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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ATF4

Z-value: 1.10

Motif logo

Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ENSG00000128272.10 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.681.8e-04Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_89182156 9.20 ENST00000379224.5
interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 9.06 ENST00000559876.1
interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 7.84 ENST00000306072.5
interferon stimulated exonuclease gene 20kDa
chr15_+_41245160 4.46 ENST00000444189.2
ENST00000446533.3
ChaC, cation transport regulator homolog 1 (E. coli)
chr6_+_126102292 2.54 ENST00000368357.3
nuclear receptor coactivator 7
chr11_-_3078838 2.45 ENST00000397111.5
cysteinyl-tRNA synthetase
chr11_-_3078616 2.37 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
cysteinyl-tRNA synthetase
chrX_+_9431324 2.34 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr7_-_115670792 2.18 ENST00000265440.7
ENST00000393485.1
transcription factor EC
chr10_+_111765562 2.04 ENST00000360162.3
adducin 3 (gamma)
chr7_-_115670804 2.03 ENST00000320239.7
transcription factor EC
chr12_-_117318788 1.88 ENST00000550505.1
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr16_+_56970567 1.63 ENST00000563911.1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr1_-_149832704 1.62 ENST00000392933.1
ENST00000369157.2
ENST00000392932.4
histone cluster 2, H4b
chr11_-_57092381 1.52 ENST00000358252.3
tankyrase 1 binding protein 1, 182kDa
chr4_+_77870856 1.49 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
septin 11
chrX_-_68385354 1.47 ENST00000361478.1
praja ring finger 1, E3 ubiquitin protein ligase
chr1_+_149804218 1.47 ENST00000610125.1
histone cluster 2, H4a
chrX_-_68385274 1.46 ENST00000374584.3
ENST00000590146.1
praja ring finger 1, E3 ubiquitin protein ligase
chr7_+_30634297 1.44 ENST00000389266.3
glycyl-tRNA synthetase
chr5_+_154135029 1.44 ENST00000518297.1
La ribonucleoprotein domain family, member 1
chr22_+_50919995 1.38 ENST00000362068.2
ENST00000395737.1
adrenomedullin 2
chr16_+_56965960 1.36 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_-_47288162 1.35 ENST00000594991.1
solute carrier family 1 (neutral amino acid transporter), member 5
chr22_+_50919944 1.35 ENST00000395738.2
adrenomedullin 2
chr19_-_47287990 1.33 ENST00000593713.1
ENST00000598022.1
ENST00000434726.2
solute carrier family 1 (neutral amino acid transporter), member 5
chr1_+_212782012 1.32 ENST00000341491.4
ENST00000366985.1
activating transcription factor 3
chr11_+_62649158 1.28 ENST00000539891.1
ENST00000536981.1
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr5_+_67586465 1.07 ENST00000336483.5
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_+_77870960 1.04 ENST00000505788.1
ENST00000510515.1
ENST00000504637.1
septin 11
chr17_+_56315936 0.98 ENST00000543544.1
lactoperoxidase
chr17_+_56315787 0.94 ENST00000262290.4
ENST00000421678.2
lactoperoxidase
chr14_+_24563262 0.92 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr5_+_179105615 0.92 ENST00000514383.1
calnexin
chr17_-_79895097 0.89 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
pyrroline-5-carboxylate reductase 1
chr17_-_79895154 0.88 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
pyrroline-5-carboxylate reductase 1
chr1_-_220220000 0.88 ENST00000366923.3
glutamyl-prolyl-tRNA synthetase
chr1_-_220219775 0.88 ENST00000609181.1
glutamyl-prolyl-tRNA synthetase
chr5_+_143584814 0.85 ENST00000507359.3
potassium channel tetramerization domain containing 16
chr19_+_33865218 0.85 ENST00000585933.2
CCAAT/enhancer binding protein (C/EBP), gamma
chr9_-_95055956 0.84 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
isoleucyl-tRNA synthetase
chr9_+_80912059 0.84 ENST00000347159.2
ENST00000376588.3
phosphoserine aminotransferase 1
chr16_-_67694597 0.81 ENST00000393919.4
ENST00000219251.8
adrenocortical dysplasia homolog (mouse)
chr10_+_50507181 0.80 ENST00000323868.4
chromosome 10 open reading frame 71
chr10_+_50507232 0.79 ENST00000374144.3
chromosome 10 open reading frame 71
chr14_+_24563510 0.79 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr1_-_204380919 0.78 ENST00000367188.4
protein phosphatase 1, regulatory subunit 15B
chr7_+_99006550 0.77 ENST00000222969.5
BUD31 homolog (S. cerevisiae)
chr17_-_76836963 0.77 ENST00000312010.6
ubiquitin specific peptidase 36
chr4_-_153457197 0.77 ENST00000281708.4
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr6_+_151187615 0.76 ENST00000441122.1
ENST00000423867.1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr5_+_33441053 0.72 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
threonyl-tRNA synthetase
chr2_-_98280383 0.71 ENST00000289228.5
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr12_-_46662772 0.70 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
solute carrier family 38, member 1
chr17_-_76836729 0.69 ENST00000587783.1
ENST00000542802.3
ENST00000586531.1
ENST00000589424.1
ENST00000590546.2
ubiquitin specific peptidase 36
chr2_+_46769798 0.68 ENST00000238738.4
ras homolog family member Q
chr5_+_33440802 0.65 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
threonyl-tRNA synthetase
chr12_+_57624119 0.65 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
serine hydroxymethyltransferase 2 (mitochondrial)
chr3_-_48130314 0.64 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
microtubule-associated protein 4
chr1_+_228353495 0.59 ENST00000366711.3
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr5_-_76935513 0.58 ENST00000306422.3
orthopedia homeobox
chr6_+_151187074 0.58 ENST00000367308.4
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr12_+_50135588 0.58 ENST00000423828.1
ENST00000550445.1
transmembrane BAX inhibitor motif containing 6
chr16_-_18908196 0.57 ENST00000565324.1
ENST00000561947.1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr17_-_40828969 0.56 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr7_+_99006232 0.54 ENST00000403633.2
BUD31 homolog (S. cerevisiae)
chr3_-_48130707 0.54 ENST00000360240.6
ENST00000383737.4
microtubule-associated protein 4
chr20_+_23342783 0.53 ENST00000544236.1
ENST00000338121.5
ENST00000542987.1
ENST00000424216.1
GDNF-inducible zinc finger protein 1
chr21_-_44495919 0.49 ENST00000398158.1
cystathionine-beta-synthase
chrX_-_15332665 0.49 ENST00000537676.1
ENST00000344384.4
ankyrin repeat and SOCS box containing 11
chr3_-_99594948 0.48 ENST00000471562.1
ENST00000495625.2
filamin A interacting protein 1-like
chr1_+_239882842 0.48 ENST00000448020.1
cholinergic receptor, muscarinic 3
chr7_-_121944491 0.45 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr3_+_148415571 0.42 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
angiotensin II receptor, type 1
chr12_+_57623869 0.39 ENST00000414700.3
ENST00000557703.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr3_-_99595037 0.39 ENST00000383694.2
filamin A interacting protein 1-like
chr8_-_38008783 0.38 ENST00000276449.4
steroidogenic acute regulatory protein
chr1_-_178840157 0.38 ENST00000367629.1
ENST00000234816.2
angiopoietin-like 1
chr12_+_57624085 0.37 ENST00000553474.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr4_-_21950356 0.36 ENST00000447367.2
ENST00000382152.2
Kv channel interacting protein 4
chr1_-_167883327 0.35 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
adenylate cyclase 10 (soluble)
chr22_+_42229100 0.35 ENST00000361204.4
sterol regulatory element binding transcription factor 2
chr1_-_167883353 0.35 ENST00000545172.1
adenylate cyclase 10 (soluble)
chr16_-_70323422 0.34 ENST00000261772.8
alanyl-tRNA synthetase
chr21_-_44495964 0.32 ENST00000398168.1
ENST00000398165.3
cystathionine-beta-synthase
chr12_-_57914275 0.31 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DNA-damage-inducible transcript 3
chr11_-_128737163 0.30 ENST00000324003.3
ENST00000392665.2
potassium inwardly-rectifying channel, subfamily J, member 1
chr19_+_49259325 0.30 ENST00000222157.3
fibroblast growth factor 21
chr1_+_241815577 0.29 ENST00000366552.2
ENST00000437684.2
WD repeat domain 64
chr12_+_57623477 0.29 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr8_-_11324273 0.28 ENST00000284486.4
family with sequence similarity 167, member A
chr5_-_145562147 0.28 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
leucyl-tRNA synthetase
chr20_+_8112824 0.28 ENST00000378641.3
phospholipase C, beta 1 (phosphoinositide-specific)
chr17_-_46703826 0.27 ENST00000550387.1
ENST00000311177.5
homeobox B9
chr11_-_77185094 0.26 ENST00000278568.4
ENST00000356341.3
p21 protein (Cdc42/Rac)-activated kinase 1
chr16_+_46918235 0.25 ENST00000340124.4
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr7_-_48068699 0.25 ENST00000412142.1
ENST00000395572.2
Sad1 and UNC84 domain containing 3
chr3_-_3151664 0.23 ENST00000256452.3
ENST00000311981.8
ENST00000430514.2
ENST00000456302.1
interleukin 5 receptor, alpha
chr17_+_39846114 0.21 ENST00000586699.1
eukaryotic translation initiation factor 1
chr7_-_48068643 0.20 ENST00000453192.2
Sad1 and UNC84 domain containing 3
chr22_-_29457832 0.19 ENST00000216071.4
chromosome 22 open reading frame 31
chr19_+_49258775 0.19 ENST00000593756.1
fibroblast growth factor 21
chr11_-_128737259 0.18 ENST00000440599.2
ENST00000392666.1
ENST00000324036.3
potassium inwardly-rectifying channel, subfamily J, member 1
chr19_-_49258606 0.18 ENST00000310160.3
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr3_-_3152031 0.18 ENST00000383846.1
ENST00000427088.1
ENST00000446632.2
ENST00000438560.1
interleukin 5 receptor, alpha
chr19_-_51192661 0.18 ENST00000391813.1
SH3 and multiple ankyrin repeat domains 1
chr7_-_48068671 0.17 ENST00000297325.4
Sad1 and UNC84 domain containing 3
chr15_+_40886199 0.16 ENST00000346991.5
ENST00000528975.1
ENST00000527044.1
cancer susceptibility candidate 5
chrX_+_48398053 0.15 ENST00000537536.1
ENST00000418627.1
TBC1 domain family, member 25
chr8_-_116680833 0.12 ENST00000220888.5
trichorhinophalangeal syndrome I
chr9_+_36169380 0.12 ENST00000335119.2
calicin
chr7_-_50860565 0.12 ENST00000403097.1
growth factor receptor-bound protein 10
chr5_+_44809027 0.12 ENST00000507110.1
mitochondrial ribosomal protein S30
chr1_-_207143802 0.11 ENST00000324852.4
ENST00000400962.3
Fc receptor, IgA, IgM, high affinity
chr12_-_50297638 0.10 ENST00000320634.3
Fas apoptotic inhibitory molecule 2
chr17_-_40829026 0.10 ENST00000412503.1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chrX_+_77359671 0.08 ENST00000373316.4
phosphoglycerate kinase 1
chr3_-_33686925 0.07 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
cytoplasmic linker associated protein 2
chrX_+_24072833 0.07 ENST00000253039.4
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr9_-_99381660 0.02 ENST00000375240.3
ENST00000463569.1
cell division cycle 14B
chr7_-_138386097 0.02 ENST00000421622.1
SVOP-like
chr1_-_20250110 0.02 ENST00000375116.3
phospholipase A2, group IIE
chr15_+_40886439 0.00 ENST00000532056.1
ENST00000399668.2
cancer susceptibility candidate 5

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 26.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.6 4.8 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.7 2.7 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.6 1.8 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.4 1.3 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.4 1.4 GO:0015965 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.4 1.4 GO:1901355 response to rapamycin(GO:1901355)
0.3 1.4 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.3 1.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.3 0.8 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.3 0.8 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.3 0.8 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.3 1.3 GO:0060356 leucine import(GO:0060356)
0.3 1.8 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.2 1.7 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.2 4.5 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 1.7 GO:0006116 NADH oxidation(GO:0006116)
0.2 1.2 GO:0051012 microtubule sliding(GO:0051012)
0.2 3.0 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.2 1.3 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.2 0.8 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.8 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.1 0.4 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 2.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.4 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.8 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 0.4 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 1.1 GO:0006983 ER overload response(GO:0006983)
0.1 0.5 GO:1904640 response to methionine(GO:1904640)
0.1 0.6 GO:0051025 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.1 0.3 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.1 0.3 GO:0080154 regulation of fertilization(GO:0080154)
0.1 1.9 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.1 0.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.2 GO:0042851 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.1 0.2 GO:0050894 determination of affect(GO:0050894)
0.1 1.1 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.1 1.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.6 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.3 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 1.5 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 2.7 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.0 0.7 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 0.6 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.7 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.6 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 4.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.1 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.5 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.2 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.2 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 2.7 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.2 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 1.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.1 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.5 3.0 GO:1990037 Lewy body core(GO:1990037)
0.3 25.4 GO:0015030 Cajal body(GO:0015030)
0.3 1.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.3 1.8 GO:0097452 GAIT complex(GO:0097452)
0.2 1.7 GO:0070552 BRISC complex(GO:0070552)
0.1 1.4 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.8 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.5 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.8 GO:0070187 telosome(GO:0070187)
0.1 0.9 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.7 GO:0005869 dynactin complex(GO:0005869)
0.0 0.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 2.0 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 4.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 1.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 7.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.7 26.1 GO:0008859 exoribonuclease II activity(GO:0008859)
1.6 4.8 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
1.5 4.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.6 1.8 GO:0004818 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.6 1.7 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.4 2.7 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.3 1.4 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.3 1.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.3 1.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.3 0.8 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.3 0.8 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.2 1.7 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 0.7 GO:0032427 GBD domain binding(GO:0032427)
0.2 1.7 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.4 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.4 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 1.1 GO:0043559 insulin binding(GO:0043559)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 0.8 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.3 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.1 1.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 1.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 1.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 3.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.9 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.8 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.6 GO:0043495 protein anchor(GO:0043495)
0.0 0.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 8.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 2.2 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 2.5 GO:0044325 ion channel binding(GO:0044325)
0.0 1.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 2.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 3.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 4.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 1.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 26.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 9.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 4.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 2.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 4.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 3.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 0.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 2.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.5 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling