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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for AR_NR3C2
Z-value: 0.45
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Transcription factors associated with AR_NR3C2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| AR | hg19_v2_chrX_+_66764375_66764465 | -0.16 | 4.4e-01 | Click! |
| NR3C2 | hg19_v2_chr4_-_149363662_149363688 | -0.02 | 9.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_56642041 Show fit | 0.97 |
ENST00000245185.5
|
metallothionein 2A |
|
| chr16_+_56666563 Show fit | 0.86 |
ENST00000570233.1
|
metallothionein 1M |
|
| chr16_+_56642489 Show fit | 0.86 |
ENST00000561491.1
|
metallothionein 2A |
|
| chr16_+_56659687 Show fit | 0.84 |
ENST00000568293.1
ENST00000330439.6 |
metallothionein 1E |
|
| chr2_+_102953608 Show fit | 0.80 |
ENST00000311734.2
ENST00000409584.1 |
interleukin 1 receptor-like 1 |
|
| chr16_+_56716336 Show fit | 0.77 |
ENST00000394485.4
ENST00000562939.1 |
metallothionein 1X |
|
| chr22_+_30477000 Show fit | 0.76 |
ENST00000403975.1
|
HORMA domain containing 2 |
|
| chr6_+_127898312 Show fit | 0.66 |
ENST00000329722.7
|
chromosome 6 open reading frame 58 |
|
| chr3_-_58563094 Show fit | 0.61 |
ENST00000464064.1
|
family with sequence similarity 107, member A |
|
| chr1_-_1149506 Show fit | 0.56 |
ENST00000379236.3
|
tumor necrosis factor receptor superfamily, member 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AR_NR3C2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.4 | 1.8 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.2 | 1.4 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.1 | 0.9 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.1 | 0.8 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.1 | 0.8 | GO:0036018 | cellular response to erythropoietin(GO:0036018) |
| 0.1 | 0.8 | GO:0051177 | meiotic sister chromatid cohesion(GO:0051177) |
| 0.0 | 0.6 | GO:0051024 | positive regulation of immunoglobulin secretion(GO:0051024) |
| 0.0 | 0.4 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 0.1 | 0.3 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.8 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 0.1 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.0 | 0.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 0.1 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.0 | 0.1 | GO:0005602 | complement component C1 complex(GO:0005602) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 0.0 | 1.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 0.9 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
| 0.3 | 0.8 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.1 | 0.4 | GO:0086089 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089) |
| 0.0 | 0.2 | GO:0016530 | metallochaperone activity(GO:0016530) |
| 0.0 | 0.2 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.0 | 0.2 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.2 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.0 | 0.2 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 0.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |