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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for AIRE

Z-value: 0.52

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Transcription factors associated with AIRE

Gene Symbol Gene ID Gene Info
AIRE
ENSG00000160224.12 autoimmune regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_45705767-0.404.9e-02Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_225811747 1.52 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr1_+_79115503 0.93 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr8_+_54764346 0.85 ENST00000297313.3
ENST00000344277.6
RGS20
regulator of G-protein signaling 20
chr12_+_75874984 0.85 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr6_+_127898312 0.80 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr1_+_165864821 0.79 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr12_+_75874580 0.68 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr11_+_35211511 0.67 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr8_+_104384616 0.60 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr6_-_32806506 0.60 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr17_+_77030267 0.58 ENST00000581774.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr19_-_10491234 0.56 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
TYK2
tyrosine kinase 2
chr5_+_118690466 0.55 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr14_-_107283278 0.53 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr1_-_169703203 0.49 ENST00000333360.7
ENST00000367781.4
ENST00000367782.4
ENST00000367780.4
ENST00000367779.4
SELE
selectin E
chr1_-_154600421 0.47 ENST00000368471.3
ENST00000292205.5
ADAR
adenosine deaminase, RNA-specific
chr22_+_36649056 0.44 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr1_-_243326612 0.42 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr10_-_106240032 0.40 ENST00000447860.1
RP11-127O4.3
RP11-127O4.3
chrM_+_12331 0.39 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr4_-_104119528 0.35 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr12_+_52643077 0.34 ENST00000553310.2
ENST00000544024.1
KRT86
keratin 86
chr17_-_39150385 0.34 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr7_-_36764004 0.31 ENST00000431169.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr9_-_25678856 0.31 ENST00000358022.3
TUSC1
tumor suppressor candidate 1
chr7_-_36764142 0.31 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr17_-_39334460 0.31 ENST00000377726.2
KRTAP4-2
keratin associated protein 4-2
chr16_+_56672571 0.30 ENST00000290705.8
MT1A
metallothionein 1A
chr21_-_44495919 0.30 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr1_-_161208013 0.29 ENST00000515452.1
ENST00000367983.4
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr10_+_127661942 0.29 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
FANK1
fibronectin type III and ankyrin repeat domains 1
chr12_+_10658489 0.28 ENST00000538173.1
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr10_-_69597810 0.27 ENST00000483798.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr14_-_55658323 0.27 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr6_+_26538566 0.25 ENST00000377575.2
HMGN4
high mobility group nucleosomal binding domain 4
chr8_+_124780672 0.24 ENST00000521166.1
ENST00000334705.7
FAM91A1
family with sequence similarity 91, member A1
chr11_-_5173599 0.24 ENST00000328942.1
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr5_+_122181128 0.23 ENST00000261369.4
SNX24
sorting nexin 24
chr13_+_50570019 0.23 ENST00000442421.1
TRIM13
tripartite motif containing 13
chr5_+_122181184 0.22 ENST00000513881.1
SNX24
sorting nexin 24
chr17_-_38721711 0.22 ENST00000578085.1
ENST00000246657.2
CCR7
chemokine (C-C motif) receptor 7
chr14_+_101123580 0.21 ENST00000556697.1
ENST00000360899.2
ENST00000553623.1
LINC00523
long intergenic non-protein coding RNA 523
chr12_+_75874460 0.21 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr3_-_139199565 0.21 ENST00000511956.1
RBP2
retinol binding protein 2, cellular
chr3_+_46412345 0.21 ENST00000292303.4
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chr1_+_40840320 0.20 ENST00000372708.1
SMAP2
small ArfGAP2
chr17_+_7210294 0.20 ENST00000336452.7
EIF5A
eukaryotic translation initiation factor 5A
chr21_-_44495964 0.20 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chr6_+_22221010 0.20 ENST00000567753.1
RP11-524C21.2
RP11-524C21.2
chr14_-_65409438 0.20 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr14_-_55658252 0.20 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr6_+_160327974 0.19 ENST00000252660.4
MAS1
MAS1 oncogene
chr17_+_41857793 0.19 ENST00000449302.3
C17orf105
chromosome 17 open reading frame 105
chr15_+_85523671 0.19 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chrM_+_5824 0.19 ENST00000361624.2
MT-CO1
mitochondrially encoded cytochrome c oxidase I
chr1_-_161207986 0.19 ENST00000506209.1
ENST00000367980.2
NR1I3
nuclear receptor subfamily 1, group I, member 3
chr11_-_8954491 0.19 ENST00000526227.1
ENST00000525780.1
ENST00000326053.5
C11orf16
chromosome 11 open reading frame 16
chr19_-_47249679 0.18 ENST00000263280.6
STRN4
striatin, calmodulin binding protein 4
chrX_-_101694853 0.17 ENST00000372749.1
NXF2B
nuclear RNA export factor 2B
chr4_-_57524061 0.16 ENST00000508121.1
HOPX
HOP homeobox
chr12_-_6579808 0.16 ENST00000535180.1
ENST00000400911.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr17_-_42019836 0.16 ENST00000225992.3
PPY
pancreatic polypeptide
chr12_-_6580094 0.15 ENST00000361716.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr2_-_202508169 0.15 ENST00000409883.2
TMEM237
transmembrane protein 237
chrX_-_100307043 0.14 ENST00000372939.1
ENST00000372935.1
ENST00000372936.3
TRMT2B
tRNA methyltransferase 2 homolog B (S. cerevisiae)
chrX_-_100307076 0.14 ENST00000338687.7
ENST00000545398.1
ENST00000372931.5
TRMT2B
tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr7_-_149194843 0.14 ENST00000458143.2
ENST00000340622.3
ZNF746
zinc finger protein 746
chr4_+_66536248 0.13 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr6_-_39290744 0.13 ENST00000507712.1
KCNK16
potassium channel, subfamily K, member 16
chr1_-_52456352 0.13 ENST00000371655.3
RAB3B
RAB3B, member RAS oncogene family
chr11_-_18956556 0.12 ENST00000302797.3
MRGPRX1
MAS-related GPR, member X1
chr8_+_105352050 0.12 ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr16_-_31147020 0.12 ENST00000568261.1
ENST00000567797.1
ENST00000317508.6
PRSS8
protease, serine, 8
chr7_+_150498783 0.12 ENST00000475536.1
ENST00000468689.1
TMEM176A
transmembrane protein 176A
chr2_-_166060571 0.12 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr19_-_35719609 0.11 ENST00000324675.3
FAM187B
family with sequence similarity 187, member B
chr16_+_50059125 0.11 ENST00000427478.2
CNEP1R1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr9_-_104198042 0.11 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr5_+_72143988 0.11 ENST00000506351.2
TNPO1
transportin 1
chr21_+_30502806 0.11 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr22_+_25202232 0.11 ENST00000400358.4
ENST00000400359.4
SGSM1
small G protein signaling modulator 1
chr11_-_5345582 0.11 ENST00000328813.2
OR51B2
olfactory receptor, family 51, subfamily B, member 2
chr12_-_76462713 0.11 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr2_+_207804278 0.11 ENST00000272852.3
CPO
carboxypeptidase O
chr15_-_81202118 0.11 ENST00000560560.1
RP11-351M8.1
Uncharacterized protein
chr2_+_201981527 0.10 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr2_-_166060552 0.10 ENST00000283254.7
ENST00000453007.1
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr9_+_100615536 0.10 ENST00000375123.3
FOXE1
forkhead box E1 (thyroid transcription factor 2)
chr14_-_24911971 0.10 ENST00000555365.1
ENST00000399395.3
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr9_-_21482312 0.10 ENST00000448696.3
IFNE
interferon, epsilon
chr20_+_44637526 0.10 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr12_+_12202785 0.10 ENST00000586576.1
ENST00000464885.2
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr3_+_193965426 0.10 ENST00000455821.1
RP11-513G11.3
RP11-513G11.3
chr12_+_4758264 0.09 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr12_+_12202774 0.09 ENST00000589718.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr1_+_174670143 0.09 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr6_+_42584847 0.09 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr1_+_207669613 0.09 ENST00000367049.4
ENST00000529814.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr10_+_82300575 0.09 ENST00000313455.4
SH2D4B
SH2 domain containing 4B
chr1_+_241815577 0.09 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chr1_+_207669573 0.09 ENST00000400960.2
ENST00000534202.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr2_+_179316163 0.08 ENST00000409117.3
DFNB59
deafness, autosomal recessive 59
chr2_+_234686976 0.08 ENST00000389758.3
MROH2A
maestro heat-like repeat family member 2A
chr5_+_32788945 0.08 ENST00000326958.1
AC026703.1
AC026703.1
chr10_-_75682535 0.08 ENST00000409178.1
C10orf55
chromosome 10 open reading frame 55
chr10_+_90660832 0.08 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr12_-_11139511 0.08 ENST00000506868.1
TAS2R50
taste receptor, type 2, member 50
chrX_+_70503433 0.07 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr3_-_33686925 0.07 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr1_-_167883327 0.07 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chr10_-_101841588 0.07 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr14_-_24912047 0.07 ENST00000553930.1
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr1_-_158300747 0.07 ENST00000451207.1
CD1B
CD1b molecule
chr7_-_137028498 0.07 ENST00000393083.2
PTN
pleiotrophin
chr1_-_198990166 0.07 ENST00000427439.1
RP11-16L9.3
RP11-16L9.3
chr6_+_42141029 0.07 ENST00000372958.1
GUCA1A
guanylate cyclase activator 1A (retina)
chr6_+_36839616 0.07 ENST00000359359.2
ENST00000510325.2
C6orf89
chromosome 6 open reading frame 89
chr8_+_128748308 0.06 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr3_+_88199099 0.06 ENST00000486971.1
C3orf38
chromosome 3 open reading frame 38
chr12_-_11287243 0.06 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr6_-_31514333 0.06 ENST00000376151.4
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr11_+_30252549 0.06 ENST00000254122.3
ENST00000417547.1
FSHB
follicle stimulating hormone, beta polypeptide
chrX_-_49041242 0.05 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chr8_-_7220490 0.05 ENST00000400078.2
ZNF705G
zinc finger protein 705G
chr20_+_21284416 0.05 ENST00000539513.1
XRN2
5'-3' exoribonuclease 2
chr16_+_3254247 0.05 ENST00000304646.2
OR1F1
olfactory receptor, family 1, subfamily F, member 1
chr3_-_121264848 0.05 ENST00000264233.5
POLQ
polymerase (DNA directed), theta
chr1_-_145826450 0.05 ENST00000462900.2
GPR89A
G protein-coupled receptor 89A
chr6_-_31514516 0.05 ENST00000303892.5
ENST00000483251.1
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr4_+_76649797 0.05 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr7_-_137028534 0.04 ENST00000348225.2
PTN
pleiotrophin
chr9_-_4666421 0.04 ENST00000381895.5
SPATA6L
spermatogenesis associated 6-like
chr9_+_42717234 0.04 ENST00000377590.1
FOXD4L2
forkhead box D4-like 2
chr12_-_11463353 0.04 ENST00000279575.1
ENST00000535904.1
ENST00000445719.2
PRB4
proline-rich protein BstNI subfamily 4
chr22_+_42017987 0.04 ENST00000405506.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chrX_-_102941596 0.04 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
MORF4L2
mortality factor 4 like 2
chr11_-_85376121 0.03 ENST00000527447.1
CREBZF
CREB/ATF bZIP transcription factor
chr4_-_120243545 0.03 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chrM_+_7586 0.03 ENST00000361739.1
MT-CO2
mitochondrially encoded cytochrome c oxidase II
chr7_+_20686946 0.03 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr20_+_54823788 0.03 ENST00000243911.2
MC3R
melanocortin 3 receptor
chr12_-_59175485 0.03 ENST00000550678.1
ENST00000552201.1
RP11-767I20.1
RP11-767I20.1
chr21_+_39644214 0.03 ENST00000438657.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_100810575 0.03 ENST00000542213.1
CDC14A
cell division cycle 14A
chr4_+_78829479 0.03 ENST00000504901.1
MRPL1
mitochondrial ribosomal protein L1
chr9_-_70178815 0.03 ENST00000377420.1
FOXD4L5
forkhead box D4-like 5
chr1_+_206223941 0.02 ENST00000367126.4
AVPR1B
arginine vasopressin receptor 1B
chr12_+_12223867 0.02 ENST00000308721.5
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr9_-_70429731 0.02 ENST00000377413.1
FOXD4L4
forkhead box D4-like 4
chr6_+_116937636 0.02 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A
radial spoke head 4 homolog A (Chlamydomonas)
chr15_+_27112948 0.02 ENST00000555060.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr2_+_219840955 0.02 ENST00000598002.1
ENST00000432733.1
LINC00608
long intergenic non-protein coding RNA 608
chr3_+_189507460 0.02 ENST00000434928.1
TP63
tumor protein p63
chr2_-_89568263 0.02 ENST00000473726.1
IGKV1-33
immunoglobulin kappa variable 1-33
chr7_-_55606346 0.02 ENST00000545390.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr2_+_1417228 0.02 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
TPO
thyroid peroxidase
chr14_-_75330537 0.01 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2
prospero homeobox 2
chr14_-_106668095 0.01 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr15_-_83209210 0.01 ENST00000561157.1
ENST00000330244.6
RPS17L
ribosomal protein S17-like
chr3_-_133648656 0.01 ENST00000408895.2
C3orf36
chromosome 3 open reading frame 36
chr9_-_114361665 0.01 ENST00000309195.5
PTGR1
prostaglandin reductase 1
chr22_-_32767017 0.01 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr6_+_167525277 0.01 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr12_-_6579833 0.01 ENST00000396308.3
VAMP1
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr19_-_16606988 0.00 ENST00000269881.3
CALR3
calreticulin 3
chr9_+_117904097 0.00 ENST00000374016.1
DEC1
deleted in esophageal cancer 1
chrX_-_153191708 0.00 ENST00000393721.1
ENST00000370028.3
ARHGAP4
Rho GTPase activating protein 4
chr2_-_127977654 0.00 ENST00000409327.1
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr9_-_113761720 0.00 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.2 0.8 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.2 0.5 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.2 0.5 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 0.8 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 1.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.6 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.1 0.7 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.6 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.2 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.1 0.2 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.0 0.1 GO:0034241 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.0 0.1 GO:1904397 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.2 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.1 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0 0.1 GO:0051586 peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0 0.2 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.5 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.3 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.2 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.1 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.6 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.1 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.2 0.5 GO:0070025 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.1 0.6 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.1 0.5 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.5 GO:0004882 androgen receptor activity(GO:0004882)
0.1 0.8 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.2 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.1 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.4 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.2 GO:0004945 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0001147 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 1.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.9 ST G ALPHA I PATHWAY G alpha i Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.8 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression