Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for BBX

Z-value: 0.36

Motif logo

logo of

Transcription factors associated with BBX

Gene Symbol Gene ID Gene Info
BBX
ENSG00000114439.14 BBX high mobility group box domain containing

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BBXhg19_v2_chr3_+_107241882_1072419040.184.0e-01Click!

Activity profile of BBX motif

Sorted Z-values of BBX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_186696425 0.92 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186697044 0.84 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr4_-_186733363 0.66 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
SORBS2
sorbin and SH3 domain containing 2
chr4_-_159080806 0.41 ENST00000590648.1
FAM198B
family with sequence similarity 198, member B
chr9_-_5833027 0.41 ENST00000339450.5
ERMP1
endoplasmic reticulum metallopeptidase 1
chr3_-_168865522 0.40 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr1_-_59043166 0.34 ENST00000371225.2
TACSTD2
tumor-associated calcium signal transducer 2
chr2_+_110656005 0.32 ENST00000437679.2
LIMS3
LIM and senescent cell antigen-like domains 3
chr7_+_117120106 0.26 ENST00000426809.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chrX_+_54834004 0.26 ENST00000375068.1
MAGED2
melanoma antigen family D, 2
chr5_+_180794269 0.26 ENST00000456475.1
OR4F3
olfactory receptor, family 4, subfamily F, member 3
chr2_+_179149636 0.24 ENST00000409631.1
OSBPL6
oxysterol binding protein-like 6
chr6_+_72922505 0.24 ENST00000401910.3
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_72922590 0.23 ENST00000523963.1
RIMS1
regulating synaptic membrane exocytosis 1
chr9_-_13175823 0.23 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr1_+_95616933 0.22 ENST00000604203.1
RP11-57H12.6
TMEM56-RWDD3 readthrough
chr5_+_140514782 0.21 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr4_-_104021009 0.20 ENST00000509245.1
ENST00000296424.4
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr7_-_130080977 0.19 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr12_-_100656134 0.17 ENST00000548313.1
DEPDC4
DEP domain containing 4
chr3_+_148583043 0.16 ENST00000296046.3
CPA3
carboxypeptidase A3 (mast cell)
chr14_+_22458631 0.16 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr14_+_75230011 0.16 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chrX_+_54834159 0.15 ENST00000375053.2
ENST00000347546.4
ENST00000375062.4
MAGED2
melanoma antigen family D, 2
chr4_+_108910870 0.15 ENST00000403312.1
ENST00000603302.1
ENST00000309522.3
HADH
hydroxyacyl-CoA dehydrogenase
chr1_+_52082751 0.14 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
OSBPL9
oxysterol binding protein-like 9
chrX_-_19817869 0.14 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chr5_+_74011328 0.14 ENST00000513336.1
HEXB
hexosaminidase B (beta polypeptide)
chr11_+_58390132 0.14 ENST00000361987.4
CNTF
ciliary neurotrophic factor
chr8_-_28347737 0.12 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
FBXO16
F-box protein 16
chr9_+_35161998 0.12 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
UNC13B
unc-13 homolog B (C. elegans)
chr1_+_229440129 0.12 ENST00000366688.3
SPHAR
S-phase response (cyclin related)
chr14_-_81425828 0.11 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr19_+_7828035 0.11 ENST00000327325.5
ENST00000394122.2
ENST00000248228.4
ENST00000334806.5
ENST00000359059.5
ENST00000357361.2
ENST00000596363.1
ENST00000595751.1
ENST00000596707.1
ENST00000597522.1
ENST00000595496.1
CLEC4M
C-type lectin domain family 4, member M
chr16_+_28763108 0.11 ENST00000357796.3
ENST00000550983.1
NPIPB9
nuclear pore complex interacting protein family, member B9
chr18_+_29769978 0.11 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr11_-_62997124 0.11 ENST00000306494.6
SLC22A25
solute carrier family 22, member 25
chr20_-_56286479 0.10 ENST00000265626.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr17_+_45331184 0.10 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr4_+_69313145 0.10 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr14_+_23235886 0.10 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
OXA1L
oxidase (cytochrome c) assembly 1-like
chrX_-_140786896 0.10 ENST00000370515.3
SPANXD
SPANX family, member D
chr17_+_66255310 0.10 ENST00000448504.2
ARSG
arylsulfatase G
chr7_+_135611542 0.10 ENST00000416501.1
AC015987.2
AC015987.2
chr3_+_51851612 0.10 ENST00000456080.1
IQCF3
IQ motif containing F3
chr6_-_133084580 0.09 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2
vanin 2
chr2_-_158182410 0.09 ENST00000419116.2
ENST00000410096.1
ERMN
ermin, ERM-like protein
chr4_+_174818390 0.08 ENST00000509968.1
ENST00000512263.1
RP11-161D15.1
RP11-161D15.1
chr2_+_210517895 0.08 ENST00000447185.1
MAP2
microtubule-associated protein 2
chr1_-_206785789 0.08 ENST00000437518.1
ENST00000367114.3
EIF2D
eukaryotic translation initiation factor 2D
chr19_+_47421933 0.08 ENST00000404338.3
ARHGAP35
Rho GTPase activating protein 35
chr1_+_152784447 0.08 ENST00000360090.3
LCE1B
late cornified envelope 1B
chr4_+_155484103 0.08 ENST00000302068.4
FGB
fibrinogen beta chain
chr6_+_31895254 0.08 ENST00000299367.5
ENST00000442278.2
C2
complement component 2
chr3_+_111260980 0.07 ENST00000438817.2
CD96
CD96 molecule
chr5_+_140729649 0.07 ENST00000523390.1
PCDHGB1
protocadherin gamma subfamily B, 1
chr4_+_129349188 0.07 ENST00000511497.1
RP11-420A23.1
RP11-420A23.1
chr17_-_16256718 0.07 ENST00000476243.1
ENST00000299736.4
CENPV
centromere protein V
chr9_-_93405352 0.06 ENST00000375765.3
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr5_+_140480083 0.06 ENST00000231130.2
PCDHB3
protocadherin beta 3
chr7_+_117120017 0.06 ENST00000003084.6
ENST00000454343.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr6_+_106534192 0.06 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr4_-_987164 0.06 ENST00000398520.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr13_+_76445187 0.06 ENST00000318245.4
C13orf45
chromosome 13 open reading frame 45
chr1_-_216978709 0.06 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr1_-_28527152 0.06 ENST00000321830.5
AL353354.1
Uncharacterized protein
chr1_-_161337662 0.06 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr1_+_117963209 0.06 ENST00000449370.2
MAN1A2
mannosidase, alpha, class 1A, member 2
chr13_+_77522632 0.05 ENST00000377462.1
IRG1
immunoresponsive 1 homolog (mouse)
chr6_+_53948328 0.05 ENST00000370876.2
MLIP
muscular LMNA-interacting protein
chr12_-_100378006 0.05 ENST00000547776.2
ENST00000329257.7
ENST00000547010.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr8_-_6783588 0.05 ENST00000297436.2
DEFA6
defensin, alpha 6, Paneth cell-specific
chr1_+_192544857 0.05 ENST00000367459.3
ENST00000469578.2
RGS1
regulator of G-protein signaling 1
chr5_-_148929848 0.04 ENST00000504676.1
ENST00000515435.1
CSNK1A1
casein kinase 1, alpha 1
chr16_-_28374829 0.04 ENST00000532254.1
NPIPB6
nuclear pore complex interacting protein family, member B6
chr5_+_179921344 0.04 ENST00000261951.4
CNOT6
CCR4-NOT transcription complex, subunit 6
chr6_-_107235378 0.04 ENST00000606430.1
RP1-60O19.1
RP1-60O19.1
chr12_-_8765446 0.04 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chr2_+_228735763 0.04 ENST00000373666.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr1_+_110577229 0.03 ENST00000369795.3
ENST00000369794.2
STRIP1
striatin interacting protein 1
chr5_+_140810132 0.03 ENST00000252085.3
PCDHGA12
protocadherin gamma subfamily A, 12
chr6_+_29424958 0.03 ENST00000377136.1
ENST00000377133.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr13_+_33160553 0.03 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr6_+_54173227 0.03 ENST00000259782.4
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr5_+_140079919 0.03 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chr15_+_54901540 0.03 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chr6_-_29343068 0.02 ENST00000396806.3
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr21_+_19617140 0.02 ENST00000299295.2
ENST00000338326.3
CHODL
chondrolectin
chr9_-_95166841 0.02 ENST00000262551.4
OGN
osteoglycin
chr13_-_81801115 0.02 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr7_+_5085452 0.02 ENST00000353796.3
ENST00000396912.1
ENST00000396904.2
RBAK
RBAK-RBAKDN
RB-associated KRAB zinc finger
RBAK-RBAKDN readthrough
chr9_-_95166884 0.01 ENST00000375561.5
OGN
osteoglycin
chr5_-_78809950 0.01 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr14_+_22771851 0.01 ENST00000390466.1
TRAV39
T cell receptor alpha variable 39
chr17_-_8263538 0.01 ENST00000535173.1
AC135178.1
HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr3_-_133380731 0.01 ENST00000260810.5
TOPBP1
topoisomerase (DNA) II binding protein 1
chr5_+_147774275 0.01 ENST00000513826.1
FBXO38
F-box protein 38
chr17_-_59668550 0.01 ENST00000521764.1
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr4_-_113558014 0.01 ENST00000503172.1
ENST00000505019.1
ENST00000309071.5
C4orf21
chromosome 4 open reading frame 21
chr11_-_105010320 0.01 ENST00000532895.1
ENST00000530950.1
CARD18
caspase recruitment domain family, member 18
chr2_-_55237484 0.01 ENST00000394609.2
RTN4
reticulon 4
chr6_-_107235331 0.01 ENST00000433965.1
ENST00000430094.1
RP1-60O19.1
RP1-60O19.1
chr15_+_65823092 0.00 ENST00000566074.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr6_-_130543958 0.00 ENST00000437477.2
ENST00000439090.2
SAMD3
sterile alpha motif domain containing 3
chr3_+_127770455 0.00 ENST00000464451.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of BBX

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.1 2.4 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.3 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.0 0.6 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0007619 courtship behavior(GO:0007619)
0.0 0.1 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.1 GO:0046968 peptide antigen transport(GO:0046968)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.2 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.0 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.1 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.0 0.2 GO:0002003 angiotensin maturation(GO:0002003)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.4 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.2 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 2.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.2 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.1 GO:0030369 ICAM-3 receptor activity(GO:0030369)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions