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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for AR_NR3C2

Z-value: 0.45

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.11 androgen receptor
NR3C2
ENSG00000151623.10 nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARhg19_v2_chrX_+_66764375_66764465-0.164.4e-01Click!
NR3C2hg19_v2_chr4_-_149363662_149363688-0.029.3e-01Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_56642041 0.97 ENST00000245185.5
MT2A
metallothionein 2A
chr16_+_56666563 0.86 ENST00000570233.1
MT1M
metallothionein 1M
chr16_+_56642489 0.86 ENST00000561491.1
MT2A
metallothionein 2A
chr16_+_56659687 0.84 ENST00000568293.1
ENST00000330439.6
MT1E
metallothionein 1E
chr2_+_102953608 0.80 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr16_+_56716336 0.77 ENST00000394485.4
ENST00000562939.1
MT1X
metallothionein 1X
chr22_+_30477000 0.76 ENST00000403975.1
HORMAD2
HORMA domain containing 2
chr6_+_127898312 0.66 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr3_-_58563094 0.61 ENST00000464064.1
FAM107A
family with sequence similarity 107, member A
chr1_-_1149506 0.56 ENST00000379236.3
TNFRSF4
tumor necrosis factor receptor superfamily, member 4
chr19_+_8117636 0.53 ENST00000253451.4
ENST00000315626.4
CCL25
chemokine (C-C motif) ligand 25
chr19_+_35630628 0.49 ENST00000588715.1
ENST00000588607.1
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_35630926 0.48 ENST00000588081.1
ENST00000589121.1
FXYD1
FXYD domain containing ion transport regulator 1
chr19_-_45657028 0.43 ENST00000429338.1
ENST00000589776.1
NKPD1
NTPase, KAP family P-loop domain containing 1
chr19_+_35630344 0.42 ENST00000455515.2
FXYD1
FXYD domain containing ion transport regulator 1
chrX_+_8432871 0.41 ENST00000381032.1
ENST00000453306.1
ENST00000444481.1
VCX3B
variable charge, X-linked 3B
chr10_+_60759378 0.40 ENST00000432535.1
LINC00844
long intergenic non-protein coding RNA 844
chr19_+_8117881 0.37 ENST00000390669.3
CCL25
chemokine (C-C motif) ligand 25
chrX_-_6453159 0.37 ENST00000381089.3
ENST00000398729.1
VCX3A
variable charge, X-linked 3A
chr12_+_5153085 0.36 ENST00000252321.3
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chrX_+_8433376 0.36 ENST00000440654.2
ENST00000381029.4
VCX3B
variable charge, X-linked 3B
chr18_-_48346298 0.35 ENST00000398439.3
MRO
maestro
chrY_+_16168097 0.34 ENST00000250823.4
VCY1B
variable charge, Y-linked 1B
chrX_-_8139308 0.34 ENST00000317103.4
VCX2
variable charge, X-linked 2
chrY_-_16098393 0.33 ENST00000250825.4
VCY
variable charge, Y-linked
chr18_-_48346415 0.30 ENST00000431965.2
ENST00000436348.2
MRO
maestro
chr3_+_169490834 0.29 ENST00000392733.1
MYNN
myoneurin
chr16_+_56672571 0.25 ENST00000290705.8
MT1A
metallothionein 1A
chr8_-_72756667 0.25 ENST00000325509.4
MSC
musculin
chr1_-_145715565 0.24 ENST00000369288.2
ENST00000369290.1
ENST00000401557.3
CD160
CD160 molecule
chr8_-_22014339 0.24 ENST00000306317.2
LGI3
leucine-rich repeat LGI family, member 3
chr18_-_48346130 0.22 ENST00000592966.1
MRO
maestro
chr1_-_49242553 0.22 ENST00000371833.3
BEND5
BEN domain containing 5
chr14_+_22309368 0.21 ENST00000390433.1
TRAV12-1
T cell receptor alpha variable 12-1
chr3_-_108476231 0.21 ENST00000295755.6
RETNLB
resistin like beta
chr11_+_48002076 0.21 ENST00000418331.2
ENST00000440289.2
PTPRJ
protein tyrosine phosphatase, receptor type, J
chr8_+_24298597 0.21 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr8_-_21669826 0.20 ENST00000517328.1
GFRA2
GDNF family receptor alpha 2
chr6_+_31638156 0.19 ENST00000409525.1
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr7_-_96654133 0.19 ENST00000486603.2
ENST00000222598.4
DLX5
distal-less homeobox 5
chr8_+_24298531 0.19 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr9_+_71650645 0.18 ENST00000396366.2
FXN
frataxin
chr19_-_8408139 0.18 ENST00000330915.3
ENST00000593649.1
ENST00000595639.1
KANK3
KN motif and ankyrin repeat domains 3
chr22_+_18632666 0.18 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr2_-_74875432 0.16 ENST00000536235.1
ENST00000421985.1
M1AP
meiosis 1 associated protein
chr14_-_23623577 0.16 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr12_-_10251603 0.15 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr14_-_24616426 0.15 ENST00000216802.5
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_+_238395803 0.14 ENST00000264605.3
MLPH
melanophilin
chr6_+_123317116 0.14 ENST00000275162.5
CLVS2
clavesin 2
chr14_+_24616588 0.14 ENST00000324103.6
ENST00000559260.1
RNF31
ring finger protein 31
chr8_-_49833978 0.14 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr13_-_26452679 0.14 ENST00000596729.1
AL138815.2
Uncharacterized protein
chr3_-_190167571 0.14 ENST00000354905.2
TMEM207
transmembrane protein 207
chr8_-_145634731 0.14 ENST00000349769.3
CPSF1
cleavage and polyadenylation specific factor 1, 160kDa
chr9_+_131683174 0.13 ENST00000372592.3
ENST00000428610.1
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr16_+_25703274 0.13 ENST00000331351.5
HS3ST4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr1_+_1846519 0.13 ENST00000378604.3
CALML6
calmodulin-like 6
chr8_-_49834299 0.13 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr3_-_118864893 0.13 ENST00000354673.2
ENST00000425327.2
IGSF11
immunoglobulin superfamily, member 11
chr16_-_25269134 0.13 ENST00000328086.7
ZKSCAN2
zinc finger with KRAB and SCAN domains 2
chr14_-_106552755 0.11 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr2_+_238395879 0.10 ENST00000445024.2
ENST00000338530.4
ENST00000409373.1
MLPH
melanophilin
chr19_-_3786354 0.10 ENST00000395040.2
ENST00000310132.6
MATK
megakaryocyte-associated tyrosine kinase
chr14_-_106668095 0.10 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr19_-_3786253 0.09 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chr14_-_106866934 0.09 ENST00000390618.2
IGHV3-38
immunoglobulin heavy variable 3-38 (non-functional)
chr1_+_93811438 0.09 ENST00000370272.4
ENST00000370267.1
DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr3_+_169490606 0.08 ENST00000349841.5
MYNN
myoneurin
chr15_+_65204075 0.08 ENST00000380230.3
ENST00000357698.3
ENST00000395720.1
ENST00000496660.1
ENST00000319580.8
ANKDD1A
ankyrin repeat and death domain containing 1A
chr14_-_21493884 0.08 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG2
NDRG family member 2
chr19_+_56187987 0.08 ENST00000411543.2
EPN1
epsin 1
chr17_+_38333263 0.08 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr3_-_188665428 0.08 ENST00000444488.1
TPRG1-AS1
TPRG1 antisense RNA 1
chr1_+_22979474 0.08 ENST00000509305.1
C1QB
complement component 1, q subcomponent, B chain
chr10_-_87551311 0.08 ENST00000536331.1
GRID1
glutamate receptor, ionotropic, delta 1
chrX_-_24045303 0.07 ENST00000328046.8
KLHL15
kelch-like family member 15
chr4_+_37892682 0.07 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr17_-_61959202 0.07 ENST00000449787.2
ENST00000456543.2
ENST00000423893.2
ENST00000332800.7
GH2
growth hormone 2
chr4_-_69215699 0.06 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr16_-_67978016 0.06 ENST00000264005.5
LCAT
lecithin-cholesterol acyltransferase
chr11_-_114271139 0.06 ENST00000325636.4
C11orf71
chromosome 11 open reading frame 71
chr2_+_242577027 0.06 ENST00000402096.1
ENST00000404914.3
ATG4B
autophagy related 4B, cysteine peptidase
chr3_+_169491171 0.06 ENST00000356716.4
MYNN
myoneurin
chr2_+_242577097 0.05 ENST00000419606.1
ENST00000474739.2
ENST00000396411.3
ENST00000425239.1
ENST00000400771.3
ENST00000430617.2
ATG4B
autophagy related 4B, cysteine peptidase
chr11_-_506739 0.05 ENST00000529306.1
ENST00000438658.2
ENST00000527485.1
ENST00000397615.2
ENST00000397614.1
RNH1
ribonuclease/angiogenin inhibitor 1
chr5_-_173043591 0.05 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
BOD1
biorientation of chromosomes in cell division 1
chr12_+_66582919 0.05 ENST00000545837.1
ENST00000457197.2
IRAK3
interleukin-1 receptor-associated kinase 3
chr2_-_231825668 0.05 ENST00000392039.2
GPR55
G protein-coupled receptor 55
chr1_-_10856694 0.05 ENST00000377022.3
ENST00000344008.5
CASZ1
castor zinc finger 1
chr17_-_61996192 0.05 ENST00000392824.4
CSHL1
chorionic somatomammotropin hormone-like 1
chr3_+_118864991 0.05 ENST00000295622.1
C3orf30
chromosome 3 open reading frame 30
chr14_-_106692191 0.05 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr19_-_14117074 0.05 ENST00000588885.1
ENST00000254325.4
RFX1
regulatory factor X, 1 (influences HLA class II expression)
chr3_-_119396193 0.04 ENST00000484810.1
ENST00000497116.1
ENST00000261070.2
COX17
COX17 cytochrome c oxidase copper chaperone
chr22_+_24030321 0.04 ENST00000401461.1
RGL4
ral guanine nucleotide dissociation stimulator-like 4
chr17_-_61996136 0.04 ENST00000342364.4
GH1
growth hormone 1
chr14_-_21493649 0.04 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG2
NDRG family member 2
chr8_+_91013577 0.04 ENST00000220764.2
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
chr10_+_26932068 0.04 ENST00000544033.1
ENST00000454991.1
LINC00202-2
RP13-16H11.7
long intergenic non-protein coding RNA 202-2
RP13-16H11.7
chr10_+_115674530 0.04 ENST00000451472.1
AL162407.1
CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein
chr12_-_56848426 0.04 ENST00000257979.4
MIP
major intrinsic protein of lens fiber
chr6_-_52774464 0.04 ENST00000370968.1
ENST00000211122.3
GSTA3
glutathione S-transferase alpha 3
chr1_+_22979676 0.04 ENST00000432749.2
ENST00000314933.6
C1QB
complement component 1, q subcomponent, B chain
chr7_-_4877677 0.04 ENST00000538469.1
RADIL
Ras association and DIL domains
chr18_+_56530136 0.03 ENST00000591083.1
ZNF532
zinc finger protein 532
chr17_-_3794021 0.03 ENST00000381769.2
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr1_+_76262552 0.03 ENST00000263187.3
MSH4
mutS homolog 4
chr3_+_118865028 0.03 ENST00000460150.1
C3orf30
chromosome 3 open reading frame 30
chr18_+_45778672 0.03 ENST00000600091.1
AC091150.1
HCG1818186; Uncharacterized protein
chr17_-_61996160 0.03 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
GH1
growth hormone 1
chr19_+_57874835 0.03 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
TRAPPC2P1
ZNF547
AC003002.4
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr8_+_91013676 0.03 ENST00000519410.1
ENST00000522161.1
ENST00000517761.1
ENST00000520227.1
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
chr3_+_13521665 0.03 ENST00000295757.3
ENST00000402259.1
ENST00000402271.1
ENST00000446613.2
ENST00000404548.1
ENST00000404040.1
HDAC11
histone deacetylase 11
chr5_-_179498703 0.03 ENST00000522208.2
RNF130
ring finger protein 130
chr17_-_6459802 0.02 ENST00000262483.8
PITPNM3
PITPNM family member 3
chr19_+_58570605 0.02 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
ZNF135
zinc finger protein 135
chr16_-_66584059 0.02 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr17_+_38498594 0.02 ENST00000394081.3
RARA
retinoic acid receptor, alpha
chrX_+_2609207 0.02 ENST00000381192.3
CD99
CD99 molecule
chr10_+_695888 0.02 ENST00000441152.2
PRR26
proline rich 26
chr1_-_27693349 0.01 ENST00000374040.3
ENST00000357582.2
ENST00000493901.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr11_+_114270752 0.01 ENST00000540163.1
RBM7
RNA binding motif protein 7
chr2_-_242576864 0.01 ENST00000407315.1
THAP4
THAP domain containing 4
chr11_+_114271314 0.01 ENST00000541475.1
RBM7
RNA binding motif protein 7
chr12_+_122241928 0.01 ENST00000604567.1
ENST00000542440.1
SETD1B
SET domain containing 1B
chrX_+_2609317 0.01 ENST00000381187.3
ENST00000381184.1
CD99
CD99 molecule
chr11_+_114271251 0.00 ENST00000375490.5
RBM7
RNA binding motif protein 7
chr4_+_75311019 0.00 ENST00000502307.1
AREG
amphiregulin
chrX_+_2609356 0.00 ENST00000381180.3
ENST00000449611.1
CD99
CD99 molecule

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 1.4 GO:0010732 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.9 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1 0.8 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.8 GO:0036018 cellular response to erythropoietin(GO:0036018)
0.1 0.8 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.1 0.3 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.2 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.1 1.9 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 0.2 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.4 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.0 0.2 GO:0018282 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.0 0.6 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.0 0.2 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.2 GO:0060242 contact inhibition(GO:0060242)
0.0 0.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.1 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.8 GO:0000795 synaptonemal complex(GO:0000795)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 0.9 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.1 1.8 GO:0046870 cadmium ion binding(GO:0046870)
0.1 0.4 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 1.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines