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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for BRCA1
Z-value: 0.39
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Transcription factors associated with BRCA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BRCA1 | hg19_v2_chr17_-_41277467_41277510 | -0.31 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_173020056 Show fit | 1.32 |
ENST00000239468.2
ENST00000404377.3 |
tumor necrosis factor (ligand) superfamily, member 18 |
|
| chr15_+_67430339 Show fit | 1.11 |
ENST00000439724.3
|
SMAD family member 3 |
|
| chr2_+_108994633 Show fit | 0.80 |
ENST00000409309.3
|
sulfotransferase family, cytosolic, 1C, member 4 |
|
| chr2_+_108994466 Show fit | 0.75 |
ENST00000272452.2
|
sulfotransferase family, cytosolic, 1C, member 4 |
|
| chr17_-_41739283 Show fit | 0.70 |
ENST00000393661.2
ENST00000318579.4 |
mesenchyme homeobox 1 |
|
| chr17_-_41738931 Show fit | 0.69 |
ENST00000329168.3
ENST00000549132.1 |
mesenchyme homeobox 1 |
|
| chr7_+_44646162 Show fit | 0.48 |
ENST00000439616.2
|
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
|
| chr1_-_160232312 Show fit | 0.45 |
ENST00000440682.1
|
DDB1 and CUL4 associated factor 8 |
|
| chr12_-_117318788 Show fit | 0.43 |
ENST00000550505.1
|
harakiri, BCL2 interacting protein (contains only BH3 domain) |
|
| chr17_+_74372662 Show fit | 0.41 |
ENST00000591651.1
ENST00000545180.1 |
sphingosine kinase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BRCA1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.2 | 1.4 | GO:0061056 | somite specification(GO:0001757) sclerotome development(GO:0061056) |
| 0.3 | 1.3 | GO:2000329 | negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
| 0.2 | 1.1 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.1 | 0.7 | GO:0061034 | olfactory bulb mitral cell layer development(GO:0061034) |
| 0.0 | 0.5 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.1 | 0.4 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.1 | 0.4 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.0 | 0.4 | GO:0001502 | cartilage condensation(GO:0001502) high-density lipoprotein particle assembly(GO:0034380) |
| 0.1 | 0.3 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 0.7 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 0.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 0.4 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 0.3 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.2 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.0 | 0.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.1 | 1.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 1.1 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.2 | 0.7 | GO:0034602 | oxoglutarate dehydrogenase (NAD+) activity(GO:0034602) |
| 0.1 | 0.4 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.0 | 0.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.2 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.4 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |