Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for CBFB

Z-value: 0.42

Motif logo

logo of

Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
CBFB
ENSG00000067955.9 core-binding factor subunit beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67063142_670631530.395.6e-02Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_131409476 2.05 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr5_+_35856951 1.36 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr2_+_103035102 1.17 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr8_+_104384616 1.09 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chrX_+_68048803 0.97 ENST00000204961.4
EFNB1
ephrin-B1
chr21_-_36421535 0.82 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
RUNX1
runt-related transcription factor 1
chr21_-_36421626 0.80 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr14_-_85996332 0.65 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr3_-_189840223 0.59 ENST00000427335.2
LEPREL1
leprecan-like 1
chr6_+_29068386 0.54 ENST00000377171.3
OR2J1
olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chr9_-_130541017 0.46 ENST00000314830.8
SH2D3C
SH2 domain containing 3C
chr17_+_32582293 0.43 ENST00000580907.1
ENST00000225831.4
CCL2
chemokine (C-C motif) ligand 2
chr6_+_45296391 0.42 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr13_-_28674693 0.39 ENST00000537084.1
ENST00000241453.7
ENST00000380982.4
FLT3
fms-related tyrosine kinase 3
chr1_+_89246647 0.34 ENST00000544045.1
PKN2
protein kinase N2
chr12_+_15125954 0.30 ENST00000266395.2
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr8_-_134072593 0.30 ENST00000427060.2
SLA
Src-like-adaptor
chr8_-_96281419 0.29 ENST00000286688.5
C8orf37
chromosome 8 open reading frame 37
chr3_-_11610255 0.29 ENST00000424529.2
VGLL4
vestigial like 4 (Drosophila)
chr1_+_209859510 0.28 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr6_-_75912508 0.27 ENST00000416123.2
COL12A1
collagen, type XII, alpha 1
chr1_-_52499443 0.24 ENST00000371614.1
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr6_+_42847649 0.23 ENST00000424341.2
ENST00000602561.1
RPL7L1
ribosomal protein L7-like 1
chr9_+_15422702 0.21 ENST00000380821.3
ENST00000421710.1
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr15_+_73976545 0.20 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
CD276
CD276 molecule
chr2_-_105030466 0.19 ENST00000449772.1
AC068535.3
AC068535.3
chr11_-_58343319 0.19 ENST00000395074.2
LPXN
leupaxin
chr4_+_74347400 0.18 ENST00000226355.3
AFM
afamin
chr2_-_64881018 0.18 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr4_+_88896819 0.18 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr7_+_120628731 0.18 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr5_-_137878887 0.17 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr3_+_132843652 0.17 ENST00000508711.1
TMEM108
transmembrane protein 108
chr11_-_9781068 0.16 ENST00000500698.1
RP11-540A21.2
RP11-540A21.2
chr19_-_14048804 0.14 ENST00000254320.3
ENST00000586075.1
PODNL1
podocan-like 1
chrX_-_49041242 0.14 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chr14_-_61116168 0.14 ENST00000247182.6
SIX1
SIX homeobox 1
chr20_+_62492566 0.14 ENST00000369916.3
ABHD16B
abhydrolase domain containing 16B
chr1_-_157014865 0.13 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr14_-_59951112 0.12 ENST00000247194.4
L3HYPDH
L-3-hydroxyproline dehydratase (trans-)
chr22_+_42665742 0.12 ENST00000332965.3
ENST00000415205.1
ENST00000446578.1
Z83851.3
Z83851.3
chr10_-_29811456 0.12 ENST00000535393.1
SVIL
supervillin
chr11_-_64885111 0.12 ENST00000528598.1
ENST00000310597.4
ZNHIT2
zinc finger, HIT-type containing 2
chr19_-_14049184 0.12 ENST00000339560.5
PODNL1
podocan-like 1
chr1_-_184006829 0.12 ENST00000361927.4
COLGALT2
collagen beta(1-O)galactosyltransferase 2
chr12_-_4754339 0.12 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr5_-_108745689 0.11 ENST00000361189.2
PJA2
praja ring finger 2, E3 ubiquitin protein ligase
chr15_+_49715293 0.11 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr12_-_53594227 0.10 ENST00000550743.2
ITGB7
integrin, beta 7
chr6_+_27925019 0.10 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr11_-_66103867 0.09 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr4_-_156297949 0.08 ENST00000515654.1
MAP9
microtubule-associated protein 9
chr3_+_157154578 0.08 ENST00000295927.3
PTX3
pentraxin 3, long
chr14_-_59950724 0.08 ENST00000481608.1
L3HYPDH
L-3-hydroxyproline dehydratase (trans-)
chr19_+_10541462 0.07 ENST00000293683.5
PDE4A
phosphodiesterase 4A, cAMP-specific
chr4_+_71091786 0.07 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr20_+_44637526 0.06 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr6_-_34524049 0.06 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr11_-_66103932 0.06 ENST00000311320.4
RIN1
Ras and Rab interactor 1
chr14_+_22748980 0.05 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr2_-_207024233 0.04 ENST00000423725.1
ENST00000233190.6
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr6_+_52051171 0.04 ENST00000340057.1
IL17A
interleukin 17A
chr15_+_64386261 0.03 ENST00000560829.1
SNX1
sorting nexin 1
chr8_+_67624653 0.03 ENST00000521198.2
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr21_-_36421401 0.02 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr6_-_34524093 0.02 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr11_-_66104237 0.01 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr1_-_240775447 0.00 ENST00000318160.4
GREM2
gremlin 2, DAN family BMP antagonist
chr20_+_43343886 0.00 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr5_+_131396222 0.00 ENST00000296870.2
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr9_-_123342415 0.00 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
CDK5RAP2
CDK5 regulatory subunit associated protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.2 1.1 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.1 0.4 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 1.4 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 1.6 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.2 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.1 0.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.4 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.2 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.2 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 1.0 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.1 GO:0060480 lung goblet cell differentiation(GO:0060480)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.1 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 0.4 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.2 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.0 0.2 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.0 1.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.5 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.1 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression