Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for AHR_ARNT2
Z-value: 1.27
Motif logo
Transcription factors associated with AHR_ARNT2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| AHR | hg19_v2_chr7_+_17338239_17338262 | 0.74 | 2.2e-05 | Click! |
| ARNT2 | hg19_v2_chr15_+_80696666_80696700, hg19_v2_chr15_+_80733570_80733659 | -0.35 | 9.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of AHR_ARNT2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.4 | GO:0072189 | ureter development(GO:0072189) |
| 0.7 | 6.2 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.4 | 5.5 | GO:0021853 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 1.3 | 5.3 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.2 | 4.7 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.8 | 4.6 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.1 | 4.6 | GO:0030517 | negative regulation of axon extension(GO:0030517) |
| 1.4 | 4.1 | GO:0045608 | negative regulation of auditory receptor cell differentiation(GO:0045608) |
| 0.4 | 3.2 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.2 | 3.2 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 5.0 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 4.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 4.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.3 | 3.7 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 3.2 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 3.0 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 2.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 2.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 2.3 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 6.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.3 | 5.3 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.3 | 5.1 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.2 | 4.9 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 1.6 | 4.8 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.0 | 4.3 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.3 | 3.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 3.5 | GO:0044390 | ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.0 | 3.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 8.3 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 6.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 4.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 3.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.2 | 2.9 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 2.3 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 2.1 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.8 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 4.1 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 3.7 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 3.5 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 3.4 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 3.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.1 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 2.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 2.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 2.4 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |