Motif ID: TFAP2B.p2

Z-value: 1.103


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TFAP2Bchr6_+_50786438-0.145.0e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_38069082 3.511 SHB
Src homology 2 domain containing adaptor protein B
chr19_+_45504686 2.509 NM_006509
 RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr6_-_160114318 2.343 NM_000636
NM_001024465
NM_001024466
 SOD2


superoxide dismutase 2, mitochondrial


chr6_-_160114186 1.958 SOD2
superoxide dismutase 2, mitochondrial
chr7_+_18126543 1.665 NM_001204144
 HDAC9
histone deacetylase 9
chr5_+_10564431 1.597 NM_001164440
 ANKRD33B
ankyrin repeat domain 33B
chr9_-_38069207 1.579 NM_003028
 SHB
Src homology 2 domain containing adaptor protein B
chr8_-_80679897 1.566 NM_001040708
NM_012258
 HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr11_+_369723 1.232 NM_178537
 B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr14_-_55369163 1.189 NM_000161
NM_001024024
NM_001024070
NM_001024071
 GCH1



GTP cyclohydrolase 1



chr7_+_6144504 1.186 NM_032172
 USP42
ubiquitin specific peptidase 42
chr1_-_184943673 1.133 NM_052966
 FAM129A
family with sequence similarity 129, member A
chr8_-_48650683 1.102 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_-_184943532 1.084 FAM129A
family with sequence similarity 129, member A
chr6_+_135502477 1.068 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr17_+_36861398 1.035 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr6_+_37137882 1.035 NM_001243186
NM_002648
 PIM1

pim-1 oncogene

chr1_-_33430285 1.024 NM_001127361
NM_153341
 RNF19B

ring finger protein 19B

chr16_+_11762235 1.012 NM_003498
 SNN
stannin
chr3_+_72937168 1.003 NM_001080393
 GXYLT2
glucoside xylosyltransferase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 134 entries
enrichment   p-value GO term description
1.91 2.42e-02 GO:0061008 hepaticobiliary system development
1.89 4.65e-02 GO:0001889 liver development
1.67 9.49e-03 GO:0007265 Ras protein signal transduction
1.60 3.43e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.56 4.82e-03 GO:0032869 cellular response to insulin stimulus
1.53 1.62e-03 GO:0045786 negative regulation of cell cycle
1.52 2.17e-03 GO:0071375 cellular response to peptide hormone stimulus
1.48 2.68e-02 GO:0043193 positive regulation of gene-specific transcription
1.47 1.09e-02 GO:0007507 heart development
1.43 1.75e-03 GO:0071495 cellular response to endogenous stimulus
1.42 5.17e-06 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.41 1.76e-02 GO:0032870 cellular response to hormone stimulus
1.41 2.22e-02 GO:0006366 transcription from RNA polymerase II promoter
1.39 2.89e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.39 2.39e-05 GO:0051253 negative regulation of RNA metabolic process
1.39 4.64e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.39 8.33e-03 GO:0016568 chromatin modification
1.38 6.30e-07 GO:0009890 negative regulation of biosynthetic process
1.38 6.61e-07 GO:0031327 negative regulation of cellular biosynthetic process
1.38 1.54e-06 GO:0010558 negative regulation of macromolecule biosynthetic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.80 3.57e-02 GO:0030496 midbody
1.72 1.30e-02 GO:0000790 nuclear chromatin
1.47 1.88e-02 GO:0031252 cell leading edge
1.33 2.81e-06 GO:0044451 nucleoplasm part
1.30 1.64e-10 GO:0005654 nucleoplasm
1.28 7.74e-04 GO:0015630 microtubule cytoskeleton
1.28 1.04e-02 GO:0005694 chromosome
1.27 5.18e-12 GO:0031981 nuclear lumen
1.26 2.13e-02 GO:0044431 Golgi apparatus part
1.25 7.86e-05 GO:0005794 Golgi apparatus
1.24 1.73e-11 GO:0070013 intracellular organelle lumen
1.24 2.63e-11 GO:0044428 nuclear part
1.23 2.60e-11 GO:0031974 membrane-enclosed lumen
1.23 3.35e-11 GO:0043233 organelle lumen
1.23 1.45e-09 GO:0005829 cytosol
1.22 2.29e-02 GO:0031982 vesicle
1.18 8.85e-06 GO:0031090 organelle membrane
1.17 2.05e-18 GO:0005634 nucleus
1.17 4.79e-03 GO:0012505 endomembrane system
1.16 1.66e-18 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
1.62 1.09e-03 GO:0003714 transcription corepressor activity
1.52 2.20e-03 GO:0010843 promoter binding
1.49 4.97e-03 GO:0000975 regulatory region DNA binding
1.49 4.97e-03 GO:0001067 regulatory region nucleic acid binding
1.49 4.97e-03 GO:0044212 transcription regulatory region DNA binding
1.47 1.85e-04 GO:0008134 transcription factor binding
1.44 4.56e-02 GO:0019901 protein kinase binding
1.43 8.43e-04 GO:0016564 transcription repressor activity
1.43 3.06e-02 GO:0004842 ubiquitin-protein ligase activity
1.41 8.95e-03 GO:0016881 acid-amino acid ligase activity
1.41 3.06e-02 GO:0019787 small conjugating protein ligase activity
1.38 8.50e-03 GO:0016563 transcription activator activity
1.38 1.61e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.37 2.28e-03 GO:0000988 protein binding transcription factor activity
1.37 2.28e-03 GO:0000989 transcription factor binding transcription factor activity
1.37 3.16e-03 GO:0003712 transcription cofactor activity
1.35 2.00e-03 GO:0019904 protein domain specific binding
1.33 7.43e-09 GO:0030528 transcription regulator activity
1.32 1.40e-05 GO:0019899 enzyme binding
1.31 2.65e-02 GO:0004674 protein serine/threonine kinase activity