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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for ATF6
Z-value: 0.58
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Transcription factors associated with ATF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF6 | hg19_v2_chr1_+_161736072_161736093 | 0.06 | 7.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_131762105 Show fit | 1.38 |
ENST00000368648.3
ENST00000355311.5 |
early B-cell factor 3 |
|
| chr18_+_77623668 Show fit | 0.89 |
ENST00000316249.3
|
potassium voltage-gated channel, subfamily G, member 2 |
|
| chr13_-_49107303 Show fit | 0.87 |
ENST00000344532.3
|
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 |
|
| chr16_+_53164833 Show fit | 0.83 |
ENST00000564845.1
|
chromodomain helicase DNA binding protein 9 |
|
| chr17_-_49337392 Show fit | 0.67 |
ENST00000376381.2
ENST00000586178.1 |
mbt domain containing 1 |
|
| chr9_+_71320557 Show fit | 0.62 |
ENST00000541509.1
|
phosphatidylinositol-4-phosphate 5-kinase, type I, beta |
|
| chr11_-_119234876 Show fit | 0.60 |
ENST00000525735.1
|
ubiquitin specific peptidase 2 |
|
| chr1_+_221051699 Show fit | 0.60 |
ENST00000366903.6
|
H2.0-like homeobox |
|
| chr8_-_8243968 Show fit | 0.57 |
ENST00000520004.1
|
Tyrosine-protein kinase SgK223 |
|
| chr21_+_38445539 Show fit | 0.52 |
ENST00000418766.1
ENST00000450533.1 ENST00000438055.1 ENST00000355666.1 ENST00000540756.1 ENST00000399010.1 |
tetratricopeptide repeat domain 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.1 | 1.2 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 1.0 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 0.9 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.2 | 0.8 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.1 | 0.7 | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) |
| 0.1 | 0.7 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 0.6 | GO:0048698 | negative regulation of collateral sprouting in absence of injury(GO:0048698) |
| 0.1 | 0.6 | GO:0021553 | olfactory nerve development(GO:0021553) |
| 0.1 | 0.6 | GO:0061034 | olfactory bulb mitral cell layer development(GO:0061034) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.2 | 1.2 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.1 | 0.9 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 0.8 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.2 | 0.6 | GO:0043293 | apoptosome(GO:0043293) |
| 0.1 | 0.6 | GO:0016589 | NURF complex(GO:0016589) |
| 0.1 | 0.6 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 0.6 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.0 | 0.5 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.1 | 1.0 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.1 | 0.9 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.0 | 0.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.3 | 0.8 | GO:0052810 | 1-phosphatidylinositol-5-kinase activity(GO:0052810) |
| 0.0 | 0.7 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 0.6 | GO:0034602 | oxoglutarate dehydrogenase (NAD+) activity(GO:0034602) |
| 0.1 | 0.6 | GO:0010465 | neurotrophin p75 receptor binding(GO:0005166) nerve growth factor receptor activity(GO:0010465) |
| 0.0 | 0.6 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.6 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 0.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.2 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.2 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.6 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.6 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.0 | 0.6 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.0 | 0.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.3 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.2 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |