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Motif ID: TP53.p2

Z-value: 0.807

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_+_36644236	3.153	NM_001220777 NM_078467	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr16_+_57406398	1.614	NM_002996	CX3CL1	chemokine (C-X3-C motif) ligand 1
chr10_-_90750955	1.589	NM_001141945	ACTA2	actin, alpha 2, smooth muscle, aorta
chr16_+_57653909	1.408	NM_001145770 NM_005682	GPR56	G protein-coupled receptor 56
chr10_+_90751044	1.334		FAS	Fas (TNF receptor superfamily, member 6)
chr18_+_57567191	1.328	NM_021127	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
chr6_-_138428477	1.284	NM_022121	PERP	PERP, TP53 apoptosis effector
chr8_-_22926406	1.203		TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b
chr15_+_89164522	1.190	NM_022767	AEN	apoptosis enhancing nuclease
chr22_-_18257194	1.179		BID	BH3 interacting domain death agonist
chr2_+_74757127	1.166		HTRA2	HtrA serine peptidase 2
chr10_+_90750384	1.163		FAS	Fas (TNF receptor superfamily, member 6)
chr16_+_57653649	1.153		GPR56	G protein-coupled receptor 56
chr6_-_101329197	1.098	NM_006828 NM_022091	ASCC3	activating signal cointegrator 1 complex subunit 3
chr6_-_101329006	1.078		ASCC3	activating signal cointegrator 1 complex subunit 3
chr22_-_18257221	1.060		BID	BH3 interacting domain death agonist
chr2_+_74757116	1.029		HTRA2	HtrA serine peptidase 2
chr4_+_103422553	1.007		NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr2_+_74756986	0.990		HTRA2	HtrA serine peptidase 2
chr1_-_150738232	0.964		CTSS	cathepsin S
chr12_+_69202796	0.941		MDM2	Mdm2 p53 binding protein homolog (mouse)
chr6_+_116692098	0.926	NM_013352	DSE	dermatan sulfate epimerase
chr2_+_74757158	0.889		HTRA2	HtrA serine peptidase 2
chr4_+_103422479	0.836	NM_001165412 NM_003998	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_+_114448026	0.831		DCLRE1B	DNA cross-link repair 1B
chr5_-_131826426	0.828	NM_002198	IRF1	interferon regulatory factor 1
chr17_-_72869068	0.809	NM_004110 NM_024417	FDXR	ferredoxin reductase
chr17_+_76210276	0.806	NM_001012270 NM_001012271 NM_001168	BIRC5	baculoviral IAP repeat containing 5
chr17_+_78234626	0.802	NM_020914 NM_020954	RNF213	ring finger protein 213
chrX_+_152086408	0.797	NM_001178113	ZNF185	zinc finger protein 185 (LIM domain)
chr5_-_95297424	0.796		ELL2	elongation factor, RNA polymerase II, 2
chr13_-_102068705	0.786	NM_052867	NALCN	sodium leak channel, non-selective
chr9_+_80911990	0.786	NM_021154 NM_058179	PSAT1	phosphoserine aminotransferase 1
chr10_+_124134206	0.764		PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_+_156052330	0.759		LMNA	lamin A/C
chr5_+_135364583	0.731	NM_000358	TGFBI	transforming growth factor, beta-induced, 68kDa
chr4_-_10118286	0.725
chr1_+_114447906	0.722	NM_022836	DCLRE1B	DNA cross-link repair 1B
chr11_-_9286832	0.715	NM_001243254 NM_015213	DENND5A	DENN/MADD domain containing 5A
chr6_+_4776826	0.702		CDYL	chromodomain protein, Y-like
chr2_+_74757243	0.672		HTRA2	HtrA serine peptidase 2
chr11_-_3078596	0.669	NM_001014437 NM_001194997 NM_001751 NM_139273	CARS	cysteinyl-tRNA synthetase
chr1_-_150738292	0.666	NM_001199739 NM_004079	CTSS	cathepsin S
chr19_+_49458151	0.661		BAX	BCL2-associated X protein
chr8_-_22926490	0.659	NM_003842 NM_147187	TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b
chr4_-_10118358	0.652		WDR1	WD repeat domain 1
chr17_+_76210329	0.649		BIRC5	baculoviral IAP repeat containing 5
chr1_-_150738255	0.642		CTSS	cathepsin S
chr5_-_95297597	0.637	NM_012081	ELL2	elongation factor, RNA polymerase II, 2
chr19_+_49458129	0.630		BAX	BCL2-associated X protein
chr3_+_127771342	0.629
chr10_+_134000335	0.628	NM_006426	DPYSL4	dihydropyrimidinase-like 4
chr9_-_95896498	0.606	NM_004148	NINJ1	ninjurin 1
chr5_+_17217474	0.596	NM_006317	BASP1	brain abundant, membrane attached signal protein 1
chr22_-_18257160	0.582		BID	BH3 interacting domain death agonist
chr10_+_124134093	0.578	NM_001001974	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr4_-_10118378	0.570		WDR1	WD repeat domain 1
chr19_-_47735858	0.569	NM_001127240 NM_001127241 NM_001127242	BBC3	BCL2 binding component 3
chr22_-_18257238	0.566	NM_001196 NM_001244569 NM_001244570 NM_197967 NM_001244567	BID	BH3 interacting domain death agonist
chr20_+_4129409	0.557	NM_175839 NM_175840 NM_175841 NM_175842	SMOX	spermine oxidase
chr4_-_2758018	0.556	NM_024309	TNIP2	TNFAIP3 interacting protein 2
chr11_+_33279167	0.551	NM_001048200 NM_005734	HIPK3	homeodomain interacting protein kinase 3
chr1_-_243418675	0.540	NM_001042404 NM_001042405 NM_014812	CEP170	centrosomal protein 170kDa
chr1_+_54519259	0.520	NM_153035	TCEANC2	transcription elongation factor A (SII) N-terminal and central domain containing 2
chr1_-_209825673	0.516	NM_001127641	LAMB3	laminin, beta 3
chr19_+_49458031	0.504	NM_004324 NM_138761 NM_138763 NM_138764	BAX	BCL2-associated X protein
chr1_+_11796211	0.496		AGTRAP	angiotensin II receptor-associated protein
chr9_+_130186714	0.494		ZNF79	zinc finger protein 79
chr1_-_209825797	0.491	NM_000228	LAMB3	laminin, beta 3
chr2_-_47168870	0.491		MCFD2	multiple coagulation factor deficiency 2
chr3_+_44380003	0.482		C3orf23	chromosome 3 open reading frame 23
chr8_-_23082572	0.481		TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a
chr1_+_11796177	0.464		AGTRAP	angiotensin II receptor-associated protein
chr12_+_22199132	0.460	NM_018686	CMAS	cytidine monophosphate N-acetylneuraminic acid synthetase
chr6_-_109804322	0.459		ZBTB24	zinc finger and BTB domain containing 24
chr19_+_44080951	0.459	NM_001193621	LOC390940	uncharacterized protein ENSP00000244321
chr20_+_4129466	0.455		SMOX	spermine oxidase
chr13_+_38923941	0.448	NM_016617	UFM1	ubiquitin-fold modifier 1
chr16_+_50776012	0.443	NM_001042412	CYLD	cylindromatosis (turban tumor syndrome)
chr21_+_42792441	0.438	NM_001144925	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr4_-_10118444	0.434		WDR1	WD repeat domain 1
chr1_-_53163985	0.430		SELRC1	Sel1 repeat containing 1
chr11_+_125757591	0.424		HYLS1	hydrolethalus syndrome 1
chr19_-_2456954	0.423	NM_032737	LMNB2	lamin B2
chr2_+_47168362	0.421		TTC7A	tetratricopeptide repeat domain 7A
chr1_-_53164023	0.421	NM_023077	SELRC1	Sel1 repeat containing 1
chr8_-_12293895	0.420		FAM86B2 FAM86B1	family with sequence similarity 86, member B2 family with sequence similarity 86, member B1
chr1_-_53164014	0.419		SELRC1	Sel1 repeat containing 1
chr8_+_120428551	0.414	NM_002514	NOV	nephroblastoma overexpressed gene
chr17_+_80332152	0.412	NM_018949	UTS2R	urotensin 2 receptor
chr21_+_26934440	0.404		MIR155HG	MIR155 host gene (non-protein coding)
chr20_-_1373571	0.402		FKBP1A	FK506 binding protein 1A, 12kDa
chr6_-_32163299	0.400	NM_022107	GPSM3	G-protein signaling modulator 3
chr12_-_6451156	0.395	NM_001065	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A
chr22_+_37447615	0.395	NM_024681	KCTD17	potassium channel tetramerisation domain containing 17
chr1_+_212781969	0.392	NM_001040619 NM_001206484 NM_001206488 NM_001674	ATF3	activating transcription factor 3
chr6_-_109775423	0.388		MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1
chr3_+_44379590	0.388	NM_001029840	C3orf23	chromosome 3 open reading frame 23
chr9_+_130186652	0.382	NM_007135	ZNF79	zinc finger protein 79
chr20_-_32891075	0.378	NM_000687	AHCY	adenosylhomocysteinase
chr1_+_3607232	0.376	NM_001126240 NM_001126241 NM_001126242 NM_001204189 NM_001204190 NM_001204191	TP73	tumor protein p73
chr1_+_11796128	0.375	NM_001040194 NM_001040195 NM_001040196 NM_001040197 NM_020350	AGTRAP	angiotensin II receptor-associated protein
chr4_-_10118296	0.372		WDR1	WD repeat domain 1
chr7_-_97501424	0.371	NM_001178077 NM_133436	ASNS	asparagine synthetase (glutamine-hydrolyzing)
chrX_-_154688260	0.370	NM_001007523 NM_001007524 NM_012151	F8A2 F8A3 F8A1	coagulation factor VIII-associated 2 coagulation factor VIII-associated 3 coagulation factor VIII-associated 1
chrX_+_154611748	0.368	NM_001007523 NM_001007524 NM_012151	F8A2 F8A3 F8A1	coagulation factor VIII-associated 2 coagulation factor VIII-associated 3 coagulation factor VIII-associated 1
chr12_+_22199219	0.363		CMAS	cytidine monophosphate N-acetylneuraminic acid synthetase
chrX_+_154114609	0.362	NM_001007523 NM_001007524 NM_012151	F8A2 F8A3 F8A1	coagulation factor VIII-associated 2 coagulation factor VIII-associated 3 coagulation factor VIII-associated 1
chr12_+_99038918	0.361	NM_001160 NM_013229 NM_181861 NM_181868 NM_181869	APAF1	apoptotic peptidase activating factor 1
chr16_-_4303761	0.357		LOC100507501	uncharacterized LOC100507501
chr20_-_43588973	0.354	NM_006809	TOMM34	translocase of outer mitochondrial membrane 34
chr4_-_7436614	0.351	NM_001085382	PSAPL1	prosaposin-like 1 (gene/pseudogene)
chr11_+_125439370	0.346		EI24	etoposide induced 2.4 mRNA
chr6_+_34204690	0.341		HMGA1	high mobility group AT-hook 1
chr16_+_67880784	0.341	NM_005796	NUTF2	nuclear transport factor 2
chr20_+_61583998	0.333	NM_022082	SLC17A9	solute carrier family 17, member 9
chr7_+_75024902	0.333	NM_198924 NM_198853	TRIM73 TRIM74	tripartite motif containing 73 tripartite motif containing 74
chr20_-_5100443	0.327	NM_182649	PCNA	proliferating cell nuclear antigen
chrX_-_109561427	0.327		AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr2_+_150186498	0.325	NM_001195685	LYPD6	LY6/PLAUR domain containing 6
chr1_-_2457988	0.320	NM_018216	PANK4	pantothenate kinase 4
chr11_+_94277005	0.320	NM_002033	PIWIL4 FUT4	piwi-like 4 (Drosophila) fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr11_+_33279859	0.320		HIPK3	homeodomain interacting protein kinase 3
chr2_+_150187028	0.318	NM_194317	LYPD6	LY6/PLAUR domain containing 6
chr9_+_119449573	0.317	NM_001099679 NM_012210	TRIM32	tripartite motif containing 32
chr10_-_47173917	0.314	NM_001040084 NM_001098845	ANXA8L2 ANXA8 ANXA8L1	annexin A8-like 2 annexin A8 annexin A8-like 1
chrX_-_153285262	0.308		IRAK1	interleukin-1 receptor-associated kinase 1
chr8_-_12293806	0.307	NM_001137610	FAM86B2 FAM86B1	family with sequence similarity 86, member B2 family with sequence similarity 86, member B1
chr3_+_127771287	0.303		SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)
chr8_-_12051533	0.300	NM_001083537	FAM86B2 FAM86B1	family with sequence similarity 86, member B2 family with sequence similarity 86, member B1
chr4_-_185747183	0.297	NM_001995	ACSL1	acyl-CoA synthetase long-chain family member 1
chr3_+_127771126	0.296	NM_013336	SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)
chr18_-_28622624	0.293	NM_001941 NM_024423	DSC3	desmocollin 3
chr20_-_45035253	0.293	NM_133171 NM_182764	ELMO2	engulfment and cell motility 2
chr9_+_137967366	0.291		OLFM1	olfactomedin 1
chr12_+_56498365	0.291		PA2G4	proliferation-associated 2G4, 38kDa
chr1_-_10532603	0.288	NM_004401 NM_213566	DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide
chr1_-_153508463	0.287		S100A6	S100 calcium binding protein A6
chr3_-_113465101	0.285	NM_025146	NAA50	N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr12_+_56498334	0.285		PA2G4	proliferation-associated 2G4, 38kDa
chr13_-_30169795	0.283	NM_003045	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr1_-_153508495	0.279		S100A6	S100 calcium binding protein A6
chr5_+_133861685	0.277	NM_015288	PHF15	PHD finger protein 15
chr20_+_61584094	0.276		SLC17A9	solute carrier family 17, member 9
chr1_-_10532513	0.272		DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide
chr2_+_209271555	0.271	NM_005048	PTH2R	parathyroid hormone 2 receptor
chr8_-_10697382	0.270		PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1
chr19_+_15783827	0.268	NM_023944	CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12
chr16_-_5147739	0.266	NM_201400 NM_201598	FAM86A	family with sequence similarity 86, member A
chr19_+_45174723	0.261	NM_001127893 NM_020219	CEACAM19	carcinoembryonic antigen-related cell adhesion molecule 19
chr7_+_128431449	0.259	NM_001201372	CCDC136	coiled-coil domain containing 136
chr20_-_1373702	0.259		FKBP1A-SDCBP2 FKBP1A	FKBP1A-SDCBP2 readthrough (non-protein coding) FK506 binding protein 1A, 12kDa
chr12_+_56498414	0.259		PA2G4	proliferation-associated 2G4, 38kDa
chr11_+_94277566	0.257		FUT4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr7_+_142495142	0.256
chr12_-_6450980	0.255		TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A
chr10_+_60028885	0.254	NM_018464	CISD1	CDGSH iron sulfur domain 1
chr17_-_61959160	0.252	NM_002059 NM_022556 NM_022557 NM_022558	GH2	growth hormone 2
chr1_+_224544550	0.249		CNIH4	cornichon homolog 4 (Drosophila)
chr16_-_1470709	0.247		C16orf91	chromosome 16 open reading frame 91
chr11_+_86085777	0.247	NM_001156474 NM_021827	CCDC81	coiled-coil domain containing 81
chr16_-_67997948	0.246	NM_001145963	SLC12A4	solute carrier family 12 (potassium/chloride transporters), member 4
chr2_+_47168312	0.246	NM_020458	TTC7A	tetratricopeptide repeat domain 7A
chr22_-_18256748	0.243	NM_001244572 NM_197966	BID	BH3 interacting domain death agonist
chr20_-_1373744	0.243	NM_000801 NM_001199786 NM_054014	FKBP1A	FK506 binding protein 1A, 12kDa
chr4_-_10118500	0.243	NM_005112 NM_017491	WDR1	WD repeat domain 1
chr1_+_151584514	0.242	NM_030918	SNX27	sorting nexin family member 27
chr3_-_46037299	0.240	NM_024513	FYCO1	FYVE and coiled-coil domain containing 1
chr3_+_71803200	0.239	NM_018971	GPR27	G protein-coupled receptor 27
chr2_+_74756531	0.239	NM_013247 NM_145074	HTRA2	HtrA serine peptidase 2
chr11_-_59383616	0.238	NM_002556	OSBP	oxysterol binding protein
chr2_-_288181	0.237	NM_001002919	FAM150B	family with sequence similarity 150, member B
chr6_+_37787592	0.236		ZFAND3	zinc finger, AN1-type domain 3
chr2_-_213403280	0.234	NM_001042599 NM_005235	ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr20_-_62205559	0.234	NM_001037335	PRIC285	peroxisomal proliferator-activated receptor A interacting complex 285
chr2_-_47168902	0.234	NM_001171508 NM_001171511	MCFD2	multiple coagulation factor deficiency 2
chr15_-_63449479	0.233	NM_015920	RPS27L	ribosomal protein S27-like
chr6_+_150285109	0.233	NM_025218	ULBP1	UL16 binding protein 1
chr5_+_162864571	0.232	NM_004060 NM_199246	CCNG1	cyclin G1
chr19_-_50979461	0.230		FAM71E1	family with sequence similarity 71, member E1
chr12_+_6603258	0.229		NCAPD2	non-SMC condensin I complex, subunit D2
chr6_-_109804432	0.227	NM_001164313 NM_014797	ZBTB24	zinc finger and BTB domain containing 24
chr1_+_32671235	0.224	NM_001160042 NM_018134	IQCC	IQ motif containing C
chr19_-_42746678	0.218		GSK3A	glycogen synthase kinase 3 alpha
chr3_-_52804871	0.218	NM_001193533 NM_003157	NEK4	NIMA (never in mitosis gene a)-related kinase 4
chr22_+_41697452	0.217	NM_017590	ZC3H7B	zinc finger CCCH-type containing 7B
chr1_-_6453362	0.215		ACOT7	acyl-CoA thioesterase 7
chr18_+_33877630	0.215	NM_025135	FHOD3	formin homology 2 domain containing 3
chr19_-_5790913	0.214		DUS3L	dihydrouridine synthase 3-like (S. cerevisiae)
chr1_+_41444968	0.214	NM_001905	CTPS	CTP synthase
chr11_+_65154040	0.214	NM_031904	FRMD8	FERM domain containing 8
chr15_+_40453209	0.213	NM_001211	BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr11_-_67572670	0.213		FAM86C2P	family with sequence similarity 86, member A pseudogene
chr7_+_100770378	0.212	NM_000602 NM_001165413	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chrX_+_129305553	0.211	NM_004794	RAB33A	RAB33A, member RAS oncogene family
chr3_-_9005070	0.209	NM_020165	RAD18	RAD18 homolog (S. cerevisiae)
chr21_+_44313359	0.209	NM_001001503 NM_021075	NDUFV3	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
chr19_+_38865424	0.208		PSMD8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr12_+_27485767	0.206	NM_001248002 NM_001248003 NM_001248004 NM_001248005 NM_020183	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2
chr8_-_10697290	0.205	NM_017884	PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.62	6.28e-04	GO:0006917	induction of apoptosis
2.61	6.75e-04	GO:0012502	induction of programmed cell death
2.17	7.88e-03	GO:0043065	positive regulation of apoptosis
2.15	9.21e-03	GO:0043068	positive regulation of programmed cell death
7.70	1.00e-02	GO:0008637	apoptotic mitochondrial changes
1.76	1.19e-02	GO:0043067	regulation of programmed cell death
2.12	1.39e-02	GO:0010942	positive regulation of cell death
1.74	1.75e-02	GO:0042981	regulation of apoptosis
1.73	2.00e-02	GO:0010941	regulation of cell death
4.55	2.00e-02	GO:0071214	cellular response to abiotic stimulus
1.89	2.89e-02	GO:0006915	apoptosis
3.22	4.02e-02	GO:0007005	mitochondrion organization
1.86	4.31e-02	GO:0012501	programmed cell death

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.69	3.27e-07	GO:0005829	cytosol
1.30	8.59e-06	GO:0044444	cytoplasmic part
1.18	1.71e-03	GO:0005737	cytoplasm

Nothing significant found in function category.