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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for BHLHE40

Z-value: 0.57

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Transcription factors associated with BHLHE40

Gene Symbol Gene ID Gene Info
BHLHE40
ENSG00000134107.4 basic helix-loop-helix family member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE40hg19_v2_chr3_+_5020801_50209520.077.4e-01Click!

Activity profile of BHLHE40 motif

Sorted Z-values of BHLHE40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_6019552 1.97 ENST00000379977.3
ENST00000397251.3
ENST00000397248.2
IL15RA
interleukin 15 receptor, alpha
chr9_-_123691047 1.55 ENST00000373887.3
TRAF1
TNF receptor-associated factor 1
chr10_-_6019455 1.26 ENST00000530685.1
ENST00000397255.3
ENST00000379971.1
ENST00000528354.1
ENST00000397250.2
ENST00000429135.2
IL15RA
interleukin 15 receptor, alpha
chr2_+_127413481 1.12 ENST00000259254.4
GYPC
glycophorin C (Gerbich blood group)
chr12_+_66217911 1.07 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr2_-_136743169 1.06 ENST00000264161.4
DARS
aspartyl-tRNA synthetase
chr1_-_165325939 1.01 ENST00000342310.3
LMX1A
LIM homeobox transcription factor 1, alpha
chr16_-_56701933 1.01 ENST00000568675.1
ENST00000569500.1
ENST00000444837.2
ENST00000379811.3
MT1G
metallothionein 1G
chr2_-_136743039 0.99 ENST00000537273.1
DARS
aspartyl-tRNA synthetase
chr22_+_41697520 0.93 ENST00000352645.4
ZC3H7B
zinc finger CCCH-type containing 7B
chr8_+_32405785 0.82 ENST00000287842.3
NRG1
neuregulin 1
chr2_-_10588630 0.79 ENST00000234111.4
ODC1
ornithine decarboxylase 1
chr8_+_32405728 0.79 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
NRG1
neuregulin 1
chr9_-_100881466 0.78 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr2_-_10587897 0.74 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr22_-_50964558 0.72 ENST00000535425.1
ENST00000439934.1
SCO2
SCO2 cytochrome c oxidase assembly protein
chr19_-_55652290 0.65 ENST00000589745.1
TNNT1
troponin T type 1 (skeletal, slow)
chr12_-_58165870 0.54 ENST00000257848.7
METTL1
methyltransferase like 1
chr8_+_99129513 0.54 ENST00000522319.1
ENST00000401707.2
POP1
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chr11_+_6624970 0.54 ENST00000420936.2
ENST00000528995.1
ILK
integrin-linked kinase
chr1_-_231376836 0.53 ENST00000451322.1
C1orf131
chromosome 1 open reading frame 131
chr3_+_133293278 0.49 ENST00000508481.1
ENST00000420115.2
ENST00000504867.1
ENST00000507408.1
ENST00000511392.1
ENST00000515421.1
CDV3
CDV3 homolog (mouse)
chr11_+_6625046 0.47 ENST00000396751.2
ILK
integrin-linked kinase
chr14_+_77924373 0.47 ENST00000216479.3
ENST00000535854.2
ENST00000555517.1
AHSA1
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr11_+_6624955 0.47 ENST00000299421.4
ENST00000537806.1
ILK
integrin-linked kinase
chr6_-_5260963 0.46 ENST00000464010.1
ENST00000468929.1
ENST00000480566.1
LYRM4
LYR motif containing 4
chr1_-_171621815 0.45 ENST00000037502.6
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr6_-_5261141 0.43 ENST00000330636.4
ENST00000500576.2
LYRM4
LYR motif containing 4
chr6_-_36842784 0.42 ENST00000373699.5
PPIL1
peptidylprolyl isomerase (cyclophilin)-like 1
chr17_+_33307503 0.42 ENST00000378526.4
ENST00000585941.1
ENST00000262327.5
ENST00000592690.1
ENST00000585740.1
LIG3
ligase III, DNA, ATP-dependent
chr7_-_100493744 0.42 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr14_+_73393040 0.40 ENST00000358377.2
ENST00000353777.3
ENST00000394234.2
ENST00000509153.1
ENST00000555042.1
DCAF4
DDB1 and CUL4 associated factor 4
chr17_-_10600818 0.40 ENST00000577427.1
ENST00000255390.5
SCO1
SCO1 cytochrome c oxidase assembly protein
chr19_+_35645618 0.40 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
FXYD5
FXYD domain containing ion transport regulator 5
chr7_+_28725585 0.39 ENST00000396298.2
CREB5
cAMP responsive element binding protein 5
chr5_+_172571445 0.35 ENST00000231668.9
ENST00000351486.5
ENST00000352523.6
ENST00000393770.4
BNIP1
BCL2/adenovirus E1B 19kDa interacting protein 1
chr1_+_213123915 0.34 ENST00000366968.4
ENST00000490792.1
VASH2
vasohibin 2
chr8_+_125985531 0.34 ENST00000319286.5
ZNF572
zinc finger protein 572
chr9_+_130565147 0.33 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
FPGS
folylpolyglutamate synthase
chr19_-_5719860 0.31 ENST00000590729.1
LONP1
lon peptidase 1, mitochondrial
chr6_+_70576457 0.31 ENST00000322773.4
COL19A1
collagen, type XIX, alpha 1
chr19_+_35645817 0.30 ENST00000423817.3
FXYD5
FXYD domain containing ion transport regulator 5
chr10_-_35379241 0.30 ENST00000374748.1
ENST00000374749.3
CUL2
cullin 2
chr18_+_580367 0.29 ENST00000327228.3
CETN1
centrin, EF-hand protein, 1
chr3_-_21792838 0.29 ENST00000281523.2
ZNF385D
zinc finger protein 385D
chr7_-_151574191 0.27 ENST00000287878.4
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr14_+_93389425 0.26 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr12_-_6677422 0.26 ENST00000382421.3
ENST00000545200.1
ENST00000399466.2
ENST00000536124.1
ENST00000540228.1
ENST00000542867.1
ENST00000545492.1
ENST00000322166.5
ENST00000545915.1
NOP2
NOP2 nucleolar protein
chr12_-_48298785 0.26 ENST00000550325.1
ENST00000546653.1
ENST00000549336.1
ENST00000535672.1
ENST00000229022.3
ENST00000548664.1
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor
chr6_+_13615554 0.24 ENST00000451315.2
NOL7
nucleolar protein 7, 27kDa
chr9_+_706842 0.24 ENST00000382293.3
KANK1
KN motif and ankyrin repeat domains 1
chr8_+_55047763 0.24 ENST00000260102.4
ENST00000519831.1
MRPL15
mitochondrial ribosomal protein L15
chr22_-_37505449 0.24 ENST00000406725.1
TMPRSS6
transmembrane protease, serine 6
chr9_-_95640218 0.23 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484
zinc finger protein 484
chr1_-_112046110 0.23 ENST00000369716.4
ADORA3
adenosine A3 receptor
chr19_-_45909585 0.22 ENST00000593226.1
ENST00000418234.2
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chrX_+_129040122 0.22 ENST00000394422.3
ENST00000371051.5
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr5_-_114880533 0.22 ENST00000274457.3
FEM1C
fem-1 homolog c (C. elegans)
chr6_-_136871957 0.22 ENST00000354570.3
MAP7
microtubule-associated protein 7
chr11_+_60609537 0.21 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr17_-_17109579 0.21 ENST00000321560.3
PLD6
phospholipase D family, member 6
chr1_-_112046289 0.21 ENST00000241356.4
ADORA3
adenosine A3 receptor
chr8_+_109455845 0.21 ENST00000220853.3
EMC2
ER membrane protein complex subunit 2
chr2_+_201676908 0.21 ENST00000409226.1
ENST00000452790.2
BZW1
basic leucine zipper and W2 domains 1
chr1_+_48688357 0.20 ENST00000533824.1
ENST00000438567.2
ENST00000236495.5
ENST00000420136.2
SLC5A9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr5_+_89770696 0.20 ENST00000504930.1
ENST00000514483.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chrX_+_129040094 0.19 ENST00000425117.2
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr22_-_50523760 0.19 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr10_-_35379524 0.19 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
CUL2
cullin 2
chr1_-_86174065 0.18 ENST00000370574.3
ENST00000431532.2
ZNHIT6
zinc finger, HIT-type containing 6
chr2_+_183989157 0.17 ENST00000541912.1
NUP35
nucleoporin 35kDa
chr1_-_43638168 0.17 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chrX_+_54556633 0.17 ENST00000336470.4
ENST00000360845.2
GNL3L
guanine nucleotide binding protein-like 3 (nucleolar)-like
chr5_+_89770664 0.17 ENST00000503973.1
ENST00000399107.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr1_+_207070775 0.16 ENST00000391929.3
ENST00000294984.2
ENST00000367093.3
IL24
interleukin 24
chr4_+_119200215 0.16 ENST00000602573.1
SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr8_-_11710979 0.16 ENST00000415599.2
CTSB
cathepsin B
chr22_-_30987849 0.16 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr11_-_6624801 0.16 ENST00000534343.1
ENST00000254605.6
RRP8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr12_-_55042140 0.15 ENST00000293371.6
ENST00000456047.2
DCD
dermcidin
chr2_+_183989083 0.15 ENST00000295119.4
NUP35
nucleoporin 35kDa
chr6_-_151773232 0.14 ENST00000444024.1
ENST00000367303.4
RMND1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr16_+_29911864 0.14 ENST00000308748.5
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr4_+_119199864 0.14 ENST00000602414.1
ENST00000602520.1
SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr1_-_43637915 0.14 ENST00000236051.2
EBNA1BP2
EBNA1 binding protein 2
chr2_+_207630081 0.14 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr20_+_23331373 0.14 ENST00000254998.2
NXT1
NTF2-like export factor 1
chr10_-_21435488 0.14 ENST00000534331.1
ENST00000529198.1
ENST00000377118.4
C10orf113
chromosome 10 open reading frame 113
chr14_+_22694606 0.13 ENST00000390463.3
TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr21_-_45079341 0.13 ENST00000443485.1
ENST00000291560.2
HSF2BP
heat shock transcription factor 2 binding protein
chr17_+_40811283 0.13 ENST00000251412.7
TUBG2
tubulin, gamma 2
chr22_-_30987837 0.13 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr9_+_37120536 0.12 ENST00000336755.5
ENST00000534928.1
ENST00000322831.6
ZCCHC7
zinc finger, CCHC domain containing 7
chr17_-_7193711 0.12 ENST00000571464.1
YBX2
Y box binding protein 2
chr19_-_3786253 0.12 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chr16_-_20362147 0.11 ENST00000396142.2
UMOD
uromodulin
chr4_+_119199904 0.11 ENST00000602483.1
ENST00000602819.1
SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr3_+_174577070 0.11 ENST00000454872.1
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr6_+_36410762 0.11 ENST00000483557.1
ENST00000498267.1
ENST00000544295.1
ENST00000449081.2
ENST00000536244.1
ENST00000460983.1
KCTD20
potassium channel tetramerization domain containing 20
chr1_+_213123976 0.10 ENST00000366965.2
ENST00000366967.2
VASH2
vasohibin 2
chr17_+_15635561 0.10 ENST00000584301.1
ENST00000580596.1
ENST00000464963.1
ENST00000437605.2
ENST00000579428.1
TBC1D26
TBC1 domain family, member 26
chr8_+_26240414 0.10 ENST00000380629.2
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr4_-_57301748 0.10 ENST00000264220.2
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr22_-_43411106 0.10 ENST00000453643.1
ENST00000263246.3
ENST00000337959.4
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr19_-_45953983 0.09 ENST00000592083.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr1_-_207095324 0.09 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr4_+_57301896 0.09 ENST00000514888.1
ENST00000264221.2
ENST00000505164.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr17_-_74733404 0.08 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2
serine/arginine-rich splicing factor 2
chr3_-_157217328 0.08 ENST00000392832.2
ENST00000543418.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr15_-_35088340 0.08 ENST00000290378.4
ACTC1
actin, alpha, cardiac muscle 1
chr1_+_118472343 0.08 ENST00000369441.3
ENST00000349139.5
WDR3
WD repeat domain 3
chr4_+_41983713 0.07 ENST00000333141.5
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr3_+_99536663 0.07 ENST00000421999.2
ENST00000463526.1
CMSS1
cms1 ribosomal small subunit homolog (yeast)
chr2_+_103236004 0.07 ENST00000233969.2
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr12_+_65004292 0.07 ENST00000542104.1
ENST00000336061.2
RASSF3
Ras association (RalGDS/AF-6) domain family member 3
chr22_-_38245304 0.07 ENST00000609454.1
ANKRD54
ankyrin repeat domain 54
chr17_+_36908984 0.06 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr1_-_231376867 0.06 ENST00000366649.2
ENST00000318906.2
ENST00000366651.3
C1orf131
chromosome 1 open reading frame 131
chrX_+_23685653 0.06 ENST00000379331.3
PRDX4
peroxiredoxin 4
chr6_-_109804412 0.06 ENST00000230122.3
ZBTB24
zinc finger and BTB domain containing 24
chr17_-_72772462 0.06 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr1_+_21835858 0.06 ENST00000539907.1
ENST00000540617.1
ENST00000374840.3
ALPL
alkaline phosphatase, liver/bone/kidney
chr13_-_38172863 0.06 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr12_-_54673871 0.06 ENST00000209875.4
CBX5
chromobox homolog 5
chr4_+_57302297 0.05 ENST00000399688.3
ENST00000512576.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr7_-_229557 0.05 ENST00000514988.1
AC145676.2
Uncharacterized protein
chr11_-_65626753 0.05 ENST00000526975.1
ENST00000531413.1
CFL1
cofilin 1 (non-muscle)
chr17_+_53046096 0.05 ENST00000376352.2
ENST00000299341.4
ENST00000405898.1
ENST00000434978.2
ENST00000398391.2
STXBP4
syntaxin binding protein 4
chr6_+_144164455 0.04 ENST00000367576.5
LTV1
LTV1 homolog (S. cerevisiae)
chr21_-_30391636 0.04 ENST00000493196.1
RWDD2B
RWD domain containing 2B
chr19_+_56154913 0.04 ENST00000270451.5
ENST00000588537.1
ZNF581
zinc finger protein 581
chr19_-_52133588 0.04 ENST00000570106.2
SIGLEC5
sialic acid binding Ig-like lectin 5
chr5_-_71616043 0.04 ENST00000508863.2
ENST00000522095.1
ENST00000513900.1
ENST00000515404.1
ENST00000457646.4
ENST00000261413.5
MRPS27
mitochondrial ribosomal protein S27
chr5_-_101834617 0.04 ENST00000513675.1
ENST00000379807.3
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr7_+_141463897 0.04 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr7_+_147830776 0.04 ENST00000538075.1
CNTNAP2
contactin associated protein-like 2
chr16_+_19729586 0.03 ENST00000564186.1
ENST00000541926.1
ENST00000433597.2
IQCK
IQ motif containing K
chr1_+_210001309 0.03 ENST00000491415.2
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr5_-_101834712 0.03 ENST00000506729.1
ENST00000389019.3
ENST00000379810.1
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr1_+_119957554 0.03 ENST00000543831.1
ENST00000433745.1
ENST00000369416.3
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr4_+_188916918 0.02 ENST00000509524.1
ENST00000326866.4
ZFP42
ZFP42 zinc finger protein
chrX_-_47518527 0.02 ENST00000333119.3
UXT
ubiquitously-expressed, prefoldin-like chaperone
chr3_+_111578583 0.02 ENST00000478922.1
ENST00000477695.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr2_-_47143160 0.02 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr16_+_29911666 0.02 ENST00000563177.1
ENST00000483405.1
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr14_-_102026643 0.01 ENST00000555882.1
ENST00000554441.1
ENST00000553729.1
ENST00000557109.1
ENST00000557532.1
ENST00000554694.1
ENST00000554735.1
ENST00000555174.1
ENST00000557661.1
DIO3OS
DIO3 opposite strand/antisense RNA (head to head)
chr6_+_31865552 0.01 ENST00000469372.1
ENST00000497706.1
C2
complement component 2
chr8_-_48872686 0.01 ENST00000314191.2
ENST00000338368.3
PRKDC
protein kinase, DNA-activated, catalytic polypeptide
chr11_-_65626797 0.01 ENST00000525451.2
CFL1
cofilin 1 (non-muscle)
chr16_+_4897912 0.01 ENST00000545171.1
UBN1
ubinuclein 1
chr5_+_94982435 0.01 ENST00000511684.1
ENST00000380005.4
RFESD
Rieske (Fe-S) domain containing
chr12_+_93861264 0.01 ENST00000549982.1
ENST00000361630.2
MRPL42
mitochondrial ribosomal protein L42
chr7_-_155326532 0.00 ENST00000406197.1
ENST00000321736.5
CNPY1
canopy FGF signaling regulator 1
chr17_-_8066843 0.00 ENST00000404970.3
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr19_+_7660716 0.00 ENST00000160298.4
ENST00000446248.2
CAMSAP3
calmodulin regulated spectrin-associated protein family, member 3
chr17_-_61850894 0.00 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr16_+_4897632 0.00 ENST00000262376.6
UBN1
ubinuclein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.4 1.5 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.3 1.1 GO:0031052 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.3 2.1 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.2 0.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.1 0.4 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 0.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.4 GO:1901859 base-excision repair, DNA ligation(GO:0006288) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.1 0.3 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.1 0.3 GO:0061110 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.3 GO:1904747 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.1 0.2 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.6 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.5 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 1.0 GO:0042048 olfactory behavior(GO:0042048)
0.1 1.0 GO:0042117 monocyte activation(GO:0042117)
0.1 1.1 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 1.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.3 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0009386 translational attenuation(GO:0009386)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.2 GO:0010635 regulation of mitochondrial fusion(GO:0010635)
0.0 0.2 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.3 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.8 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.4 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.1 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.4 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 1.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 1.6 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.3 GO:0072584 caveolin-mediated endocytosis(GO:0072584)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.1 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.3 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.0 GO:0071109 superior temporal gyrus development(GO:0071109)
0.0 0.3 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.5 GO:0030891 VCB complex(GO:0030891)
0.1 1.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.5 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 0.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.4 GO:0030430 host cell cytoplasm(GO:0030430) host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648) host cell cytoplasm part(GO:0033655)
0.0 0.3 GO:0070545 PeBoW complex(GO:0070545)
0.0 1.6 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.5 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 0.2 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.2 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.4 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.3 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.3 1.1 GO:0035501 MH1 domain binding(GO:0035501)
0.2 1.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.3 GO:0070364 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.1 0.4 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 1.6 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.3 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 0.7 GO:0004645 phosphorylase activity(GO:0004645)
0.1 0.3 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.3 GO:0038181 bile acid receptor activity(GO:0038181) vitamin D response element binding(GO:0070644)
0.0 0.6 GO:0031014 troponin T binding(GO:0031014)
0.0 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.4 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.5 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.4 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 1.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 3.2 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.7 GO:0017080 sodium channel regulator activity(GO:0017080)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.5 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR