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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ATF4

Z-value: 1.10

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.681.8e-04Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_89182156 9.20 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 9.06 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 7.84 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_41245160 4.46 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr6_+_126102292 2.54 ENST00000368357.3
NCOA7
nuclear receptor coactivator 7
chr11_-_3078838 2.45 ENST00000397111.5
CARS
cysteinyl-tRNA synthetase
chr11_-_3078616 2.37 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
CARS
cysteinyl-tRNA synthetase
chrX_+_9431324 2.34 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr7_-_115670792 2.18 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr10_+_111765562 2.04 ENST00000360162.3
ADD3
adducin 3 (gamma)
chr7_-_115670804 2.03 ENST00000320239.7
TFEC
transcription factor EC
chr12_-_117318788 1.88 ENST00000550505.1
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr16_+_56970567 1.63 ENST00000563911.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr1_-_149832704 1.62 ENST00000392933.1
ENST00000369157.2
ENST00000392932.4
HIST2H4B
histone cluster 2, H4b
chr11_-_57092381 1.52 ENST00000358252.3
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr4_+_77870856 1.49 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
SEPT11
septin 11
chrX_-_68385354 1.47 ENST00000361478.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr1_+_149804218 1.47 ENST00000610125.1
HIST2H4A
histone cluster 2, H4a
chrX_-_68385274 1.46 ENST00000374584.3
ENST00000590146.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr7_+_30634297 1.44 ENST00000389266.3
GARS
glycyl-tRNA synthetase
chr5_+_154135029 1.44 ENST00000518297.1
LARP1
La ribonucleoprotein domain family, member 1
chr22_+_50919995 1.38 ENST00000362068.2
ENST00000395737.1
ADM2
adrenomedullin 2
chr16_+_56965960 1.36 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_-_47288162 1.35 ENST00000594991.1
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr22_+_50919944 1.35 ENST00000395738.2
ADM2
adrenomedullin 2
chr19_-_47287990 1.33 ENST00000593713.1
ENST00000598022.1
ENST00000434726.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr1_+_212782012 1.32 ENST00000341491.4
ENST00000366985.1
ATF3
activating transcription factor 3
chr11_+_62649158 1.28 ENST00000539891.1
ENST00000536981.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr5_+_67586465 1.07 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_+_77870960 1.04 ENST00000505788.1
ENST00000510515.1
ENST00000504637.1
SEPT11
septin 11
chr17_+_56315936 0.98 ENST00000543544.1
LPO
lactoperoxidase
chr17_+_56315787 0.94 ENST00000262290.4
ENST00000421678.2
LPO
lactoperoxidase
chr14_+_24563262 0.92 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr5_+_179105615 0.92 ENST00000514383.1
CANX
calnexin
chr17_-_79895097 0.89 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_-_79895154 0.88 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
PYCR1
pyrroline-5-carboxylate reductase 1
chr1_-_220220000 0.88 ENST00000366923.3
EPRS
glutamyl-prolyl-tRNA synthetase
chr1_-_220219775 0.88 ENST00000609181.1
EPRS
glutamyl-prolyl-tRNA synthetase
chr5_+_143584814 0.85 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr19_+_33865218 0.85 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr9_-_95055956 0.84 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr9_+_80912059 0.84 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chr16_-_67694597 0.81 ENST00000393919.4
ENST00000219251.8
ACD
adrenocortical dysplasia homolog (mouse)
chr10_+_50507181 0.80 ENST00000323868.4
C10orf71
chromosome 10 open reading frame 71
chr10_+_50507232 0.79 ENST00000374144.3
C10orf71
chromosome 10 open reading frame 71
chr14_+_24563510 0.79 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr1_-_204380919 0.78 ENST00000367188.4
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr7_+_99006550 0.77 ENST00000222969.5
BUD31
BUD31 homolog (S. cerevisiae)
chr17_-_76836963 0.77 ENST00000312010.6
USP36
ubiquitin specific peptidase 36
chr4_-_153457197 0.77 ENST00000281708.4
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr6_+_151187615 0.76 ENST00000441122.1
ENST00000423867.1
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr5_+_33441053 0.72 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
TARS
threonyl-tRNA synthetase
chr2_-_98280383 0.71 ENST00000289228.5
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr12_-_46662772 0.70 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
SLC38A1
solute carrier family 38, member 1
chr17_-_76836729 0.69 ENST00000587783.1
ENST00000542802.3
ENST00000586531.1
ENST00000589424.1
ENST00000590546.2
USP36
ubiquitin specific peptidase 36
chr2_+_46769798 0.68 ENST00000238738.4
RHOQ
ras homolog family member Q
chr5_+_33440802 0.65 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
TARS
threonyl-tRNA synthetase
chr12_+_57624119 0.65 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr3_-_48130314 0.64 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr1_+_228353495 0.59 ENST00000366711.3
IBA57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr5_-_76935513 0.58 ENST00000306422.3
OTP
orthopedia homeobox
chr6_+_151187074 0.58 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr12_+_50135588 0.58 ENST00000423828.1
ENST00000550445.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr16_-_18908196 0.57 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr17_-_40828969 0.56 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr7_+_99006232 0.54 ENST00000403633.2
BUD31
BUD31 homolog (S. cerevisiae)
chr3_-_48130707 0.54 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chr20_+_23342783 0.53 ENST00000544236.1
ENST00000338121.5
ENST00000542987.1
ENST00000424216.1
GZF1
GDNF-inducible zinc finger protein 1
chr21_-_44495919 0.49 ENST00000398158.1
CBS
cystathionine-beta-synthase
chrX_-_15332665 0.49 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr3_-_99594948 0.48 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr1_+_239882842 0.48 ENST00000448020.1
CHRM3
cholinergic receptor, muscarinic 3
chr7_-_121944491 0.45 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr3_+_148415571 0.42 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
AGTR1
angiotensin II receptor, type 1
chr12_+_57623869 0.39 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr3_-_99595037 0.39 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr8_-_38008783 0.38 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr1_-_178840157 0.38 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chr12_+_57624085 0.37 ENST00000553474.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr4_-_21950356 0.36 ENST00000447367.2
ENST00000382152.2
KCNIP4
Kv channel interacting protein 4
chr1_-_167883327 0.35 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chr22_+_42229100 0.35 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr1_-_167883353 0.35 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr16_-_70323422 0.34 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chr21_-_44495964 0.32 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chr12_-_57914275 0.31 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DDIT3
DNA-damage-inducible transcript 3
chr11_-_128737163 0.30 ENST00000324003.3
ENST00000392665.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr19_+_49259325 0.30 ENST00000222157.3
FGF21
fibroblast growth factor 21
chr1_+_241815577 0.29 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chr12_+_57623477 0.29 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr8_-_11324273 0.28 ENST00000284486.4
FAM167A
family with sequence similarity 167, member A
chr5_-_145562147 0.28 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
LARS
leucyl-tRNA synthetase
chr20_+_8112824 0.28 ENST00000378641.3
PLCB1
phospholipase C, beta 1 (phosphoinositide-specific)
chr17_-_46703826 0.27 ENST00000550387.1
ENST00000311177.5
HOXB9
homeobox B9
chr11_-_77185094 0.26 ENST00000278568.4
ENST00000356341.3
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr16_+_46918235 0.25 ENST00000340124.4
GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr7_-_48068699 0.25 ENST00000412142.1
ENST00000395572.2
SUN3
Sad1 and UNC84 domain containing 3
chr3_-_3151664 0.23 ENST00000256452.3
ENST00000311981.8
ENST00000430514.2
ENST00000456302.1
IL5RA
interleukin 5 receptor, alpha
chr17_+_39846114 0.21 ENST00000586699.1
EIF1
eukaryotic translation initiation factor 1
chr7_-_48068643 0.20 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr22_-_29457832 0.19 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr19_+_49258775 0.19 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr11_-_128737259 0.18 ENST00000440599.2
ENST00000392666.1
ENST00000324036.3
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr19_-_49258606 0.18 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr3_-_3152031 0.18 ENST00000383846.1
ENST00000427088.1
ENST00000446632.2
ENST00000438560.1
IL5RA
interleukin 5 receptor, alpha
chr19_-_51192661 0.18 ENST00000391813.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr7_-_48068671 0.17 ENST00000297325.4
SUN3
Sad1 and UNC84 domain containing 3
chr15_+_40886199 0.16 ENST00000346991.5
ENST00000528975.1
ENST00000527044.1
CASC5
cancer susceptibility candidate 5
chrX_+_48398053 0.15 ENST00000537536.1
ENST00000418627.1
TBC1D25
TBC1 domain family, member 25
chr8_-_116680833 0.12 ENST00000220888.5
TRPS1
trichorhinophalangeal syndrome I
chr9_+_36169380 0.12 ENST00000335119.2
CCIN
calicin
chr7_-_50860565 0.12 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr5_+_44809027 0.12 ENST00000507110.1
MRPS30
mitochondrial ribosomal protein S30
chr1_-_207143802 0.11 ENST00000324852.4
ENST00000400962.3
FCAMR
Fc receptor, IgA, IgM, high affinity
chr12_-_50297638 0.10 ENST00000320634.3
FAIM2
Fas apoptotic inhibitory molecule 2
chr17_-_40829026 0.10 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chrX_+_77359671 0.08 ENST00000373316.4
PGK1
phosphoglycerate kinase 1
chr3_-_33686925 0.07 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chrX_+_24072833 0.07 ENST00000253039.4
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr9_-_99381660 0.02 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr7_-_138386097 0.02 ENST00000421622.1
SVOPL
SVOP-like
chr1_-_20250110 0.02 ENST00000375116.3
PLA2G2E
phospholipase A2, group IIE
chr15_+_40886439 0.00 ENST00000532056.1
ENST00000399668.2
CASC5
cancer susceptibility candidate 5

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 26.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.6 4.8 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.7 2.7 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.6 1.8 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.4 1.3 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.4 1.4 GO:0015965 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.4 1.4 GO:1901355 response to rapamycin(GO:1901355)
0.3 1.4 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.3 1.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.3 0.8 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.3 0.8 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.3 0.8 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.3 1.3 GO:0060356 leucine import(GO:0060356)
0.3 1.8 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.2 1.7 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.2 4.5 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 1.7 GO:0006116 NADH oxidation(GO:0006116)
0.2 1.2 GO:0051012 microtubule sliding(GO:0051012)
0.2 3.0 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.2 1.3 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.2 0.8 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.8 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.1 0.4 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 2.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.4 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.8 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 0.4 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 1.1 GO:0006983 ER overload response(GO:0006983)
0.1 0.5 GO:1904640 response to methionine(GO:1904640)
0.1 0.6 GO:0051025 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.1 0.3 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.1 0.3 GO:0080154 regulation of fertilization(GO:0080154)
0.1 1.9 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.1 0.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.2 GO:0042851 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.1 0.2 GO:0050894 determination of affect(GO:0050894)
0.1 1.1 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.1 1.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.6 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.3 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 1.5 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 2.7 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.0 0.7 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 0.6 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.7 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.6 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 4.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.1 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.5 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.2 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.2 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 2.7 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.2 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 1.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.1 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.5 3.0 GO:1990037 Lewy body core(GO:1990037)
0.3 25.4 GO:0015030 Cajal body(GO:0015030)
0.3 1.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.3 1.8 GO:0097452 GAIT complex(GO:0097452)
0.2 1.7 GO:0070552 BRISC complex(GO:0070552)
0.1 1.4 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.8 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.5 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.8 GO:0070187 telosome(GO:0070187)
0.1 0.9 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.7 GO:0005869 dynactin complex(GO:0005869)
0.0 0.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 2.0 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 4.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 1.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 7.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.7 26.1 GO:0008859 exoribonuclease II activity(GO:0008859)
1.6 4.8 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
1.5 4.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.6 1.8 GO:0004818 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.6 1.7 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.4 2.7 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.3 1.4 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.3 1.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.3 1.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.3 0.8 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.3 0.8 GO:0050421 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.2 1.7 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 0.7 GO:0032427 GBD domain binding(GO:0032427)
0.2 1.7 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.4 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.4 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 1.1 GO:0043559 insulin binding(GO:0043559)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 0.8 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.3 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.1 1.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 1.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 1.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 3.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.9 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.8 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.6 GO:0043495 protein anchor(GO:0043495)
0.0 0.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 8.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 2.2 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 2.5 GO:0044325 ion channel binding(GO:0044325)
0.0 1.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 2.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 3.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 4.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 1.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 26.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 9.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 4.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 2.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 4.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 3.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 0.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 2.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.5 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling