ISMARA results: ACAUUCA

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ACAUUCA

Z-value: 0.56

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miRNA associated with seed ACAUUCA

Name	miRBASE accession
hsa-miR-181a-5p miRBase	MIMAT0000256
hsa-miR-181b-5p miRBase	MIMAT0000257
hsa-miR-181c-5p miRBase	MIMAT0000258
hsa-miR-181d-5p miRBase	MIMAT0002821
hsa-miR-4262 miRBase	MIMAT0016894

Activity profile of ACAUUCA motif

Sorted Z-values of ACAUUCA motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_91793675 Show fit	0.38	ENST00000375835.4 ENST00000375830.1	SHC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SHC (Src homology 2 domain containing) transforming protein 3
chr10_+_102106829 Show fit	0.36	ENST00000370355.2	SCD Ensembl NCBI GeneCards UniProt NextProt Show fit	stearoyl-CoA desaturase (delta-9-desaturase)
chr5_-_100238956 Show fit	0.33	ENST00000231461.5	ST8SIA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr3_-_179169330 Show fit	0.33	ENST00000232564.3	GNB4 Ensembl NCBI GeneCards UniProt NextProt Show fit	guanine nucleotide binding protein (G protein), beta polypeptide 4
chr2_-_208030647 Show fit	0.32	ENST00000309446.6	KLF7 Ensembl NCBI GeneCards UniProt NextProt Show fit	Kruppel-like factor 7 (ubiquitous)
chr12_+_120884222 Show fit	0.30	ENST00000551765.1 ENST00000229384.5	GATC Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamyl-tRNA(Gln) amidotransferase, subunit C
chr1_+_214161272 Show fit	0.30	ENST00000498508.2 ENST00000366958.4	PROX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	prospero homeobox 1
chr16_-_46865047 Show fit	0.30	ENST00000394806.2	C16orf87 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 16 open reading frame 87
chr5_+_156887027 Show fit	0.29	ENST00000435489.2 ENST00000311946.7	NIPAL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	NIPA-like domain containing 4
chr14_+_53019822 Show fit	0.28	ENST00000321662.6	GPR137C Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 137C

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ACAUUCA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1	0.3	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.1	0.3	GO:0002194	hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0	0.3	GO:0090625	mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0	0.3	GO:1904550	chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0	0.3	GO:0060978	angiogenesis involved in coronary vascular morphogenesis(GO:0060978)
0.0	0.3	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0	0.3	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.3	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.3	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)

Showing 1 to 10 of 107 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0	0.3	GO:1990589	ATF4-CREB1 transcription factor complex(GO:1990589)
0.0	0.3	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.0	0.3	GO:0031209	SCAR complex(GO:0031209)
0.0	0.3	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.2	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.2	GO:0035838	growing cell tip(GO:0035838)
0.0	0.2	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.2	GO:0042587	glycogen granule(GO:0042587)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1	0.3	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0	0.3	GO:1990763	arrestin family protein binding(GO:1990763)
0.0	0.3	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.3	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.3	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.1	0.2	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
0.1	0.2	GO:0098808	mRNA cap binding(GO:0098808)
0.1	0.2	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.2	GO:0010861	thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)

Showing 1 to 10 of 64 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.4	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	PID IL2 1PATHWAY	IL2-mediated signaling events
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Showing 1 to 4 of 4 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.5	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.5	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.4	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR

Showing 1 to 9 of 9 entries

Results for ACAUUCA

Z-value: 0.56

Motif logo

miRNA associated with seed ACAUUCA

Activity profile of ACAUUCA motif

Sorted Z-values of ACAUUCA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ACAUUCA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: