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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for ATF6

Z-value: 0.58

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Transcription factors associated with ATF6

Gene Symbol Gene ID Gene Info
ATF6
ENSG00000118217.5 activating transcription factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF6hg19_v2_chr1_+_161736072_1617360930.067.8e-01Click!

Activity profile of ATF6 motif

Sorted Z-values of ATF6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_131762105 1.38 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr18_+_77623668 0.89 ENST00000316249.3
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr13_-_49107303 0.87 ENST00000344532.3
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr16_+_53164833 0.83 ENST00000564845.1
CHD9
chromodomain helicase DNA binding protein 9
chr17_-_49337392 0.67 ENST00000376381.2
ENST00000586178.1
MBTD1
mbt domain containing 1
chr9_+_71320557 0.62 ENST00000541509.1
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr11_-_119234876 0.60 ENST00000525735.1
USP2
ubiquitin specific peptidase 2
chr1_+_221051699 0.60 ENST00000366903.6
HLX
H2.0-like homeobox
chr8_-_8243968 0.57 ENST00000520004.1
SGK223
Tyrosine-protein kinase SgK223
chr21_+_38445539 0.52 ENST00000418766.1
ENST00000450533.1
ENST00000438055.1
ENST00000355666.1
ENST00000540756.1
ENST00000399010.1
TTC3
tetratricopeptide repeat domain 3
chr12_+_56661033 0.52 ENST00000433805.2
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr12_+_56660633 0.51 ENST00000308197.5
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr2_+_219745020 0.51 ENST00000258411.3
WNT10A
wingless-type MMTV integration site family, member 10A
chr16_+_69373471 0.49 ENST00000569637.2
NIP7
NIP7, nucleolar pre-rRNA processing protein
chr4_-_39640513 0.49 ENST00000511809.1
ENST00000505729.1
SMIM14
small integral membrane protein 14
chr19_-_42759300 0.48 ENST00000222329.4
ERF
Ets2 repressor factor
chr17_-_66951474 0.47 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr6_+_24775641 0.42 ENST00000378054.2
ENST00000476555.1
GMNN
geminin, DNA replication inhibitor
chr3_+_184529948 0.41 ENST00000436792.2
ENST00000446204.2
ENST00000422105.1
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr3_+_184529929 0.41 ENST00000287546.4
ENST00000437079.3
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr14_-_23822061 0.41 ENST00000397260.3
SLC22A17
solute carrier family 22, member 17
chr14_-_23822080 0.40 ENST00000397267.1
ENST00000354772.3
SLC22A17
solute carrier family 22, member 17
chr6_+_132891461 0.40 ENST00000275198.1
TAAR6
trace amine associated receptor 6
chr8_+_29952914 0.40 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr1_-_211752073 0.39 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr19_+_38810447 0.39 ENST00000263372.3
KCNK6
potassium channel, subfamily K, member 6
chr1_+_222791417 0.38 ENST00000344922.5
ENST00000344441.6
ENST00000344507.1
MIA3
melanoma inhibitory activity family, member 3
chr3_-_33759699 0.38 ENST00000399362.4
ENST00000359576.5
ENST00000307312.7
CLASP2
cytoplasmic linker associated protein 2
chr3_-_33759541 0.38 ENST00000468888.2
CLASP2
cytoplasmic linker associated protein 2
chr5_+_41904431 0.38 ENST00000381647.2
C5orf51
chromosome 5 open reading frame 51
chr7_+_16793160 0.38 ENST00000262067.4
TSPAN13
tetraspanin 13
chr5_+_78532003 0.38 ENST00000396137.4
JMY
junction mediating and regulatory protein, p53 cofactor
chr17_+_6554971 0.37 ENST00000391428.2
C17orf100
chromosome 17 open reading frame 100
chr21_-_38445470 0.36 ENST00000399098.1
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr15_-_23692381 0.36 ENST00000567107.1
ENST00000345070.5
ENST00000312015.5
GOLGA6L2
golgin A6 family-like 2
chr1_-_15850676 0.36 ENST00000440484.1
ENST00000333868.5
CASP9
caspase 9, apoptosis-related cysteine peptidase
chr17_+_66511540 0.36 ENST00000588188.2
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr21_-_38445297 0.35 ENST00000430792.1
ENST00000399103.1
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr2_-_105946491 0.34 ENST00000393359.2
TGFBRAP1
transforming growth factor, beta receptor associated protein 1
chr21_-_38445011 0.34 ENST00000464265.1
ENST00000399102.1
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr17_+_65821780 0.34 ENST00000321892.4
ENST00000335221.5
ENST00000306378.6
BPTF
bromodomain PHD finger transcription factor
chr14_+_68086515 0.33 ENST00000261783.3
ARG2
arginase 2
chr7_-_100808843 0.33 ENST00000249330.2
VGF
VGF nerve growth factor inducible
chr6_+_127588020 0.33 ENST00000309649.3
ENST00000610162.1
ENST00000610153.1
ENST00000608991.1
ENST00000480444.1
RNF146
ring finger protein 146
chr7_-_86849883 0.33 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr11_-_77791156 0.32 ENST00000281031.4
NDUFC2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
chr1_-_78149041 0.32 ENST00000414381.1
ENST00000370798.1
ZZZ3
zinc finger, ZZ-type containing 3
chr4_-_119757239 0.32 ENST00000280551.6
SEC24D
SEC24 family member D
chr13_-_101327028 0.32 ENST00000328767.5
ENST00000342624.5
ENST00000376234.3
ENST00000423847.1
TMTC4
transmembrane and tetratricopeptide repeat containing 4
chr5_+_68389807 0.31 ENST00000380860.4
ENST00000504103.1
ENST00000502979.1
SLC30A5
solute carrier family 30 (zinc transporter), member 5
chr10_+_102759045 0.31 ENST00000370220.1
LZTS2
leucine zipper, putative tumor suppressor 2
chr10_-_94333784 0.31 ENST00000265986.6
IDE
insulin-degrading enzyme
chr8_-_38126635 0.31 ENST00000529359.1
PPAPDC1B
phosphatidic acid phosphatase type 2 domain containing 1B
chr1_-_25573977 0.31 ENST00000243189.7
C1orf63
chromosome 1 open reading frame 63
chr1_-_25573937 0.31 ENST00000417642.2
ENST00000431849.2
C1orf63
chromosome 1 open reading frame 63
chr6_-_6007200 0.31 ENST00000244766.2
NRN1
neuritin 1
chr17_-_39968406 0.31 ENST00000393928.1
LEPREL4
leprecan-like 4
chr15_+_96869165 0.31 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr4_-_24914576 0.30 ENST00000502801.1
ENST00000428116.2
CCDC149
coiled-coil domain containing 149
chr8_+_29953163 0.30 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr22_-_39548627 0.30 ENST00000216133.5
CBX7
chromobox homolog 7
chr7_-_100808394 0.29 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr1_+_156830607 0.29 ENST00000368196.3
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr7_+_44646162 0.29 ENST00000439616.2
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr12_+_147052 0.29 ENST00000594563.1
AC026369.1
Uncharacterized protein
chr20_-_34638841 0.29 ENST00000565493.1
LINC00657
long intergenic non-protein coding RNA 657
chr6_+_127587755 0.28 ENST00000368314.1
ENST00000476956.1
ENST00000609447.1
ENST00000356799.2
ENST00000477776.1
ENST00000609944.1
RNF146
ring finger protein 146
chr1_+_156830678 0.28 ENST00000524377.1
ENST00000358660.3
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr11_+_28131821 0.27 ENST00000379199.2
ENST00000303459.6
METTL15
methyltransferase like 15
chr7_+_116593568 0.27 ENST00000446490.1
ST7
suppression of tumorigenicity 7
chr3_+_100211412 0.27 ENST00000323523.4
ENST00000403410.1
ENST00000449609.1
TMEM45A
transmembrane protein 45A
chr17_+_65821636 0.27 ENST00000544778.2
BPTF
bromodomain PHD finger transcription factor
chr14_-_64970494 0.27 ENST00000608382.1
ZBTB25
zinc finger and BTB domain containing 25
chr12_-_110011288 0.26 ENST00000540016.1
ENST00000266839.5
MMAB
methylmalonic aciduria (cobalamin deficiency) cblB type
chr13_-_36920615 0.25 ENST00000494062.2
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr7_+_116593433 0.25 ENST00000323984.3
ENST00000393449.1
ST7
suppression of tumorigenicity 7
chr10_+_35415719 0.25 ENST00000474362.1
ENST00000374721.3
CREM
cAMP responsive element modulator
chr7_+_12726474 0.25 ENST00000396662.1
ENST00000356797.3
ENST00000396664.2
ARL4A
ADP-ribosylation factor-like 4A
chr1_-_15850839 0.25 ENST00000348549.5
ENST00000546424.1
CASP9
caspase 9, apoptosis-related cysteine peptidase
chr11_+_28129795 0.24 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr21_-_38445443 0.24 ENST00000360525.4
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr1_+_33005020 0.24 ENST00000373510.4
ENST00000316459.4
ZBTB8A
zinc finger and BTB domain containing 8A
chr9_+_133978190 0.24 ENST00000372312.3
AIF1L
allograft inflammatory factor 1-like
chr1_-_161993616 0.24 ENST00000294794.3
OLFML2B
olfactomedin-like 2B
chr10_+_112257596 0.24 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr4_-_39640700 0.23 ENST00000295958.5
SMIM14
small integral membrane protein 14
chr9_-_127703333 0.23 ENST00000373555.4
GOLGA1
golgin A1
chr14_+_105190514 0.23 ENST00000330877.2
ADSSL1
adenylosuccinate synthase like 1
chr11_-_77790865 0.23 ENST00000534029.1
ENST00000525085.1
ENST00000527806.1
ENST00000528164.1
ENST00000528251.1
ENST00000530054.1
NDUFC2
NDUFC2-KCTD14
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NDUFC2-KCTD14 readthrough
chr17_-_57184260 0.23 ENST00000376149.3
ENST00000393066.3
TRIM37
tripartite motif containing 37
chr1_+_185126291 0.23 ENST00000367500.4
SWT1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr15_-_52030293 0.23 ENST00000560491.1
ENST00000267838.3
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr5_+_99871004 0.22 ENST00000312637.4
FAM174A
family with sequence similarity 174, member A
chr9_-_77643307 0.22 ENST00000376834.3
ENST00000376830.3
C9orf41
chromosome 9 open reading frame 41
chr2_-_211036051 0.22 ENST00000418791.1
ENST00000452086.1
ENST00000281772.9
KANSL1L
KAT8 regulatory NSL complex subunit 1-like
chr9_+_71320596 0.22 ENST00000265382.3
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr22_+_38864041 0.22 ENST00000216014.4
ENST00000409006.3
KDELR3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr4_+_128982430 0.22 ENST00000512292.1
ENST00000508819.1
LARP1B
La ribonucleoprotein domain family, member 1B
chr17_-_39968855 0.22 ENST00000355468.3
ENST00000590496.1
LEPREL4
leprecan-like 4
chr8_+_97657449 0.22 ENST00000220763.5
CPQ
carboxypeptidase Q
chr11_+_20409070 0.21 ENST00000331079.6
PRMT3
protein arginine methyltransferase 3
chr4_+_128982416 0.21 ENST00000326639.6
LARP1B
La ribonucleoprotein domain family, member 1B
chr4_-_169931393 0.21 ENST00000504480.1
ENST00000306193.3
CBR4
carbonyl reductase 4
chr2_+_28615669 0.21 ENST00000379619.1
ENST00000264716.4
FOSL2
FOS-like antigen 2
chr9_-_77643189 0.20 ENST00000376837.3
C9orf41
chromosome 9 open reading frame 41
chr1_-_113498616 0.20 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr10_+_35416090 0.20 ENST00000354759.3
CREM
cAMP responsive element modulator
chr1_-_78148324 0.20 ENST00000370801.3
ENST00000433749.1
ZZZ3
zinc finger, ZZ-type containing 3
chr9_+_133454943 0.20 ENST00000319725.9
FUBP3
far upstream element (FUSE) binding protein 3
chr5_+_122110691 0.20 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
SNX2
sorting nexin 2
chr10_+_23728198 0.20 ENST00000376495.3
OTUD1
OTU domain containing 1
chr11_-_118927816 0.20 ENST00000534233.1
ENST00000532752.1
ENST00000525859.1
ENST00000404233.3
ENST00000532421.1
ENST00000543287.1
ENST00000527310.2
ENST00000529972.1
HYOU1
hypoxia up-regulated 1
chr10_+_35415978 0.19 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chr6_-_84937314 0.19 ENST00000257766.4
ENST00000403245.3
KIAA1009
KIAA1009
chr9_-_79520989 0.19 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
PRUNE2
prune homolog 2 (Drosophila)
chr19_+_2269485 0.19 ENST00000582888.4
ENST00000602676.2
ENST00000322297.4
ENST00000583542.4
OAZ1
ornithine decarboxylase antizyme 1
chr14_-_35183755 0.19 ENST00000555765.1
CFL2
cofilin 2 (muscle)
chr4_-_99850243 0.19 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
EIF4E
eukaryotic translation initiation factor 4E
chr9_+_36036430 0.19 ENST00000377966.3
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr13_+_114238997 0.19 ENST00000538138.1
ENST00000375370.5
TFDP1
transcription factor Dp-1
chr4_-_24914508 0.19 ENST00000504487.1
CCDC149
coiled-coil domain containing 149
chr17_-_15466850 0.19 ENST00000438826.3
ENST00000225576.3
ENST00000519970.1
ENST00000518321.1
ENST00000428082.2
ENST00000522212.2
TVP23C
TVP23C-CDRT4
trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)
TVP23C-CDRT4 readthrough
chr18_+_56530794 0.18 ENST00000590285.1
ENST00000586085.1
ENST00000589288.1
ZNF532
zinc finger protein 532
chr8_-_38126675 0.18 ENST00000531823.1
ENST00000534339.1
ENST00000524616.1
ENST00000422581.2
ENST00000424479.2
ENST00000419686.2
PPAPDC1B
phosphatidic acid phosphatase type 2 domain containing 1B
chr5_+_94890778 0.18 ENST00000380009.4
ARSK
arylsulfatase family, member K
chr9_-_131709858 0.17 ENST00000372586.3
DOLK
dolichol kinase
chr8_-_75233563 0.17 ENST00000342232.4
JPH1
junctophilin 1
chr7_+_44646177 0.17 ENST00000443864.2
ENST00000447398.1
ENST00000449767.1
ENST00000419661.1
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr12_+_57853918 0.17 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI1
GLI family zinc finger 1
chr19_-_42927251 0.17 ENST00000597001.1
LIPE
lipase, hormone-sensitive
chr20_+_39657454 0.17 ENST00000361337.2
TOP1
topoisomerase (DNA) I
chr17_+_7211656 0.17 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr6_+_24775153 0.17 ENST00000356509.3
ENST00000230056.3
GMNN
geminin, DNA replication inhibitor
chr13_-_36920872 0.16 ENST00000451493.1
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr11_-_35547151 0.16 ENST00000378878.3
ENST00000529303.1
ENST00000278360.3
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr4_+_75310851 0.16 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr14_+_50087468 0.16 ENST00000305386.2
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr7_+_128379449 0.16 ENST00000479257.1
CALU
calumenin
chr12_+_1100370 0.16 ENST00000543086.3
ENST00000546231.2
ENST00000397203.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr14_+_103388976 0.16 ENST00000299155.5
AMN
amnion associated transmembrane protein
chr9_+_131038425 0.15 ENST00000320188.5
ENST00000608796.1
ENST00000419867.2
ENST00000418976.1
SWI5
SWI5 recombination repair homolog (yeast)
chr13_-_36920420 0.15 ENST00000438666.2
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr9_+_71394945 0.15 ENST00000394264.3
FAM122A
family with sequence similarity 122A
chr20_+_34042962 0.15 ENST00000446710.1
ENST00000420564.1
CEP250
centrosomal protein 250kDa
chr6_-_151773232 0.15 ENST00000444024.1
ENST00000367303.4
RMND1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chrX_-_100872911 0.15 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr6_+_159290917 0.15 ENST00000367072.1
C6orf99
chromosome 6 open reading frame 99
chr2_+_183580954 0.15 ENST00000264065.7
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr7_+_44646218 0.15 ENST00000444676.1
ENST00000222673.5
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr14_-_77495007 0.15 ENST00000238647.3
IRF2BPL
interferon regulatory factor 2 binding protein-like
chr4_-_1242764 0.15 ENST00000514210.1
ENST00000382952.3
ENST00000290921.6
CTBP1
C-terminal binding protein 1
chr14_-_35183886 0.15 ENST00000298159.6
CFL2
cofilin 2 (muscle)
chr1_-_185126037 0.15 ENST00000367506.5
ENST00000367504.3
TRMT1L
tRNA methyltransferase 1 homolog (S. cerevisiae)-like
chr6_-_33756867 0.14 ENST00000293760.5
LEMD2
LEM domain containing 2
chr5_-_171881491 0.14 ENST00000311601.5
SH3PXD2B
SH3 and PX domains 2B
chr12_-_76953453 0.14 ENST00000549570.1
OSBPL8
oxysterol binding protein-like 8
chr2_-_40006289 0.14 ENST00000260619.6
ENST00000454352.2
THUMPD2
THUMP domain containing 2
chrX_-_128977781 0.14 ENST00000357166.6
ZDHHC9
zinc finger, DHHC-type containing 9
chr1_+_87794150 0.14 ENST00000370544.5
LMO4
LIM domain only 4
chr17_-_19771242 0.14 ENST00000361658.2
ULK2
unc-51 like autophagy activating kinase 2
chr14_+_64970662 0.13 ENST00000556965.1
ENST00000554015.1
ZBTB1
zinc finger and BTB domain containing 1
chr11_-_28129656 0.13 ENST00000263181.6
KIF18A
kinesin family member 18A
chr4_+_108745711 0.13 ENST00000394684.4
SGMS2
sphingomyelin synthase 2
chr2_+_242254507 0.13 ENST00000391973.2
SEPT2
septin 2
chr4_+_141264597 0.13 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chrX_-_100914781 0.13 ENST00000431597.1
ENST00000458024.1
ENST00000413506.1
ENST00000440675.1
ENST00000328766.5
ENST00000356824.4
ARMCX2
armadillo repeat containing, X-linked 2
chr15_+_76135622 0.13 ENST00000338677.4
ENST00000267938.4
ENST00000569423.1
UBE2Q2
ubiquitin-conjugating enzyme E2Q family member 2
chr3_+_183415558 0.13 ENST00000305135.5
YEATS2
YEATS domain containing 2
chr16_-_86588627 0.13 ENST00000565482.1
ENST00000564364.1
ENST00000561989.1
ENST00000543303.2
ENST00000381214.5
ENST00000360900.6
ENST00000322911.6
ENST00000546093.1
ENST00000569000.1
ENST00000562994.1
ENST00000561522.1
MTHFSD
methenyltetrahydrofolate synthetase domain containing
chr1_-_193028632 0.13 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr3_-_121468513 0.13 ENST00000494517.1
ENST00000393667.3
GOLGB1
golgin B1
chr10_+_121410882 0.13 ENST00000369085.3
BAG3
BCL2-associated athanogene 3
chr1_+_87170577 0.13 ENST00000482504.1
SH3GLB1
SH3-domain GRB2-like endophilin B1
chr4_+_668348 0.13 ENST00000511290.1
MYL5
myosin, light chain 5, regulatory
chr6_+_159291090 0.12 ENST00000367073.4
ENST00000608817.1
C6orf99
chromosome 6 open reading frame 99
chr10_-_104953009 0.12 ENST00000470299.1
ENST00000343289.5
NT5C2
5'-nucleotidase, cytosolic II
chr7_+_92861653 0.12 ENST00000251739.5
ENST00000305866.5
ENST00000544910.1
ENST00000541136.1
ENST00000458530.1
ENST00000535481.1
ENST00000317751.6
CCDC132
coiled-coil domain containing 132
chr9_+_35538616 0.12 ENST00000455600.1
RUSC2
RUN and SH3 domain containing 2
chr2_-_190649082 0.12 ENST00000392350.3
ENST00000392349.4
ORMDL1
ORM1-like 1 (S. cerevisiae)
chr1_-_193028426 0.12 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr3_-_121468602 0.12 ENST00000340645.5
GOLGB1
golgin B1
chr2_+_242254679 0.12 ENST00000428282.1
ENST00000360051.3
SEPT2
septin 2
chr1_+_202976493 0.11 ENST00000367242.3
TMEM183A
transmembrane protein 183A
chr3_+_169684553 0.11 ENST00000337002.4
ENST00000480708.1
SEC62
SEC62 homolog (S. cerevisiae)
chr16_+_22217577 0.11 ENST00000263026.5
EEF2K
eukaryotic elongation factor-2 kinase
chr19_+_10527449 0.11 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr11_-_113746212 0.11 ENST00000537642.1
ENST00000537706.1
ENST00000544750.1
ENST00000260188.5
ENST00000540925.1
USP28
ubiquitin specific peptidase 28
chr7_+_128379346 0.11 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
CALU
calumenin
chr21_-_46237883 0.11 ENST00000397893.3
SUMO3
small ubiquitin-like modifier 3
chr4_+_75311019 0.11 ENST00000502307.1
AREG
amphiregulin
chr7_-_158622210 0.11 ENST00000251527.5
ESYT2
extended synaptotagmin-like protein 2
chr14_-_106092403 0.11 ENST00000390543.2
IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr8_-_124408652 0.11 ENST00000287394.5
ATAD2
ATPase family, AAA domain containing 2
chr6_-_31865452 0.11 ENST00000375530.4
ENST00000375537.4
EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr1_-_226129083 0.11 ENST00000420304.2
LEFTY2
left-right determination factor 2
chr17_+_30348024 0.11 ENST00000327564.7
ENST00000584368.1
ENST00000394713.3
ENST00000341671.7
LRRC37B
leucine rich repeat containing 37B
chr10_+_89622870 0.10 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chr8_+_22422749 0.10 ENST00000523900.1
SORBS3
sorbin and SH3 domain containing 3
chr10_+_93558069 0.10 ENST00000371627.4
TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr16_+_2570340 0.10 ENST00000568263.1
ENST00000293971.6
ENST00000302956.4
ENST00000413459.3
ENST00000566706.1
ENST00000569879.1
AMDHD2
amidohydrolase domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.1 0.6 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1 0.6 GO:0021553 olfactory nerve development(GO:0021553)
0.1 0.6 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.1 0.3 GO:1901143 insulin catabolic process(GO:1901143)
0.1 0.1 GO:1903895 negative regulation of IRE1-mediated unfolded protein response(GO:1903895)
0.1 0.6 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.1 1.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.3 GO:0015728 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 0.7 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 0.3 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.7 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.1 0.3 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 0.5 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.2 GO:1903028 positive regulation of opsonization(GO:1903028)
0.1 1.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 0.5 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.6 GO:0032025 response to cobalt ion(GO:0032025)
0.0 1.0 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.4 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.1 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.0 0.5 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.1 GO:0034059 response to anoxia(GO:0034059)
0.0 0.3 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0 0.2 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.5 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.1 GO:0002572 pro-T cell differentiation(GO:0002572)
0.0 0.1 GO:0039019 regulation of polarized epithelial cell differentiation(GO:0030860) pronephric nephron development(GO:0039019)
0.0 0.1 GO:1903778 protein localization to vacuolar membrane(GO:1903778)
0.0 0.0 GO:0048696 regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 0.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.1 GO:1904397 negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.0 0.1 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.0 0.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.0 0.4 GO:0003085 negative regulation of systemic arterial blood pressure(GO:0003085)
0.0 0.3 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.3 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.0 0.2 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.0 0.1 GO:1990180 mitochondrial tRNA 3'-end processing(GO:1990180)
0.0 0.6 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.2 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298) intrinsic apoptotic signaling pathway in response to hypoxia(GO:1990144)
0.0 0.2 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.2 GO:0006489 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.0 0.1 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.1 GO:0003193 pulmonary valve formation(GO:0003193) visceral motor neuron differentiation(GO:0021524) foramen ovale closure(GO:0035922)
0.0 0.1 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.2 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.0 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.0 0.3 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.1 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.0 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.2 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.1 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 0.0 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0010731 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.0 0.1 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.2 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0033263 CORVET complex(GO:0033263)
0.2 0.6 GO:0043293 apoptosome(GO:0043293)
0.1 1.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.9 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.6 GO:0016589 NURF complex(GO:0016589)
0.1 0.2 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 0.6 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.2 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.0 0.8 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.6 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.3 GO:0097227 sperm annulus(GO:0097227)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.0 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.1 GO:0005642 annulate lamellae(GO:0005642)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.2 0.6 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 0.6 GO:0010465 neurotrophin p75 receptor binding(GO:0005166) nerve growth factor receptor activity(GO:0010465)
0.1 1.0 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 1.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.3 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 0.5 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 0.2 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.4 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.1 0.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.5 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.3 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.3 GO:0043559 insulin binding(GO:0043559)
0.0 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.1 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.2 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.6 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.0 GO:0097258 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.0 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.0 GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.0 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.1 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.6 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.2 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.6 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.6 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.6 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.2 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.2 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis