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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for BBX
Z-value: 0.36
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Transcription factors associated with BBX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BBX | hg19_v2_chr3_+_107241882_107241904 | 0.18 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_186696425 Show fit | 0.92 |
ENST00000430503.1
ENST00000319454.6 ENST00000450341.1 |
sorbin and SH3 domain containing 2 |
|
| chr4_-_186697044 Show fit | 0.84 |
ENST00000437304.2
|
sorbin and SH3 domain containing 2 |
|
| chr4_-_186733363 Show fit | 0.66 |
ENST00000393523.2
ENST00000393528.3 ENST00000449407.2 |
sorbin and SH3 domain containing 2 |
|
| chr4_-_159080806 Show fit | 0.41 |
ENST00000590648.1
|
family with sequence similarity 198, member B |
|
| chr9_-_5833027 Show fit | 0.41 |
ENST00000339450.5
|
endoplasmic reticulum metallopeptidase 1 |
|
| chr3_-_168865522 Show fit | 0.40 |
ENST00000464456.1
|
MDS1 and EVI1 complex locus |
|
| chr1_-_59043166 Show fit | 0.34 |
ENST00000371225.2
|
tumor-associated calcium signal transducer 2 |
|
| chr2_+_110656005 Show fit | 0.32 |
ENST00000437679.2
|
LIM and senescent cell antigen-like domains 3 |
|
| chr7_+_117120106 Show fit | 0.26 |
ENST00000426809.1
|
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) |
|
| chrX_+_54834004 Show fit | 0.26 |
ENST00000375068.1
|
melanoma antigen family D, 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BBX
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 0.6 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.0 | 0.4 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.0 | 0.4 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.1 | 0.3 | GO:1902161 | positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161) |
| 0.0 | 0.3 | GO:0090191 | negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) |
| 0.0 | 0.2 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.0 | 0.2 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 0.0 | 0.2 | GO:0002003 | angiotensin maturation(GO:0002003) |
| 0.0 | 0.1 | GO:0007619 | courtship behavior(GO:0007619) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.0 | 0.2 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.0 | 0.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.0 | 0.1 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.0 | 0.1 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 0.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 0.3 | GO:0005260 | channel-conductance-controlling ATPase activity(GO:0005260) |
| 0.1 | 0.2 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.0 | 0.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.1 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.0 | 0.1 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.1 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.0 | 0.1 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |