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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for AAUACUG
Z-value: 0.78
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miRNA associated with seed AAUACUG
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_156588350 Show fit | 2.89 |
ENST00000296518.7
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr13_-_72441315 Show fit | 2.47 |
ENST00000305425.4
ENST00000313174.7 ENST00000354591.4 |
dachshund homolog 1 (Drosophila) |
|
| chr1_+_84543734 Show fit | 1.95 |
ENST00000370689.2
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr1_+_61547894 Show fit | 1.69 |
ENST00000403491.3
|
nuclear factor I/A |
|
| chr7_-_11871815 Show fit | 1.56 |
ENST00000423059.4
|
thrombospondin, type I, domain containing 7A |
|
| chr10_-_81205373 Show fit | 1.29 |
ENST00000372336.3
|
zinc finger, CCHC domain containing 24 |
|
| chr9_-_14314066 Show fit | 1.29 |
ENST00000397575.3
|
nuclear factor I/B |
|
| chr12_+_79258547 Show fit | 1.28 |
ENST00000457153.2
|
synaptotagmin I |
|
| chr13_-_107187462 Show fit | 1.25 |
ENST00000245323.4
|
ephrin-B2 |
|
| chr10_+_102106829 Show fit | 1.07 |
ENST00000370355.2
|
stearoyl-CoA desaturase (delta-9-desaturase) |
Network of associatons between targets according to the STRING database.
First level regulatory network of AAUACUG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.9 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.4 | 2.9 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.3 | 2.5 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.1 | 1.6 | GO:0048845 | venous blood vessel morphogenesis(GO:0048845) |
| 0.0 | 1.5 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.4 | 1.3 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.2 | 1.3 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.4 | 1.1 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.0 | 1.1 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.1 | 1.0 | GO:0060120 | auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 2.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.3 | 1.3 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 1.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 1.0 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.1 | 1.0 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 0.9 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 0.9 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 2.3 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.1 | 1.9 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 1.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 1.4 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.2 | 1.3 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.0 | 1.2 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.2 | 1.1 | GO:0016215 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.0 | 1.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 1.0 | GO:0005112 | Notch binding(GO:0005112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.9 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 0.8 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.8 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 2.8 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 2.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.3 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 1.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.1 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.0 | 1.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 1.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.9 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.9 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |