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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for AGCUGCC
Z-value: 0.44
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miRNA associated with seed AGCUGCC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-22-3p
|
MIMAT0000077 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29527702 Show fit | 2.13 |
ENST00000377050.4
|
ubiquitin D |
|
| chr8_+_17354587 Show fit | 1.81 |
ENST00000494857.1
ENST00000522656.1 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
|
| chr7_+_73703728 Show fit | 0.93 |
ENST00000361545.5
ENST00000223398.6 |
CAP-GLY domain containing linker protein 2 |
|
| chr1_-_212873267 Show fit | 0.64 |
ENST00000243440.1
|
basic leucine zipper transcription factor, ATF-like 3 |
|
| chr2_-_208030647 Show fit | 0.61 |
ENST00000309446.6
|
Kruppel-like factor 7 (ubiquitous) |
|
| chr8_-_48651648 Show fit | 0.59 |
ENST00000408965.3
|
CCAAT/enhancer binding protein (C/EBP), delta |
|
| chr14_+_70078303 Show fit | 0.56 |
ENST00000342745.4
|
KIAA0247 |
|
| chr11_-_64646086 Show fit | 0.56 |
ENST00000320631.3
|
EH-domain containing 1 |
|
| chr8_+_41435696 Show fit | 0.54 |
ENST00000396987.3
ENST00000519853.1 |
1-acylglycerol-3-phosphate O-acyltransferase 6 |
|
| chr2_+_74425689 Show fit | 0.52 |
ENST00000394053.2
ENST00000409804.1 ENST00000264090.4 ENST00000394050.3 ENST00000409601.1 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCUGCC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.1 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.6 | 1.8 | GO:1903410 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 0.1 | 0.6 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.0 | 0.6 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.2 | 0.5 | GO:1902568 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 0.1 | 0.5 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.0 | 0.5 | GO:0048149 | behavioral response to ethanol(GO:0048149) |
| 0.0 | 0.5 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 0.4 | GO:2000364 | regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366) |
| 0.1 | 0.4 | GO:0001712 | ectodermal cell fate commitment(GO:0001712) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.9 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 0.6 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.0 | 0.5 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.0 | 0.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 0.3 | GO:0005606 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
| 0.0 | 0.3 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 0.3 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 0.2 | GO:1903439 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.0 | 0.2 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.5 | 1.8 | GO:0005289 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.0 | 0.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.2 | 0.5 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
| 0.1 | 0.5 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.0 | 0.5 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 0.5 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 0.4 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.0 | 0.4 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.0 | 0.4 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.3 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.5 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.5 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.4 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.3 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.3 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |