Motif ID: bHLH_family.p2

Z-value: 1.692


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ID1chr20_+_30193083-0.724.5e-05Click!
TFE3chrX_-_489009320.717.2e-05Click!
HEY1chr8_-_806798970.629.9e-04Click!
ARNTL2chr12_+_274857670.582.2e-03Click!
HEYLchr1_-_401053410.395.1e-02Click!
CLOCKchr4_-_564129680.386.2e-02Click!
HEY2chr6_+_1260708950.386.3e-02Click!
OLIG2chr21_+_343982100.377.1e-02Click!
MNTchr17_-_2304217-0.331.1e-01Click!
NPAS2chr2_+_101436491-0.321.2e-01Click!
HES6chr2_-_239148545,
chr2_-_239148626		-0.223.0e-01Click!
ARNTLchr11_+_132992600.174.2e-01Click!
MXD3chr5_-_176738831-0.145.0e-01Click!
MLXIPLchr7_-_73038814-0.116.0e-01Click!
MITFchr3_+_698129610.116.1e-01Click!
MXD4chr4_-_22637060.106.4e-01Click!
MXI1chr10_+_111969988,
chr10_+_111985628		-0.077.2e-01Click!
OLIG1chr21_+_34444004,
chr21_+_34442550		0.019.6e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_89182038 9.688 NM_002201
 ISG20
interferon stimulated exonuclease gene 20kDa
chr14_-_55369163 6.900 NM_000161
NM_001024024
NM_001024070
NM_001024071
 GCH1



GTP cyclohydrolase 1



chr8_+_17354562 5.476 NM_001008539
 SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr6_+_37137882 4.721 NM_001243186
NM_002648
 PIM1

pim-1 oncogene

chr6_+_138188352 4.653 NM_006290
 TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr19_+_18284578 4.322 NM_006332
 IFI30
interferon, gamma-inducible protein 30
chr5_-_150466696 4.170 NM_001252391
NM_001252392
 TNIP1

TNFAIP3 interacting protein 1

chr19_+_676346 3.939 NM_005860
 FSTL3
follistatin-like 3 (secreted glycoprotein)
chr21_+_37507209 3.878 NM_001236
 CBR3
carbonyl reductase 3
chr1_+_183155393 3.806 LAMC2
laminin, gamma 2
chr17_+_40440481 3.728 STAT5A
signal transducer and activator of transcription 5A
chr1_-_154193044 3.663 C1orf43
chromosome 1 open reading frame 43
chr19_-_10764449 3.621 LOC147727
uncharacterized LOC147727
chr9_+_115913266 3.602 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr15_+_67358194 3.496 NM_005902
 SMAD3
SMAD family member 3
chr8_-_8750739 3.392 NM_004225
 MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr5_-_150467220 2.862 NM_001252390
 TNIP1
TNFAIP3 interacting protein 1
chr12_-_121734543 2.841 NM_172226
 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr22_+_41697452 2.815 NM_017590
 ZC3H7B
zinc finger CCCH-type containing 7B
chr7_+_28448970 2.749 LOC401317
uncharacterized LOC401317

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.01 2.38e-02 GO:0042254 ribosome biogenesis
1.98 1.67e-02 GO:0007005 mitochondrion organization
1.36 9.23e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.36 2.45e-02 GO:0016265 death
1.35 1.59e-02 GO:0009892 negative regulation of metabolic process
1.35 2.80e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.35 4.07e-02 GO:0008219 cell death
1.31 3.35e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.30 1.69e-04 GO:0010467 gene expression
1.29 3.85e-02 GO:0009893 positive regulation of metabolic process
1.25 2.84e-02 GO:0016070 RNA metabolic process
1.24 3.31e-03 GO:0048523 negative regulation of cellular process
1.23 2.05e-02 GO:0030154 cell differentiation
1.21 3.97e-05 GO:0051179 localization
1.20 5.81e-03 GO:0006810 transport
1.20 3.89e-02 GO:0048519 negative regulation of biological process
1.19 5.97e-03 GO:0051234 establishment of localization
1.17 1.72e-02 GO:0007275 multicellular organismal development
1.17 3.35e-02 GO:0048856 anatomical structure development
1.15 1.47e-02 GO:0044260 cellular macromolecule metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
4.41 3.21e-02 GO:0005732 small nucleolar ribonucleoprotein complex
1.73 1.48e-08 GO:0005730 nucleolus
1.53 1.53e-02 GO:0048471 perinuclear region of cytoplasm
1.34 4.13e-02 GO:0031967 organelle envelope
1.32 8.18e-07 GO:0031981 nuclear lumen
1.30 4.90e-07 GO:0044428 nuclear part
1.27 1.91e-06 GO:0031974 membrane-enclosed lumen
1.26 1.82e-05 GO:0043233 organelle lumen
1.26 2.03e-05 GO:0070013 intracellular organelle lumen
1.22 3.12e-03 GO:0005829 cytosol
1.20 5.71e-04 GO:0043228 non-membrane-bounded organelle
1.20 5.71e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.14 2.51e-05 GO:0044422 organelle part
1.14 4.22e-05 GO:0044446 intracellular organelle part
1.14 5.10e-05 GO:0005634 nucleus
1.12 5.23e-08 GO:0005737 cytoplasm
1.11 3.67e-03 GO:0044444 cytoplasmic part
1.09 7.09e-09 GO:0005622 intracellular
1.09 9.82e-09 GO:0044424 intracellular part
1.09 1.17e-03 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.18 6.91e-14 GO:0005515 protein binding
1.08 5.17e-07 GO:0005488 binding