Motif ID: TGIF1.p2

Z-value: 0.905


Transcription factors associated with TGIF1.p2:

Gene SymbolEntrez IDGene Name
TGIF1 7050 TGFB-induced factor homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TGIF1chr18_+_3447607-0.271.9e-01Click!


Activity profile for motif TGIF1.p2.

activity profile for motif TGIF1.p2


Sorted Z-values histogram for motif TGIF1.p2

Sorted Z-values for motif TGIF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TGIF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_79086087 3.454 NM_006820
IFI44L
interferon-induced protein 44-like
chr3_-_123339178 2.156 MYLK
myosin light chain kinase
chr12_+_78225068 1.464 NM_014903
NAV3
neuron navigator 3
chr22_+_36044412 1.375 NM_030641
APOL6
apolipoprotein L, 6
chr5_-_150466696 1.235 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr3_-_127541975 1.215 NM_001003794
MGLL
monoglyceride lipase
chr13_-_34250899 1.208 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_-_123339423 1.191 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr3_-_127541160 1.175 NM_007283
MGLL
monoglyceride lipase
chr5_-_58571916 1.169 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_134639195 1.168 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr4_+_186990308 1.134 NM_003265
TLR3
toll-like receptor 3
chr1_-_186649421 1.072 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_85882093 0.988 NM_001244962
FRMD3
FERM domain containing 3
chr5_-_19988293 0.985 NM_001167667
NM_004934
CDH18

cadherin 18, type 2

chr6_+_80714389 0.943 TTK
TTK protein kinase
chr9_+_127420690 0.917 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr5_-_58882274 0.909 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr13_-_33859835 0.883 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_86666211 0.879 NM_012193
FZD4
frizzled family receptor 4
chr5_+_115298136 0.857 NM_173800
AQPEP
laeverin
chr6_+_80714321 0.836 NM_001166691
NM_003318
TTK

TTK protein kinase

chr3_+_31574431 0.830 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr10_-_90750955 0.780 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_+_31574119 0.776 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr11_+_19734821 0.772 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr14_+_21525980 0.728 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr11_+_63871240 0.703 NM_013280
FLRT1
fibronectin leucine rich transmembrane protein 1
chr5_-_36301999 0.690 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr2_+_143886898 0.685 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr10_-_69455926 0.682 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr11_+_131240370 0.680 NM_001048209
NTM
neurotrimin
chr10_-_14372807 0.678 NM_018027
FRMD4A
FERM domain containing 4A
chr1_+_65613771 0.674 NM_013410
AK4
adenylate kinase 4
chr2_+_143886969 0.672 ARHGAP15
Rho GTPase activating protein 15
chr20_+_18794369 0.657 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr15_-_43559054 0.645 NM_004245
NM_201631
TGM5

transglutaminase 5

chr4_-_122137781 0.642 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr5_-_150467220 0.629 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr4_-_185747051 0.627 ACSL1
acyl-CoA synthetase long-chain family member 1
chr4_+_55095263 0.622 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr2_+_27719702 0.617 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr2_-_202563353 0.613 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr3_+_23244703 0.611 NM_152653
UBE2E2
ubiquitin-conjugating enzyme E2E 2
chr17_-_39661803 0.610 NM_002274
NM_153490
KRT13

keratin 13

chr4_-_122085475 0.605 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr3_+_23244486 0.595 UBE2E2
ubiquitin-conjugating enzyme E2E 2
chr18_-_51880942 0.595 NM_139171
STARD6
StAR-related lipid transfer (START) domain containing 6
chr1_-_120935893 0.584 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr4_-_89205667 0.567 PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr10_+_104005307 0.565 GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr12_+_113229548 0.564 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr21_+_43933983 0.564 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr1_+_65613211 0.558 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr1_-_145039631 0.554 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr4_+_128703402 0.543 NM_014278
HSPA4L
heat shock 70kDa protein 4-like
chr16_+_30210548 0.534 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr7_-_100493481 0.533 NM_000665
NM_015831
ACHE

acetylcholinesterase

chr3_+_46395574 0.529 CCR2
chemokine (C-C motif) receptor 2
chr10_-_49812996 0.525 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr4_+_55095433 0.515 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr22_-_37640287 0.510 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr13_-_60325073 0.505


chr17_-_4851797 0.492 NM_005022
PFN1
profilin 1
chr3_-_49967194 0.486 NM_001142501
NM_032355
MON1A

