Motif ID: TP53.p2

Z-value: 0.807


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TP53chr17_-_75907310.481.5e-02Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_36644236 3.153 NM_001220777
NM_078467
 CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr16_+_57406398 1.614 NM_002996
 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr10_-_90750955 1.589 NM_001141945
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr16_+_57653909 1.408 NM_001145770
NM_005682
 GPR56

G protein-coupled receptor 56

chr10_+_90751044 1.334 FAS
Fas (TNF receptor superfamily, member 6)
chr18_+_57567191 1.328 NM_021127
 PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr6_-_138428477 1.284 NM_022121
 PERP
PERP, TP53 apoptosis effector
chr8_-_22926406 1.203 TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr15_+_89164522 1.190 NM_022767
 AEN
apoptosis enhancing nuclease
chr22_-_18257194 1.179 BID
BH3 interacting domain death agonist
chr2_+_74757127 1.166 HTRA2
HtrA serine peptidase 2
chr10_+_90750384 1.163 FAS
Fas (TNF receptor superfamily, member 6)
chr16_+_57653649 1.153 GPR56
G protein-coupled receptor 56
chr6_-_101329197 1.098 NM_006828
NM_022091
 ASCC3

activating signal cointegrator 1 complex subunit 3

chr6_-_101329006 1.078 ASCC3
activating signal cointegrator 1 complex subunit 3
chr22_-_18257221 1.060 BID
BH3 interacting domain death agonist
chr2_+_74757116 1.029 HTRA2
HtrA serine peptidase 2
chr4_+_103422553 1.007 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr2_+_74756986 0.990 HTRA2
HtrA serine peptidase 2
chr1_-_150738232 0.964 CTSS
cathepsin S

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
7.70 1.00e-02 GO:0008637 apoptotic mitochondrial changes
4.55 2.00e-02 GO:0071214 cellular response to abiotic stimulus
3.22 4.02e-02 GO:0007005 mitochondrion organization
2.62 6.28e-04 GO:0006917 induction of apoptosis
2.61 6.75e-04 GO:0012502 induction of programmed cell death
2.17 7.88e-03 GO:0043065 positive regulation of apoptosis
2.15 9.21e-03 GO:0043068 positive regulation of programmed cell death
2.12 1.39e-02 GO:0010942 positive regulation of cell death
1.89 2.89e-02 GO:0006915 apoptosis
1.86 4.31e-02 GO:0012501 programmed cell death
1.76 1.19e-02 GO:0043067 regulation of programmed cell death
1.74 1.75e-02 GO:0042981 regulation of apoptosis
1.73 2.00e-02 GO:0010941 regulation of cell death

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.69 3.27e-07 GO:0005829 cytosol
1.30 8.59e-06 GO:0044444 cytoplasmic part
1.18 1.71e-03 GO:0005737 cytoplasm

Nothing significant found in function category.