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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for AACACUG
Z-value: 0.82
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miRNA associated with seed AACACUG
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_84543734 Show fit | 3.38 |
ENST00000370689.2
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr3_+_39851094 Show fit | 2.91 |
ENST00000302541.6
|
myosin VIIA and Rab interacting protein |
|
| chr10_-_81205373 Show fit | 2.85 |
ENST00000372336.3
|
zinc finger, CCHC domain containing 24 |
|
| chr4_-_186877502 Show fit | 2.62 |
ENST00000431902.1
ENST00000284776.7 ENST00000415274.1 |
sorbin and SH3 domain containing 2 |
|
| chr6_-_16761678 Show fit | 2.45 |
ENST00000244769.4
ENST00000436367.1 |
ataxin 1 |
|
| chr1_+_61547894 Show fit | 2.45 |
ENST00000403491.3
|
nuclear factor I/A |
|
| chr12_-_42877764 Show fit | 2.06 |
ENST00000455697.1
|
prickle homolog 1 (Drosophila) |
|
| chr10_-_33623564 Show fit | 2.04 |
ENST00000374875.1
ENST00000374822.4 |
neuropilin 1 |
|
| chr17_+_68165657 Show fit | 1.87 |
ENST00000243457.3
|
potassium inwardly-rectifying channel, subfamily J, member 2 |
|
| chr17_-_8534067 Show fit | 1.81 |
ENST00000360416.3
ENST00000269243.4 |
myosin, heavy chain 10, non-muscle |
Network of associatons between targets according to the STRING database.
First level regulatory network of AACACUG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.1 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.5 | 3.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 2.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 2.4 | GO:0072189 | ureter development(GO:0072189) |
| 0.5 | 2.1 | GO:2000691 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.4 | 2.0 | GO:1902378 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.5 | 1.9 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.1 | 1.9 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 1.8 | GO:0032094 | response to food(GO:0032094) |
| 0.6 | 1.7 | GO:0021793 | chemorepulsion of branchiomotor axon(GO:0021793) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 3.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 3.6 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 2.8 | GO:0031045 | dense core granule(GO:0031045) |
| 0.4 | 2.5 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.0 | 2.2 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 1.9 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.4 | 1.8 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.0 | 1.2 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 1.2 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.2 | 3.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 2.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.4 | 2.5 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.2 | 2.0 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.1 | 1.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 1.8 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 1.6 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 1.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 1.3 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.1 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.6 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 1.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 1.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.1 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 1.0 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.9 | PID IFNG PATHWAY | IFN-gamma pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.1 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 2.1 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.4 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 1.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 1.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |