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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for AGUGCAA

Z-value: 0.95

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miRNA associated with seed AGUGCAA

NamemiRBASE accession
hsa-miR-130a-3p
MIMAT0000425
hsa-miR-130b-3p
MIMAT0000691
hsa-miR-301a-3p
MIMAT0000688
hsa-miR-301b-3p
MIMAT0004958
hsa-miR-454-3p
MIMAT0003885
hsa-miR-3666
MIMAT0018088
hsa-miR-4295
MIMAT0016844

Activity profile of AGUGCAA motif

Sorted Z-values of AGUGCAA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_64211112 4.13 ENST00000295902.6
PRICKLE2
prickle homolog 2 (Drosophila)
chr1_+_61547894 3.87 ENST00000403491.3
NFIA
nuclear factor I/A
chr7_-_11871815 3.77 ENST00000423059.4
THSD7A
thrombospondin, type I, domain containing 7A
chr20_-_39317868 3.60 ENST00000373313.2
MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr1_+_84543734 3.51 ENST00000370689.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr18_+_72922710 3.35 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr4_+_55524085 2.98 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr8_-_93115445 2.83 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_-_14314066 2.72 ENST00000397575.3
NFIB
nuclear factor I/B
chr8_-_22550815 2.69 ENST00000317216.2
EGR3
early growth response 3
chr18_+_8717369 2.67 ENST00000359865.3
ENST00000400050.3
ENST00000306285.7
SOGA2
SOGA family member 2
chr6_-_16761678 2.65 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr7_-_15726296 2.41 ENST00000262041.5
MEOX2
mesenchyme homeobox 2
chr13_-_107187462 2.22 ENST00000245323.4
EFNB2
ephrin-B2
chr6_+_15246501 2.16 ENST00000341776.2
JARID2
jumonji, AT rich interactive domain 2
chr7_+_114562172 2.15 ENST00000393486.1
ENST00000257724.3
MDFIC
MyoD family inhibitor domain containing
chr10_-_81205373 2.14 ENST00000372336.3
ZCCHC24
zinc finger, CCHC domain containing 24
chr7_-_27183263 2.11 ENST00000222726.3
HOXA5
homeobox A5
chr10_-_33623564 2.09 ENST00000374875.1
ENST00000374822.4
NRP1
neuropilin 1
chr6_-_111136513 2.01 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr9_-_140196703 1.99 ENST00000356628.2
NRARP
NOTCH-regulated ankyrin repeat protein
chr3_+_124223586 1.95 ENST00000393496.1
KALRN
kalirin, RhoGEF kinase
chr3_-_15901278 1.89 ENST00000399451.2
ANKRD28
ankyrin repeat domain 28
chr20_+_34700333 1.81 ENST00000441639.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr6_+_136172820 1.75 ENST00000308191.6
PDE7B
phosphodiesterase 7B
chr7_+_116312411 1.68 ENST00000456159.1
ENST00000397752.3
ENST00000318493.6
MET
met proto-oncogene
chr3_-_124774802 1.66 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr17_+_61086917 1.66 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr8_-_4852218 1.65 ENST00000400186.3
ENST00000602723.1
CSMD1
CUB and Sushi multiple domains 1
chr17_+_65821780 1.63 ENST00000321892.4
ENST00000335221.5
ENST00000306378.6
BPTF
bromodomain PHD finger transcription factor
chr3_-_18466787 1.59 ENST00000338745.6
ENST00000450898.1
SATB1
SATB homeobox 1
chr11_-_45687128 1.57 ENST00000308064.2
CHST1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr1_+_178694300 1.54 ENST00000367635.3
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr6_-_41909561 1.51 ENST00000372991.4
CCND3
cyclin D3
chr2_+_177053307 1.50 ENST00000331462.4
HOXD1
homeobox D1
chr2_+_173600671 1.49 ENST00000409036.1
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr6_+_143929307 1.48 ENST00000427704.2
ENST00000305766.6
PHACTR2
phosphatase and actin regulator 2
chr3_+_194406603 1.44 ENST00000329759.4
FAM43A
family with sequence similarity 43, member A
chr14_-_91526922 1.42 ENST00000418736.2
ENST00000261991.3
RPS6KA5
ribosomal protein S6 kinase, 90kDa, polypeptide 5
chr1_+_12227035 1.41 ENST00000376259.3
ENST00000536782.1
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr2_+_28615669 1.38 ENST00000379619.1
ENST00000264716.4
FOSL2
FOS-like antigen 2
chrX_+_66764375 1.37 ENST00000374690.3
AR
androgen receptor
chrX_+_118108571 1.36 ENST00000304778.7
LONRF3
LON peptidase N-terminal domain and ring finger 3
chr11_-_82782861 1.34 ENST00000524635.1
ENST00000526205.1
ENST00000527633.1
ENST00000533486.1
ENST00000533276.2
RAB30
RAB30, member RAS oncogene family
chr2_-_101767715 1.31 ENST00000376840.4
ENST00000409318.1
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr20_+_10199468 1.26 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr3_+_110790590 1.23 ENST00000485303.1
PVRL3
poliovirus receptor-related 3
chr4_-_152147579 1.21 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3D19
SH3 domain containing 19
chr6_+_148663729 1.21 ENST00000367467.3
SASH1
SAM and SH3 domain containing 1
chr19_+_11200038 1.20 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr5_-_90679145 1.19 ENST00000265138.3
ARRDC3
arrestin domain containing 3
chr8_+_70378852 1.16 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
SULF1
sulfatase 1
chr11_+_92085262 1.15 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3
FAT atypical cadherin 3
chr12_-_118541743 1.12 ENST00000359236.5
VSIG10
V-set and immunoglobulin domain containing 10
chr20_+_11871371 1.11 ENST00000254977.3
BTBD3
BTB (POZ) domain containing 3
chr8_-_81787006 1.10 ENST00000327835.3
ZNF704
zinc finger protein 704
chr4_+_26862400 1.10 ENST00000467011.1
ENST00000412829.2
STIM2
stromal interaction molecule 2
chr7_+_106809406 1.06 ENST00000468410.1
ENST00000478930.1
ENST00000464009.1
ENST00000222574.4
HBP1
HMG-box transcription factor 1
chr4_-_25864581 1.06 ENST00000399878.3
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr17_-_76870222 1.03 ENST00000585421.1
TIMP2
TIMP metallopeptidase inhibitor 2
chr5_-_107006596 1.03 ENST00000333274.6
EFNA5
ephrin-A5
chr5_+_122110691 1.02 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
SNX2
sorting nexin 2
chr10_+_35535943 1.02 ENST00000490012.2
ENST00000374706.1
ENST00000493157.2
CCNY
cyclin Y
chr10_+_63661053 1.01 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr10_-_102279586 1.00 ENST00000370345.3
ENST00000451524.1
ENST00000370329.5
SEC31B
SEC31 homolog B (S. cerevisiae)
chr12_-_25102252 1.00 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr21_-_44846999 0.99 ENST00000270162.6
SIK1
salt-inducible kinase 1
chr12_-_12419703 0.98 ENST00000543091.1
ENST00000261349.4
LRP6
low density lipoprotein receptor-related protein 6
chr7_+_94139105 0.95 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr4_+_87856129 0.94 ENST00000395146.4
ENST00000507468.1
AFF1
AF4/FMR2 family, member 1
chr18_+_13218769 0.91 ENST00000399848.3
ENST00000361205.4
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chrX_-_74376108 0.91 ENST00000339447.4
ENST00000373394.3
ENST00000529949.1
ENST00000534524.1
ENST00000253577.3
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr15_-_77363513 0.90 ENST00000267970.4
TSPAN3
tetraspanin 3
chr7_+_115850547 0.90 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES
testis derived transcript (3 LIM domains)
chr3_-_141868357 0.88 ENST00000489671.1
ENST00000475734.1
ENST00000467072.1
ENST00000499676.2
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_+_145567173 0.87 ENST00000296575.3
HHIP
hedgehog interacting protein
chr1_-_225615599 0.83 ENST00000421383.1
ENST00000272163.4
LBR
lamin B receptor
chr1_+_214161272 0.83 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr18_-_53255766 0.83 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
TCF4
transcription factor 4
chr20_+_1246908 0.83 ENST00000381873.3
ENST00000381867.1
SNPH
syntaphilin
chr1_+_97187318 0.82 ENST00000609116.1
ENST00000370198.1
ENST00000370197.1
ENST00000426398.2
ENST00000394184.3
PTBP2
polypyrimidine tract binding protein 2
chr2_-_180129484 0.82 ENST00000428443.3
SESTD1
SEC14 and spectrin domains 1
chr1_-_36022979 0.81 ENST00000469892.1
ENST00000325722.3
KIAA0319L
KIAA0319-like
chr4_-_163085141 0.79 ENST00000427802.2
ENST00000306100.5
FSTL5
follistatin-like 5
chr4_-_141075330 0.75 ENST00000509479.2
MAML3
mastermind-like 3 (Drosophila)
chr10_-_131762105 0.75 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr15_-_49338748 0.74 ENST00000559471.1
SECISBP2L
SECIS binding protein 2-like
chr14_-_75593708 0.73 ENST00000557673.1
ENST00000238616.5
NEK9
NIMA-related kinase 9
chr17_-_61920280 0.72 ENST00000448276.2
ENST00000577990.1
SMARCD2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr18_+_46065393 0.71 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr4_-_85887503 0.71 ENST00000509172.1
ENST00000322366.6
ENST00000295888.4
ENST00000502713.1
WDFY3
WD repeat and FYVE domain containing 3
chr5_-_112630598 0.70 ENST00000302475.4
MCC
mutated in colorectal cancers
chr19_+_47421933 0.69 ENST00000404338.3
ARHGAP35
Rho GTPase activating protein 35
chr12_+_96588143 0.69 ENST00000228741.3
ENST00000547249.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr11_-_10315741 0.69 ENST00000256190.8
SBF2
SET binding factor 2
chr3_+_25469724 0.69 ENST00000437042.2
RARB
retinoic acid receptor, beta
chr1_+_20208870 0.68 ENST00000375120.3
OTUD3
OTU domain containing 3
chr9_-_107690420 0.68 ENST00000423487.2
ENST00000374733.1
ENST00000374736.3
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr12_-_53893399 0.66 ENST00000267079.2
MAP3K12
mitogen-activated protein kinase kinase kinase 12
chr2_+_203879568 0.66 ENST00000449802.1
NBEAL1
neurobeachin-like 1
chr4_-_89744457 0.65 ENST00000395002.2
FAM13A
family with sequence similarity 13, member A
chr4_-_78740511 0.65 ENST00000504123.1
ENST00000264903.4
ENST00000515441.1
CNOT6L
CCR4-NOT transcription complex, subunit 6-like
chr18_-_72921303 0.65 ENST00000322342.3
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr10_-_30348439 0.65 ENST00000375377.1
KIAA1462
KIAA1462
chr17_-_19771216 0.64 ENST00000395544.4
ULK2
unc-51 like autophagy activating kinase 2
chr11_-_74109422 0.64 ENST00000298198.4
PGM2L1
phosphoglucomutase 2-like 1
chr1_+_52682052 0.63 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr11_-_46940074 0.63 ENST00000378623.1
ENST00000534404.1
LRP4
low density lipoprotein receptor-related protein 4
chr3_-_72496035 0.62 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr4_+_129730779 0.60 ENST00000226319.6
PHF17
jade family PHD finger 1
chr20_-_36156125 0.59 ENST00000397135.1
ENST00000397137.1
BLCAP
bladder cancer associated protein
chr12_+_93965451 0.58 ENST00000548537.1
SOCS2
suppressor of cytokine signaling 2
chr20_+_4666882 0.57 ENST00000379440.4
ENST00000430350.2
PRNP
prion protein
chr3_+_179370517 0.57 ENST00000263966.3
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr9_-_134145880 0.56 ENST00000372269.3
ENST00000464831.1
FAM78A
family with sequence similarity 78, member A
chr3_+_57261743 0.56 ENST00000288266.3
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr5_-_137368708 0.56 ENST00000033079.3
FAM13B
family with sequence similarity 13, member B
chr1_+_173684047 0.55 ENST00000546011.1
ENST00000209884.4
KLHL20
kelch-like family member 20
chr2_+_56411131 0.55 ENST00000407595.2
CCDC85A
coiled-coil domain containing 85A
chr18_-_19284724 0.55 ENST00000580981.1
ENST00000289119.2
ABHD3
abhydrolase domain containing 3
chr10_+_89622870 0.55 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chr22_+_40573921 0.55 ENST00000454349.2
ENST00000335727.9
TNRC6B
trinucleotide repeat containing 6B
chr1_+_12290121 0.55 ENST00000358136.3
ENST00000356315.4
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr7_+_155089486 0.54 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr8_+_96145974 0.53 ENST00000315367.3
PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr4_+_170541660 0.52 ENST00000513761.1
ENST00000347613.4
CLCN3
chloride channel, voltage-sensitive 3
chr18_+_20513782 0.52 ENST00000399722.2
ENST00000399725.2
ENST00000399721.2
ENST00000583594.1
RBBP8
retinoblastoma binding protein 8
chr3_+_61547585 0.52 ENST00000295874.10
ENST00000474889.1
PTPRG
protein tyrosine phosphatase, receptor type, G
chr15_-_52030293 0.52 ENST00000560491.1
ENST00000267838.3
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr1_-_22109682 0.51 ENST00000400301.1
ENST00000532737.1
USP48
ubiquitin specific peptidase 48
chr14_-_35182994 0.51 ENST00000341223.3
CFL2
cofilin 2 (muscle)
chr18_-_12657988 0.51 ENST00000410092.3
ENST00000409402.4
SPIRE1
spire-type actin nucleation factor 1
chr16_-_23521710 0.51 ENST00000562117.1
ENST00000567468.1
ENST00000562944.1
ENST00000309859.4
GGA2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr21_-_40685477 0.50 ENST00000342449.3
BRWD1
bromodomain and WD repeat domain containing 1
chr15_-_31283798 0.50 ENST00000435680.1
ENST00000425768.1
MTMR10
myotubularin related protein 10
chr9_-_79520989 0.49 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
PRUNE2
prune homolog 2 (Drosophila)
chr6_-_91006461 0.49 ENST00000257749.4
ENST00000343122.3
ENST00000406998.2
ENST00000453877.1
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr10_-_14590644 0.48 ENST00000378470.1
FAM107B
family with sequence similarity 107, member B
chr6_+_89790490 0.48 ENST00000336032.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr3_-_114790179 0.48 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_28696111 0.47 ENST00000373839.3
PHACTR4
phosphatase and actin regulator 4
chrX_-_24045303 0.47 ENST00000328046.8
KLHL15
kelch-like family member 15
chr11_+_120207787 0.47 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr11_+_120894781 0.47 ENST00000529397.1
ENST00000528512.1
ENST00000422003.2
TBCEL
tubulin folding cofactor E-like
chr6_+_35182176 0.47 ENST00000394681.1
ENST00000274938.7
SCUBE3
signal peptide, CUB domain, EGF-like 3
chr5_-_138210977 0.47 ENST00000274711.6
ENST00000521094.2
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr9_-_36400213 0.47 ENST00000259605.6
ENST00000353739.4
RNF38
ring finger protein 38
chr1_-_225840747 0.47 ENST00000366843.2
ENST00000366844.3
ENAH
enabled homolog (Drosophila)
chr8_+_27491572 0.47 ENST00000301904.3
SCARA3
scavenger receptor class A, member 3
chr8_-_30891078 0.46 ENST00000339382.2
ENST00000475541.1
PURG
purine-rich element binding protein G
chr16_-_18812746 0.46 ENST00000546206.2
ENST00000562819.1
ENST00000562234.2
ENST00000304414.7
ENST00000567078.2
ARL6IP1
RP11-1035H13.3
ADP-ribosylation factor-like 6 interacting protein 1
Uncharacterized protein
chr5_+_75699040 0.45 ENST00000274364.6
IQGAP2
IQ motif containing GTPase activating protein 2
chr17_-_46623441 0.45 ENST00000330070.4
HOXB2
homeobox B2
chr2_-_86948245 0.45 ENST00000439940.2
ENST00000604011.1
CHMP3
RNF103-CHMP3
charged multivesicular body protein 3
RNF103-CHMP3 readthrough
chr17_+_47865917 0.43 ENST00000259021.4
ENST00000454930.2
ENST00000509773.1
ENST00000510819.1
ENST00000424009.2
KAT7
K(lysine) acetyltransferase 7
chr2_-_86790593 0.43 ENST00000263856.4
ENST00000409225.2
CHMP3
charged multivesicular body protein 3
chr8_-_92053212 0.42 ENST00000285419.3
TMEM55A
transmembrane protein 55A
chr2_+_86947296 0.42 ENST00000283632.4
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr3_+_152017181 0.41 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr2_+_120517174 0.41 ENST00000263708.2
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr17_+_5031687 0.40 ENST00000250066.6
ENST00000304328.5
USP6
ubiquitin specific peptidase 6 (Tre-2 oncogene)
chr6_-_170599561 0.39 ENST00000366756.3
DLL1
delta-like 1 (Drosophila)
chr4_+_166248775 0.39 ENST00000261507.6
ENST00000507013.1
ENST00000393766.2
ENST00000504317.1
MSMO1
methylsterol monooxygenase 1
chr7_+_24612935 0.39 ENST00000222644.5
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr13_+_28813645 0.38 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr1_+_200708671 0.38 ENST00000358823.2
CAMSAP2
calmodulin regulated spectrin-associated protein family, member 2
chr20_+_57267669 0.37 ENST00000356091.6
NPEPL1
aminopeptidase-like 1
chr10_-_126432619 0.37 ENST00000337318.3
FAM53B
family with sequence similarity 53, member B
chr17_-_62340581 0.36 ENST00000258991.3
ENST00000583738.1
ENST00000584379.1
TEX2
testis expressed 2
chr19_+_17581253 0.36 ENST00000252595.7
ENST00000598424.1
SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr10_-_32636106 0.36 ENST00000263062.8
ENST00000319778.6
EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr7_-_127032741 0.35 ENST00000393313.1
ENST00000265827.3
ENST00000434602.1
ZNF800
zinc finger protein 800
chr11_+_113930291 0.35 ENST00000335953.4
ZBTB16
zinc finger and BTB domain containing 16
chr5_-_94620239 0.35 ENST00000515393.1
MCTP1
multiple C2 domains, transmembrane 1
chr3_+_107241783 0.35 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
BBX
bobby sox homolog (Drosophila)
chr8_+_28351707 0.34 ENST00000537916.1
ENST00000523546.1
ENST00000240093.3
FZD3
frizzled family receptor 3
chr12_-_92539614 0.34 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr2_+_191273052 0.33 ENST00000417958.1
ENST00000432036.1
ENST00000392328.1
MFSD6
major facilitator superfamily domain containing 6
chr9_+_108006880 0.33 ENST00000374723.1
ENST00000374720.3
ENST00000374724.1
SLC44A1
solute carrier family 44 (choline transporter), member 1
chr6_+_21593972 0.33 ENST00000244745.1
ENST00000543472.1
SOX4
SRY (sex determining region Y)-box 4
chr15_+_40532058 0.33 ENST00000260404.4
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr13_+_113344542 0.33 ENST00000487903.1
ENST00000375630.2
ENST00000375645.3
ENST00000283558.8
ATP11A
ATPase, class VI, type 11A
chr16_-_77468945 0.32 ENST00000282849.5
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr7_-_106301405 0.32 ENST00000523505.1
CCDC71L
coiled-coil domain containing 71-like
chr17_-_58469474 0.32 ENST00000300896.4
USP32
ubiquitin specific peptidase 32
chr1_-_52344471 0.32 ENST00000352171.7
ENST00000354831.7
NRD1
nardilysin (N-arginine dibasic convertase)
chr2_-_164592497 0.31 ENST00000333129.3
ENST00000409634.1
FIGN
fidgetin
chr22_-_21213029 0.31 ENST00000572273.1
ENST00000255882.6
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr20_-_5591626 0.31 ENST00000379019.4
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr12_+_109915179 0.31 ENST00000434735.2
UBE3B
ubiquitin protein ligase E3B
chr7_-_123389104 0.30 ENST00000223023.4
WASL
Wiskott-Aldrich syndrome-like
chr17_-_7382834 0.30 ENST00000380599.4
ZBTB4
zinc finger and BTB domain containing 4
chr7_+_23636992 0.30 ENST00000307471.3
ENST00000409765.1
CCDC126
coiled-coil domain containing 126
chr1_+_116184566 0.29 ENST00000355485.2
ENST00000369510.4
VANGL1
VANGL planar cell polarity protein 1
chrX_-_18372792 0.28 ENST00000251900.4
SCML2
sex comb on midleg-like 2 (Drosophila)
chr1_+_52521928 0.28 ENST00000489308.2
BTF3L4
basic transcription factor 3-like 4
chr2_-_105946491 0.28 ENST00000393359.2
TGFBRAP1
transforming growth factor, beta receptor associated protein 1
chr9_-_74980113 0.28 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr13_-_21476900 0.27 ENST00000400602.2
ENST00000255305.6
XPO4
exportin 4
chr22_+_50781723 0.27 ENST00000359139.3
ENST00000395741.3
ENST00000395744.3
PPP6R2
protein phosphatase 6, regulatory subunit 2

Network of associatons between targets according to the STRING database.

First level regulatory network of AGUGCAA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
1.0 3.0 GO:0038162 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.7 2.0 GO:0060435 bronchiole development(GO:0060435)
0.7 3.3 GO:0060023 soft palate development(GO:0060023)
0.6 1.7 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.5 2.2 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.5 3.5 GO:0097338 response to clozapine(GO:0097338)
0.5 2.8 GO:0001757 somite specification(GO:0001757)
0.5 1.4 GO:0048808 male genitalia morphogenesis(GO:0048808) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) male anatomical structure morphogenesis(GO:0090598)
0.5 0.5 GO:0021569 rhombomere 3 development(GO:0021569)
0.4 1.3 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.4 2.1 GO:0061552 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.4 1.2 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.4 1.2 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.4 2.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 1.5 GO:0032485 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.3 1.7 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.3 2.7 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.3 1.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 1.4 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.3 1.9 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.3 0.8 GO:0002194 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 1.2 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 0.5 GO:0061386 closure of optic fissure(GO:0061386)
0.2 1.1 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.2 2.0 GO:0014807 regulation of somitogenesis(GO:0014807)
0.2 0.9 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.2 0.6 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 1.0 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.2 1.3 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.2 0.5 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 0.7 GO:0015917 aminophospholipid transport(GO:0015917) regulation of high-density lipoprotein particle assembly(GO:0090107)
0.2 2.2 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.2 1.0 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 0.4 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.4 GO:0072720 response to dithiothreitol(GO:0072720)
0.1 0.6 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535)
0.1 2.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 3.9 GO:0072189 ureter development(GO:0072189)
0.1 0.5 GO:1903984 negative regulation of ribosome biogenesis(GO:0090071) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.4 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.1 1.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.4 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 0.5 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.3 GO:0036515 serotonergic neuron axon guidance(GO:0036515) negative regulation of mitotic cell cycle, embryonic(GO:0045976)
0.1 1.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 1.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.6 GO:0035973 aggrephagy(GO:0035973)
0.1 2.2 GO:0006012 galactose metabolic process(GO:0006012)
0.1 0.5 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.3 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 0.6 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.1 0.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.5 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.5 GO:0040038 cleavage furrow formation(GO:0036089) polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.1 0.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.9 GO:0015886 heme transport(GO:0015886)
0.1 0.8 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.3 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.8 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.1 0.2 GO:0006679 glucosylceramide biosynthetic process(GO:0006679)
0.1 1.0 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 1.4 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.1 GO:2000790 regulation of mesenchymal cell proliferation involved in lung development(GO:2000790) negative regulation of mesenchymal cell proliferation involved in lung development(GO:2000791)
0.1 0.2 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.1 2.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 1.4 GO:0060004 reflex(GO:0060004)
0.0 0.5 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 2.2 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.7 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.3 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.0 0.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.2 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.1 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0 0.3 GO:0042426 choline catabolic process(GO:0042426)
0.0 0.1 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.0 1.7 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.3 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.3 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.5 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.6 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.5 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.7 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.2 GO:0071638 negative regulation of T-helper 2 cell differentiation(GO:0045629) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 1.0 GO:0016577 histone demethylation(GO:0016577)
0.0 0.7 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 1.6 GO:1990090 cellular response to nerve growth factor stimulus(GO:1990090)
0.0 0.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.3 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.5 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.7 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 1.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.4 GO:0035886 vascular smooth muscle cell differentiation(GO:0035886)
0.0 0.5 GO:0009650 UV protection(GO:0009650)
0.0 0.1 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.1 GO:1903517 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.0 0.9 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.9 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.3 GO:0010225 response to UV-C(GO:0010225)
0.0 0.0 GO:1904562 phosphatidylinositol 5-phosphate metabolic process(GO:1904562)
0.0 0.0 GO:0051771 nitric oxide transport(GO:0030185) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.3 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.0 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.0 0.0 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.0 0.4 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.3 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 1.1 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 0.2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.4 2.6 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.3 1.0 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.2 2.0 GO:0097443 sorting endosome(GO:0097443)
0.2 1.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.2 1.0 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 1.4 GO:0043196 varicosity(GO:0043196)
0.2 1.6 GO:0016589 NURF complex(GO:0016589)
0.2 2.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 3.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.4 GO:0034657 GID complex(GO:0034657)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.0 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.7 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 3.0 GO:0042629 mast cell granule(GO:0042629)
0.1 0.5 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 1.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 2.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.6 GO:0016600 flotillin complex(GO:0016600)
0.0 0.3 GO:0033263 CORVET complex(GO:0033263)
0.0 0.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 1.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 2.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.8 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 5.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 1.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 3.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.1 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.1 GO:0030120 vesicle coat(GO:0030120)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0051286 cell tip(GO:0051286)
0.0 0.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.5 GO:1990752 microtubule end(GO:1990752)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.3 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.2 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.3 GO:0034046 poly(G) binding(GO:0034046)
0.3 1.0 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.3 0.8 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.2 0.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.7 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 1.4 GO:0004882 androgen receptor activity(GO:0004882)
0.2 1.6 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.2 1.0 GO:1990460 leptin receptor binding(GO:1990460)
0.2 3.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.6 GO:1904288 BAT3 complex binding(GO:1904288)
0.2 0.6 GO:0019961 interferon binding(GO:0019961)
0.2 1.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.2 1.0 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 2.5 GO:0030957 Tat protein binding(GO:0030957)
0.1 2.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.5 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 0.9 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 1.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 0.5 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.7 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 0.3 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 0.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.9 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.1 0.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.6 GO:1903135 cupric ion binding(GO:1903135)
0.1 0.7 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.6 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.9 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 3.2 GO:0032452 histone demethylase activity(GO:0032452)
0.1 0.6 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 0.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.9 GO:0015232 heme transporter activity(GO:0015232)
0.1 2.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.6 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.8 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 1.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 1.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.3 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.9 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 2.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 2.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.7 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.2 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224) RNA polymerase II transcription coactivator binding(GO:0001225)
0.0 0.3 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.0 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.5 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 2.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 1.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.7 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.0 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 1.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0052726 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0051766 inositol trisphosphate kinase activity(GO:0051766)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.7 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.3 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 6.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.1 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.0 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.0 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 7.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.5 PID IL3 PATHWAY IL3-mediated signaling events
0.1 5.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 1.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 0.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 1.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 3.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.4 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.1 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 3.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.8 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 PID FOXO PATHWAY FoxO family signaling
0.0 0.1 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.1 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.6 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 3.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.7 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 2.6 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 1.0 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.1 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.8 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 2.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE