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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for BARHL2
Z-value: 1.12
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Transcription factors associated with BARHL2
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_154751629 Show fit | 3.90 |
ENST00000424998.1
|
CNKSR family member 3 |
|
| chr1_-_173020056 Show fit | 3.31 |
ENST00000239468.2
ENST00000404377.3 |
tumor necrosis factor (ligand) superfamily, member 18 |
|
| chr7_-_22234381 Show fit | 3.11 |
ENST00000458533.1
|
Rap guanine nucleotide exchange factor (GEF) 5 |
|
| chr8_+_86089619 Show fit | 2.99 |
ENST00000256117.5
ENST00000416274.2 |
E2F transcription factor 5, p130-binding |
|
| chr8_+_86089460 Show fit | 2.97 |
ENST00000418930.2
|
E2F transcription factor 5, p130-binding |
|
| chr21_+_43619796 Show fit | 2.86 |
ENST00000398457.2
|
ATP-binding cassette, sub-family G (WHITE), member 1 |
|
| chr2_-_208031943 Show fit | 2.84 |
ENST00000421199.1
ENST00000457962.1 |
Kruppel-like factor 7 (ubiquitous) |
|
| chr1_-_8000872 Show fit | 2.76 |
ENST00000377507.3
|
tumor necrosis factor receptor superfamily, member 9 |
|
| chr2_+_152214098 Show fit | 2.42 |
ENST00000243347.3
|
tumor necrosis factor, alpha-induced protein 6 |
|
| chr2_-_203736150 Show fit | 2.06 |
ENST00000457524.1
ENST00000421334.1 |
islet cell autoantigen 1,69kDa-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.3 | GO:2000329 | negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
| 0.1 | 3.2 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
| 0.6 | 3.0 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.7 | 2.9 | GO:0009726 | detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099) |
| 0.0 | 2.9 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.5 | 2.8 | GO:2001183 | negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183) |
| 0.1 | 2.6 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.1 | 2.4 | GO:0030728 | ovulation(GO:0030728) |
| 0.0 | 1.9 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.3 | 1.7 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 5.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 3.0 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 2.6 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 2.5 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 2.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 2.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 1.6 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.0 | 1.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.3 | 1.4 | GO:0070826 | paraferritin complex(GO:0070826) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
| 0.2 | 3.1 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.2 | 3.0 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 1.0 | 2.9 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.1 | 2.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 2.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 2.6 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 2.6 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.8 | 2.4 | GO:0008457 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.0 | 1.9 | GO:0000149 | SNARE binding(GO:0000149) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 5.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 5.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.6 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.4 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 1.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.1 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 2.9 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 2.9 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 2.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.7 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 1.5 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 1.4 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 1.4 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 1.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |