ISMARA results: CDC5L

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for CDC5L

Z-value: 0.65

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Transcription factors associated with CDC5L

Gene Symbol	Gene ID	Gene Info
CDC5L Ensembl NCBI GeneCards UniProt NextProt	ENSG00000096401.7	cell division cycle 5 like

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CDC5L	hg19_v2_chr6_+_44355257_44355315	-0.09	6.8e-01	Click!

Activity profile of CDC5L motif

Sorted Z-values of CDC5L motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_74606223 Show fit	2.44	ENST00000307407.3 ENST00000401931.1	IL8 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 8
chr15_+_62359175 Show fit	2.22	ENST00000355522.5	C2CD4A Ensembl NCBI GeneCards UniProt NextProt Show fit	C2 calcium-dependent domain containing 4A
chr5_-_61031495 Show fit	2.22	ENST00000506550.1 ENST00000512882.2	CTD-2170G1.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTD-2170G1.2
chr2_+_102721023 Show fit	2.15	ENST00000409589.1 ENST00000409329.1	IL1R1 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 1 receptor, type I
chr2_+_228678550 Show fit	2.03	ENST00000409189.3 ENST00000358813.4	CCL20 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 20
chr14_+_22458631 Show fit	1.80	ENST00000390444.1	TRAV16 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 16
chr21_+_43619796 Show fit	1.75	ENST00000398457.2	ABCG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATP-binding cassette, sub-family G (WHITE), member 1
chr11_-_102651343 Show fit	1.73	ENST00000279441.4 ENST00000539681.1	MMP10 Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix metallopeptidase 10 (stromelysin 2)
chr5_+_118690466 Show fit	1.44	ENST00000503646.1	TNFAIP8 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor, alpha-induced protein 8
chr3_-_127541194 Show fit	1.43	ENST00000453507.2	MGLL Ensembl NCBI GeneCards UniProt NextProt Show fit	monoglyceride lipase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CDC5L

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.2	GO:0030574	collagen catabolic process(GO:0030574)
0.4	2.3	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.7	2.2	GO:2000661	positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.7	2.0	GO:0045362	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.4	1.8	GO:0055099	detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
0.0	1.5	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.2	1.4	GO:2000124	regulation of endocannabinoid signaling pathway(GO:2000124)
0.0	1.4	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3	1.3	GO:0035880	embryonic nail plate morphogenesis(GO:0035880)
0.1	1.3	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)

Showing 1 to 10 of 120 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.3	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	1.5	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	1.2	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	1.2	GO:0031941	filamentous actin(GO:0031941)
0.1	1.0	GO:0036021	endolysosome lumen(GO:0036021)
0.1	1.0	GO:0030478	actin cap(GO:0030478)
0.0	0.8	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.8	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.1	0.7	GO:0005577	fibrinogen complex(GO:0005577)
0.2	0.6	GO:0097489	multivesicular body, internal vesicle lumen(GO:0097489)

Showing 1 to 10 of 50 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	GO:0031489	myosin V binding(GO:0031489)
0.5	2.2	GO:0004909	interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0	2.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.7	2.0	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
0.0	2.0	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.6	1.8	GO:0034041	sterol-transporting ATPase activity(GO:0034041)
0.1	1.4	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.3	1.3	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.1	1.3	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.1	1.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)

Showing 1 to 10 of 90 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.0	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	2.6	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	1.8	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.8	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	1.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.8	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.0	0.7	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.7	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	3.2	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	2.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	1.8	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	1.8	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	1.7	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	1.6	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	1.5	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	1.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	1.0	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling

Showing 1 to 10 of 26 entries

Results for CDC5L

Z-value: 0.65

Motif logo

Transcription factors associated with CDC5L

Activity-expression correlation:

Activity profile of CDC5L motif

Sorted Z-values of CDC5L motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CDC5L

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: