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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for AGGUAGU

Z-value: 0.74

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miRNA associated with seed AGGUAGU

NamemiRBASE accession
hsa-miR-196a-5p
MIMAT0000226
hsa-miR-196b-5p
MIMAT0001080

Activity profile of AGGUAGU motif

Sorted Z-values of AGGUAGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_164528866 2.78 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr7_-_27183263 2.54 ENST00000222726.3
HOXA5
homeobox A5
chr7_+_94023873 2.44 ENST00000297268.6
COL1A2
collagen, type I, alpha 2
chr1_-_92351769 2.42 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr7_+_89841000 1.95 ENST00000287908.3
STEAP2
STEAP family member 2, metalloreductase
chr20_+_37434329 1.93 ENST00000299824.1
ENST00000373331.2
PPP1R16B
protein phosphatase 1, regulatory subunit 16B
chr17_+_68165657 1.93 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr8_-_28243934 1.77 ENST00000521185.1
ENST00000520290.1
ENST00000344423.5
ZNF395
zinc finger protein 395
chr7_-_27196267 1.65 ENST00000242159.3
HOXA7
homeobox A7
chr18_+_6834472 1.65 ENST00000581099.1
ENST00000419673.2
ENST00000531294.1
ARHGAP28
Rho GTPase activating protein 28
chr12_-_59313270 1.34 ENST00000379141.4
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chrX_+_118108571 1.34 ENST00000304778.7
LONRF3
LON peptidase N-terminal domain and ring finger 3
chr2_-_39664405 1.27 ENST00000341681.5
ENST00000263881.3
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr17_-_46688334 1.16 ENST00000239165.7
HOXB7
homeobox B7
chr15_+_66994561 1.10 ENST00000288840.5
SMAD6
SMAD family member 6
chr12_-_42877764 1.10 ENST00000455697.1
PRICKLE1
prickle homolog 1 (Drosophila)
chr12_-_25102252 1.09 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr3_-_28390581 1.05 ENST00000479665.1
AZI2
5-azacytidine induced 2
chr3_+_110790590 1.02 ENST00000485303.1
PVRL3
poliovirus receptor-related 3
chr20_+_306221 0.94 ENST00000342665.2
SOX12
SRY (sex determining region Y)-box 12
chr12_+_12870055 0.94 ENST00000228872.4
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chrX_+_135067576 0.91 ENST00000370701.1
ENST00000370698.3
ENST00000370695.4
SLC9A6
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
chr4_+_113066552 0.84 ENST00000309733.5
C4orf32
chromosome 4 open reading frame 32
chr6_-_134373732 0.82 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr9_-_72287191 0.77 ENST00000265381.4
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr14_-_88459503 0.75 ENST00000393568.4
ENST00000261304.2
GALC
galactosylceramidase
chr8_-_82754427 0.74 ENST00000353788.4
ENST00000520618.1
ENST00000518183.1
ENST00000396330.2
ENST00000519119.1
ENST00000345957.4
SNX16
sorting nexin 16
chr1_+_65210772 0.72 ENST00000371072.4
ENST00000294428.3
RAVER2
ribonucleoprotein, PTB-binding 2
chr9_-_111882195 0.70 ENST00000374586.3
TMEM245
transmembrane protein 245
chr8_+_37594130 0.68 ENST00000518526.1
ENST00000523887.1
ENST00000276461.5
ERLIN2
ER lipid raft associated 2
chr16_-_4166186 0.68 ENST00000294016.3
ADCY9
adenylate cyclase 9
chr2_+_32390925 0.65 ENST00000440718.1
ENST00000379343.2
ENST00000282587.5
ENST00000435660.1
ENST00000538303.1
ENST00000357055.3
ENST00000406369.1
SLC30A6
solute carrier family 30 (zinc transporter), member 6
chr7_-_27205136 0.64 ENST00000396345.1
ENST00000343483.6
HOXA9
homeobox A9
chr9_+_125026882 0.64 ENST00000297908.3
ENST00000373730.3
ENST00000546115.1
ENST00000344641.3
MRRF
mitochondrial ribosome recycling factor
chr3_-_69435224 0.63 ENST00000398540.3
FRMD4B
FERM domain containing 4B
chr2_+_189839046 0.63 ENST00000304636.3
ENST00000317840.5
COL3A1
collagen, type III, alpha 1
chr9_-_125693757 0.62 ENST00000373656.3
ZBTB26
zinc finger and BTB domain containing 26
chr12_+_65004292 0.62 ENST00000542104.1
ENST00000336061.2
RASSF3
Ras association (RalGDS/AF-6) domain family member 3
chr7_-_120498357 0.61 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12
tetraspanin 12
chr2_+_109335929 0.61 ENST00000283195.6
RANBP2
RAN binding protein 2
chr10_-_38146510 0.61 ENST00000395867.3
ZNF248
zinc finger protein 248
chrX_+_105066524 0.61 ENST00000243300.9
ENST00000428173.2
NRK
Nik related kinase
chr1_+_18958008 0.55 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr17_+_28705921 0.54 ENST00000225719.4
CPD
carboxypeptidase D
chr4_-_18023350 0.54 ENST00000539056.1
ENST00000382226.5
ENST00000326877.4
LCORL
ligand dependent nuclear receptor corepressor-like
chr10_+_180987 0.53 ENST00000381591.1
ZMYND11
zinc finger, MYND-type containing 11
chr15_+_52043758 0.52 ENST00000249700.4
ENST00000539962.2
TMOD2
tropomodulin 2 (neuronal)
chr3_+_158991025 0.50 ENST00000337808.6
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr21_-_39870339 0.49 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr9_-_16870704 0.49 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr14_+_19553365 0.48 ENST00000409832.3
POTEG
POTE ankyrin domain family, member G
chr20_+_277737 0.48 ENST00000382352.3
ZCCHC3
zinc finger, CCHC domain containing 3
chr3_+_159557637 0.47 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr15_-_44486632 0.43 ENST00000484674.1
FRMD5
FERM domain containing 5
chr2_+_204192942 0.41 ENST00000295851.5
ENST00000261017.5
ABI2
abl-interactor 2
chr14_-_34931458 0.39 ENST00000298130.4
SPTSSA
serine palmitoyltransferase, small subunit A
chr14_-_20020272 0.39 ENST00000551509.1
POTEM
POTE ankyrin domain family, member M
chr16_+_22217577 0.38 ENST00000263026.5
EEF2K
eukaryotic elongation factor-2 kinase
chrX_-_24690771 0.36 ENST00000379145.1
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chrX_-_41782249 0.36 ENST00000442742.2
ENST00000421587.2
ENST00000378166.4
ENST00000318588.9
ENST00000361962.4
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr1_+_109102652 0.36 ENST00000370035.3
ENST00000405454.1
FAM102B
family with sequence similarity 102, member B
chr11_+_63580855 0.35 ENST00000294244.4
C11orf84
chromosome 11 open reading frame 84
chr12_+_51442101 0.35 ENST00000550929.1
ENST00000262055.4
ENST00000550442.1
ENST00000549340.1
ENST00000548209.1
ENST00000548251.1
ENST00000550814.1
ENST00000547660.1
ENST00000380123.2
ENST00000548401.1
ENST00000418425.2
ENST00000547008.1
ENST00000552739.1
LETMD1
LETM1 domain containing 1
chr21_+_30671189 0.34 ENST00000286800.3
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr9_+_128509624 0.33 ENST00000342287.5
ENST00000373487.4
PBX3
pre-B-cell leukemia homeobox 3
chr9_-_79520989 0.33 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
PRUNE2
prune homolog 2 (Drosophila)
chr22_+_50781723 0.32 ENST00000359139.3
ENST00000395741.3
ENST00000395744.3
PPP6R2
protein phosphatase 6, regulatory subunit 2
chr1_+_113615794 0.31 ENST00000361127.5
LRIG2
leucine-rich repeats and immunoglobulin-like domains 2
chr5_-_37371278 0.31 ENST00000231498.3
NUP155
nucleoporin 155kDa
chr9_-_14693417 0.31 ENST00000380916.4
ZDHHC21
zinc finger, DHHC-type containing 21
chr1_+_153232160 0.30 ENST00000368742.3
LOR
loricrin
chr6_-_33267101 0.30 ENST00000497454.1
RGL2
ral guanine nucleotide dissociation stimulator-like 2
chr17_+_2699697 0.30 ENST00000254695.8
ENST00000366401.4
ENST00000542807.1
RAP1GAP2
RAP1 GTPase activating protein 2
chr3_+_49209023 0.27 ENST00000332780.2
KLHDC8B
kelch domain containing 8B
chr6_+_107349392 0.26 ENST00000443043.1
ENST00000405204.2
ENST00000311381.5
C6orf203
chromosome 6 open reading frame 203
chr2_+_113239710 0.26 ENST00000233336.6
TTL
tubulin tyrosine ligase
chr7_+_104654623 0.25 ENST00000311117.3
ENST00000334877.4
ENST00000257745.4
ENST00000334914.7
ENST00000478990.1
ENST00000495267.1
ENST00000476671.1
KMT2E
lysine (K)-specific methyltransferase 2E
chr5_-_39074479 0.25 ENST00000514735.1
ENST00000296782.5
ENST00000357387.3
RICTOR
RPTOR independent companion of MTOR, complex 2
chr15_-_34502278 0.24 ENST00000559515.1
ENST00000256544.3
ENST00000560108.1
ENST00000559462.1
KATNBL1
katanin p80 subunit B-like 1
chr12_-_57400227 0.23 ENST00000300101.2
ZBTB39
zinc finger and BTB domain containing 39
chr7_+_94285637 0.23 ENST00000482108.1
ENST00000488574.1
PEG10
paternally expressed 10
chr1_-_205601064 0.22 ENST00000357992.4
ENST00000289703.4
ELK4
ELK4, ETS-domain protein (SRF accessory protein 1)
chr2_+_242641442 0.21 ENST00000313552.6
ENST00000406941.1
ING5
inhibitor of growth family, member 5
chrX_-_134186144 0.21 ENST00000370775.2
FAM127B
family with sequence similarity 127, member B
chr15_+_38544476 0.21 ENST00000299084.4
SPRED1
sprouty-related, EVH1 domain containing 1
chr3_+_61547585 0.19 ENST00000295874.10
ENST00000474889.1
PTPRG
protein tyrosine phosphatase, receptor type, G
chr10_+_72238517 0.19 ENST00000263563.6
PALD1
phosphatase domain containing, paladin 1
chr1_-_179198702 0.19 ENST00000502732.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr14_+_100705322 0.18 ENST00000262238.4
YY1
YY1 transcription factor
chr11_+_7273181 0.17 ENST00000318881.6
SYT9
synaptotagmin IX
chr6_-_42419649 0.17 ENST00000372922.4
ENST00000541110.1
ENST00000372917.4
TRERF1
transcriptional regulating factor 1
chr2_+_232260254 0.16 ENST00000287590.5
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr4_+_56212270 0.16 ENST00000264228.4
SRD5A3
steroid 5 alpha-reductase 3
chr7_+_77325738 0.16 ENST00000334955.8
RSBN1L
round spermatid basic protein 1-like
chr12_+_118814344 0.15 ENST00000397564.2
SUDS3
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr11_-_796197 0.15 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr8_+_92082424 0.14 ENST00000285420.4
ENST00000404789.3
OTUD6B
OTU domain containing 6B
chr21_+_42539701 0.14 ENST00000330333.6
ENST00000328735.6
ENST00000347667.5
BACE2
beta-site APP-cleaving enzyme 2
chr8_-_110988070 0.14 ENST00000524391.1
KCNV1
potassium channel, subfamily V, member 1
chr16_+_69221028 0.14 ENST00000336278.4
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr19_-_51054299 0.14 ENST00000599957.1
LRRC4B
leucine rich repeat containing 4B
chr16_+_70380732 0.13 ENST00000302243.7
DDX19A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
chr12_-_58240470 0.13 ENST00000548823.1
ENST00000398073.2
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr16_-_4987065 0.12 ENST00000590782.2
ENST00000345988.2
PPL
periplakin
chr20_-_31071239 0.12 ENST00000359676.5
C20orf112
chromosome 20 open reading frame 112
chr10_+_97803151 0.12 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
CCNJ
cyclin J
chr3_+_14989076 0.12 ENST00000413118.1
ENST00000425241.1
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr2_-_50574856 0.11 ENST00000342183.5
NRXN1
neurexin 1
chr1_-_115259337 0.11 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr17_-_46682321 0.10 ENST00000225648.3
ENST00000484302.2
HOXB6
homeobox B6
chr4_+_106473768 0.10 ENST00000265154.2
ENST00000420470.2
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38
chr4_+_71587669 0.10 ENST00000381006.3
ENST00000226328.4
RUFY3
RUN and FYVE domain containing 3
chr22_+_30279144 0.10 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr20_-_5591626 0.10 ENST00000379019.4
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr19_+_32836499 0.10 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507
zinc finger protein 507
chrX_+_2746850 0.09 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
GYG2
glycogenin 2
chr2_+_32582086 0.09 ENST00000421745.2
BIRC6
baculoviral IAP repeat containing 6
chr12_-_29534074 0.09 ENST00000546839.1
ENST00000360150.4
ENST00000552155.1
ENST00000550353.1
ENST00000548441.1
ENST00000552132.1
ERGIC2
ERGIC and golgi 2
chr3_+_122513642 0.09 ENST00000261038.5
DIRC2
disrupted in renal carcinoma 2
chr14_+_55493920 0.09 ENST00000395472.2
ENST00000555846.1
SOCS4
suppressor of cytokine signaling 4
chr5_+_178286925 0.09 ENST00000322434.3
ZNF354B
zinc finger protein 354B
chr3_-_120003941 0.09 ENST00000464295.1
GPR156
G protein-coupled receptor 156
chr12_-_123450986 0.08 ENST00000344275.7
ENST00000442833.2
ENST00000280560.8
ENST00000540285.1
ENST00000346530.5
ABCB9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr6_+_24403144 0.08 ENST00000274747.7
ENST00000543597.1
ENST00000535061.1
ENST00000378353.1
ENST00000378386.3
ENST00000443868.2
MRS2
MRS2 magnesium transporter
chr14_-_57735528 0.07 ENST00000340918.7
ENST00000413566.2
EXOC5
exocyst complex component 5
chr17_+_55333876 0.07 ENST00000284073.2
MSI2
musashi RNA-binding protein 2
chr1_-_21113105 0.06 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
HP1BP3
heterochromatin protein 1, binding protein 3
chr11_-_110167352 0.06 ENST00000533991.1
ENST00000528498.1
ENST00000405097.1
ENST00000528900.1
ENST00000530301.1
ENST00000343115.4
RDX
radixin
chr21_+_47878757 0.06 ENST00000400274.1
ENST00000427143.2
ENST00000318711.7
ENST00000457905.3
ENST00000466639.1
ENST00000435722.3
ENST00000417564.2
DIP2A
DIP2 disco-interacting protein 2 homolog A (Drosophila)
chr7_-_75368248 0.06 ENST00000434438.2
ENST00000336926.6
HIP1
huntingtin interacting protein 1
chrX_-_77150985 0.05 ENST00000358075.6
MAGT1
magnesium transporter 1
chrX_+_48554986 0.05 ENST00000376687.3
ENST00000453214.2
SUV39H1
suppressor of variegation 3-9 homolog 1 (Drosophila)
chr16_-_30621663 0.05 ENST00000287461.3
ZNF689
zinc finger protein 689
chr19_-_47975417 0.05 ENST00000236877.6
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr9_+_6413317 0.05 ENST00000276893.5
ENST00000381373.3
UHRF2
ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
chr5_-_131132614 0.05 ENST00000307968.7
ENST00000307954.8
FNIP1
folliculin interacting protein 1
chr2_+_170590321 0.05 ENST00000392647.2
KLHL23
kelch-like family member 23
chr3_+_101504200 0.04 ENST00000422132.1
NXPE3
neurexophilin and PC-esterase domain family, member 3
chr6_-_99797522 0.04 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr22_+_48972118 0.04 ENST00000358295.5
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr19_+_47104493 0.04 ENST00000291295.9
ENST00000597743.1
CALM3
calmodulin 3 (phosphorylase kinase, delta)
chrX_-_24045303 0.03 ENST00000328046.8
KLHL15
kelch-like family member 15
chr17_-_48278983 0.02 ENST00000225964.5
COL1A1
collagen, type I, alpha 1
chr8_-_68255912 0.02 ENST00000262215.3
ENST00000519436.1
ARFGEF1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr11_-_110583451 0.02 ENST00000260283.4
ENST00000528829.1
ARHGAP20
Rho GTPase activating protein 20
chr12_+_123868320 0.01 ENST00000402868.3
ENST00000330479.4
SETD8
SET domain containing (lysine methyltransferase) 8
chr1_-_51984908 0.01 ENST00000371730.2
EPS15
epidermal growth factor receptor pathway substrate 15
chr4_+_20702059 0.01 ENST00000444671.2
ENST00000510700.1
ENST00000506745.1
ENST00000514663.1
ENST00000509469.1
ENST00000515339.1
ENST00000513861.1
ENST00000502374.1
ENST00000538990.1
ENST00000511160.1
ENST00000504630.1
ENST00000513590.1
ENST00000514292.1
ENST00000502938.1
ENST00000509625.1
ENST00000505160.1
ENST00000507634.1
ENST00000513459.1
ENST00000511089.1
PACRGL
PARK2 co-regulated-like
chr1_+_60280458 0.01 ENST00000455990.1
ENST00000371208.3
HOOK1
hook microtubule-tethering protein 1
chr17_+_53342311 0.01 ENST00000226067.5
HLF
hepatic leukemia factor
chr5_+_148724993 0.01 ENST00000513661.1
ENST00000329271.3
ENST00000416916.2
GRPEL2
GrpE-like 2, mitochondrial (E. coli)
chr2_-_69870835 0.00 ENST00000409085.4
ENST00000406297.3
AAK1
AP2 associated kinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of AGGUAGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0060435 bronchiole development(GO:0060435)
0.6 1.9 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.6 2.4 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.6 1.7 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.5 1.9 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.3 1.1 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.3 1.3 GO:0032474 otolith morphogenesis(GO:0032474)
0.2 1.9 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 1.0 GO:0044565 dendritic cell proliferation(GO:0044565)
0.2 1.7 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.2 0.6 GO:0060720 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.2 1.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.2 1.1 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 2.5 GO:0043589 skin morphogenesis(GO:0043589)
0.2 0.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.4 GO:0034059 response to anoxia(GO:0034059)
0.1 0.7 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.9 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.7 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.9 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 2.8 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 0.5 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.1 0.3 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.1 0.3 GO:0032485 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.1 0.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.5 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 0.7 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.1 0.8 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.1 0.3 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.6 GO:0032790 ribosome disassembly(GO:0032790)
0.1 0.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.2 GO:0060979 vasculogenesis involved in coronary vascular morphogenesis(GO:0060979)
0.0 1.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 1.2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.2 GO:0016095 polyprenol catabolic process(GO:0016095)
0.0 0.3 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.4 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.6 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.1 GO:1904562 phosphatidylinositol 5-phosphate metabolic process(GO:1904562)
0.0 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.1 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.0 0.4 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.7 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.2 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.8 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.7 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.6 GO:0010842 retina layer formation(GO:0010842)
0.0 0.5 GO:0043586 tongue development(GO:0043586)
0.0 0.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.0 0.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.0 0.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.1 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.2 GO:0032688 response to UV-C(GO:0010225) negative regulation of interferon-beta production(GO:0032688)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.2 3.1 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.7 GO:0044308 axonal spine(GO:0044308)
0.1 0.6 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.7 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.9 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.4 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 1.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.4 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0070698 type I activin receptor binding(GO:0070698)
0.3 1.9 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 2.4 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.2 3.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 1.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 1.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.4 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.4 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.6 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.9 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.1 0.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.2 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.1 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.2 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 1.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.6 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 7.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.0 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.4 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.5 PID TNF PATHWAY TNF receptor signaling pathway
0.0 2.2 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.6 PID ENDOTHELIN PATHWAY Endothelins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.7 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.9 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions