ISMARA results: CDX1

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for CDX1

Z-value: 0.69

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Transcription factors associated with CDX1

Gene Symbol	Gene ID	Gene Info
CDX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000113722.12	caudal type homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CDX1	hg19_v2_chr5_+_149546334_149546364	-0.22	2.9e-01	Click!

Activity profile of CDX1 motif

Sorted Z-values of CDX1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_52779433 Show fit	3.00	ENST00000257951.3	KRT84 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 84
chr16_-_18887627 Show fit	1.16	ENST00000563235.1	SMG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SMG1 phosphatidylinositol 3-kinase-related kinase
chr7_+_79765071 Show fit	0.80	ENST00000457358.2	GNAI1 Ensembl NCBI GeneCards UniProt NextProt Show fit	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr12_+_8995832 Show fit	0.68	ENST00000541459.1	A2ML1 Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha-2-macroglobulin-like 1
chr12_-_9268707 Show fit	0.60	ENST00000318602.7	A2M Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha-2-macroglobulin
chr11_+_7618413 Show fit	0.60	ENST00000528883.1	PPFIBP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_+_47489240 Show fit	0.58	ENST00000371901.3	CYP4X1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 4, subfamily X, polypeptide 1
chr14_+_65878565 Show fit	0.56	ENST00000556518.1 ENST00000557164.1	FUT8 Ensembl NCBI GeneCards UniProt NextProt Show fit	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr6_+_116832789 Show fit	0.56	ENST00000368599.3	FAM26E Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 26, member E
chr12_+_19358228 Show fit	0.50	ENST00000424268.1 ENST00000543806.1	PLEKHA5 Ensembl NCBI GeneCards UniProt NextProt Show fit	pleckstrin homology domain containing, family A member 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.0	GO:0035878	nail development(GO:0035878)
0.1	0.9	GO:0097338	response to clozapine(GO:0097338)
0.1	0.8	GO:1904322	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1	0.7	GO:0031284	positive regulation of guanylate cyclase activity(GO:0031284)
0.0	0.7	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0	0.7	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.2	0.6	GO:0036071	N-glycan fucosylation(GO:0036071)
0.1	0.6	GO:0035583	sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0	0.6	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	0.6	GO:0050667	homocysteine metabolic process(GO:0050667)

Showing 1 to 10 of 86 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0045095	keratin filament(GO:0045095)
0.0	1.2	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	1.1	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	1.0	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.9	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.8	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.0	0.7	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.6	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	0.5	GO:0005605	basal lamina(GO:0005605)
0.0	0.4	GO:0032591	dendritic spine membrane(GO:0032591)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.0	GO:0030280	structural constituent of epidermis(GO:0030280)
0.0	1.2	GO:0042162	telomeric DNA binding(GO:0042162)
0.1	1.0	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.1	0.9	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.8	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.8	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	0.7	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.7	GO:0005132	type I interferon receptor binding(GO:0005132)
0.2	0.6	GO:0019959	interleukin-8 binding(GO:0019959)
0.2	0.6	GO:0046921	glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)

Showing 1 to 10 of 52 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.9	PID IL3 PATHWAY	IL3-mediated signaling events
0.8	PID S1P S1P4 PATHWAY	S1P4 pathway
0.7	PID CONE PATHWAY	Visual signal transduction: Cones
0.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
1.2	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.9	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.8	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.8	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.6	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.6	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters

Showing 1 to 10 of 11 entries

Results for CDX1

Z-value: 0.69

Motif logo

Transcription factors associated with CDX1

Activity-expression correlation:

Activity profile of CDX1 motif

Sorted Z-values of CDX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: