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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for BARHL1
Z-value: 1.60
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Transcription factors associated with BARHL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARHL1 | hg19_v2_chr9_+_135457530_135457572 | -0.28 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_100111580 Show fit | 5.08 |
ENST00000605497.1
|
palmdelphin |
|
| chr7_+_13141097 Show fit | 4.99 |
ENST00000411542.1
|
AC011288.2 |
|
| chr4_-_186732048 Show fit | 3.99 |
ENST00000448662.2
ENST00000439049.1 ENST00000420158.1 ENST00000431808.1 ENST00000319471.9 |
sorbin and SH3 domain containing 2 |
|
| chr2_+_120687335 Show fit | 3.96 |
ENST00000544261.1
|
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) |
|
| chr3_-_18480260 Show fit | 2.70 |
ENST00000454909.2
|
SATB homeobox 1 |
|
| chr11_-_33913708 Show fit | 2.66 |
ENST00000257818.2
|
LIM domain only 2 (rhombotin-like 1) |
|
| chr9_-_3469181 Show fit | 2.62 |
ENST00000366116.2
|
Uncharacterized protein |
|
| chr1_+_100111479 Show fit | 2.61 |
ENST00000263174.4
|
palmdelphin |
|
| chr16_-_30032610 Show fit | 2.53 |
ENST00000574405.1
|
double C2-like domains, alpha |
|
| chr4_-_186877806 Show fit | 2.51 |
ENST00000355634.5
|
sorbin and SH3 domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.2 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 9.9 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.8 | 5.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 4.9 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.9 | 4.3 | GO:0043504 | mitochondrial DNA repair(GO:0043504) |
| 0.2 | 4.3 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.8 | 4.2 | GO:2000470 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.6 | 3.5 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.4 | 3.5 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.0 | 3.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 11.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 7.1 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 6.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.3 | 5.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 5.1 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 5.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 4.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 4.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 4.1 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 14.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 6.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 5.8 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.2 | 5.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 4.6 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.2 | 4.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 4.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 4.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 4.3 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.8 | 4.2 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 5.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 4.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 4.2 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 3.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 3.4 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 2.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 2.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 5.3 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 4.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 4.5 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.2 | 4.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 3.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 3.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 3.7 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 3.7 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 3.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |