 0.404 NM_014569
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr2_-_63815761 0.399 NM_015910
 WDPCP
WD repeat containing planar cell polarity effector
chr4_+_84457256 0.398 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr1_-_212588239 0.395 NM_001198862
NM_018252
 TMEM206

transmembrane protein 206

chr19_+_39882018 0.394 MED29
mediator complex subunit 29
chr8_-_66546394 0.385 ARMC1
armadillo repeat containing 1
chr6_+_88182704 0.383 SLC35A1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr12_+_80603232 0.378 NM_173591
 OTOGL
otogelin-like
chrY_+_2709630 0.370 RPS4Y1
ribosomal protein S4, Y-linked 1
chr7_+_99102272 0.369 NM_145102
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr16_+_53468362 0.368 RBL2
retinoblastoma-like 2 (p130)
chr19_+_45909868 0.368 CD3EAP
CD3e molecule, epsilon associated protein
chr4_+_25378816 0.366 NM_013367
 ANAPC4
anaphase promoting complex subunit 4
chr3_-_52864687 0.365 NM_001166449
NM_002218
 ITIH4

inter-alpha-trypsin inhibitor heavy chain family, member 4

chr19_-_44617271 0.354 LOC100379224
uncharacterized LOC100379224
chr16_+_53468344 0.352 NM_005611
 RBL2
retinoblastoma-like 2 (p130)
chr9_-_104160876 0.350 NM_019051
 MRPL50
mitochondrial ribosomal protein L50
chr3_-_183735617 0.345 NM_001023587
NM_005688
 ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr14_-_20881577 0.338 NM_007110
 TEP1
telomerase-associated protein 1
chr7_-_134001502 0.337 SLC35B4
solute carrier family 35, member B4
chr6_+_88182624 0.333 NM_001168398
NM_006416
 SLC35A1

solute carrier family 35 (CMP-sialic acid transporter), member A1

chr19_-_44905754 0.329 NM_152354
 ZNF285
ZFP112
zinc finger protein 285
zinc finger protein 112 homolog (mouse)
chr16_+_53468390 0.329 RBL2
retinoblastoma-like 2 (p130)
chr7_-_134001749 0.324 NM_032826
 SLC35B4
solute carrier family 35, member B4
chr3_+_169940246 0.322 PRKCI
protein kinase C, iota
chr10_-_121355978 0.309 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr5_-_102898450 0.307 NM_031438
 NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr19_-_56904869 0.307 NM_144690
 ZNF582
zinc finger protein 582
chr17_+_15603046 0.306 ZNF286A
zinc finger protein 286A
chr1_+_149871154 0.303 NM_016074
 BOLA1
bolA homolog 1 (E. coli)
chr2_-_63815581 0.299 WDPCP
WD repeat containing planar cell polarity effector
chr3_-_113775363 0.297 NM_020817
 KIAA1407
KIAA1407
chr6_+_99968851 0.294 NM_001195131
 LOC100130890
uncharacterized LOC100130890
chr7_-_132766834 0.293 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr19_+_50529294 0.291 ZNF473
zinc finger protein 473
chr3_+_180319898 0.288 NM_001042601
NM_133462
 TTC14

tetratricopeptide repeat domain 14

chr10_+_93558068 0.286 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr7_+_99102601 0.274 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr20_-_25677173 0.273 NM_015655
 ZNF337
zinc finger protein 337
chr14_-_77889231 0.269 NM_001113475
 NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr15_+_66874506 0.268


chr11_+_134123406 0.267 NM_014384
 ACAD8
acyl-CoA dehydrogenase family, member 8
chr19_+_37407230 0.266 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
 ZNF568





zinc finger protein 568





chrX_+_149737019 0.260 NM_000252
 MTM1
myotubularin 1
chr3_+_183903970 0.260 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr18_+_56807115 0.259 NM_033280
 SEC11C
SEC11 homolog C (S. cerevisiae)
chr16_+_69984625 0.257 NM_001136214
 CLEC18A
C-type lectin domain family 18, member A
chr15_+_75315931 0.253 PPCDC
phosphopantothenoylcysteine decarboxylase
chr19_+_58920118 0.252 ZNF584
zinc finger protein 584
chr3_+_183903862 0.250 NM_018358
 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr20_+_39657612 0.245 TOP1
topoisomerase (DNA) I
chr13_-_99404883 0.243 NM_005073
 SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr8_-_110346272 0.240 NM_032869
 NUDCD1
NudC domain containing 1
chr15_-_83735892 0.239 BTBD1
BTB (POZ) domain containing 1
chr1_-_3773760 0.238 NM_014704
 CEP104
centrosomal protein 104kDa
chr19_-_37958338 0.236 NM_152484
 ZNF569
zinc finger protein 569
chr19_+_58920007 0.236 NM_173548
 ZNF584
zinc finger protein 584
chr19_-_44809126 0.234 NM_004234
 ZNF235
zinc finger protein 235
chr1_+_179051111 0.232 NM_022371
 TOR3A
torsin family 3, member A
chr18_+_71815745 0.228 NM_014177
 TIMM21
translocase of inner mitochondrial membrane 21 homolog (yeast)
chr13_-_79233266 0.227 NM_024546
 RNF219
ring finger protein 219
chr2_-_241500167 0.224 ANKMY1
ankyrin repeat and MYND domain containing 1
chr19_-_39881631 0.222 NM_019088
 PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr4_+_86396251 0.221 NM_001025616
 ARHGAP24
Rho GTPase activating protein 24
chr12_-_133532847 0.220 NM_183238
NM_001164715
 ZNF605

zinc finger protein 605

chr2_+_162164785 0.216 NM_005805
 PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr15_-_83736105 0.215 NM_001011885
NM_025238
 BTBD1

BTB (POZ) domain containing 1

chr19_+_57831824 0.214 NM_213598
 ZNF543
zinc finger protein 543
chr15_+_75315926 0.211 NM_021823
 PPCDC
phosphopantothenoylcysteine decarboxylase
chr5_+_61602065 0.211 KIF2A
kinesin heavy chain member 2A
chr1_+_3773844 0.210 NM_004402
 DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr16_+_2802656 0.208 SRRM2
serine/arginine repetitive matrix 2
chr5_+_140474198 0.207 NM_018936
 PCDHB2
protocadherin beta 2
chr19_+_54041332 0.205 NM_001079906
NM_001253798
NM_001253799
 ZNF331


zinc finger protein 331


chr16_+_53468406 0.204 RBL2
retinoblastoma-like 2 (p130)
chr2_+_88991166 0.203 NM_144563
 RPIA
ribose 5-phosphate isomerase A
chr1_+_38478366 0.202 NM_016037
 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr2_-_172290435 0.197 METTL8
methyltransferase like 8
chr8_-_56685869 0.197 NM_152417
 TMEM68
transmembrane protein 68
chr1_-_120935943 0.196 NM_001004340
NM_001017986
NM_001244910
 FCGR1A
FCGR1B


Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)


chr1_-_212588073 0.195 TMEM206
transmembrane protein 206
chr10_+_93558182 0.195 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr10_-_38265452 0.193 NM_145011
 ZNF25
zinc finger protein 25
chr15_+_22833394 0.190 NM_001102610
NM_052903
 TUBGCP5

tubulin, gamma complex associated protein 5

chr19_+_50529276 0.189 ZNF473
zinc finger protein 473
chr18_+_72163335 0.188 NM_018235
 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr18_-_46987016 0.185 NM_017653
 DYM
dymeclin
chr16_+_53468373 0.184 RBL2
retinoblastoma-like 2 (p130)
chr9_-_104145800 0.183 NM_001127610
 BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr5_+_145317297 0.179 SH3RF2
SH3 domain containing ring finger 2
chr19_-_58090071 0.178 NM_017879
 ZNF416
zinc finger protein 416
chr7_+_142985307 0.176 NM_032982
NM_032983
 CASP2

caspase 2, apoptosis-related cysteine peptidase

chr11_+_65268313 0.171 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr15_+_91643429 0.169 NM_014848
 SV2B
synaptic vesicle glycoprotein 2B
chrX_+_149737083 0.169 MTM1
myotubularin 1
chr12_-_10324675 0.166 NM_001172632
NM_001172633
NM_002543
 OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr5_-_145562235 0.166 NM_020117
 LARS
leucyl-tRNA synthetase
chr12_-_12291374 0.164 LRP6
low density lipoprotein receptor-related protein 6
chr11_+_94800055 0.163 NM_032102
 SRSF8
serine/arginine-rich splicing factor 8
chr19_-_58514136 0.162 ZNF606
zinc finger protein 606
chr2_+_172290796 0.161 DCAF17
DDB1 and CUL4 associated factor 17
chr19_-_35264091 0.161 NM_001007248
 ZNF599
zinc finger protein 599
chr6_-_116601085 0.159 TSPYL1
TSPY-like 1
chr19_-_38183135 0.159 NM_152605
 ZNF781
zinc finger protein 781
chr10_-_98325100 0.158 TM9SF3
transmembrane 9 superfamily member 3
chr14_+_97263681 0.157 NM_003384
 VRK1
vaccinia related kinase 1
chr19_+_39881950 0.156 NM_017592
 MED29
mediator complex subunit 29
chr19_+_58331067 0.154 LOC100293516
zinc finger protein
chr6_+_35704858 0.154 NM_145028
 C6orf81
chromosome 6 open reading frame 81
chr1_+_38478408 0.153 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr5_-_92916924 0.149 FLJ42709
uncharacterized LOC441094
chrX_-_129402753 0.149 NM_017666
 ZNF280C
zinc finger protein 280C
chr2_-_231084600 0.146 NM_004509
NM_004510
NM_080424
 SP110


SP110 nuclear body protein


chr20_-_45985411 0.146 NM_012408
NM_183047
NM_183048
 ZMYND8


zinc finger, MYND-type containing 8


chr9_+_15422875 0.144 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr2_+_27886750 0.141 SLC4A1AP
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr19_+_58987751 0.140 NM_017908
 ZNF446
zinc finger protein 446
chr9_+_15422862 0.140 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.35 5.63e-11 GO:0006355 regulation of transcription, DNA-dependent
2.25 9.56e-11 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.19 4.29e-10 GO:0010556 regulation of macromolecule biosynthetic process
2.26 4.51e-10 GO:0051252 regulation of RNA metabolic process
2.13 5.13e-10 GO:0031326 regulation of cellular biosynthetic process
2.10 9.82e-10 GO:0009889 regulation of biosynthetic process
2.10 5.92e-09 GO:0010468 regulation of gene expression
2.00 4.72e-08 GO:0051171 regulation of nitrogen compound metabolic process
1.99 1.47e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.74 3.30e-06 GO:0031323 regulation of cellular metabolic process
1.70 3.22e-05 GO:0080090 regulation of primary metabolic process
1.71 4.48e-05 GO:0060255 regulation of macromolecule metabolic process
1.60 2.56e-04 GO:0019222 regulation of metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 2.47e-06 GO:0005634 nucleus
1.28 7.80e-06 GO:0043229 intracellular organelle
1.28 9.36e-06 GO:0043226 organelle
1.31 2.82e-05 GO:0043231 intracellular membrane-bounded organelle
1.30 3.12e-05 GO:0043227 membrane-bounded organelle
1.17 3.01e-03 GO:0005622 intracellular
1.18 4.00e-03 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.57 4.72e-15 GO:0008270 zinc ion binding
2.36 1.52e-13 GO:0046914 transition metal ion binding
2.26 1.06e-11 GO:0003677 DNA binding
1.92 5.55e-10 GO:0003676 nucleic acid binding
1.72 7.40e-08 GO:0046872 metal ion binding
1.70 1.48e-07 GO:0043169 cation binding
1.70 1.72e-07 GO:0043167 ion binding