Motif ID: ZIC1..3.p2

Z-value: 1.049


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ZIC3chrX_+_1366483130.349.7e-02Click!
ZIC1chr3_+_147127151-0.291.6e-01Click!
ZIC2chr13_+_100633977,
chr13_+_100634257		0.262.1e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_160183510 0.975 ACAT2
acetyl-CoA acetyltransferase 2
chr6_+_160183062 0.972 ACAT2
acetyl-CoA acetyltransferase 2
chr19_+_13263890 0.928 IER2
immediate early response 2
chr4_+_156588811 0.888 NM_001130684
 GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr17_-_27278471 0.885 NM_001033561
NM_020889
 PHF12

PHD finger protein 12

chr7_-_27224762 0.880 NM_005523
 HOXA11
homeobox A11
chr8_+_22225173 0.798 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr4_-_174450529 0.768 HAND2
heart and neural crest derivatives expressed 2
chr1_-_236030170 0.668


chr12_-_6798419 0.664 ZNF384
zinc finger protein 384
chr19_+_50145369 0.612 NM_021228
 SCAF1
SR-related CTD-associated factor 1
chr1_-_55352920 0.555 NM_014762
 DHCR24
24-dehydrocholesterol reductase
chr1_-_55352893 0.549 DHCR24
24-dehydrocholesterol reductase
chrX_-_13956530 0.546 GPM6B
glycoprotein M6B
chr8_+_22224997 0.544 NM_001135153
 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr2_+_8822112 0.541 NM_002166
 ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr19_+_39899749 0.539


chr5_+_121647385 0.538 SNCAIP
synuclein, alpha interacting protein
chr15_+_60296420 0.537 NM_012182
 FOXB1
forkhead box B1
chr1_-_55352818 0.535 DHCR24
24-dehydrocholesterol reductase

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 108 entries
enrichment   p-value GO term description
3.86 2.22e-02 GO:0009954 proximal/distal pattern formation
2.38 1.21e-02 GO:0035107 appendage morphogenesis
2.38 1.21e-02 GO:0035108 limb morphogenesis
2.29 2.87e-02 GO:0048736 appendage development
2.29 2.87e-02 GO:0060173 limb development
2.20 4.34e-06 GO:0003002 regionalization
2.13 5.29e-03 GO:0009952 anterior/posterior pattern formation
2.04 5.18e-03 GO:0048732 gland development
1.96 1.91e-05 GO:0007411 axon guidance
1.90 1.89e-05 GO:0048598 embryonic morphogenesis
1.90 1.65e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.86 4.32e-03 GO:0035295 tube development
1.85 1.40e-05 GO:0007409 axonogenesis
1.85 3.78e-02 GO:0051129 negative regulation of cellular component organization
1.83 1.90e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.80 1.64e-03 GO:0007389 pattern specification process
1.78 9.73e-05 GO:0048812 neuron projection morphogenesis
1.77 8.86e-03 GO:0060284 regulation of cell development
1.77 1.00e-02 GO:0001501 skeletal system development
1.77 1.26e-02 GO:0022603 regulation of anatomical structure morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
3.59 8.21e-03 GO:0034704 calcium channel complex
2.20 1.12e-03 GO:0034703 cation channel complex
1.77 3.41e-02 GO:0034702 ion channel complex
1.50 5.37e-03 GO:0030054 cell junction
1.27 6.08e-04 GO:0044459 plasma membrane part
1.13 4.58e-03 GO:0005634 nucleus
1.06 9.63e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
2.60 3.24e-03 GO:0005262 calcium channel activity
2.03 1.77e-02 GO:0022843 voltage-gated cation channel activity
1.82 4.51e-02 GO:0010843 promoter binding
1.79 4.31e-03 GO:0005261 cation channel activity
1.74 2.74e-03 GO:0016563 transcription activator activity
1.63 2.30e-03 GO:0019904 protein domain specific binding
1.57 1.40e-07 GO:0001071 nucleic acid binding transcription factor activity
1.57 1.40e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.55 3.17e-04 GO:0043565 sequence-specific DNA binding
1.48 2.98e-02 GO:0008324 cation transmembrane transporter activity
1.46 1.14e-04 GO:0030528 transcription regulator activity
1.17 9.14e-09 GO:0005515 protein binding
1.07 6.23e-04 GO:0005488 binding