Motif ID: ZIC1..3.p2

Z-value: 1.049


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ZIC3chrX_+_1366483130.349.7e-02Click!
ZIC1chr3_+_147127151-0.291.6e-01Click!
ZIC2chr13_+_100633977,
chr13_+_100634257
0.262.1e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_160183510 0.975 ACAT2
acetyl-CoA acetyltransferase 2
chr6_+_160183062 0.972 ACAT2
acetyl-CoA acetyltransferase 2
chr19_+_13263890 0.928 IER2
immediate early response 2
chr4_+_156588811 0.888 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr17_-_27278471 0.885 NM_001033561
NM_020889
PHF12

PHD finger protein 12

chr7_-_27224762 0.880 NM_005523
HOXA11
homeobox A11
chr8_+_22225173 0.798 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr4_-_174450529 0.768 HAND2
heart and neural crest derivatives expressed 2
chr1_-_236030170 0.668


chr12_-_6798419 0.664 ZNF384
zinc finger protein 384
chr19_+_50145369 0.612 NM_021228
SCAF1
SR-related CTD-associated factor 1
chr1_-_55352920 0.555 NM_014762
DHCR24
24-dehydrocholesterol reductase
chr1_-_55352893 0.549 DHCR24
24-dehydrocholesterol reductase
chrX_-_13956530 0.546 GPM6B
glycoprotein M6B
chr8_+_22224997 0.544 NM_001135153
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr2_+_8822112 0.541 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr19_+_39899749 0.539


chr5_+_121647385 0.538 SNCAIP
synuclein, alpha interacting protein
chr15_+_60296420 0.537 NM_012182
FOXB1
forkhead box B1
chr1_-_55352818 0.535 DHCR24
24-dehydrocholesterol reductase
chr19_-_14629227 0.533 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr6_-_3456513 0.531 SLC22A23
solute carrier family 22, member 23
chr4_+_156587861 0.529 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr7_+_100027253 0.515 NM_019606
MEPCE
methylphosphate capping enzyme
chr7_+_130131921 0.506 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr1_-_12677347 0.503 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr15_+_60296506 0.500 FOXB1
forkhead box B1
chr11_-_64527369 0.486 PYGM
phosphorylase, glycogen, muscle
chr9_-_113800243 0.483 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr12_-_6798528 0.475 NM_133476
ZNF384
zinc finger protein 384
chrX_-_51812249 0.473 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr1_-_55352881 0.471 DHCR24
24-dehydrocholesterol reductase
chr10_-_48416692 0.469 NM_016204
GDF2
growth differentiation factor 2
chr16_+_3405888 0.464 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr12_-_49392909 0.458 NM_015086
DDN
dendrin
chr11_-_64901995 0.442 NM_032431
NM_172230
SYVN1

synovial apoptosis inhibitor 1, synoviolin

chr2_-_201936386 0.441 FAM126B
family with sequence similarity 126, member B
chr8_-_22014263 0.430 NM_139278
LGI3
leucine-rich repeat LGI family, member 3
chr3_-_12200850 0.426 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr5_+_161275541 0.424 NM_001127645
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr5_-_141704575 0.416 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr14_+_101292483 0.410


chr3_+_31574431 0.402 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr22_+_39853534 0.401 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr11_+_63871240 0.391 NM_013280
FLRT1
fibronectin leucine rich transmembrane protein 1
chr11_-_64901943 0.387 SYVN1
synovial apoptosis inhibitor 1, synoviolin
chrX_+_70364707 0.382 NLGN3
neuroligin 3
chr12_+_54943358 0.381 PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr1_+_36690038 0.380 THRAP3
thyroid hormone receptor associated protein 3
chr12_-_6798619 0.377 NM_001039920
NM_001135734
ZNF384

zinc finger protein 384

chr11_-_85376061 0.375 CREBZF
CREB/ATF bZIP transcription factor
chr17_-_37307694 0.371 PLXDC1
plexin domain containing 1
chr7_-_112726143 0.370 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chrX_+_51927918 0.369 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr12_+_2999994 0.366 NM_001160408
NM_003324
TULP3

tubby like protein 3

chrX_+_70364680 0.365 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3


chr17_+_7788094 0.364 NM_001005271
CHD3
chromodomain helicase DNA binding protein 3
chr6_-_6007632 0.362 NM_016588
NRN1
neuritin 1
chr20_+_57466509 0.361 GNAS
GNAS complex locus
chrX_+_70364728 0.358 NLGN3
neuroligin 3
chr2_+_9983570 0.357 NM_005680
TAF1B
TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
chr22_-_19166276 0.355 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr15_-_93616891 0.352 NM_001166288
NM_001166289
RGMA

RGM domain family, member A

chr20_+_57466248 0.351 NM_000516
NM_001077488
NM_001077489
NM_080426
GNAS



GNAS complex locus



chrX_+_51636608 0.350 NM_001005333
NM_006986
MAGED1

melanoma antigen family D, 1

chr8_-_134584012 0.349 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr12_+_54943176 0.346 NM_000924
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr6_-_139695349 0.346 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr3_-_12200339 0.346 TIMP4
TIMP metallopeptidase inhibitor 4
chr19_-_51568323 0.344 NM_015596
KLK13
kallikrein-related peptidase 13
chr14_+_64971417 0.343 ZBTB1
zinc finger and BTB domain containing 1
chr8_-_124544376 0.342 NM_148177
FBXO32
F-box protein 32
chr2_+_70142152 0.341 NM_001202513
NM_001202514
NM_002357
MXD1


MAX dimerization protein 1


chr22_-_19166296 0.336 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr19_+_16435632 0.336 NM_016270
KLF2
Kruppel-like factor 2 (lung)
chr16_+_6533758 0.335 RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr7_+_130131172 0.335 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr7_+_100027404 0.329 MEPCE
methylphosphate capping enzyme
chr19_-_14629235 0.329


chr4_+_24797203 0.324 SOD3
superoxide dismutase 3, extracellular
chr12_-_112036257 0.321 ATXN2
ataxin 2
chr12_-_4554779 0.321 NM_020996
FGF6
fibroblast growth factor 6
chr5_+_161275897 0.320 NM_001127646
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr19_-_47164289 0.319 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr2_-_25194484 0.316 DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr19_-_14629160 0.316 NM_006145
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr4_+_72052354 0.314 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr14_+_85996512 0.313 FLRT2
fibronectin leucine rich transmembrane protein 2
chr7_-_92465876 0.312 CDK6
cyclin-dependent kinase 6
chr4_+_24797084 0.312 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr2_-_51259239 0.311 NRXN1
neurexin 1
chr9_+_130854127 0.311 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr17_-_27278324 0.310 PHF12
PHD finger protein 12
chr22_-_19166133 0.309 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr15_-_93617091 0.309 NM_001166283
RGMA
RGM domain family, member A
chr3_-_45838112 0.308 SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr19_+_55795766 0.307 BRSK1
BR serine/threonine kinase 1
chr19_+_58790306 0.302 NM_021089
ZNF8
zinc finger protein 8
chr8_+_22102644 0.302 POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr14_-_103988829 0.300 CKB
creatine kinase, brain
chr4_-_110354914 0.299 1/2-SBSRNA4
lncRNA_BC009800
chr16_+_67063214 0.294 CBFB
core-binding factor, beta subunit
chr12_-_53448167 0.293 LOC283335
uncharacterized LOC283335
chr6_+_44095357 0.290 NM_018426
TMEM63B
transmembrane protein 63B
chr6_-_31869768 0.287 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr19_+_18208596 0.285 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr19_-_6481765 0.285 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr12_+_109273856 0.284 NM_001917
DAO
D-amino-acid oxidase
chr19_+_55795533 0.280 NM_032430
BRSK1
BR serine/threonine kinase 1
chr12_+_54447660 0.280 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chrX_+_9432980 0.278 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr6_-_166401403 0.277 LINC00473
long intergenic non-protein coding RNA 473
chr1_-_35658430 0.276 SFPQ
splicing factor proline/glutamine-rich
chr7_-_27213873 0.276 NM_018951
HOXA10
homeobox A10
chr19_-_46405854 0.272 NM_001012643
MYPOP
Myb-related transcription factor, partner of profilin
chr15_+_100106214 0.271 MEF2A
myocyte enhancer factor 2A
chr8_+_22102618 0.270 NM_001722
POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr21_-_47648618 0.269 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr5_-_66492574 0.268 NM_005582
CD180
CD180 molecule
chr1_+_165513439 0.268 NM_001005214
LRRC52
leucine rich repeat containing 52
chr2_+_217498205 0.267 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr5_-_141704468 0.267 SPRY4
sprouty homolog 4 (Drosophila)
chr2_+_149402559 0.266 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr11_+_33279167 0.266 NM_001048200
NM_005734
HIPK3

homeodomain interacting protein kinase 3

chr1_-_206945725 0.265 NM_000572
IL10
interleukin 10
chr1_-_112531669 0.263 NM_004980
NM_172198
KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

chr1_+_220701523 0.263 MARK1
MAP/microtubule affinity-regulating kinase 1
chr9_-_122131579 0.262 NM_014618
DBC1
deleted in bladder cancer 1
chr2_-_208989081 0.261 NM_006891
CRYGD
crystallin, gamma D
chr3_+_10028579 0.261 LOC442075
uncharacterized LOC442075
chr7_-_150946031 0.260 SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr11_+_19734821 0.260 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr5_-_94620277 0.260 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr17_-_39306053 0.259 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr20_+_37555055 0.259 FAM83D
family with sequence similarity 83, member D
chr16_-_2059759 0.258 NM_178167
ZNF598
zinc finger protein 598
chr3_+_101568325 0.257 NM_031419
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr17_-_36955676 0.257 PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr12_+_12869818 0.256 NM_004064
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr11_-_85376159 0.256 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chr2_-_26101091 0.254


chr2_-_31361284 0.253 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr1_+_38158176 0.252 CDCA8
cell division cycle associated 8
chr20_+_37554954 0.251 NM_030919
FAM83D
family with sequence similarity 83, member D
chr1_-_20834609 0.251 NM_024544
MUL1
mitochondrial E3 ubiquitin protein ligase 1
chrX_+_153409724 0.250 NM_020061
OPN1LW
opsin 1 (cone pigments), long-wave-sensitive
chr19_-_40919270 0.249 NM_020956
NM_181882
PRX

periaxin

chr22_-_19512001 0.248 CLDN5
claudin 5
chr2_+_25016174 0.248 NM_001199803
NM_024322
CENPO

centromere protein O

chr14_-_103989112 0.247 CKB
creatine kinase, brain
chr1_-_86622107 0.247 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr6_-_3456734 0.246 NM_015482
SLC22A23
solute carrier family 22, member 23
chr22_-_37823503 0.246 NM_052906
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr16_+_84224722 0.245 NM_001145400
NM_139174
ADAD2

adenosine deaminase domain containing 2

chr22_+_21996615 0.244 SDF2L1
stromal cell-derived factor 2-like 1
chr19_-_55881740 0.244 NM_000641
IL11
interleukin 11
chr17_+_42219300 0.243 C17orf53
chromosome 17 open reading frame 53
chr2_-_26101329 0.243 ASXL2
additional sex combs like 2 (Drosophila)
chr6_-_166401526 0.242 LINC00473
long intergenic non-protein coding RNA 473
chr17_-_31620005 0.242 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr8_+_22102845 0.242 POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr10_-_73848263 0.242 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr9_-_73483933 0.242 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr17_-_80044975 0.241 FASN
fatty acid synthase
chr1_+_33283193 0.241 S100PBP
S100P binding protein
chr1_-_20834516 0.240 MUL1
mitochondrial E3 ubiquitin protein ligase 1
chr17_+_42219382 0.240 C17orf53
chromosome 17 open reading frame 53
chr22_-_44258210 0.240 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr7_-_150038689 0.239 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr14_+_101292451 0.239 MEG3
maternally expressed 3 (non-protein coding)
chr19_+_58962954 0.239 NM_207395
ZNF324B
zinc finger protein 324B
chr12_+_121124958 0.239 MLEC
malectin
chr7_-_123388711 0.239 NM_003941
WASL
Wiskott-Aldrich syndrome-like
chr22_-_19165872 0.239 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr17_+_42219235 0.237 NM_001171251
NM_024032
C17orf53

chromosome 17 open reading frame 53

chr1_+_36689996 0.236 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr17_+_39382878 0.236 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr16_+_88705000 0.236 NM_013278
IL17C
interleukin 17C
chr2_-_99347588 0.235 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr19_+_59070557 0.235 LOC100131691
uncharacterized LOC100131691
chrX_+_151903218 0.233 NM_001102576
NM_153478
CSAG1

chondrosarcoma associated gene 1

chr4_+_75858205 0.233 NM_015393
PARM1
prostate androgen-regulated mucin-like protein 1
chrX_+_38663503 0.231 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr1_+_13910251 0.230 NM_006474
NM_198389
PDPN

podoplanin

chr19_-_46295647 0.229 DMWD
dystrophia myotonica, WD repeat containing
chr2_+_217498082 0.228 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr2_-_26101301 0.228 NM_018263
ASXL2
additional sex combs like 2 (Drosophila)
chr8_+_19796840 0.228 LPL
lipoprotein lipase
chr22_+_42229137 0.227 SREBF2
sterol regulatory element binding transcription factor 2
chr1_+_101361688 0.227 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr1_+_101361671 0.227 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr4_+_166248816 0.226 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr6_+_160182988 0.226 NM_005891
ACAT2
acetyl-CoA acetyltransferase 2
chr16_-_2059795 0.226 ZNF598
zinc finger protein 598
chr22_+_21996572 0.226 SDF2L1
stromal cell-derived factor 2-like 1
chr2_+_149402321 0.225 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr16_-_84220570 0.224 NM_001243156
NM_001243157
NM_001243158
NM_001243159
NM_001243160
NM_005679
NM_139353
TAF1C






TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa






chr12_-_72666305 0.224 LOC283392
uncharacterized LOC283392
chr16_+_24802421 0.224 TNRC6A
trinucleotide repeat containing 6A
chr17_-_57970077 0.224 NM_001193609
NM_001193610
NM_001193611
NM_001193612
NM_001193613
NM_016261
TUBD1





tubulin, delta 1






Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 1.10e-12 GO:0050794 regulation of cellular process
1.20 1.44e-11 GO:0050789 regulation of biological process
1.18 1.07e-10 GO:0065007 biological regulation
1.34 6.67e-10 GO:0048856 anatomical structure development
1.36 2.86e-09 GO:0048731 system development
1.52 3.34e-09 GO:0009653 anatomical structure morphogenesis
1.29 1.10e-08 GO:0032502 developmental process
1.40 6.04e-08 GO:0048869 cellular developmental process
1.41 7.94e-08 GO:0030154 cell differentiation
1.49 8.73e-08 GO:0007399 nervous system development
1.26 2.64e-07 GO:0019222 regulation of metabolic process
1.28 3.46e-07 GO:0007275 multicellular organismal development
1.26 2.54e-06 GO:0023052 signaling
2.20 4.34e-06 GO:0003002 regionalization
1.31 8.49e-06 GO:0010468 regulation of gene expression
1.25 9.84e-06 GO:0031323 regulation of cellular metabolic process
1.54 1.26e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.30 1.37e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.85 1.40e-05 GO:0007409 axonogenesis
1.57 1.72e-05 GO:0048699 generation of neurons
1.30 1.82e-05 GO:0009889 regulation of biosynthetic process
1.90 1.89e-05 GO:0048598 embryonic morphogenesis
1.83 1.90e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.96 1.91e-05 GO:0007411 axon guidance
1.30 1.99e-05 GO:0031326 regulation of cellular biosynthetic process
1.39 2.88e-05 GO:0023051 regulation of signaling
1.31 3.91e-05 GO:0048519 negative regulation of biological process
1.31 4.62e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.24 5.21e-05 GO:0080090 regulation of primary metabolic process
1.62 5.66e-05 GO:0030182 neuron differentiation
1.32 6.46e-05 GO:0006355 regulation of transcription, DNA-dependent
1.30 6.99e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.51 7.04e-05 GO:0032879 regulation of localization
1.73 8.62e-05 GO:0000904 cell morphogenesis involved in differentiation
1.28 8.81e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.78 9.73e-05 GO:0048812 neuron projection morphogenesis
1.25 9.93e-05 GO:0060255 regulation of macromolecule metabolic process
1.59 1.01e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.25 1.02e-04 GO:0016043 cellular component organization
1.62 1.03e-04 GO:0010628 positive regulation of gene expression
1.52 1.09e-04 GO:0022008 neurogenesis
1.32 1.13e-04 GO:0048523 negative regulation of cellular process
1.67 1.48e-04 GO:0048666 neuron development
1.24 1.54e-04 GO:0007165 signal transduction
1.30 2.59e-04 GO:0051252 regulation of RNA metabolic process
1.52 3.23e-04 GO:0009891 positive regulation of biosynthetic process
1.50 3.27e-04 GO:0048468 cell development
1.46 3.61e-04 GO:0010646 regulation of cell communication
1.70 3.84e-04 GO:0031175 neuron projection development
1.61 4.85e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.55 5.45e-04 GO:2000026 regulation of multicellular organismal development
1.52 5.54e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.62 5.98e-04 GO:0000902 cell morphogenesis
1.38 7.06e-04 GO:0009966 regulation of signal transduction
1.48 8.87e-04 GO:0050793 regulation of developmental process
1.26 1.01e-03 GO:0048518 positive regulation of biological process
1.54 1.63e-03 GO:0051049 regulation of transport
1.80 1.64e-03 GO:0007389 pattern specification process
1.48 1.72e-03 GO:0006351 transcription, DNA-dependent
1.27 1.98e-03 GO:0048522 positive regulation of cellular process
1.21 2.48e-03 GO:0071840 cellular component organization or biogenesis
1.64 2.60e-03 GO:0032990 cell part morphogenesis
1.57 2.75e-03 GO:0032989 cellular component morphogenesis
1.19 3.14e-03 GO:0051716 cellular response to stimulus
1.64 3.26e-03 GO:0048858 cell projection morphogenesis
1.31 3.42e-03 GO:0048583 regulation of response to stimulus
1.38 3.98e-03 GO:0009893 positive regulation of metabolic process
1.25 3.99e-03 GO:0071842 cellular component organization at cellular level
1.86 4.32e-03 GO:0035295 tube development
1.37 4.59e-03 GO:0051239 regulation of multicellular organismal process
2.04 5.18e-03 GO:0048732 gland development
2.13 5.29e-03 GO:0009952 anterior/posterior pattern formation
1.53 6.12e-03 GO:0051254 positive regulation of RNA metabolic process
1.30 6.31e-03 GO:0007166 cell surface receptor linked signaling pathway
1.07 7.00e-03 GO:0009987 cellular process
1.51 7.53e-03 GO:0009790 embryo development
1.49 7.56e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.48 8.30e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.34 8.73e-03 GO:0065009 regulation of molecular function
1.77 8.86e-03 GO:0060284 regulation of cell development
1.53 9.62e-03 GO:0030030 cell projection organization
1.77 1.00e-02 GO:0001501 skeletal system development
2.38 1.21e-02 GO:0035107 appendage morphogenesis
2.38 1.21e-02 GO:0035108 limb morphogenesis
1.44 1.24e-02 GO:0009888 tissue development
1.77 1.26e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.54 1.44e-02 GO:0009887 organ morphogenesis
1.69 1.51e-02 GO:0060429 epithelium development
1.28 1.59e-02 GO:0048513 organ development
1.90 1.65e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.37 1.70e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.58 1.71e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.36 1.96e-02 GO:0031325 positive regulation of cellular metabolic process
1.28 2.03e-02 GO:0006464 protein modification process
3.86 2.22e-02 GO:0009954 proximal/distal pattern formation
1.50 2.36e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.71 2.84e-02 GO:0009894 regulation of catabolic process
2.29 2.87e-02 GO:0048736 appendage development
2.29 2.87e-02 GO:0060173 limb development
1.56 3.03e-02 GO:0006935 chemotaxis
1.56 3.03e-02 GO:0042330 taxis
1.61 3.16e-02 GO:0010648 negative regulation of cell communication
1.57 3.25e-02 GO:0048585 negative regulation of response to stimulus
1.61 3.25e-02 GO:0032583 regulation of gene-specific transcription
1.58 3.71e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.85 3.78e-02 GO:0051129 negative regulation of cellular component organization
1.14 3.91e-02 GO:0032501 multicellular organismal process
1.65 4.04e-02 GO:0009792 embryo development ending in birth or egg hatching

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 6.08e-04 GO:0044459 plasma membrane part
2.20 1.12e-03 GO:0034703 cation channel complex
1.13 4.58e-03 GO:0005634 nucleus
1.50 5.37e-03 GO:0030054 cell junction
3.59 8.21e-03 GO:0034704 calcium channel complex
1.06 9.63e-03 GO:0005622 intracellular
1.77 3.41e-02 GO:0034702 ion channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 9.14e-09 GO:0005515 protein binding
1.57 1.40e-07 GO:0001071 nucleic acid binding transcription factor activity
1.57 1.40e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.46 1.14e-04 GO:0030528 transcription regulator activity
1.55 3.17e-04 GO:0043565 sequence-specific DNA binding
1.07 6.23e-04 GO:0005488 binding
1.63 2.30e-03 GO:0019904 protein domain specific binding
1.74 2.74e-03 GO:0016563 transcription activator activity
2.60 3.24e-03 GO:0005262 calcium channel activity
1.79 4.31e-03 GO:0005261 cation channel activity
2.03 1.77e-02 GO:0022843 voltage-gated cation channel activity
1.48 2.98e-02 GO:0008324 cation transmembrane transporter activity
1.82 4.51e-02 GO:0010843 promoter binding