MON1 homolog A (yeast)

chr3_-_49066858 0.486 NM_000884
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr9_-_130540911 0.484 NM_170600
SH2D3C
SH2 domain containing 3C
chr17_-_4851827 0.483 PFN1
profilin 1
chr16_+_29471206 0.483 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr17_+_57232859 0.482 NM_018304
PRR11
proline rich 11
chr17_-_4851688 0.479 PFN1
profilin 1
chr6_+_126070895 0.478 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr4_+_128703480 0.478 HSPA4L
heat shock 70kDa protein 4-like
chr16_-_3030473 0.472 NM_004203
NM_182687
PKMYT1

protein kinase, membrane associated tyrosine/threonine 1

chr5_-_58652671 0.469 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_109415514 0.468 NM_014454
SESN1
sestrin 1
chr9_+_2622099 0.463 VLDLR
very low density lipoprotein receptor
chr14_-_73360792 0.460 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr9_+_2622134 0.456 VLDLR
very low density lipoprotein receptor
chr7_+_21468293 0.456


chr12_-_109027654 0.456 NM_003006
SELPLG
selectin P ligand
chr1_+_26737232 0.455 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr3_-_14220071 0.451 NM_001145769
NM_004628
XPC

xeroderma pigmentosum, complementation group C

chr10_+_94352960 0.450 KIF11
kinesin family member 11
chr4_+_119948554 0.445 SYNPO2
synaptopodin 2
chr9_+_2622052 0.440 VLDLR
very low density lipoprotein receptor
chr5_-_95748688 0.439 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr9_+_706744 0.437 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr19_-_51530781 0.436 NM_144947
KLK11
kallikrein-related peptidase 11
chr1_+_65613971 0.434 AK4
adenylate kinase 4
chr3_-_142166782 0.433 NM_001042604
NM_019001
XRN1

5'-3' exoribonuclease 1

chr2_-_172750724 0.431 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr10_+_54074037 0.428 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr12_-_109027565 0.428 SELPLG
selectin P ligand
chr2_-_119605758 0.422 NM_001426
EN1
engrailed homeobox 1
chr2_+_185463235 0.421 ZNF804A
zinc finger protein 804A
chr11_-_64901995 0.420 NM_032431
NM_172230
SYVN1

synovial apoptosis inhibitor 1, synoviolin

chr6_+_26368405 0.418 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr11_-_64901943 0.417 SYVN1
synovial apoptosis inhibitor 1, synoviolin
chr15_-_76352068 0.408 NRG4
neuregulin 4
chr17_+_28256873 0.407 NM_001145053
EFCAB5
EF-hand calcium binding domain 5
chr3_-_49066813 0.407 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr5_+_149865310 0.402 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr6_+_136172802 0.398 NM_018945
PDE7B
phosphodiesterase 7B
chr2_+_185463092 0.397 NM_194250
ZNF804A
zinc finger protein 804A
chr10_+_104005254 0.395 NM_001199378
NM_001199379
NM_004193
GBF1


golgi brefeldin A resistant guanine nucleotide exchange factor 1


chr13_+_27844463 0.394 NM_206827
RASL11A
RAS-like, family 11, member A
chr2_+_167744996 0.388 NM_001079810
NM_001199143
NM_152381
XIRP2


xin actin-binding repeat containing 2


chr13_+_108922560 0.387 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chrX_-_63450486 0.385 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr3_-_49066760 0.380 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr10_+_98592658 0.380 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr18_+_61554938 0.377 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr22_+_46692637 0.377 NM_016426
GTSE1
G-2 and S-phase expressed 1
chr19_-_14228362 0.371 NM_002730
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr15_-_72522062 0.368 NM_001206799
PKM2
pyruvate kinase, muscle
chr1_+_203097427 0.366 ADORA1
adenosine A1 receptor
chr3_+_67048726 0.360 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr6_-_41130921 0.358 NM_018965
TREM2
triggering receptor expressed on myeloid cells 2
chr11_-_57195052 0.354 NM_017611
SLC43A3
solute carrier family 43, member 3
chr2_+_97202463 0.350 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr8_-_145060594 0.349 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr6_+_31913852 0.347 CFB
complement factor B
chr3_-_10332408 0.346 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr5_+_133984234 0.345 NM_001252231
NM_021982
SEC24A

SEC24 family, member A (S. cerevisiae)

chr11_+_73661363 0.344 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr16_+_57673206 0.343 NM_001145774
GPR56
G protein-coupled receptor 56
chr7_+_101928390 0.341 NM_020979
SH2B2
SH2B adaptor protein 2
chr2_+_242127923 0.341 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr8_+_80523048 0.340 NM_001199214
NM_007029
STMN2

stathmin-like 2

chr2_-_176866925 0.339 NM_030650
KIAA1715
KIAA1715
chrX_-_128788913 0.339 NM_017413
APLN
apelin
chr5_-_146833150 0.339 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr7_+_101928417 0.338 SH2B2
SH2B adaptor protein 2
chrX_-_153775774 0.338 NM_001042351
G6PD
glucose-6-phosphate dehydrogenase
chrX_+_153775561 0.335 NM_001099857
NM_001145255
IKBKG

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

chr11_-_8954534 0.335 NM_020643
C11orf16
chromosome 11 open reading frame 16
chr17_+_13972841 0.335 COX10
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
chr7_-_97501680 0.334 ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr17_+_57233100 0.334 PRR11
proline rich 11
chr20_+_8112762 0.334 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr10_+_69869249 0.334 NM_032578
MYPN
myopalladin
chr9_-_35115844 0.333 NM_025182
FAM214B
family with sequence similarity 214, member B
chr16_+_31366519 0.332 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr18_+_21693316 0.332 TTC39C
tetratricopeptide repeat domain 39C
chr19_-_39235113 0.330 NM_144691
CAPN12
calpain 12
chr5_-_169724782 0.330 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_-_57004674 0.328 NM_005161
APLNR
apelin receptor
chr8_-_134115309 0.328 NM_001045556
NM_001045557
SLA

Src-like-adaptor

chr10_+_60028885 0.328 NM_018464
CISD1
CDGSH iron sulfur domain 1
chr18_+_32073343 0.326 DTNA
dystrobrevin, alpha
chr8_-_15095791 0.326 NM_139167
SGCZ
sarcoglycan, zeta
chr4_-_123542165 0.324 NM_001207006
NM_021803
IL21

interleukin 21

chr4_+_71494460 0.323 NM_031889
ENAM
enamelin
chr1_+_39875175 0.322 NM_015038
KIAA0754
KIAA0754
chr5_+_173472737 0.321 HMP19
HMP19 protein
chr11_-_568419 0.320 MIR210HG
MIR210 host gene (non-protein coding)
chrX_-_154563735 0.318 NM_001289
CLIC2
chloride intracellular channel 2
chr13_+_108922205 0.316 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr12_-_109027615 0.312 SELPLG
selectin P ligand
chr4_-_89205887 0.308 NM_152542
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr6_-_119031230 0.307 NM_001178035
CEP85L
centrosomal protein 85kDa-like
chr2_+_220436953 0.306 NM_002191
INHA
inhibin, alpha
chr16_-_28621279 0.305 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr17_+_16945766 0.305 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr7_-_97501737 0.304 NM_001178075
NM_001178076
NM_001673
NM_183356
ASNS



asparagine synthetase (glutamine-hydrolyzing)



chr17_+_41857802 0.301 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chrX_+_153776061 0.299 NM_003639
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr5_-_41071404 0.298 NM_173489
HEATR7B2
HEAT repeat family member 7B2
chr4_-_185747183 0.296 NM_001995
ACSL1
acyl-CoA synthetase long-chain family member 1
chr3_-_122283423 0.292 NM_001146103
NM_031458
PARP9

poly (ADP-ribose) polymerase family, member 9

chr3_+_178254223 0.291 NM_181361
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr17_-_39525873 0.290 NM_002279
KRT33B
keratin 33B
chr12_-_25348031 0.290 NM_001082972
NM_001082973
NM_001204101
NM_001204102
NM_018272
CASC1




cancer susceptibility candidate 1




chr12_+_124773709 0.289 NM_181709
FAM101A
family with sequence similarity 101, member A
chr10_+_91498724 0.289 KIF20B
kinesin family member 20B
chr1_-_44482996 0.286 NM_006934
NM_201649
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr3_-_183273407 0.286 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr9_-_117554809 0.285 NM_001204344
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr6_+_37225506 0.285 NM_017772
TBC1D22B
TBC1 domain family, member 22B
chr6_+_29274402 0.284 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr16_-_55989942 0.282 NM_001190158
CES5A
carboxylesterase 5A
chr5_-_64777703 0.282 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr17_-_45933138 0.282 NM_199262
SP6
Sp6 transcription factor
chr8_-_145060563 0.280 PARP10
poly (ADP-ribose) polymerase family, member 10
chr8_-_103251002 0.279 NM_001172477
NM_001172478
NM_015713
RRM2B


ribonucleotide reductase M2 B (TP53 inducible)


chr2_-_100721792 0.279 NM_001025108
AFF3
AF4/FMR2 family, member 3
chr6_-_41130820 0.276 TREM2
triggering receptor expressed on myeloid cells 2
chr20_+_54987167 0.275 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr17_-_39341126 0.274 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr11_+_35198199 0.274 CD44
CD44 molecule (Indian blood group)
chr16_+_88636841 0.273 ZC3H18
zinc finger CCCH-type containing 18
chr12_-_125473618 0.273 NM_032656
DHX37
DEAH (Asp-Glu-Ala-His) box polypeptide 37
chr12_-_51740422 0.272 NM_001971
CELA1
chymotrypsin-like elastase family, member 1
chr22_-_37640187 0.271 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr5_-_75008245 0.271 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr7_-_130371305 0.270 NM_052933
TSGA13
testis specific, 13
chr22_-_36013303 0.270 NM_005368
NM_203378
MB

myoglobin

chrX_+_153775828 0.268 IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr22_-_39052579 0.268 NM_001013647
LOC646851
putative uncharacterized protein LOC388900

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 7.51e-04 GO:0009987 cellular process
1.28 7.91e-04 GO:0023052 signaling
1.28 3.54e-03 GO:0007165 signal transduction
2.39 6.43e-03 GO:0003012 muscle system process
1.23 1.06e-02 GO:0051716 cellular response to stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 1.22e-02 GO:0005515 protein binding
1.44 4.66e-02 GO:0005102 receptor binding