ISMARA results: AGCAGCA

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for AGCAGCA

Z-value: 0.92

Motif logo

miRNA associated with seed AGCAGCA

Name	miRBASE accession
hsa-miR-15a-5p miRBase	MIMAT0000068
hsa-miR-15b-5p miRBase	MIMAT0000417
hsa-miR-16-5p miRBase	MIMAT0000069
hsa-miR-195-5p miRBase	MIMAT0000461
hsa-miR-424-5p miRBase	MIMAT0001341
hsa-miR-497-5p miRBase	MIMAT0002820
hsa-miR-6838-5p miRBase	MIMAT0027578

Activity profile of AGCAGCA motif

Sorted Z-values of AGCAGCA motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_76944621 Show fit	4.95	ENST00000306602.1	CXCL10 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-X-C motif) ligand 10
chr16_+_57406368 Show fit	3.08	ENST00000006053.6 ENST00000563383.1	CX3CL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-X3-C motif) ligand 1
chr8_+_23386305 Show fit	2.96	ENST00000519973.1	SLC25A37 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 25 (mitochondrial iron transporter), member 37
chr19_+_4229495 Show fit	2.92	ENST00000221847.5	EBI3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Epstein-Barr virus induced 3
chr8_+_23430157 Show fit	2.88	ENST00000399967.3	FP15737 Ensembl NCBI GeneCards UniProt NextProt Show fit	FP15737
chr1_+_65613217 Show fit	2.66	ENST00000545314.1	AK4 Ensembl NCBI GeneCards UniProt NextProt Show fit	adenylate kinase 4
chr8_+_17354587 Show fit	2.63	ENST00000494857.1 ENST00000522656.1	SLC7A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr5_+_127419449 Show fit	2.55	ENST00000262461.2 ENST00000343225.4	SLC12A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr6_-_134639180 Show fit	2.50	ENST00000367858.5	SGK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serum/glucocorticoid regulated kinase 1
chr3_-_123603137 Show fit	2.40	ENST00000360304.3 ENST00000359169.1 ENST00000346322.5 ENST00000360772.3	MYLK Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain kinase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of AGCAGCA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.2	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)
1.0	3.1	GO:0050902	leukocyte adhesive activation(GO:0050902)
0.3	3.1	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
1.0	3.0	GO:0048250	mitochondrial iron ion transport(GO:0048250)
0.2	2.9	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.9	2.6	GO:1903410	lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.9	2.6	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.4	2.5	GO:2001038	regulation of cellular response to drug(GO:2001038)
0.3	2.5	GO:0070294	renal sodium ion absorption(GO:0070294)
0.2	2.5	GO:0060413	atrial septum morphogenesis(GO:0060413)

Showing 1 to 10 of 253 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	2.5	GO:0032587	ruffle membrane(GO:0032587)
0.0	2.2	GO:0005643	nuclear pore(GO:0005643)
0.2	1.9	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.2	1.8	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	1.6	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	1.4	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	1.4	GO:0016328	lateral plasma membrane(GO:0016328)
0.1	1.3	GO:0033010	paranodal junction(GO:0033010)
0.0	1.3	GO:0097542	ciliary tip(GO:0097542)

Showing 1 to 10 of 96 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	5.0	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.1	3.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.2	3.0	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.1	2.8	GO:0017081	chloride channel regulator activity(GO:0017081)
0.5	2.7	GO:0046899	nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.7	2.6	GO:0005292	high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.2	2.6	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.4	2.4	GO:0038049	transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.2	2.3	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	2.2	GO:0005109	frizzled binding(GO:0005109)

Showing 1 to 10 of 161 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	3.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	2.9	PID IL27 PATHWAY	IL27-mediated signaling events
0.1	2.9	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	2.7	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	2.2	PID NOTCH PATHWAY	Notch signaling pathway
0.1	2.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	1.9	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	1.8	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	1.1	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	4.1	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	3.1	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	2.6	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	2.4	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.1	2.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	2.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	2.2	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	1.9	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1	1.9	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac

Showing 1 to 10 of 69 entries

Results for AGCAGCA

Z-value: 0.92

Motif logo

miRNA associated with seed AGCAGCA

Activity profile of AGCAGCA motif

Sorted Z-values of AGCAGCA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of AGCAGCA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: