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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for AAUCUCA

Z-value: 0.15

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miRNA associated with seed AAUCUCA

NamemiRBASE accession
hsa-miR-216a-5p
MIMAT0000273

Activity profile of AAUCUCA motif

Sorted Z-values of AAUCUCA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_22932080 0.47 ENST00000584787.1
ENST00000361524.3
ENST00000538137.2
ZNF521
zinc finger protein 521
chr11_+_74459876 0.22 ENST00000299563.4
RNF169
ring finger protein 169
chr7_+_12250886 0.22 ENST00000444443.1
ENST00000396667.3
TMEM106B
transmembrane protein 106B
chr9_-_20622478 0.19 ENST00000355930.6
ENST00000380338.4
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr18_+_59992527 0.17 ENST00000586569.1
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr6_-_44265411 0.12 ENST00000371505.4
TCTE1
t-complex-associated-testis-expressed 1
chr6_+_42749759 0.11 ENST00000314073.5
GLTSCR1L
GLTSCR1-like
chrX_-_20284958 0.10 ENST00000379565.3
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr17_-_73975444 0.09 ENST00000293217.5
ENST00000537812.1
ACOX1
acyl-CoA oxidase 1, palmitoyl
chr13_-_31038370 0.07 ENST00000399489.1
ENST00000339872.4
HMGB1
high mobility group box 1
chr4_+_99916765 0.06 ENST00000296411.6
METAP1
methionyl aminopeptidase 1
chr5_+_122424816 0.05 ENST00000407847.4
PRDM6
PR domain containing 6
chr1_-_53793584 0.05 ENST00000354412.3
ENST00000347547.2
ENST00000306052.6
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr18_+_59854480 0.04 ENST00000256858.6
ENST00000398130.2
KIAA1468
KIAA1468
chr1_-_67896095 0.02 ENST00000370994.4
SERBP1
SERPINE1 mRNA binding protein 1
chr17_+_30677136 0.02 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
ZNF207
zinc finger protein 207
chr14_-_80677970 0.02 ENST00000438257.4
DIO2
deiodinase, iodothyronine, type II
chr13_-_45915221 0.01 ENST00000309246.5
ENST00000379060.4
ENST00000379055.1
ENST00000527226.1
ENST00000379056.1
TPT1
tumor protein, translationally-controlled 1
chr5_+_149109825 0.01 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr5_-_178054105 0.01 ENST00000316308.4
CLK4
CDC-like kinase 4
chr17_+_53342311 0.01 ENST00000226067.5
HLF
hepatic leukemia factor
chr7_+_35840542 0.01 ENST00000435235.1
ENST00000399034.2
ENST00000350320.6
ENST00000469679.2
SEPT7
septin 7
chr10_+_11206925 0.00 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr15_+_40733387 0.00 ENST00000416165.1
BAHD1
bromo adjacent homology domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of AAUCUCA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0071810 circadian temperature homeostasis(GO:0060086) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009)
0.0 0.1 GO:0002840 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.1 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)