ISMARA results: BACH2

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for BACH2

Z-value: 0.62

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Transcription factors associated with BACH2

Gene Symbol	Gene ID	Gene Info
BACH2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000112182.10	BTB domain and CNC homolog 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
BACH2	hg19_v2_chr6_-_91006461_91006517, hg19_v2_chr6_-_91006627_91006641	-0.27	2.0e-01	Click!

Activity profile of BACH2 motif

Sorted Z-values of BACH2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_102668879 Show fit	2.63	ENST00000315274.6	MMP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix metallopeptidase 1 (interstitial collagenase)
chr1_-_153521597 Show fit	1.30	ENST00000368712.1	S100A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A3
chr1_-_153521714 Show fit	1.29	ENST00000368713.3	S100A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A3
chr15_+_89182156 Show fit	1.07	ENST00000379224.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr12_+_7023735 Show fit	1.04	ENST00000538763.1 ENST00000544774.1 ENST00000545045.2	ENO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	enolase 2 (gamma, neuronal)
chr12_+_7023491 Show fit	1.01	ENST00000541477.1 ENST00000229277.1	ENO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	enolase 2 (gamma, neuronal)
chr15_+_89182178 Show fit	0.95	ENST00000559876.1	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr9_-_35112376 Show fit	0.93	ENST00000488109.2	FAM214B Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 214, member B
chr1_+_156096336 Show fit	0.83	ENST00000504687.1 ENST00000473598.2	LMNA Ensembl NCBI GeneCards UniProt NextProt Show fit	lamin A/C
chrX_-_154563889 Show fit	0.82	ENST00000369449.2 ENST00000321926.4	CLIC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	chloride intracellular channel 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	GO:0061621	NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.6	2.8	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.1	2.5	GO:0032461	positive regulation of protein oligomerization(GO:0032461)
0.4	2.1	GO:0035105	sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0	1.2	GO:0006298	mismatch repair(GO:0006298)
0.1	0.9	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.8	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0	0.8	GO:1903543	positive regulation of exosomal secretion(GO:1903543)
0.0	0.8	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.1	0.6	GO:0006196	AMP catabolic process(GO:0006196)

Showing 1 to 10 of 64 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.9	GO:0015030	Cajal body(GO:0015030)
0.3	2.3	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.2	2.1	GO:0005638	lamin filament(GO:0005638)
0.3	0.8	GO:0033565	ESCRT-0 complex(GO:0033565)
0.0	0.8	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	0.8	GO:0031143	pseudopodium(GO:0031143)
0.0	0.7	GO:0031430	M band(GO:0031430)
0.0	0.5	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.5	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.1	0.4	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Showing 1 to 10 of 21 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.9	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.9	2.8	GO:0008859	exoribonuclease II activity(GO:0008859)
0.3	2.3	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	1.6	GO:0004896	cytokine receptor activity(GO:0004896)
0.2	1.2	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.1	1.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.9	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	0.8	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.1	0.6	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.1	0.6	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
1.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.5	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.4	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.2	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	3.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	2.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	2.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.8	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.7	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.6	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.6	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.5	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway

Showing 1 to 10 of 11 entries

Results for BACH2

Z-value: 0.62

Motif logo

Transcription factors associated with BACH2

Activity-expression correlation:

Activity profile of BACH2 motif

Sorted Z-values of BACH2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: