Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for AUGGCAC
Z-value: 0.78
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miRNA associated with seed AUGGCAC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-183-5p.1
|
MIMAT0000261 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_130031358 Show fit | 3.94 |
ENST00000368149.2
|
Rho GTPase activating protein 18 |
|
| chr8_+_120220561 Show fit | 3.29 |
ENST00000276681.6
|
mal, T-cell differentiation protein 2 (gene/pseudogene) |
|
| chr12_+_27396901 Show fit | 2.75 |
ENST00000541191.1
ENST00000389032.3 |
serine/threonine kinase 38 like |
|
| chr10_+_112631547 Show fit | 2.52 |
ENST00000280154.7
ENST00000393104.2 |
programmed cell death 4 (neoplastic transformation inhibitor) |
|
| chr12_-_95044309 Show fit | 2.40 |
ENST00000261226.4
|
transmembrane and coiled-coil domain family 3 |
|
| chr3_+_37903432 Show fit | 2.31 |
ENST00000443503.2
|
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
|
| chr7_-_11871815 Show fit | 2.16 |
ENST00000423059.4
|
thrombospondin, type I, domain containing 7A |
|
| chr12_+_20522179 Show fit | 1.84 |
ENST00000359062.3
|
phosphodiesterase 3A, cGMP-inhibited |
|
| chr8_-_93115445 Show fit | 1.79 |
ENST00000523629.1
|
runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
|
| chr5_+_148960931 Show fit | 1.76 |
ENST00000333677.6
|
Rho guanine nucleotide exchange factor (GEF) 37 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AUGGCAC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | GO:0030833 | regulation of actin filament polymerization(GO:0030833) |
| 0.3 | 3.3 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.0 | 2.7 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.8 | 2.5 | GO:0060940 | myofibroblast differentiation(GO:0036446) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) regulation of myofibroblast differentiation(GO:1904760) |
| 0.3 | 1.8 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.1 | 1.7 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.5 | 1.5 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.0 | 1.5 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.5 | 1.4 | GO:0021538 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.4 | 1.2 | GO:0021793 | chemorepulsion of branchiomotor axon(GO:0021793) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 2.0 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 1.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 1.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 1.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.3 | 1.5 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 1.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.2 | 1.2 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 0.4 | 1.1 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.0 | 1.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 2.0 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 1.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.6 | 1.8 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.2 | 1.5 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 1.5 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.1 | 1.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 1.3 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.3 | 1.2 | GO:0048763 | HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763) |
| 0.2 | 1.2 | GO:0052848 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.8 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.6 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.4 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 1.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 1.1 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.8 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.8 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.7 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 1.5 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 1.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.2 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.0 | 0.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.6 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |