Project
Inflammatory response time course, HUVEC (Wada et al., 2009)
Navigation
Downloads
Results for BACH1_NFE2_NFE2L2
Z-value: 0.97
Motif logo
Transcription factors associated with BACH1_NFE2_NFE2L2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000156273.11 | BTB domain and CNC homolog 1 | |
| ENSG00000123405.9 | nuclear factor, erythroid 2 | |
| ENSG00000116044.11 | nuclear factor, erythroid 2 like 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BACH1 | hg19_v2_chr21_+_30671189_30671207, hg19_v2_chr21_+_30671690_30671762 | -0.48 | 1.5e-02 | Click! |
| NFE2 | hg19_v2_chr12_-_54691668_54691725, hg19_v2_chr12_-_54694758_54694805, hg19_v2_chr12_-_54689532_54689551, hg19_v2_chr12_-_54694807_54694905 | -0.22 | 2.8e-01 | Click! |
| NFE2L2 | hg19_v2_chr2_-_178128528_178128574, hg19_v2_chr2_-_178257401_178257432, hg19_v2_chr2_-_178128250_178128300 | -0.11 | 6.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH1_NFE2_NFE2L2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.1 | 6.7 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.4 | 4.0 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.2 | 3.8 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.0 | 3.5 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 2.7 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.2 | 2.4 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.0 | 2.2 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 0.3 | 2.1 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 0.1 | 2.1 | GO:0030220 | platelet formation(GO:0030220) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.4 | 5.3 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 2.9 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 2.5 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 2.3 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 2.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 1.9 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.6 | 1.7 | GO:0044753 | amphisome(GO:0044753) |
| 0.2 | 1.6 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 1.5 | GO:0031430 | M band(GO:0031430) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.6 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.2 | 5.3 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 4.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.8 | 3.8 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 3.8 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 2.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 2.2 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.3 | 2.1 | GO:0004471 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.0 | 2.0 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.0 | 1.6 | GO:0051117 | ATPase binding(GO:0051117) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 3.6 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 3.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.3 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 1.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.2 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 3.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 2.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 2.8 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 2.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 2.1 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.3 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |