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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ARID3A
Z-value: 0.64
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Transcription factors associated with ARID3A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARID3A | hg19_v2_chr19_+_926000_926046 | 0.37 | 7.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_76957214 Show fit | 4.25 |
ENST00000306621.3
|
chemokine (C-X-C motif) ligand 11 |
|
| chr12_+_113344582 Show fit | 2.44 |
ENST00000202917.5
ENST00000445409.2 ENST00000452357.2 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr1_+_145438469 Show fit | 1.85 |
ENST00000369317.4
|
thioredoxin interacting protein |
|
| chr13_-_33780133 Show fit | 1.11 |
ENST00000399365.3
|
StAR-related lipid transfer (START) domain containing 13 |
|
| chr7_-_139763521 Show fit | 0.97 |
ENST00000263549.3
|
poly (ADP-ribose) polymerase family, member 12 |
|
| chr12_+_97306295 Show fit | 0.84 |
ENST00000457368.2
|
neural precursor cell expressed, developmentally down-regulated 1 |
|
| chr4_-_169239921 Show fit | 0.83 |
ENST00000514995.1
ENST00000393743.3 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
|
| chr4_+_70916119 Show fit | 0.82 |
ENST00000246896.3
ENST00000511674.1 |
histatin 1 |
|
| chr8_+_11961898 Show fit | 0.81 |
ENST00000400085.3
|
zinc finger protein 705D |
|
| chr10_+_91092241 Show fit | 0.79 |
ENST00000371811.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARID3A
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.2 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.0 | 2.3 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.0 | 2.0 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 1.7 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.0 | 1.2 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.2 | 1.1 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.0 | 1.0 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.3 | 0.8 | GO:0045897 | positive regulation of transcription during mitosis(GO:0045897) |
| 0.2 | 0.8 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 0.8 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.8 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 0.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 0.5 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 0.5 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 0.5 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.5 | GO:0001673 | male germ cell nucleus(GO:0001673) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.2 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.2 | 2.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 1.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.8 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.2 | 0.7 | GO:0030305 | heparanase activity(GO:0030305) |
| 0.1 | 0.7 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.1 | 0.6 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.0 | 0.6 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 0.6 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 0.5 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 1.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.4 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.1 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 2.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 0.8 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 0.7 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.7 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.7 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.6 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |