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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for AAGGCAC
Z-value: 0.57
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miRNA associated with seed AAGGCAC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-124-3p.1
|
MIMAT0000422 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_72385437 Show fit | 0.59 |
ENST00000418754.2
ENST00000542969.2 ENST00000334456.5 |
phosphodiesterase 2A, cGMP-stimulated |
|
| chr2_+_112812778 Show fit | 0.57 |
ENST00000283206.4
|
transmembrane protein 87B |
|
| chr5_-_59189545 Show fit | 0.54 |
ENST00000340635.6
|
phosphodiesterase 4D, cAMP-specific |
|
| chr3_-_164913777 Show fit | 0.48 |
ENST00000475390.1
|
SLIT and NTRK-like family, member 3 |
|
| chr5_+_127419449 Show fit | 0.47 |
ENST00000262461.2
ENST00000343225.4 |
solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
|
| chr7_-_25019760 Show fit | 0.47 |
ENST00000352860.1
ENST00000353930.1 ENST00000431825.2 ENST00000313367.2 |
oxysterol binding protein-like 3 |
|
| chr17_-_8151353 Show fit | 0.45 |
ENST00000315684.8
|
CTS telomere maintenance complex component 1 |
|
| chr7_-_108096822 Show fit | 0.45 |
ENST00000379028.3
ENST00000413765.2 ENST00000379022.4 |
neuronal cell adhesion molecule |
|
| chr3_+_29322803 Show fit | 0.44 |
ENST00000396583.3
ENST00000383767.2 |
RNA binding motif, single stranded interacting protein 3 |
|
| chr5_-_179780312 Show fit | 0.42 |
ENST00000253778.8
|
glutamine-fructose-6-phosphate transaminase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AAGGCAC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 0.2 | 0.5 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.1 | 0.5 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.1 | 0.5 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.0 | 0.5 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.0 | 0.5 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 0.4 | GO:0071934 | thiamine transmembrane transport(GO:0071934) |
| 0.1 | 0.4 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.1 | 0.4 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.1 | 0.4 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.6 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 0.5 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.4 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.4 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
| 0.0 | 0.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 0.2 | GO:0042565 | RNA nuclear export complex(GO:0042565) |
| 0.1 | 0.2 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.0 | 0.2 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 0.2 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 0.5 | GO:0019798 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.0 | 0.5 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 0.5 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 0.5 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 0.4 | GO:0015403 | thiamine uptake transmembrane transporter activity(GO:0015403) |
| 0.0 | 0.4 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.4 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.0 | 0.4 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 0.4 | GO:0015377 | cation:chloride symporter activity(GO:0015377) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 0.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.5 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.4 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.3 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.3 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |