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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for BRCA1

Z-value: 0.39

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.15 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277467_41277510-0.311.4e-01Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_173020056 1.32 ENST00000239468.2
ENST00000404377.3
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr15_+_67430339 1.11 ENST00000439724.3
SMAD3
SMAD family member 3
chr2_+_108994633 0.80 ENST00000409309.3
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr2_+_108994466 0.75 ENST00000272452.2
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr17_-_41739283 0.70 ENST00000393661.2
ENST00000318579.4
MEOX1
mesenchyme homeobox 1
chr17_-_41738931 0.69 ENST00000329168.3
ENST00000549132.1
MEOX1
mesenchyme homeobox 1
chr7_+_44646162 0.48 ENST00000439616.2
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr1_-_160232312 0.45 ENST00000440682.1
DCAF8
DDB1 and CUL4 associated factor 8
chr12_-_117318788 0.43 ENST00000550505.1
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr17_+_74372662 0.41 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr8_+_22022800 0.38 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chr10_-_36813162 0.38 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr11_-_119234876 0.35 ENST00000525735.1
USP2
ubiquitin specific peptidase 2
chr10_+_28822636 0.35 ENST00000442148.1
ENST00000448193.1
WAC
WW domain containing adaptor with coiled-coil
chr3_-_127455200 0.33 ENST00000398101.3
MGLL
monoglyceride lipase
chr18_+_19749386 0.32 ENST00000269216.3
GATA6
GATA binding protein 6
chr12_-_95510743 0.31 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr2_+_203879568 0.28 ENST00000449802.1
NBEAL1
neurobeachin-like 1
chr8_-_72459885 0.26 ENST00000523987.1
RP11-1102P16.1
Uncharacterized protein
chr10_+_104404644 0.25 ENST00000462202.2
TRIM8
tripartite motif containing 8
chr18_+_55888767 0.24 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr5_+_139027877 0.22 ENST00000302517.3
CXXC5
CXXC finger protein 5
chr19_+_46850320 0.22 ENST00000391919.1
PPP5C
protein phosphatase 5, catalytic subunit
chr9_+_135457530 0.21 ENST00000263610.2
BARHL1
BarH-like homeobox 1
chr19_+_46850251 0.20 ENST00000012443.4
PPP5C
protein phosphatase 5, catalytic subunit
chr18_-_23671139 0.19 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr19_+_55888186 0.18 ENST00000291934.3
TMEM190
transmembrane protein 190
chr6_+_42981922 0.18 ENST00000326974.4
ENST00000244670.8
KLHDC3
kelch domain containing 3
chr17_-_27230035 0.18 ENST00000378895.4
ENST00000394901.3
DHRS13
dehydrogenase/reductase (SDR family) member 13
chr10_-_95504 0.18 ENST00000447903.2
TUBB8
tubulin, beta 8 class VIII
chr7_+_44646177 0.18 ENST00000443864.2
ENST00000447398.1
ENST00000449767.1
ENST00000419661.1
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr1_+_10271674 0.17 ENST00000377086.1
KIF1B
kinesin family member 1B
chr6_+_12717892 0.17 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chrX_+_10124977 0.17 ENST00000380833.4
CLCN4
chloride channel, voltage-sensitive 4
chr17_+_36584662 0.16 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr8_-_81083341 0.15 ENST00000519303.2
TPD52
tumor protein D52
chr17_-_60142609 0.15 ENST00000397786.2
MED13
mediator complex subunit 13
chr2_-_158182410 0.15 ENST00000419116.2
ENST00000410096.1
ERMN
ermin, ERM-like protein
chr19_-_48059113 0.15 ENST00000391901.3
ENST00000314121.4
ENST00000448976.1
ZNF541
zinc finger protein 541
chr11_-_71823266 0.14 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chrX_-_70288234 0.13 ENST00000276105.3
ENST00000374274.3
SNX12
sorting nexin 12
chr4_+_619347 0.11 ENST00000255622.6
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr10_-_95209 0.10 ENST00000332708.5
ENST00000309812.4
TUBB8
tubulin, beta 8 class VIII
chr19_-_40324767 0.10 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr12_-_12491608 0.10 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr12_-_117319236 0.10 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr13_+_30002846 0.09 ENST00000542829.1
MTUS2
microtubule associated tumor suppressor candidate 2
chr19_+_45394477 0.09 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_-_160232291 0.09 ENST00000368074.1
ENST00000447377.1
DCAF8
DDB1 and CUL4 associated factor 8
chr1_-_160232197 0.08 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
DCAF8
DDB1 and CUL4 associated factor 8
chr5_-_68665084 0.08 ENST00000509462.1
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr2_-_179914760 0.08 ENST00000420890.2
ENST00000409284.1
ENST00000443758.1
ENST00000446116.1
CCDC141
coiled-coil domain containing 141
chr20_-_48530230 0.07 ENST00000422556.1
SPATA2
spermatogenesis associated 2
chr2_+_223725652 0.06 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr8_+_22022653 0.06 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr6_-_66417107 0.06 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr15_-_58358607 0.06 ENST00000249750.4
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chrX_+_49644470 0.05 ENST00000508866.2
USP27X
ubiquitin specific peptidase 27, X-linked
chr7_+_99717230 0.05 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr12_-_122879969 0.05 ENST00000540304.1
CLIP1
CAP-GLY domain containing linker protein 1
chr8_-_16859690 0.05 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr10_-_69597810 0.05 ENST00000483798.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr7_-_99716952 0.04 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr17_+_21730180 0.04 ENST00000584398.1
UBBP4
ubiquitin B pseudogene 4
chr7_-_23510086 0.04 ENST00000258729.3
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr14_+_103058948 0.04 ENST00000262241.6
RCOR1
REST corepressor 1
chr6_-_137314371 0.04 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
RP11-55K22.5
chr20_+_52105495 0.04 ENST00000439873.2
AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr14_-_94942548 0.03 ENST00000298845.7
SERPINA9
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
chr20_+_31749574 0.03 ENST00000253362.2
BPIFA2
BPI fold containing family A, member 2
chr15_-_88799948 0.03 ENST00000394480.2
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr1_-_227505289 0.03 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr6_+_33172407 0.03 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr5_+_140079919 0.03 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chr6_+_123100620 0.02 ENST00000368444.3
FABP7
fatty acid binding protein 7, brain
chr14_-_94942527 0.02 ENST00000448305.2
SERPINA9
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
chr2_-_134326009 0.02 ENST00000409261.1
ENST00000409213.1
NCKAP5
NCK-associated protein 5
chr1_-_232598163 0.01 ENST00000308942.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr17_-_42019836 0.01 ENST00000225992.3
PPY
pancreatic polypeptide
chr10_-_102289611 0.01 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NDUFB8
SEC31B
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr13_-_50018241 0.01 ENST00000409308.1
CAB39L
calcium binding protein 39-like
chr12_-_49418407 0.01 ENST00000526209.1
KMT2D
lysine (K)-specific methyltransferase 2D
chr14_-_75179774 0.00 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr3_+_184056614 0.00 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chr4_-_48782259 0.00 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRYL
FRY-like
chr3_-_176914238 0.00 ENST00000430069.1
ENST00000428970.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:2000329 negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.2 1.4 GO:0061056 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.2 1.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.4 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.7 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.1 0.3 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 0.3 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1 0.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.3 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.1 1.5 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.2 GO:1904647 response to rotenone(GO:1904647)
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.5 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.4 GO:0001502 cartilage condensation(GO:0001502) high-density lipoprotein particle assembly(GO:0034380)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.4 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.2 GO:0002079 inner acrosomal membrane(GO:0002079)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 0.7 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 0.4 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis