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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ACCCUGU

Z-value: 0.27

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miRNA associated with seed ACCCUGU

NamemiRBASE accession
hsa-miR-10a-5p
MIMAT0000253
hsa-miR-10b-5p
MIMAT0000254

Activity profile of ACCCUGU motif

Sorted Z-values of ACCCUGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_146859623 0.40 ENST00000379448.4
ENST00000513320.1
ZNF827
zinc finger protein 827
chr7_-_92463210 0.32 ENST00000265734.4
CDK6
cyclin-dependent kinase 6
chr6_-_10415470 0.31 ENST00000379604.2
ENST00000379613.3
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_110082487 0.30 ENST00000527748.1
GPR61
G protein-coupled receptor 61
chr2_+_64681219 0.28 ENST00000238875.5
LGALSL
lectin, galactoside-binding-like
chr19_+_13135386 0.22 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr20_+_55204351 0.21 ENST00000201031.2
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr15_+_42066632 0.20 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr5_-_45696253 0.20 ENST00000303230.4
HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr22_+_45559722 0.19 ENST00000347635.4
ENST00000407019.2
ENST00000424634.1
ENST00000417702.1
ENST00000425733.2
ENST00000430547.1
NUP50
nucleoporin 50kDa
chr7_+_20370746 0.18 ENST00000222573.4
ITGB8
integrin, beta 8
chr14_+_45366472 0.18 ENST00000325192.3
C14orf28
chromosome 14 open reading frame 28
chr2_+_23608064 0.18 ENST00000486442.1
KLHL29
kelch-like family member 29
chr6_-_91006461 0.17 ENST00000257749.4
ENST00000343122.3
ENST00000406998.2
ENST00000453877.1
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr17_-_49198216 0.17 ENST00000262013.7
ENST00000357122.4
SPAG9
sperm associated antigen 9
chr14_+_70078303 0.17 ENST00000342745.4
KIAA0247
KIAA0247
chr5_-_160973649 0.17 ENST00000393959.1
ENST00000517547.1
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr17_-_48207157 0.16 ENST00000330175.4
ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr17_-_76713100 0.15 ENST00000585509.1
CYTH1
cytohesin 1
chr10_-_121632266 0.15 ENST00000360003.3
ENST00000369077.3
MCMBP
minichromosome maintenance complex binding protein
chr22_-_17602200 0.15 ENST00000399875.1
CECR6
cat eye syndrome chromosome region, candidate 6
chr2_+_166326157 0.14 ENST00000421875.1
ENST00000314499.7
ENST00000409664.1
CSRNP3
cysteine-serine-rich nuclear protein 3
chrX_+_9431324 0.14 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr10_-_62149433 0.13 ENST00000280772.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr18_+_9136758 0.13 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr21_+_45285050 0.12 ENST00000291572.8
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr9_-_127533519 0.12 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr4_-_53525406 0.12 ENST00000451218.2
ENST00000441222.3
USP46
ubiquitin specific peptidase 46
chr1_-_39339777 0.12 ENST00000397572.2
MYCBP
MYC binding protein
chr8_+_1449532 0.12 ENST00000421627.2
DLGAP2
discs, large (Drosophila) homolog-associated protein 2
chr17_+_34058639 0.11 ENST00000268864.3
RASL10B
RAS-like, family 10, member B
chr4_+_47033345 0.11 ENST00000295454.3
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr14_+_23775971 0.11 ENST00000250405.5
BCL2L2
BCL2-like 2
chr1_-_38325256 0.11 ENST00000373036.4
MTF1
metal-regulatory transcription factor 1
chr3_-_142166904 0.11 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr5_+_143584814 0.11 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr12_-_77459306 0.11 ENST00000547316.1
ENST00000416496.2
ENST00000550669.1
ENST00000322886.7
E2F7
E2F transcription factor 7
chr3_+_85008089 0.10 ENST00000383699.3
CADM2
cell adhesion molecule 2
chr10_-_75173785 0.10 ENST00000535178.1
ENST00000372921.5
ENST00000372919.4
ANXA7
annexin A7
chr14_+_33408449 0.10 ENST00000346562.2
ENST00000341321.4
ENST00000548645.1
ENST00000356141.4
ENST00000357798.5
NPAS3
neuronal PAS domain protein 3
chr12_-_133405288 0.09 ENST00000204726.3
GOLGA3
golgin A3
chr9_+_100263912 0.09 ENST00000259365.4
TMOD1
tropomodulin 1
chr17_-_27621125 0.09 ENST00000579665.1
ENST00000225388.4
NUFIP2
nuclear fragile X mental retardation protein interacting protein 2
chr15_-_56209306 0.09 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
chr2_+_176981307 0.09 ENST00000249501.4
HOXD10
homeobox D10
chr2_-_208030647 0.09 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chrX_+_117629766 0.08 ENST00000276204.6
ENST00000276202.7
DOCK11
dedicator of cytokinesis 11
chr17_+_46125707 0.08 ENST00000584137.1
ENST00000362042.3
ENST00000585291.1
ENST00000357480.5
NFE2L1
nuclear factor, erythroid 2-like 1
chr19_+_19496624 0.08 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A
GATA zinc finger domain containing 2A
chr2_+_121103706 0.08 ENST00000295228.3
INHBB
inhibin, beta B
chr5_+_167181917 0.08 ENST00000519204.1
TENM2
teneurin transmembrane protein 2
chr1_+_109632425 0.08 ENST00000338272.8
TMEM167B
transmembrane protein 167B
chr22_+_39898325 0.08 ENST00000325301.2
ENST00000404569.1
MIEF1
mitochondrial elongation factor 1
chr18_+_19749386 0.07 ENST00000269216.3
GATA6
GATA binding protein 6
chr9_-_23821273 0.07 ENST00000380110.4
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr9_+_77112244 0.07 ENST00000376896.3
RORB
RAR-related orphan receptor B
chr14_-_47812321 0.07 ENST00000357362.3
ENST00000486952.2
ENST00000426342.1
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr7_-_106301405 0.07 ENST00000523505.1
CCDC71L
coiled-coil domain containing 71-like
chr10_+_72972281 0.07 ENST00000335350.6
UNC5B
unc-5 homolog B (C. elegans)
chr11_+_66025167 0.06 ENST00000394067.2
ENST00000316924.5
ENST00000421552.1
ENST00000394078.1
KLC2
kinesin light chain 2
chr9_+_129567282 0.06 ENST00000449886.1
ENST00000373464.4
ENST00000450858.1
ZBTB43
zinc finger and BTB domain containing 43
chr3_-_179754706 0.06 ENST00000465751.1
ENST00000467460.1
PEX5L
peroxisomal biogenesis factor 5-like
chr17_+_45727204 0.06 ENST00000290158.4
KPNB1
karyopherin (importin) beta 1
chr6_+_117002339 0.06 ENST00000413340.1
ENST00000368564.1
ENST00000356348.1
KPNA5
karyopherin alpha 5 (importin alpha 6)
chr9_+_112403088 0.06 ENST00000448454.2
PALM2
paralemmin 2
chr2_-_166060571 0.06 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr11_-_115375107 0.05 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1
cell adhesion molecule 1
chr6_-_146135880 0.05 ENST00000237281.4
FBXO30
F-box protein 30
chr2_+_111878483 0.05 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2L11
BCL2-like 11 (apoptosis facilitator)
chr10_-_79686284 0.05 ENST00000372391.2
ENST00000372388.2
DLG5
discs, large homolog 5 (Drosophila)
chr1_-_94374946 0.05 ENST00000370238.3
GCLM
glutamate-cysteine ligase, modifier subunit
chr4_+_184020398 0.05 ENST00000403733.3
ENST00000378925.3
WWC2
WW and C2 domain containing 2
chr1_-_217262969 0.05 ENST00000361525.3
ESRRG
estrogen-related receptor gamma
chrX_+_49687216 0.05 ENST00000376088.3
CLCN5
chloride channel, voltage-sensitive 5
chr10_+_98592009 0.05 ENST00000540664.1
ENST00000371103.3
LCOR
ligand dependent nuclear receptor corepressor
chr17_+_36861735 0.05 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr10_-_128994422 0.05 ENST00000522781.1
FAM196A
family with sequence similarity 196, member A
chr20_+_31407692 0.05 ENST00000375571.5
MAPRE1
microtubule-associated protein, RP/EB family, member 1
chr3_-_196159268 0.05 ENST00000381887.3
ENST00000535858.1
ENST00000428095.1
ENST00000296328.4
UBXN7
UBX domain protein 7
chr2_-_206950781 0.04 ENST00000403263.1
INO80D
INO80 complex subunit D
chr18_+_43914159 0.04 ENST00000588679.1
ENST00000269439.7
ENST00000543885.1
RNF165
ring finger protein 165
chr19_+_1407517 0.04 ENST00000336761.6
ENST00000233078.4
DAZAP1
DAZ associated protein 1
chr12_+_69864129 0.04 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
FRS2
fibroblast growth factor receptor substrate 2
chr9_-_115983641 0.03 ENST00000238256.3
FKBP15
FK506 binding protein 15, 133kDa
chr11_-_18656028 0.03 ENST00000336349.5
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr4_-_114900831 0.03 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr18_-_45456930 0.03 ENST00000262160.6
ENST00000587269.1
SMAD2
SMAD family member 2
chr1_-_19283163 0.03 ENST00000455833.2
IFFO2
intermediate filament family orphan 2
chr9_-_130661916 0.03 ENST00000373142.1
ENST00000373146.1
ENST00000373144.3
ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr4_-_100575781 0.03 ENST00000511828.1
RP11-766F14.2
Protein LOC285556
chr1_-_39347255 0.03 ENST00000454994.2
ENST00000357771.3
GJA9
gap junction protein, alpha 9, 59kDa
chr4_+_3076388 0.03 ENST00000355072.5
HTT
huntingtin
chr9_-_95527079 0.02 ENST00000356884.6
ENST00000375512.3
BICD2
bicaudal D homolog 2 (Drosophila)
chr5_+_149109825 0.02 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr1_+_169337172 0.02 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr3_-_9994021 0.02 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr16_+_50187556 0.02 ENST00000561678.1
ENST00000357464.3
PAPD5
PAP associated domain containing 5
chr10_-_88281494 0.02 ENST00000298767.5
WAPAL
wings apart-like homolog (Drosophila)
chr3_+_238273 0.02 ENST00000256509.2
CHL1
cell adhesion molecule L1-like
chr17_-_1359443 0.02 ENST00000574295.1
ENST00000398970.5
ENST00000300574.2
CRK
v-crk avian sarcoma virus CT10 oncogene homolog
chr5_+_179921430 0.02 ENST00000393356.1
CNOT6
CCR4-NOT transcription complex, subunit 6
chr17_+_4487294 0.02 ENST00000338859.4
SMTNL2
smoothelin-like 2
chr1_+_89990431 0.01 ENST00000330947.2
ENST00000358200.4
LRRC8B
leucine rich repeat containing 8 family, member B
chr1_-_85156216 0.01 ENST00000342203.3
ENST00000370612.4
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr9_-_86595503 0.01 ENST00000376281.4
ENST00000376264.2
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr11_+_113930291 0.01 ENST00000335953.4
ZBTB16
zinc finger and BTB domain containing 16
chr2_-_69870835 0.01 ENST00000409085.4
ENST00000406297.3
AAK1
AP2 associated kinase 1
chr7_-_44924939 0.01 ENST00000395699.2
PURB
purine-rich element binding protein B
chr13_+_98086445 0.01 ENST00000245304.4
RAP2A
RAP2A, member of RAS oncogene family
chr19_-_55954230 0.01 ENST00000376325.4
SHISA7
shisa family member 7
chr14_+_99947715 0.01 ENST00000389879.5
ENST00000557441.1
ENST00000555049.1
ENST00000555842.1
CCNK
cyclin K
chr5_+_63461642 0.01 ENST00000296615.6
ENST00000381081.2
ENST00000389100.4
RNF180
ring finger protein 180
chrX_-_129402857 0.01 ENST00000447817.1
ENST00000370978.4
ZNF280C
zinc finger protein 280C
chrX_-_54384425 0.01 ENST00000375169.3
ENST00000354646.2
WNK3
WNK lysine deficient protein kinase 3
chr7_-_112430647 0.01 ENST00000312814.6
TMEM168
transmembrane protein 168
chr8_-_41655107 0.01 ENST00000347528.4
ENST00000289734.7
ENST00000379758.2
ENST00000396945.1
ENST00000396942.1
ENST00000352337.4
ANK1
ankyrin 1, erythrocytic
chr15_+_44719394 0.00 ENST00000260327.4
ENST00000396780.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr1_+_28052456 0.00 ENST00000373954.6
ENST00000419687.2
FAM76A
family with sequence similarity 76, member A
chr11_+_18344106 0.00 ENST00000534641.1
ENST00000525831.1
ENST00000265963.4
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr4_+_154125565 0.00 ENST00000338700.5
TRIM2
tripartite motif containing 2
chr4_-_111119804 0.00 ENST00000394607.3
ENST00000302274.3
ELOVL6
ELOVL fatty acid elongase 6
chr2_-_37193606 0.00 ENST00000379213.2
ENST00000263918.4
STRN
striatin, calmodulin binding protein
chr17_-_29151794 0.00 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr17_-_56084578 0.00 ENST00000582730.2
ENST00000584773.1
ENST00000585096.1
ENST00000258962.4
SRSF1
serine/arginine-rich splicing factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ACCCUGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003409 optic cup structural organization(GO:0003409)
0.0 0.1 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.0 0.3 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.1 GO:0071930 positive regulation of DNA endoreduplication(GO:0032877) negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0 0.1 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 0.1 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.0 0.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.2 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.3 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.1 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.0 0.1 GO:0060139 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.0 0.1 GO:1904387 cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.0 0.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.0 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 0.1 GO:0031291 Ran protein signal transduction(GO:0031291)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0098855 HCN channel complex(GO:0098855)
0.1 0.2 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 0.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.1 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0050816 phosphoserine binding(GO:0050815) phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)