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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for BACH1_NFE2_NFE2L2

Z-value: 0.97

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Transcription factors associated with BACH1_NFE2_NFE2L2

Gene Symbol Gene ID Gene Info
BACH1
ENSG00000156273.11 BTB domain and CNC homolog 1
NFE2
ENSG00000123405.9 nuclear factor, erythroid 2
NFE2L2
ENSG00000116044.11 nuclear factor, erythroid 2 like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BACH1hg19_v2_chr21_+_30671189_30671207,
hg19_v2_chr21_+_30671690_30671762		-0.481.5e-02Click!
NFE2hg19_v2_chr12_-_54691668_54691725,
hg19_v2_chr12_-_54694758_54694805,
hg19_v2_chr12_-_54689532_54689551,
hg19_v2_chr12_-_54694807_54694905		-0.222.8e-01Click!
NFE2L2hg19_v2_chr2_-_178128528_178128574,
hg19_v2_chr2_-_178257401_178257432,
hg19_v2_chr2_-_178128250_178128300		-0.116.1e-01Click!

Activity profile of BACH1_NFE2_NFE2L2 motif

Sorted Z-values of BACH1_NFE2_NFE2L2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_6019984 7.78 ENST00000525219.2
IL15RA
interleukin 15 receptor, alpha
chr10_-_6019552 7.57 ENST00000379977.3
ENST00000397251.3
ENST00000397248.2
IL15RA
interleukin 15 receptor, alpha
chr10_-_6019455 4.40 ENST00000530685.1
ENST00000397255.3
ENST00000379971.1
ENST00000528354.1
ENST00000397250.2
ENST00000429135.2
IL15RA
interleukin 15 receptor, alpha
chr4_-_76944621 3.85 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chrX_-_154563889 3.12 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr11_-_102668879 2.89 ENST00000315274.6
MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr7_-_1199781 2.34 ENST00000397083.1
ENST00000401903.1
ENST00000316495.3
ZFAND2A
zinc finger, AN1-type domain 2A
chr12_-_10151773 2.07 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr6_-_84140757 2.05 ENST00000541327.1
ENST00000369705.3
ENST00000543031.1
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr7_-_115670792 1.99 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr12_+_56075330 1.93 ENST00000394252.3
METTL7B
methyltransferase like 7B
chr7_-_115670804 1.84 ENST00000320239.7
TFEC
transcription factor EC
chr5_+_179247759 1.73 ENST00000389805.4
ENST00000504627.1
ENST00000402874.3
ENST00000510187.1
SQSTM1
sequestosome 1
chr14_+_35761580 1.56 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr6_-_3157760 1.56 ENST00000333628.3
TUBB2A
tubulin, beta 2A class IIa
chr16_+_57662138 1.51 ENST00000562414.1
ENST00000561969.1
ENST00000562631.1
ENST00000563445.1
ENST00000565338.1
ENST00000567702.1
GPR56
G protein-coupled receptor 56
chr16_+_57662419 1.49 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56
G protein-coupled receptor 56
chr6_-_35888905 1.47 ENST00000510290.1
ENST00000423325.2
ENST00000373822.1
SRPK1
SRSF protein kinase 1
chr14_+_35761540 1.40 ENST00000261479.4
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr10_+_91087651 1.38 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr16_-_1429627 1.32 ENST00000248104.7
UNKL
unkempt family zinc finger-like
chr5_+_118690466 1.29 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr1_+_165796753 1.26 ENST00000367879.4
UCK2
uridine-cytidine kinase 2
chr9_+_116917807 1.23 ENST00000356083.3
COL27A1
collagen, type XXVII, alpha 1
chr12_-_57522813 1.21 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr14_+_58711539 1.20 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr7_+_112063192 1.18 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr1_-_200992827 1.18 ENST00000332129.2
ENST00000422435.2
KIF21B
kinesin family member 21B
chr1_+_36554470 1.08 ENST00000373178.4
ADPRHL2
ADP-ribosylhydrolase like 2
chr20_-_634000 1.07 ENST00000381962.3
SRXN1
sulfiredoxin 1
chr17_+_74372662 1.04 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr1_-_109968973 1.04 ENST00000271308.4
ENST00000538610.1
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr18_+_158513 0.98 ENST00000400266.3
ENST00000580410.1
ENST00000383589.2
ENST00000261601.7
USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr16_+_83986827 0.92 ENST00000393306.1
ENST00000565123.1
OSGIN1
oxidative stress induced growth inhibitor 1
chr14_+_103589789 0.91 ENST00000558056.1
ENST00000560869.1
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr6_-_35888824 0.89 ENST00000361690.3
ENST00000512445.1
SRPK1
SRSF protein kinase 1
chr3_+_183903811 0.86 ENST00000429586.2
ENST00000292808.5
ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr16_+_30077055 0.84 ENST00000564595.2
ENST00000569798.1
ALDOA
aldolase A, fructose-bisphosphate
chr11_+_35160709 0.83 ENST00000415148.2
ENST00000433354.2
ENST00000449691.2
ENST00000437706.2
ENST00000360158.4
ENST00000428726.2
ENST00000526669.2
ENST00000433892.2
ENST00000278386.6
ENST00000434472.2
ENST00000352818.4
ENST00000442151.2
CD44
CD44 molecule (Indian blood group)
chr19_-_49658387 0.83 ENST00000595625.1
HRC
histidine rich calcium binding protein
chr19_-_49658641 0.82 ENST00000252825.4
HRC
histidine rich calcium binding protein
chr9_-_113018835 0.81 ENST00000374517.5
TXN
thioredoxin
chr3_-_48057890 0.78 ENST00000434267.1
MAP4
microtubule-associated protein 4
chr16_+_56642489 0.78 ENST00000561491.1
MT2A
metallothionein 2A
chr6_-_138428613 0.78 ENST00000421351.3
PERP
PERP, TP53 apoptosis effector
chr16_+_56642041 0.76 ENST00000245185.5
MT2A
metallothionein 2A
chr16_-_1429674 0.75 ENST00000403703.1
ENST00000397464.1
ENST00000402641.2
UNKL
unkempt family zinc finger-like
chr6_-_11807277 0.75 ENST00000379415.2
ADTRP
androgen-dependent TFPI-regulating protein
chr10_-_71892555 0.74 ENST00000307864.1
AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chr18_-_55253989 0.74 ENST00000262093.5
FECH
ferrochelatase
chr22_+_21369316 0.74 ENST00000413302.2
ENST00000402329.3
ENST00000336296.2
ENST00000401443.1
ENST00000443995.3
P2RX6
purinergic receptor P2X, ligand-gated ion channel, 6
chr18_+_21693306 0.72 ENST00000540918.2
TTC39C
tetratricopeptide repeat domain 39C
chr5_-_137911049 0.71 ENST00000297185.3
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr1_-_12677714 0.71 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr12_+_75874580 0.69 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr11_-_65430251 0.69 ENST00000534283.1
ENST00000527749.1
ENST00000533187.1
ENST00000525693.1
ENST00000534558.1
ENST00000532879.1
ENST00000532999.1
RELA
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr16_+_30077098 0.68 ENST00000395240.3
ENST00000566846.1
ALDOA
aldolase A, fructose-bisphosphate
chr14_-_65409502 0.63 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr8_-_30585294 0.62 ENST00000546342.1
ENST00000541648.1
ENST00000537535.1
GSR
glutathione reductase
chr7_-_98741642 0.62 ENST00000361368.2
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr22_-_45608324 0.61 ENST00000496226.1
ENST00000251993.7
KIAA0930
KIAA0930
chr5_+_135385202 0.61 ENST00000514554.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr14_-_65409438 0.60 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr16_+_89988259 0.60 ENST00000554444.1
ENST00000556565.1
TUBB3
Tubulin beta-3 chain
chr10_-_13544945 0.60 ENST00000378605.3
ENST00000341083.3
BEND7
BEN domain containing 7
chr7_-_98741714 0.59 ENST00000361125.1
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr17_-_33390667 0.57 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr12_+_64845660 0.56 ENST00000331710.5
TBK1
TANK-binding kinase 1
chr16_+_66442411 0.55 ENST00000499966.1
LINC00920
long intergenic non-protein coding RNA 920
chr20_+_60878005 0.55 ENST00000253003.2
ADRM1
adhesion regulating molecule 1
chr1_-_162838551 0.55 ENST00000367910.1
ENST00000367912.2
ENST00000367911.2
C1orf110
chromosome 1 open reading frame 110
chr1_-_150208320 0.55 ENST00000534220.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr12_-_58026451 0.54 ENST00000552350.1
ENST00000548888.1
B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr20_-_61274656 0.53 ENST00000370520.3
RP11-93B14.6
HCG2018282; Uncharacterized protein
chr2_-_10588630 0.52 ENST00000234111.4
ODC1
ornithine decarboxylase 1
chr9_-_113018746 0.52 ENST00000374515.5
TXN
thioredoxin
chr16_+_74330673 0.52 ENST00000219313.4
ENST00000540379.1
ENST00000567958.1
ENST00000568615.2
PSMD7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr12_-_122238464 0.51 ENST00000546227.1
RHOF
ras homolog family member F (in filopodia)
chr17_+_79935464 0.51 ENST00000581647.1
ENST00000580534.1
ENST00000579684.1
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr17_+_30771279 0.51 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr18_-_55253871 0.50 ENST00000382873.3
FECH
ferrochelatase
chr11_+_60699222 0.49 ENST00000536409.1
TMEM132A
transmembrane protein 132A
chr8_-_101348408 0.48 ENST00000519527.1
ENST00000522369.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr11_-_3862206 0.48 ENST00000351018.4
RHOG
ras homolog family member G
chr18_+_61637159 0.47 ENST00000397985.2
ENST00000353706.2
ENST00000542677.1
ENST00000397988.3
ENST00000448851.1
SERPINB8
serpin peptidase inhibitor, clade B (ovalbumin), member 8
chr10_+_91061712 0.47 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr3_-_186262166 0.47 ENST00000307944.5
CRYGS
crystallin, gamma S
chr17_+_21191341 0.45 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
MAP2K3
mitogen-activated protein kinase kinase 3
chr10_-_75173785 0.45 ENST00000535178.1
ENST00000372921.5
ENST00000372919.4
ANXA7
annexin A7
chr1_-_115238207 0.45 ENST00000520113.2
ENST00000369538.3
ENST00000353928.6
AMPD1
adenosine monophosphate deaminase 1
chr8_-_30585439 0.45 ENST00000221130.5
GSR
glutathione reductase
chr1_-_150208291 0.45 ENST00000533654.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr3_-_170588163 0.44 ENST00000295830.8
RPL22L1
ribosomal protein L22-like 1
chr1_+_160160283 0.44 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chrX_+_153770421 0.43 ENST00000369609.5
ENST00000369607.1
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr6_+_56819895 0.43 ENST00000370748.3
BEND6
BEN domain containing 6
chr19_+_6531010 0.43 ENST00000245817.3
TNFSF9
tumor necrosis factor (ligand) superfamily, member 9
chr16_+_30211181 0.41 ENST00000395138.2
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr1_+_160160346 0.41 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr3_+_42727011 0.41 ENST00000287777.4
KLHL40
kelch-like family member 40
chr10_-_76868931 0.41 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13
dual specificity phosphatase 13
chr19_+_12949251 0.41 ENST00000251472.4
MAST1
microtubule associated serine/threonine kinase 1
chr16_+_8736232 0.41 ENST00000562973.1
METTL22
methyltransferase like 22
chr21_+_19273574 0.41 ENST00000400128.1
CHODL
chondrolectin
chr11_-_9025541 0.40 ENST00000525100.1
ENST00000309166.3
ENST00000531090.1
NRIP3
nuclear receptor interacting protein 3
chr11_-_111794446 0.40 ENST00000527950.1
CRYAB
crystallin, alpha B
chr2_-_233641265 0.40 ENST00000438786.1
ENST00000409779.1
ENST00000233826.3
KCNJ13
potassium inwardly-rectifying channel, subfamily J, member 13
chr12_-_71182695 0.40 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr19_-_46285646 0.39 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr12_-_57030115 0.38 ENST00000379441.3
ENST00000179765.5
ENST00000551812.1
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr1_-_150208363 0.37 ENST00000436748.2
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chrX_-_65859096 0.37 ENST00000456230.2
EDA2R
ectodysplasin A2 receptor
chr11_+_62649158 0.36 ENST00000539891.1
ENST00000536981.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr12_+_75874460 0.36 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr20_-_43280361 0.36 ENST00000372874.4
ADA
adenosine deaminase
chr11_-_65430554 0.35 ENST00000308639.9
ENST00000406246.3
RELA
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr22_+_39916558 0.34 ENST00000337304.2
ENST00000396680.1
ATF4
activating transcription factor 4
chr22_+_45072958 0.34 ENST00000403581.1
PRR5
proline rich 5 (renal)
chr12_+_104680659 0.34 ENST00000526691.1
ENST00000531691.1
ENST00000388854.3
ENST00000354940.6
ENST00000526390.1
ENST00000531689.1
TXNRD1
thioredoxin reductase 1
chr6_+_53948328 0.34 ENST00000370876.2
MLIP
muscular LMNA-interacting protein
chrX_+_56590002 0.34 ENST00000338222.5
UBQLN2
ubiquilin 2
chr16_-_69760409 0.33 ENST00000561500.1
ENST00000439109.2
ENST00000564043.1
ENST00000379046.2
ENST00000379047.3
NQO1
NAD(P)H dehydrogenase, quinone 1
chr17_-_1395954 0.33 ENST00000359786.5
MYO1C
myosin IC
chr10_+_106013923 0.33 ENST00000539281.1
GSTO1
glutathione S-transferase omega 1
chr7_+_134212312 0.33 ENST00000359579.4
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr20_-_43280325 0.32 ENST00000537820.1
ADA
adenosine deaminase
chr17_-_73150629 0.32 ENST00000356033.4
ENST00000405458.3
ENST00000409753.3
HN1
hematological and neurological expressed 1
chr6_-_24877490 0.32 ENST00000540914.1
ENST00000378023.4
FAM65B
family with sequence similarity 65, member B
chr2_-_169887827 0.32 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr1_+_14075903 0.32 ENST00000343137.4
ENST00000503842.1
ENST00000407521.3
ENST00000505823.1
PRDM2
PR domain containing 2, with ZNF domain
chr12_-_109251345 0.31 ENST00000360239.3
ENST00000326495.5
ENST00000551165.1
SSH1
slingshot protein phosphatase 1
chr17_-_39623681 0.31 ENST00000225899.3
KRT32
keratin 32
chr20_-_1306391 0.31 ENST00000339987.3
SDCBP2
syndecan binding protein (syntenin) 2
chr10_+_99349450 0.30 ENST00000370640.3
C10orf62
chromosome 10 open reading frame 62
chr10_+_122216316 0.30 ENST00000398250.1
ENST00000439221.1
ENST00000398248.1
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr10_+_106014468 0.30 ENST00000369710.4
ENST00000369713.5
ENST00000445155.1
GSTO1
glutathione S-transferase omega 1
chr3_+_100053625 0.30 ENST00000497785.1
NIT2
nitrilase family, member 2
chr3_-_170587974 0.30 ENST00000463836.1
RPL22L1
ribosomal protein L22-like 1
chr14_-_81687575 0.29 ENST00000434192.2
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chrX_-_103087136 0.29 ENST00000243298.2
RAB9B
RAB9B, member RAS oncogene family
chr1_-_150208412 0.29 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr5_+_68530697 0.29 ENST00000256443.3
ENST00000514676.1
CDK7
cyclin-dependent kinase 7
chr9_-_26947453 0.29 ENST00000397292.3
PLAA
phospholipase A2-activating protein
chr19_-_54604083 0.28 ENST00000391761.1
ENST00000356532.3
ENST00000359649.4
ENST00000358375.4
ENST00000391760.1
ENST00000351806.4
OSCAR
osteoclast associated, immunoglobulin-like receptor
chr19_+_38865176 0.28 ENST00000215071.4
PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr11_+_6866883 0.28 ENST00000299454.4
ENST00000379831.2
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr22_+_45072925 0.28 ENST00000006251.7
PRR5
proline rich 5 (renal)
chr20_-_1306351 0.28 ENST00000381812.1
SDCBP2
syndecan binding protein (syntenin) 2
chr5_+_68530668 0.28 ENST00000506563.1
CDK7
cyclin-dependent kinase 7
chr16_-_11036300 0.27 ENST00000331808.4
DEXI
Dexi homolog (mouse)
chr19_-_10444188 0.27 ENST00000293677.6
RAVER1
ribonucleoprotein, PTB-binding 1
chr8_-_30585217 0.27 ENST00000520888.1
ENST00000414019.1
GSR
glutathione reductase
chr20_-_1309809 0.27 ENST00000360779.3
SDCBP2
syndecan binding protein (syntenin) 2
chr9_-_34458531 0.27 ENST00000379089.1
ENST00000379087.1
ENST00000379084.1
ENST00000379081.1
ENST00000379080.1
ENST00000422409.1
ENST00000379078.1
ENST00000445726.1
ENST00000297620.4
FAM219A
family with sequence similarity 219, member A
chr11_-_111781454 0.27 ENST00000533280.1
CRYAB
crystallin, alpha B
chr2_-_220173685 0.26 ENST00000423636.2
ENST00000442029.1
ENST00000412847.1
PTPRN
protein tyrosine phosphatase, receptor type, N
chr18_+_21594384 0.26 ENST00000584250.1
TTC39C
tetratricopeptide repeat domain 39C
chr15_+_78833071 0.26 ENST00000559365.1
PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr12_-_121454148 0.26 ENST00000535367.1
ENST00000538296.1
ENST00000445832.3
ENST00000536407.2
ENST00000366211.2
ENST00000539736.1
ENST00000288757.3
ENST00000537817.1
C12orf43
chromosome 12 open reading frame 43
chr17_-_10741762 0.26 ENST00000580256.2
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr9_+_92219919 0.25 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr20_+_18488528 0.25 ENST00000377465.1
SEC23B
Sec23 homolog B (S. cerevisiae)
chr4_-_168155300 0.25 ENST00000541637.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr1_-_150208498 0.25 ENST00000314136.8
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_+_14075865 0.25 ENST00000413440.1
PRDM2
PR domain containing 2, with ZNF domain
chr17_-_4448361 0.25 ENST00000572759.1
MYBBP1A
MYB binding protein (P160) 1a
chr19_+_8943074 0.25 ENST00000595891.1
MBD3L1
methyl-CpG binding domain protein 3-like 1
chr14_-_25078864 0.24 ENST00000216338.4
ENST00000557220.2
ENST00000382548.4
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr19_+_39390320 0.23 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr14_+_103800513 0.23 ENST00000560338.1
ENST00000560763.1
ENST00000558316.1
ENST00000558265.1
EIF5
eukaryotic translation initiation factor 5
chr4_-_87374283 0.23 ENST00000361569.2
MAPK10
mitogen-activated protein kinase 10
chr16_+_67261008 0.23 ENST00000304800.9
ENST00000563953.1
ENST00000565201.1
TMEM208
transmembrane protein 208
chr6_-_32374900 0.23 ENST00000374995.3
ENST00000374993.1
ENST00000414363.1
ENST00000540315.1
ENST00000544175.1
ENST00000429232.2
ENST00000454136.3
ENST00000446536.2
BTNL2
butyrophilin-like 2 (MHC class II associated)
chr20_+_18488137 0.23 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chr18_-_50240 0.23 ENST00000573909.1
RP11-683L23.1
Tubulin beta-8 chain-like protein LOC260334
chr19_+_38865398 0.22 ENST00000585598.1
ENST00000602911.1
ENST00000592561.1
PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr11_+_67007518 0.22 ENST00000530342.1
ENST00000308783.5
KDM2A
lysine (K)-specific demethylase 2A
chr14_+_79745746 0.22 ENST00000281127.7
NRXN3
neurexin 3
chr1_-_39339777 0.22 ENST00000397572.2
MYCBP
MYC binding protein
chrX_+_75392771 0.22 ENST00000373358.3
ENST00000373357.3
PBDC1
polysaccharide biosynthesis domain containing 1
chr11_-_14541872 0.22 ENST00000419365.2
ENST00000530457.1
ENST00000532256.1
ENST00000533068.1
PSMA1
proteasome (prosome, macropain) subunit, alpha type, 1
chr3_-_170587815 0.22 ENST00000466674.1
RPL22L1
ribosomal protein L22-like 1
chr17_-_3794021 0.21 ENST00000381769.2
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr19_-_16582754 0.21 ENST00000602151.1
ENST00000597937.1
ENST00000535753.2
EPS15L1
epidermal growth factor receptor pathway substrate 15-like 1
chr1_-_94374946 0.21 ENST00000370238.3
GCLM
glutamate-cysteine ligase, modifier subunit
chr4_+_95917383 0.21 ENST00000512312.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr18_-_35065710 0.21 ENST00000589229.1
ENST00000587819.1
CELF4
CUGBP, Elav-like family member 4
chr17_-_40333099 0.21 ENST00000607371.1
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr2_-_190044480 0.21 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr20_+_17680587 0.21 ENST00000427254.1
ENST00000377805.3
BANF2
barrier to autointegration factor 2
chr10_+_85899196 0.20 ENST00000372134.3
GHITM
growth hormone inducible transmembrane protein
chr15_+_42841008 0.20 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
HAUS2
HAUS augmin-like complex, subunit 2
chr2_+_54342533 0.20 ENST00000406041.1
ACYP2
acylphosphatase 2, muscle type
chr2_-_89399845 0.20 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr6_+_160327974 0.20 ENST00000252660.4
MAS1
MAS1 oncogene
chr15_+_78833105 0.19 ENST00000558341.1
ENST00000559437.1
PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr14_+_52456193 0.19 ENST00000261700.3
C14orf166
chromosome 14 open reading frame 166
chr15_+_65337708 0.19 ENST00000334287.2
SLC51B
solute carrier family 51, beta subunit
chr5_+_8457793 0.19 ENST00000606459.1
MIR4458HG
MIR4458 host gene (non-protein coding)
chr19_-_46285736 0.19 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH1_NFE2_NFE2L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.4 1.2 GO:0070541 response to platinum ion(GO:0070541)
0.4 1.2 GO:1902534 single-organism membrane invagination(GO:1902534)
0.4 4.0 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.4 1.2 GO:0007518 myoblast fate determination(GO:0007518)
0.3 1.0 GO:0046521 sphingoid catabolic process(GO:0046521)
0.3 1.0 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.3 1.3 GO:0009224 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.3 1.5 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.3 1.2 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.3 2.1 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.3 1.0 GO:0014040 positive regulation of Schwann cell differentiation(GO:0014040)
0.2 3.8 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.2 0.7 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.2 1.2 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.2 2.4 GO:0035092 sperm chromatin condensation(GO:0035092)
0.2 1.3 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.1 1.4 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1 1.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 0.5 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.8 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.3 GO:1990737 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.6 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.6 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 0.3 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.4 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.1 0.3 GO:1904719 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.1 0.8 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 1.7 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.3 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 1.6 GO:0043248 proteasome assembly(GO:0043248)
0.1 1.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.2 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.1 0.3 GO:0016095 polyprenol catabolic process(GO:0016095)
0.1 0.7 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 6.7 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 1.7 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 0.4 GO:0060356 leucine import(GO:0060356)
0.1 0.2 GO:1904387 cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 2.7 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.1 0.4 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.1 0.5 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.3 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 2.1 GO:0030220 platelet formation(GO:0030220)
0.1 0.8 GO:0002934 desmosome organization(GO:0002934)
0.1 0.4 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.1 0.4 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.5 GO:0035897 proteolysis in other organism(GO:0035897)
0.1 0.5 GO:0032264 IMP salvage(GO:0032264)
0.1 0.2 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1 0.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.5 GO:0006528 asparagine metabolic process(GO:0006528)
0.1 0.9 GO:0051601 exocyst localization(GO:0051601)
0.0 0.3 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0071109 superior temporal gyrus development(GO:0071109)
0.0 0.1 GO:0050894 determination of affect(GO:0050894)
0.0 0.2 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.6 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.1 GO:0097195 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099) pilomotor reflex(GO:0097195)
0.0 1.9 GO:0043486 histone exchange(GO:0043486)
0.0 0.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.2 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.4 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 2.2 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.1 GO:1904222 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0070340 detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0051414 response to cortisol(GO:0051414)
0.0 0.8 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 3.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.3 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.2 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.3 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.0 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0 0.1 GO:0001660 fever generation(GO:0001660)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.6 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.0 0.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.5 GO:0009651 response to salt stress(GO:0009651)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.3 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.2 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.0 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.2 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.0 0.4 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.0 0.5 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 0.1 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.3 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.6 GO:0006370 termination of RNA polymerase I transcription(GO:0006363) 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.1 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.0 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 9.6 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.1 GO:0097106 postsynaptic density organization(GO:0097106)
0.0 0.1 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.2 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0044753 amphisome(GO:0044753)
0.4 5.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 1.0 GO:0071159 NF-kappaB complex(GO:0071159)
0.2 2.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.2 1.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.6 GO:0070985 TFIIK complex(GO:0070985)
0.1 0.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 1.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.9 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)
0.1 0.4 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.2 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 1.0 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 20.3 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.7 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 2.3 GO:0000502 proteasome complex(GO:0000502)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 1.5 GO:0031430 M band(GO:0031430)
0.0 2.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.9 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.7 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 2.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0005610 laminin-5 complex(GO:0005610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.4 1.3 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.3 2.1 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.3 1.0 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.2 0.7 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.2 0.5 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.2 1.0 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 5.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 20.6 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 1.5 GO:0046870 cadmium ion binding(GO:0046870)
0.1 3.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.3 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.3 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.1 0.3 GO:0003955 NAD(P)H dehydrogenase (quinone) activity(GO:0003955)
0.1 0.6 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.1 0.3 GO:0047718 indanol dehydrogenase activity(GO:0047718)
0.1 2.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.9 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.2 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.4 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.1 0.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.2 GO:0048185 activin binding(GO:0048185)
0.1 0.7 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.5 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.2 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.2 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.1 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.0 1.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 1.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0042835 BRE binding(GO:0042835)
0.0 0.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.3 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.2 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 2.0 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 1.0 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 2.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.0 GO:0004370 glycerol kinase activity(GO:0004370)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.6 GO:0051117 ATPase binding(GO:0051117)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.0 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 4.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.7 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.0 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 3.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.5 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 3.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.1 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 2.3 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.4 PID BMP PATHWAY BMP receptor signaling
0.0 1.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.2 PID AURORA B PATHWAY Aurora B signaling
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.4 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 2.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 8.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 2.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.6 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 1.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 2.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.2 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.0 0.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling